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99 Member Publications for April

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COVID-19: Famotidine, Histamine, Mast Cells, and Mechanisms.
1. Front Pharmacol - published April 9, 2021
2. Malone RW, Tisdall P, Fremont-Smith P, Liu Y, Huang XP, White KM, Miorin L, Moreno E, Alon A, Delaforge E, Hennecker CD, Wang G, Pottel J, Blair RV, Roy CJ, Smith N, Hall JM, Tomera KM, Shapiro G, Mittermaier A, Kruse AC, García-Sastre A, Roth BL, Glasspool-Malone J, Ricke DO
Silencing of Oncogenic KRAS by Mutant-Selective Small Interfering RNA.
1. ACS Pharmacol Transl Sci - published April 9, 2021
2. Papke B, Azam SH, Feng AY, Gutierrez-Ford C, Huggins H, Pallan PS, Van Swearingen AED, Egli M, Cox AD, Der CJ, Pecot CV
Variations outside the conserved motifs of PB1 catalytic active site may affect replication efficiency of the RNP complex of influenza A virus.
1. Virology - published April 9, 2021
2. Waters K, Wan HJ, Han L, Xue J, Ykema M, Tao YJ, Wan XF
Caught in Action: X-ray Structure of Thymidylate Synthase with Noncovalent Intermediate Analog.
1. Biochemistry - published April 8, 2021
2. Kholodar SA, Finer-Moore JS, Świderek K, Arafet K, Moliner V, Stroud RM, Kohen A
Enzymatic bypass and the structural basis of miscoding opposite the DNA adduct 1,N²-ethenodeoxyguanosine by human DNA translesion polymerase η.
1. J Biol Chem - published April 8, 2021
2. Ghodke PP, Mali JR, Patra A, Rizzo CJ, Guengerich FP, Egli M
Current opinion on risk assessment of cosmetics.
1. J Toxicol Environ Health B Crit Rev - published April 8, 2021
2. Kim KB, Kwack SJ, Lee JY, Kacew S, Lee BM
A biphenyl inhibitor of eIF4E targeting an internal binding site enables the design of cell-permeable PROTAC-degraders.
1. Eur J Med Chem - published April 8, 2021
2. Fischer PD, Papadopoulos E, Dempersmier JM, Wang ZF, Nowak RP, Donovan KA, Kalabathula J, Gorgulla C, Junghanns PPM, Kabha E, Dimitrakakis N, Petrov OI, Mitsiades C, Ducho C, Gelev V, Fischer ES, Wagner G, Arthanari H
The C99 domain of the amyloid precursor protein resides in the disordered membrane phase.
1. J Biol Chem - published April 8, 2021
2. Capone R, Tiwari A, Hadziselimovic A, Peskova Y, Hutchison JM, Sanders CR, Kenworthy AK
DNAJC9 integrates heat shock molecular chaperones into the histone chaperone network.
1. Mol Cell - published April 8, 2021
2. Hammond CM, Bao H, Hendriks IA, Carraro M, García-Nieto A, Liu Y, Reverón-Gómez N, Spanos C, Chen L, Rappsilber J, Nielsen ML, Patel DJ, Huang H, Groth A
XFEL Crystal Structures of Peroxidase Compound II.
1. Angew Chem Int Ed Engl - published April 7, 2021
2. Kwon H, Basran J, Pathak C, Hussain M, Freeman SL, Fielding AJ, Bailey AJ, Stefanou N, Sparkes HA, Tosha T, Yamashita K, Hirata K, Murakami H, Ueno G, Ago H, Tono K, Yamamoto M, Sawai H, Shiro Y, Sugimoto H, Raven E, Moody PCE
Rational engraftment of quaternary-interactive acidic loops for anti-HIV-1 antibody improvement.
1. J Virol - published April 7, 2021
2. Liu Q, Zhang P, Miao H, Lin Y, Kwon YD, Kwong PD, Rikhtegaran-Tehrani Z, Seaman MS, DeVico AL, Sajadi MM, Lusso P
Prefusion F-Based Polyanhydride Nanovaccine Induces Both Humoral and Cell-Mediated Immunity Resulting in Long-Lasting Protection against Respiratory Syncytial Virus.
1. J Immunol - published April 7, 2021
2. Stephens LM, Ross KA, Waldstein KA, Legge KL, McLellan JS, Narasimhan B, Varga SM
Substrate discrimination and quality control require each catalytic activity of TRAMP and the nuclear RNA exosome.
1. Proc Natl Acad Sci U S A - published April 6, 2021
2. Das M, Zattas D, Zinder JC, Wasmuth EV, Henri J, Lima CD
Mapping temperature-dependent conformational change in the voltage-sensing domain of an engineered heat-activated K⁺ channel.
