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113 Member Publications for November

Previous Month

Role of Interleukin-1 Family Members and Signaling Pathways in KSHV Pathogenesis.
1. Front Cell Infect Microbiol - published November 16, 2020
2. Barrett L, Chen J, Dai L, Plaisance-Bonstaff K, Del Valle L, Qin Z
Structure and reconstitution of a hydrolase complex that may release peptidoglycan from the membrane after polymerization.
1. Nat Microbiol - published November 9, 2020
2. Schaefer K, Owens TW, Page JE, Santiago M, Kahne D, Walker S
A framework for understanding the functions of biomolecular condensates across scales.
1. Nat Rev Mol Cell Biol - published November 9, 2020
2. Lyon AS, Peeples WB, Rosen MK
The Diversity and Similarity of Transmembrane Trimerization of TNF Receptors.
1. Front Cell Dev Biol - published November 9, 2020
2. Zhao L, Fu Q, Pan L, Piai A, Chou JJ
Discovery of allosteric binding sites by crystallographic fragment screening.
1. Curr Opin Struct Biol - published November 7, 2020
2. Krojer T, Fraser JS, von Delft F
¹H, ¹³C, and ¹⁵N backbone chemical shift assignments of coronavirus-2 non-structural protein Nsp10.
1. Biomol NMR Assign - published November 7, 2020
2. Kubatova N, Qureshi NS, Altincekic N, Abele R, Bains JK, Ceylan B, Ferner J, Fuks C, Hargittay B, Hutchison MT, de Jesus V, Kutz F, Wirtz Martin MA, Meiser N, Linhard V, Pyper DJ, Trucks S, Fürtig B, Hengesbach M, Löhr F, Richter C, Saxena K, Schlundt A, Schwalbe H, Sreeramulu S, Wacker A, Weigand JE, Wirmer-Bartoschek J, Wöhnert J
Highlight: young research groups in Germany - 3rd edition.
1. Biol Chem - published November 6, 2020
2. Lassak J, Schlundt A
Perspective on Crystallographic Studies of Antibody Structures.
1. Monoclon Antib Immunodiagn Immunother - published November 6, 2020
2. Murali R
Review - Comparative mapping of selected structural determinants on the extracellular domains of cholinesterase-like cell-adhesion molecules.
1. Neuropharmacology - published November 6, 2020
2. Comoletti D, Trobiani L, Chatonnet A, Bourne Y, Marchot P
Identification of phenothiazine derivatives as UHM-binding inhibitors of early spliceosome assembly.
1. Nat Commun - published November 6, 2020
2. Jagtap PKA, Kubelka T, Soni K, Will CL, Garg D, Sippel C, Kapp TG, Potukuchi HK, Schorpp K, Hadian K, Kessler H, Lührmann R, Hausch F, Bach T, Sattler M
Rational design of highly potent broad-spectrum enterovirus inhibitors targeting the nonstructural protein 2C.
1. PLoS Biol - published November 6, 2020
2. Bauer L, Manganaro R, Zonsics B, Hurdiss DL, Zwaagstra M, Donselaar T, Welter NGE, van Kleef RGDM, Lopez ML, Bevilacqua F, Raman T, Ferla S, Bassetto M, Neyts J, Strating JRPM, Westerink RHS, Brancale A, van Kuppeveld FJM
Translation and Replication Dynamics of Single RNA Viruses.
1. Cell - published November 6, 2020
2. Boersma S, Rabouw HH, Bruurs LJM, Pavlovič T, van Vliet ALW, Beumer J, Clevers H, van Kuppeveld FJM, Tanenbaum ME
Developing new ceramide analogs and identifying novel sphingolipid-controlled genes against a virus-associated lymphoma.
1. Blood - published November 5, 2020
2. Chen J, Goyal N, Dai L, Lin Z, Del Valle L, Zabaleta J, Liu J, Post SR, Foroozesh M, Qin Z
De novo design of potent and resilient hACE2 decoys to neutralize SARS-CoV-2.
1. Science - published November 5, 2020
2. Linsky TW, Vergara R, Codina N, Nelson JW, Walker MJ, Su W, Barnes CO, Hsiang TY, Esser-Nobis K, Yu K, Reneer ZB, Hou YJ, Priya T, Mitsumoto M, Pong A, Lau UY, Mason ML, Chen J, Chen A, Berrocal T, Peng H, Clairmont NS, Castellanos J, Lin YR, Josephson-Day A, Baric RS, Fuller DH, Walkey CD, Ross TM, Swanson R, Bjorkman PJ, Gale M Jr, Blancas-Mejia LM, Yen HL, Silva DA
An ultrapotent synthetic nanobody neutralizes SARS-CoV-2 by stabilizing inactive Spike.
1. Science - published November 5, 2020
2. Schoof M, Faust B, Saunders RA, Sangwan S, Rezelj V, Hoppe N, Boone M, Billesbølle CB, Puchades C, Azumaya CM, Kratochvil HT, Zimanyi M, Deshpande I, Liang J, Dickinson S, Nguyen HC, Chio CM, Merz GE, Thompson MC, Diwanji D, Schaefer K, Anand AA, Dobzinski N, Zha BS, Simoneau CR, Leon K, White KM, Chio US, Gupta M, Jin M, Li F, Liu Y, Zhang K, Bulkley D, Sun M, Smith AM, Rizo AN, Moss F, Brilot AF, Pourmal S, Trenker R, Pospiech T, Gupta S, Barsi-Rhyne B, Belyy V, Barile-Hill AW, Nock S, Liu Y, Krogan NJ, Ralston CY, Swaney DL, García-Sastre A, Ott M, Vignuzzi M, QCRG Structural Biology Consortium., Walter P, Manglik A
Correlated cryogenic fluorescence microscopy and electron cryo-tomography shows that exogenous TRIM5α can form hexagonal lattices or autophagy aggregates in vivo.
