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  • The mobile element that conveys methicillin resistance to staph includes a gene that encodes for Cch. Learn more about Phoebe Rice's Chicago lab.

  • AlkD (grey) crystal structure bound to DNA containing 3-deaza-3-methyldeoxyadenosine (light green), from Brandt Eichman. Read the full story.

  • Jalview Developer Geoff Barton's desk with the JalviewAbacus (right) and displayed a dendrogram (tree) for the set of sequences shown in the alignment, using Jalview linked to Chimera. Read the full story here.

  • The Project MAC display system, circa 1965. Read more about the history of molecular graphics software and UCSF Chimera in our SBGrid Tale featuring Bob Langridge and Tom Ferrin.

  • You'll find SBGrid in ~350 structural biology labs located at over 100 different institutions in about 20 countries around the world. See full map and read more in eLIFE.

  • Daniel Panne's group, which relocated in 2018 to the University of Leicester, looks at the language of gene regulation and visualizes the catalytic core of p300. Read the full story.

  • The SBGrid Consortium provides structural biologists worldwide with access to the software they need to discover the shapes of the molecules of life. Read more in eLIFE.

  • The AdipoR2 structure revealing the presence of a bound fatty acid at a zinc binding site, from Sebastien Granier's lab at the French National Institute of Health and Medical Research (INSERM), Institut de Génomique Fonctionnelle, Montpellier France. Read more.

  • Tom Rapoport's group at Harvard Medical School captured the crystal structure of the active translocon being pushed through the hourglass-shaped SecY protein-conducting channel. You can find out more about the science and learn some personal history in our Member Tale.

  • The first high-resolution (2.8 Å) X-ray crystal structure of the transcription initiation complex of Mycobacterium smegmatis, from the laboratory of Seth Darst at Rockefeller University.

    Image courtesy of E. Campbell.

  • In traditional X-ray crystallography, X-rays bombard 1 crystal 100s of times. This syringe, developed for a dynamic temperature experiment in James Fraser's lab at UCSF, shoots 1,000s of crystals into an X-ray-free electron laser beam, one at a time. Learn more.

    Image courtesy of Alexander Wolff.

Recent Software Updates

Feb 20 | DeepEMhancer

(Deep cryo-EM Map Enhancer) a python package designed to perform non-linear post-processing of cryo-EM maps for local sharpening, automatic… >>

Feb 15 | NMRViewJ

used to visualize and Analyze Nuclear Magnetic Resonance Data. >>

Feb 15 | BUSTER

a software system containing crystallographic structure refinement using Bayesian statistical methods (BUSTER), ligand fitting (rhofit) and… >>

Feb 15 | autoPROC

combines third-party processing programs with new tools for automated data processing of single-sweep, multi-sweep and multi-crystal X-ray … >>

Feb 14 | Situs

a program package for modeling of atomic resolution structures into low-resolution density maps. The software supports both rigid-body and … >>

Feb 14 | OccuPy

a fast and simple python module and program to estimate local scaling of cryo-EM maps, to approximate relative occupancy and/or resolution,… >>

Feb 13 | POKY

a software suite for multidimensional NMR and 3D structure calculation of biomolecules. >>

Thanks to the National Science Foundation

With partial support from the NIH R25 Continuing Education for Structural Biology Mentors #GM151273, in collaboration with Co-PI Jamaine Davis; the NSF Research Coordination Network MCB #0639193, and NSF EAGER #1448069. Please cite SBGrid's eLife paper and follow our publication guidelines.

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SBGrid Webinar Series

Join us for our Software Webinar Series - Tuesdays at 12pm ET - to hear from software developers about what's new in structural biology. Community members connect via Zoom. Subscribe …

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The Crystal Whisperer

In structural biology. there are few more onerous tasks than coaxing reluctant proteins into crystals. “Unfortunately, that is really a huge bottleneck,” says Sarah E.J. Bowman, who heads the National …

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Data in Motion

For nearly a century, protein crystallography has focused on certain X-ray signals to reveal the atomic architecture of proteins. But even a structure solved to the reigning gold standard of …

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