1. Proc Natl Acad Sci U S A - published April 6, 2021
2. Chen H, Deng J, Cui Q, Chanda B, Henzler-Wildman K
The mechanistic basis of protection by non-neutralizing anti-alphavirus antibodies.
1. Cell Rep - published April 6, 2021
2. Earnest JT, Holmes AC, Basore K, Mack M, Fremont DH, Diamond MS
Potent neutralization of Rift Valley fever virus by human monoclonal antibodies through fusion inhibition.
1. Proc Natl Acad Sci U S A - published April 6, 2021
2. Chapman NS, Zhao H, Kose N, Westover JB, Kalveram B, Bombardi R, Rodriguez J, Sutton R, Genualdi J, LaBeaud AD, Mutuku FM, Pittman PR, Freiberg AN, Gowen BB, Fremont DH, Crowe JE Jr
Discovery and characterization of a novel family of prokaryotic nanocompartments involved in sulfur metabolism.
1. Elife - published April 6, 2021
2. Nichols RJ, LaFrance B, Phillips NR, Radford DR, Oltrogge LM, Valentin-Alvarado LE, Bischoff AJ, Nogales E, Savage DF
Fusion peptide priming reduces immune responses to HIV-1 envelope trimer base.
1. Cell Rep - published April 6, 2021
2. Corrigan AR, Duan H, Cheng C, Gonelli CA, Ou L, Xu K, DeMouth ME, Geng H, Narpala S, O'Connell S, Zhang B, Zhou T, Basappa M, Boyington JC, Chen SJ, O'Dell S, Pegu A, Stephens T, Tsybovsky Y, van Schooten J, Todd JP, Wang S, VRC Production Program., Doria-Rose NA, Foulds KE, Koup RA, McDermott AB, van Gils MJ, Kwong PD, Mascola JR
Experimental evaluation of super-resolution imaging and magnification choice in single-particle cryo-EM.
1. J Struct Biol X - published April 5, 2021
2. Feathers JR, Spoth KA, Fromme JC
MENSAdb: a thorough structural analysis of membrane protein dimers.
1. Database (Oxford) - published April 5, 2021
2. Matos-Filipe P, Preto AJ, Koukos PI, Mourão J, Bonvin AMJJ, Moreira IS
Targeted Quantification of Detergent-Insoluble RNA-Binding Proteins in Human Brain Reveals Stage and Disease Specific Co-aggregation in Alzheimer's Disease.
1. Front Mol Neurosci - published April 5, 2021
2. Guo Q, Dammer EB, Zhou M, Kundinger SR, Gearing M, Lah JJ, Levey AI, Shulman JM, Seyfried NT
The neutralizing antibody, LY-CoV555, protects against SARS-CoV-2 infection in non-human primates.
1. Sci Transl Med - published April 5, 2021
2. Jones BE, Brown-Augsburger PL, Corbett KS, Westendorf K, Davies J, Cujec TP, Wiethoff CM, Blackbourne JL, Heinz BA, Foster D, Higgs RE, Balasubramaniam D, Wang L, Zhang Y, Yang ES, Bidshahri R, Kraft L, Hwang Y, Žentelis S, Jepson KR, Goya R, Smith MA, Collins DW, Hinshaw SJ, Tycho SA, Pellacani D, Xiang P, Muthuraman K, Sobhanifar S, Piper MH, Triana FJ, Hendle J, Pustilnik A, Adams AC, Berens SJ, Baric RS, Martinez DR, Cross RW, Geisbert TW, Borisevich V, Abiona O, Belli HM, de Vries M, Mohamed A, Dittmann M, Samanovic MI, Mulligan MJ, Goldsmith JA, Hsieh CL, Johnson NV, Wrapp D, McLellan JS, Barnhart BC, Graham BS, Mascola JR, Hansen CL, Falconer E
Computational analyses reveal spatial relationships between nuclear pore complexes and specific lamins.
1. J Cell Biol - published April 5, 2021
2. Kittisopikul M, Shimi T, Tatli M, Tran JR, Zheng Y, Medalia O, Jaqaman K, Adam SA, Goldman RD
Deconstructing Noncovalent Kelch-like ECH-Associated Protein 1 (Keap1) Inhibitors into Fragments to Reconstruct New Potent Compounds.
1. J Med Chem - published April 5, 2021
2. Pallesen JS, Narayanan D, Tran KT, Solbak SMØ, Marseglia G, Sørensen LME, Høj LJ, Munafò F, Carmona RMC, Garcia AD, Desu HL, Brambilla R, Johansen TN, Popowicz GM, Sattler M, Gajhede M, Bach A
Fecal microbiota transplantation for recurrent Clostridioides difficile infection associates with functional alterations in circulating microRNAs.
1. Gastroenterology - published April 5, 2021
2. Monaghan TM, Seekatz AM, Markham NO, Yau TO, Hatziapostolou M, Jilani T, Christodoulou N, Roach B, Birli E, Pomenya O, Louie T, Lacy DB, Kim P, Lee C, Kao D, Polytarchou C
The acyl chains of phosphoinositide PIP3 alter the structure and function of nuclear receptor Steroidogenic Factor-1 (NR5A1).
1. J Lipid Res - published April 2, 2021
2. Bryant JM, Malabanan MM, Vanderloop BH, Nichols CM, Haratipour Z, Poon KT, Sherrod SD, McLean JA, Blind RD
Glycosylation Limits Forward Trafficking of the Tetraspan Membrane Protein PMP22.
1. J Biol Chem - published April 2, 2021
2. Marinko JT, Wright MT, Schlebach JP, Clowes KR, Heintzman DR, Plate L, Sanders CR
A model for a partnership of lipid transfer proteins and scramblases in membrane expansion and organelle biogenesis.
1. Proc Natl Acad Sci U S A - published April 2, 2021
2. Ghanbarpour A, Valverde DP, Melia TJ, Reinisch KM
Death Domain Fold proteins in immune signaling and transcriptional regulation.
1. FEBS J - published April 2, 2021
2. Huoh YS, Hur S
Intestinal Sulfation is Essential to Protect Against Colitis and Colonic Carcinogenesis.
1. Gastroenterology - published April 2, 2021
2. Xu P, Xi Y, Zhu J, Zhang M, Luka Z, Stolz DB, Cai X, Xie Y, Xu M, Ren S, Huang Z, Yang D, York JD, Ma X, Xie W
Biosynthesis of d-glycero-l-gluco-Heptose in the Capsular Polysaccharides of Campylobacter jejuni.
1. Biochemistry - published April 2, 2021
2. Huddleston JP, Anderson TK, Girardi NM, Thoden JB, Taylor Z, Holden HM, Raushel FM
Vaccination with prefusion-stabilized respiratory syncytial virus fusion protein induces genetically and antigenically diverse antibody responses.
1. Immunity - published April 2, 2021
2. Mukhamedova M, Wrapp D, Shen CH, Gilman MSA, Ruckwardt TJ, Schramm CA, Ault L, Chang L, Derrien-Colemyn A, Lucas SAM, Ransier A, Darko S, Phung E, Wang L, Zhang Y, Rush SA, Madan B, Stewart-Jones GBE, Costner PJ, Holman LA, Hickman SP, Berkowitz NM, Doria-Rose NA, Morabito KM, DeKosky BJ, Gaudinski MR, Chen GL, Crank MC, Misasi J, Sullivan NJ, Douek DC, Kwong PD, Graham BS, McLellan JS, Mascola JR
Gasdermin D pore structure reveals preferential release of mature interleukin-1.
1. Nature - published April 2, 2021
2. Xia S, Zhang Z, Magupalli VG, Pablo JL, Dong Y, Vora SM, Wang L, Fu TM, Jacobson MP, Greka A, Lieberman J, Ruan J, Wu H
The crystal structure of yeast regulatory subunit reveals key evolutionary insights into Protein Kinase A oligomerization.
1. J Struct Biol - published April 2, 2021
2. Bardeci NG, Tofolón E, Trajtenberg F, Caramelo J, Larrieux N, Rossi S, Buschiazzo A, Moreno S
NMR Model of the Entire Membrane-Interacting Region of the HIV-1 Fusion Protein and Its Perturbation of Membrane Morphology.
1. J Am Chem Soc - published April 2, 2021
2. Piai A, Fu Q, Sharp AK, Bighi B, Brown AM, Chou JJ
Synthesis and Biological Evaluation of (-) and (+)-Spiroleucettadine and Analogues.
1. ChemMedChem - published April 2, 2021
2. Badart MP, Barnes EM, Cording AP, Gilmer SCL, Billinghurst ID, Edupuganti VVSR, Lessene G, Bland AR, Bower RL, Rana Z, Ferguson SA, Opel Reading HK, Cook GM, Rosengren RJ, Krause KL, Gamble AB, Ashton JC, Hawkins BC
Smoothened transduces hedgehog signals via activity-dependent sequestration of PKA catalytic subunits.
1. PLoS Biol - published April 2, 2021
2. Arveseth CD, Happ JT, Hedeen DS, Zhu JF, Capener JL, Klatt Shaw D, Deshpande I, Liang J, Xu J, Stubben SL, Nelson IB, Walker MF, Kawakami K, Inoue A, Krogan NJ, Grunwald DJ, Hüttenhain R, Manglik A, Myers BR
Directed evolution for high functional production and stability of a challenging G protein-coupled receptor.
1. Sci Rep - published April 2, 2021
2. Waltenspühl Y, Jeliazkov JR, Kummer L, Plückthun A
Programmed flagellar ejection in Caulobacter crescentus leaves PL-subcomplexes.
1. J Mol Biol - published April 2, 2021
2. Kaplan M, Wang Y, Chreifi G, Zhang L, Chang YW, Jensen GJ
Viral packaging ATPases utilize a glutamate switch to couple ATPase activity and DNA translocation.
1. Proc Natl Acad Sci U S A - published April 2, 2021
2. Pajak J, Atz R, Hilbert BJ, Morais MC, Kelch BA, Jardine PJ, Arya G
Ion mobility-mass spectrometry reveals the role of peripheral myelin protein dimers in peripheral neuropathy.
1. Proc Natl Acad Sci U S A - published April 2, 2021
2. Fantin SM, Parson KF, Yadav P, Juliano B, Li GC, Sanders CR, Ohi MD, Ruotolo BT
Protein design and variant prediction using autoregressive generative models.
1. Nat Commun - published April 2, 2021
2. Shin JE, Riesselman AJ, Kollasch AW, McMahon C, Simon E, Sander C, Manglik A, Kruse AC, Marks DS
Inhibition of polar actin assembly by astral microtubules is required for cytokinesis.
1. Nat Commun - published April 2, 2021
2. Chen A, Ulloa Severino L, Panagiotou TC, Moraes TF, Yuen DA, Lavoie BD, Wilde A
Autophagosome biogenesis comes out of the black box.
1. Nat Cell Biol - published April 2, 2021
2. Chang C, Jensen LE, Hurley JH
There's more to death than life: non-catalytic functions in kinase and pseudokinase signaling.
1. J Biol Chem - published April 2, 2021
2. Mace PD, Murphy JM
Protomer alignment modulates specificity of RNA substrate recognition by Ire1.
1. Elife - published April 2, 2021
2. Li W, Crotty K, Garrido Ruiz D, Voorhies M, Rivera C, Sil A, Mullins RD, Jacobson MP, Peschek J, Walter P
Protective Liquid Crystal Nanoparticles for Targeted Delivery of PslG: A Biofilm Dispersing Enzyme.
1. ACS Infect Dis - published April 2, 2021
2. Thorn CR, Raju D, Lacdao I, Gilbert S, Sivarajah P, Howell PL, Prestidge CA, Thomas N
A survey of the kinome pharmacopeia reveals multiple scaffolds and targets for the development of novel anthelmintics.
1. Sci Rep - published April 2, 2021
2. Knox J, Joly N, Linossi EM, Carmona-Negrón JA, Jura N, Pintard L, Zuercher W, Roy PJ
Discovery of a Potent Degrader for Fibroblast Growth Factor Receptor 1/2.
1. Angew Chem Int Ed Engl - published April 2, 2021
2. Du G, Jiang J, Wu Q, Henning NJ, Donovan KA, Yue H, Che J, Lu W, Fischer ES, Bardeesy N, Zhang T, Gray NS
¹H, ¹³C, ¹⁵N and ³¹P chemical shift assignment for stem-loop 4 from the 5'-UTR of SARS-CoV-2.
1. Biomol NMR Assign - published April 2, 2021
2. Vögele J, Ferner JP, Altincekic N, Bains JK, Ceylan B, Fürtig B, Grün JT, Hengesbach M, Hohmann KF, Hymon D, Knezic B, Löhr F, Peter SA, Pyper D, Qureshi NS, Richter C, Schlundt A, Schwalbe H, Stirnal E, Sudakov A, Wacker A, Weigand JE, Wirmer-Bartoschek J, Wöhnert J, Duchardt-Ferner E
N-Linked Glycosylation on Anthrax Toxin Receptor 1 Is Essential for Seneca Valley Virus Infection.
1. Viruses - published April 2, 2021
2. Jayawardena N, Miles LA, Burga LN, Rudin C, Wolf M, Poirier JT, Bostina M
HIV-1 Entry and Membrane Fusion Inhibitors.
1. Viruses - published April 2, 2021
2. Xiao T, Cai Y, Chen B
The oxidoreductase PYROXD1 uses NAD(P)⁺ as an antioxidant to sustain tRNA ligase activity in pre-tRNA splicing and unfolded protein response.
1. Mol Cell - published April 2, 2021
2. Asanović I, Strandback E, Kroupova A, Pasajlic D, Meinhart A, Tsung-Pin P, Djokovic N, Anrather D, Schuetz T, Suskiewicz MJ, Sillamaa S, Köcher T, Beveridge R, Nikolic K, Schleiffer A, Jinek M, Hartl M, Clausen T, Penninger J, Macheroux P, Weitzer S, Martinez J
Physiological interactions with personal-protective clothing, physically demanding work and global warming: An Asia-Pacific perspective.
1. J Therm Biol - published April 1, 2021
2. Taylor NAS, Lee JY, Kim S, Notley SR
The emerging structural complexity of G-quadruplex RNAs.
1. RNA - published April 1, 2021
2. Banco MT, Ferré-D'Amaré AR
Fluorogenic aptamers resolve the flexibility of RNA junctions using orientation-dependent FRET.
1. RNA - published April 1, 2021
2. Jeng SCY, Trachman RJ 3rd, Weissenboeck F, Truong L, Link KA, Jepsen MDE, Knutson JR, Andersen ES, Ferré-D'Amaré AR, Unrau PJ
Transport mechanisms at the malaria parasite-host cell interface.
1. PLoS Pathog - published April 1, 2021
2. Beck JR, Ho CM
Histologic and racial/ethnic patterns of appendiceal cancer among young patients.
1. Cancer Epidemiol Biomarkers Prev - published April 1, 2021
2. Gibbs T, Washington MK, Eng C, Idrees K, Davis J, Holowatyj AN
Posttranslational regulation of FOXA1 by Polycomb and BUB3/USP7 deubiquitin complex in prostate cancer.
1. Sci Adv - published April 1, 2021
2. Park SH, Fong KW, Kim J, Wang F, Lu X, Lee Y, Brea LT, Wadosky K, Guo C, Abdulkadir SA, Crispino JD, Fang D, Ntziachristos P, Liu X, Li X, Wan Y, Goodrich DW, Zhao JC, Yu J
High-throughput, single-copy sequencing reveals SARS-CoV-2 spike variants coincident with mounting humoral immunity during acute COVID-19.
1. PLoS Pathog - published April 1, 2021
2. Ko SH, Bayat Mokhtari E, Mudvari P, Stein S, Stringham CD, Wagner D, Ramelli S, Ramos-Benitez MJ, Strich JR, Davey RT Jr, Zhou T, Misasi J, Kwong PD, Chertow DS, Sullivan NJ, Boritz EA
Electron microscopy shows that binding of monoclonal antibody PT25-2 primes integrin αIIbβ3 for ligand binding.
1. Blood Adv - published April 1, 2021
2. Nešić D, Bush M, Spasic A, Li J, Kamata T, Handa M, Filizola M, Walz T, Coller BS
Antivirulence DsbA inhibitors attenuate Salmonella enterica serovar Typhimurium fitness without detectable resistance.
1. FASEB Bioadv - published April 1, 2021
2. Dhouib R, Vagenas D, Hong Y, Verderosa AD, Martin JL, Heras B, Totsika M
Structure-based phylogeny identifies Avoralstat as a TMPRSS2 inhibitor that prevents SARS-CoV-2 infection in mice.
1. J Clin Invest - published April 1, 2021
2. Sun YJ, Velez G, Parsons DE, Li K, Ortiz ME, Sharma S, McCray PB Jr, Bassuk AG, Mahajan VB
Generation of an Allelic Series at the Ahr Locus Using an Edited Recombinant Approach.
1. Toxicol Sci - published April 1, 2021
2. Wilson RH, Carney PR, Glover E, Parrott JC, Rojas BL, Moran SM, Yee JS, Nukaya M, Goetz NA, Rubinstein CD, Krentz KJ, Xing Y, Bradfield CA
Allosteric communication in DNA polymerase clamp loaders relies on a critical hydrogen-bonded junction.
1. Elife - published April 1, 2021
2. Subramanian S, Gorday K, Marcus K, Orellana MR, Ren P, Luo XR, O'Donnell ME, Kuriyan J
Understanding the Function of Mammalian Sirtuins and Protein Lysine Acylation.
1. Annu Rev Biochem - published April 1, 2021
2. Wang M, Lin H
Clinical, neuroimaging and molecular spectrum of TECPR2-associated hereditary sensory and autonomic neuropathy with intellectual disability.
1. Hum Mutat - published April 1, 2021
2. Neuser S, Brechmann B, Heimer G, Brösse I, Schubert S, O'Grady L, Zech M, Srivastava S, Sweetser DA, Dincer Y, Mall V, Winkelmann J, Behrends C, Darras BT, Graham RJ, Jayakar P, Byrne B, El Bar-Aluma B, Haberman Y, Szeinberg A, Aldhalaan HM, Hashem M, Tenaiji AA, Ismayl O, Al Nuaimi AE, Maher K, Ibrahim S, Khan F, Houlden H, Ramakumaran VS, Pagnamenta AT, Posey JE, Lupski JR, Tan WH, ElGhazali G, Herman I, Muñoz T, Repetto GM, Seitz A, Krumbiegel M, Cecilia Poli M, Kini U, Efthymiou S, Meiler J, Maroofian R, Alkuraya FS, Jamra RA, Popp B, Ben-Zeev B, Ebrahimi-Fakhari D
Acylboronates in Polarity-Reversed Generation of Acyl Palladium(II) Intermediates.
1. Org Lett - published April 1, 2021
2. Trofimova A, Holownia A, Tien CH, Širvinskas MJ, Yudin AK
Human ACE2 receptor polymorphisms and altered susceptibility to SARS-CoV-2.
1. Commun Biol - published April 1, 2021
2. Suryamohan K, Diwanji D, Stawiski EW, Gupta R, Miersch S, Liu J, Chen C, Jiang YP, Fellouse FA, Sathirapongsasuti JF, Albers PK, Deepak T, Saberianfar R, Ratan A, Washburn G, Mis M, Santhosh D, Somasekar S, Hiranjith GH, Vargas D, Mohan S, Phalke S, Kuriakose B, Antony A, Ustav M Jr, Schuster SC, Sidhu S, Junutula JR, Jura N, Seshagiri S
Convergence of a common solution for broad ebolavirus neutralization by glycan cap-directed human antibodies.
1. Cell Rep - published April 1, 2021
2. Murin CD, Gilchuk P, Ilinykh PA, Huang K, Kuzmina N, Shen X, Bruhn JF, Bryan AL, Davidson E, Doranz BJ, Williamson LE, Copps J, Alkutkar T, Flyak AI, Bukreyev A, Crowe JE Jr, Ward AB
The tissue protective functions of interleukin-22 can be decoupled from pro-inflammatory actions through structure-based design.
1. Immunity - published April 1, 2021
2. Saxton RA, Henneberg LT, Calafiore M, Su L, Jude KM, Hanash AM, Garcia KC
Selective expansion of regulatory T cells using an orthogonal IL-2/IL-2 receptor system facilitates transplantation tolerance.
1. J Clin Invest - published April 1, 2021
2. Hirai T, Ramos TL, Lin PY, Simonetta F, Su LL, Picton LK, Baker J, Lin JX, Li P, Seo K, Lohmeyer JK, Wagers SB, Mavers M, Leonard WJ, Blazar BR, Garcia KC, Negrin RS
A Helicase Unwinds Hexanucleotide Repeat RNA G-Quadruplexes and Facilitates Repeat-Associated Non-AUG Translation.
1. J Am Chem Soc - published April 1, 2021
2. Liu H, Lu YN, Paul T, Periz G, Banco MT, Ferré-D'Amaré AR, Rothstein JD, Hayes LR, Myong S, Wang J
Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking.
1. Sci Adv - published April 1, 2021
2. Schuller M, Correy GJ, Gahbauer S, Fearon D, Wu T, Díaz RE, Young ID, Carvalho Martins L, Smith DH, Schulze-Gahmen U, Owens TW, Deshpande I, Merz GE, Thwin AC, Biel JT, Peters JK, Moritz M, Herrera N, Kratochvil HT, QCRG Structural Biology Consortium., Aimon A, Bennett JM, Brandao Neto J, Cohen AE, Dias A, Douangamath A, Dunnett L, Fedorov O, Ferla MP, Fuchs MR, Gorrie-Stone TJ, Holton JM, Johnson MG, Krojer T, Meigs G, Powell AJ, Rack JGM, Rangel VL, Russi S, Skyner RE, Smith CA, Soares AS, Wierman JL, Zhu K, O'Brien P, Jura N, Ashworth A, Irwin JJ, Thompson MC, Gestwicki JE, von Delft F, Shoichet BK, Fraser JS, Ahel I
State of the structure address on MET receptor activation by HGF.
1. Biochem Soc Trans - published April 1, 2021
2. Linossi EM, Estevam GO, Oshima M, Fraser JS, Collisson EA, Jura N
Towards advancing scientific knowledge of climate change impacts on short-duration rainfall extremes.
1. Philos Trans A Math Phys Eng Sci - published April 1, 2021
2. Fowler HJ, Ali H, Allan RP, Ban N, Barbero R, Berg P, Blenkinsop S, Cabi NS, Chan S, Dale M, Dunn RJH, Ekström M, Evans JP, Fosser G, Golding B, Guerreiro SB, Hegerl GC, Kahraman A, Kendon EJ, Lenderink G, Lewis E, Li X, O'Gorman PA, Orr HG, Peat KL, Prein AF, Pritchard D, Schär C, Sharma A, Stott PA, Villalobos-Herrera R, Villarini G, Wasko C, Wehner MF, Westra S, Whitford A
Elevated Asparagine Biosynthesis Drives Brain Tumor Stem Cell Metabolic Plasticity and Resistance to Oxidative Stress.
1. Mol Cancer Res - published April 1, 2021
2. Thomas TM, Miyaguchi K, Edwards LA, Wang H, Wollebo H, Aiguo L, Murali R, Wang Y, Braas D, Michael JS, Andres A, Zhang M, Khalili K, Gottlieb RA, Perez JM, Yu JS
Nickel as a Virulence Factor in the Class I Bacterial Carcinogen, Helicobacter pylori.
1. Semin Cancer Biol - published April 1, 2021
2. Maroney MJ, Ciurli S
Molecular mechanism of Nramp-family transition metal transport.
1. J Mol Biol - published April 1, 2021
2. Bozzi AT, Gaudet R
On the molecular nature of large-pore channels.
1. J Mol Biol - published April 1, 2021
2. Syrjanen J, Michalski K, Kawate T, Furukawa H
Adjuvanting a subunit COVID-19 vaccine to induce protective immunity.
1. Nature - published April 1, 2021
2. Arunachalam PS, Walls AC, Golden N, Atyeo C, Fischinger S, Li C, Aye P, Navarro MJ, Lai L, Edara VV, Röltgen K, Rogers K, Shirreff L, Ferrell DE, Wrenn S, Pettie D, Kraft JC, Miranda MC, Kepl E, Sydeman C, Brunette N, Murphy M, Fiala B, Carter L, White AG, Trisal M, Hsieh CL, Russell-Lodrigue K, Monjure C, Dufour J, Spencer S, Doyle-Meyer L, Bohm RP, Maness NJ, Roy C, Plante JA, Plante KS, Zhu A, Gorman MJ, Shin S, Shen X, Fontenot J, Gupta S, O'Hagan DT, Van Der Most R, Rappuoli R, Coffman RL, Novack D, McLellan JS, Subramaniam S, Montefiori D, Boyd SD, Flynn JL, Alter G, Villinger F, Kleanthous H, Rappaport J, Suthar MS, King NP, Veesler D, Pulendran B
Structural perspective on ancient neuropeptide Y -like system reveals hallmark features for peptide recognition and receptor activation.
1. J Mol Biol - published April 1, 2021
2. Mikhailowitsch Gershkovich M, Elisabeth Groß V, Vu O, Tabea Schoeder C, Meiler J, Prömel S, Kaiser A
Water structure around a left-handed Z-DNA fragment analyzed by cryo neutron crystallography.
1. Nucleic Acids Res - published April 1, 2021
2. Harp JM, Coates L, Sullivan B, Egli M
Sources and pollution path identification of PAHs in karst aquifers: an example from Liulin karst water system, northern China.
1. J Contam Hydrol - published April 1, 2021
2. Wu X, Gao X, Tan T, Li C, Yan R, Chi Z, Feng Y, Gong P, Fang J, Zhang X, Aihemaiti K, Xu D
A collagen glucosyltransferase drives lung adenocarcinoma progression in mice.
1. Commun Biol - published April 1, 2021
2. Guo HF, Bota-Rabassedas N, Terajima M, Leticia Rodriguez B, Gibbons DL, Chen Y, Banerjee P, Tsai CL, Tan X, Liu X, Yu J, Tokmina-Roszyk M, Stawikowska R, Fields GB, Miller MD, Wang X, Lee J, Dalby KN, Creighton CJ, Phillips GN Jr, Tainer JA, Yamauchi M, Kurie JM
Structural basis for Clostridium perfringens enterotoxin targeting of claudins at tight junctions in mammalian gut.
1. Proc Natl Acad Sci U S A - published April 1, 2021
2. Vecchio AJ, Rathnayake SS, Stroud RM
Integrated mutational landscape analysis of uterine leiomyosarcomas.
1. Proc Natl Acad Sci U S A - published April 1, 2021
2. Choi J, Manzano A, Dong W, Bellone S, Bonazzoli E, Zammataro L, Yao X, Deshpande A, Zaidi S, Guglielmi A, Gnutti B, Nagarkatti N, Tymon-Rosario JR, Harold J, Mauricio D, Zeybek B, Menderes G, Altwerger G, Jeong K, Zhao S, Buza N, Hui P, Ravaggi A, Bignotti E, Romani C, Todeschini P, Zanotti L, Odicino F, Pecorelli S, Ardighieri L, Bilguvar K, Quick CM, Silasi DA, Huang GS, Andikyan V, Clark M, Ratner E, Azodi M, Imielinski M, Schwartz PE, Alexandrov LB, Lifton RP, Schlessinger J, Santin AD
Respiratory mucus as a virus-host range determinant.
1. Trends Microbiol - published April 1, 2021
2. Wallace LE, Liu M, van Kuppeveld FJM, de Vries E, de Haan CAM
Photocatalytic LPOR forms helical lattices that shape membranes for chlorophyll synthesis.
1. Nat Plants - published April 1, 2021
2. Nguyen HC, Melo AA, Kruk J, Frost A, Gabruk M
Novel RT-ddPCR assays for measuring the levels of subgenomic and genomic SARS-CoV-2 transcripts.
1. Methods - published April 1, 2021
2. Telwatte S, Martin HA, Marczak R, Fozouni P, Vallejo-Gracia A, Kumar GR, Murray V, Lee S, Ott M, Wong JK, Yukl SA
Editorial overview: Microtubules in nervous system development.
1. Dev Neurobiol - published April 1, 2021
2. Bradke F, Roll-Mecak A
Structural insights into the mechanisms and pharmacology of K_2P potassium channels.
1. J Mol Biol - published April 1, 2021
2. Natale AM, Deal PE, Minor DL Jr
Increased resistance of SARS-CoV-2 variant P.1 to antibody neutralization.
1. Cell Host Microbe - published April 1, 2021
2. Wang P, Casner RG, Nair MS, Wang M, Yu J, Cerutti G, Liu L, Kwong PD, Huang Y, Shapiro L, Ho DD
Chaperone-mediated autophagy prevents collapse of the neuronal metastable proteome.
1. Cell - published April 1, 2021
2. Bourdenx M, Martín-Segura A, Scrivo A, Rodriguez-Navarro JA, Kaushik S, Tasset I, Diaz A, Storm NJ, Xin Q, Juste YR, Stevenson E, Luengo E, Clement CC, Choi SJ, Krogan NJ, Mosharov EV, Santambrogio L, Grueninger F, Collin L, Swaney DL, Sulzer D, Gavathiotis E, Cuervo AM
Reconstitution of cargo-induced LC3 lipidation in mammalian selective autophagy.
1. Sci Adv - published April 1, 2021
2. Chang C, Shi X, Jensen LE, Yokom AL, Fracchiolla D, Martens S, Hurley JH
Should All Memory B Cells Recruited to the Germinal Center Be Antigen Specific?
1. Monoclon Antib Immunodiagn Immunother - published April 1, 2021
2. Pashov A, Murali R
Truncating SRCAP variants outside the Floating-Harbor syndrome locus cause a distinct neurodevelopmental disorder with a specific DNA methylation signature.
1. Am J Hum Genet - published April 1, 2021
2. Rots D, Chater-Diehl E, Dingemans AJM, Goodman SJ, Siu MT, Cytrynbaum C, Choufani S, Hoang N, Walker S, Awamleh Z, Charkow J, Meyn S, Pfundt R, Rinne T, Gardeitchik T, de Vries BBA, Deden AC, Leenders E, Kwint M, Stumpel CTRM, Stevens SJC, Vermeulen JR, van Harssel JVT, Bosch DGM, van Gassen KLI, van Binsbergen E, de Geus CM, Brackel H, Hempel M, Lessel D, Denecke J, Slavotinek A, Strober J, Crunk A, Folk L, Wentzensen IM, Yang H, Zou F, Millan F, Person R, Xie Y, Liu S, Ousager LB, Larsen M, Schultz-Rogers L, Morava E, Klee EW, Berry IR, Campbell J, Lindstrom K, Pruniski B, Neumeyer AM, Radley JA, Phornphutkul C, Schmidt B, Wilson WG, Õunap K, Reinson K, Pajusalu S, van Haeringen A, Ruivenkamp C, Cuperus R, Santos-Simarro F, Palomares-Bralo M, Pacio-Míguez M, Ritter A, Bhoj E, Tønne E, Tveten K, Cappuccio G, Brunetti-Pierri N, Rowe L, Bunn J, Saenz M, Platzer K, Mertens M, Caluseriu O, Nowaczyk MJM, Cohn RD, Kannu P, Alkhunaizi E, Chitayat D, Scherer SW, Brunner HG, Vissers LELM, Kleefstra T, Koolen DA, Weksberg R
Arpin Regulates Migration Persistence by Interacting with Both Tankyrases and the Arp2/3 Complex.
1. Int J Mol Sci - published April 1, 2021
2. Simanov G, Dang I, Fokin AI, Oguievetskaia K, Campanacci V, Cherfils J, Gautreau AM
Using Internet Search Queries to Assess Public Awareness of the Healthy Cities Approach: A Case Study in Shenzhen, China.
1. Int J Environ Res Public Health - published April 1, 2021
2. Yang J, Zhang Y, Xiao Y, Shen S, Su M, Bai Y, Zhou J, Gong P