1. Proc Natl Acad Sci U S A - published November 5, 2020
2. Carter SD, Mamede JI, Hope TJ, Jensen GJ
Structural basis of antagonizing the vitamin K catalytic cycle for anticoagulation.
1. Science - published November 5, 2020
2. Liu S, Li S, Shen G, Sukumar N, Krezel AM, Li W
Selection, biophysical and structural analysis of synthetic nanobodies that effectively neutralize SARS-CoV-2.
1. Nat Commun - published November 4, 2020
2. Custódio TF, Das H, Sheward DJ, Hanke L, Pazicky S, Pieprzyk J, Sorgenfrei M, Schroer MA, Gruzinov AY, Jeffries CM, Graewert MA, Svergun DI, Dobrev N, Remans K, Seeger MA, McInerney GM, Murrell B, Hällberg BM, Löw C
Dual pathways of human immunodeficiency virus (HIV-1) envelope glycoprotein trafficking modulate the selective exclusion of uncleaved oligomers from virions.
1. J Virol - published November 4, 2020
2. Zhang S, Nguyen HT, Ding H, Wang J, Zou S, Liu L, Guha D, Gabuzda D, Ho DD, Kappes JC, Sodroski J
The charged linker modulates conformations and molecular interactions of Hsp90.
1. Chembiochem - published November 4, 2020
2. López A, Elimelech AR, Klimm K, Sattler M
Gene- and Species-Specific Hox mRNA Translation by Ribosome Expansion Segments.
1. Mol Cell - published November 4, 2020
2. Leppek K, Fujii K, Quade N, Susanto TT, Boehringer D, Lenarčič T, Xue S, Genuth NR, Ban N, Barna M
The ABCs of Sterol Transport.
1. Annu Rev Physiol - published November 3, 2020
2. Plummer AM, Culbertson AT, Liao M
Dynamic DNA-bound PCNA complexes co-ordinate Okazaki fragment synthesis, processing and ligation.
1. J Mol Biol - published November 3, 2020
2. Matsumoto Y, Brooks RC, Sverzhinsky A, Pascal JM, Tomkinson AE
Compromised Humoral Functional Evolution Tracks with SARS-CoV-2 Mortality.
1. Cell - published November 3, 2020
2. Zohar T, Loos C, Fischinger S, Atyeo C, Wang C, Slein MD, Burke J, Yu J, Feldman J, Hauser BM, Caradonna T, Schmidt AG, Cai Y, Streeck H, Ryan ET, Barouch DH, Charles RC, Lauffenburger DA, Alter G
Nearest-neighbor NMR spectroscopy: categorizing spectral peaks by their adjacent nuclei.
1. Nat Commun - published November 3, 2020
2. Behera SP, Dubey A, Chen WN, De Paula VS, Zhang M, Sgourakis NG, Bermel W, Wagner G, Coote PW, Arthanari H
Quick COVID-19 Healers Sustain Anti-SARS-CoV-2 Antibody Production.
1. Cell - published November 3, 2020
2. Chen Y, Zuiani A, Fischinger S, Mullur J, Atyeo C, Travers M, Lelis FJN, Pullen KM, Martin H, Tong P, Gautam A, Habibi S, Bensko J, Gakpo D, Feldman J, Hauser BM, Caradonna TM, Cai Y, Burke JS, Lin J, Lederer JA, Lam EC, Lavine CL, Seaman MS, Chen B, Schmidt AG, Balazs AB, Lauffenburger DA, Alter G, Wesemann DR
The two-stage interaction of Ebola virus VP40 with nucleoprotein results in a switch from viral RNA synthesis to virion assembly/budding.
1. Protein Cell - published November 3, 2020
2. Wu L, Jin D, Wang D, Jing X, Gong P, Qin Y, Chen M
Yeast Nup84-Nup133 complex structure details flexibility and reveals conservation of the membrane anchoring ALPS motif.
1. Nat Commun - published November 2, 2020
2. Nordeen SA, Turman DL, Schwartz TU
A high-affinity antibody against the CSP N-terminal domain lacks Plasmodium falciparum inhibitory activity.
1. J Exp Med - published November 2, 2020
2. Thai E, Costa G, Weyrich A, Murugan R, Oyen D, Flores-Garcia Y, Prieto K, Bosch A, Valleriani A, Wu NC, Pholcharee T, Scally SW, Wilson IA, Wardemann H, Julien JP, Levashina EA
Diversity in recognition and function of human γδ T cells.
1. Immunol Rev - published November 2, 2020
2. Castro CD, Boughter CT, Broughton AE, Ramesh A, Adams EJ
Molecular Surgery: Proteomics of a Rare Genetic Disease Gives Insight into Common Causes of Blindness.
1. iScience - published November 2, 2020
2. Velez G, Mahajan VB
Hedgehog pathway activation through nanobody-mediated conformational blockade of the Patched sterol conduit.
1. Proc Natl Acad Sci U S A - published November 2, 2020
2. Zhang Y, Lu WJ, Bulkley DP, Liang J, Ralko A, Han S, Roberts KJ, Li A, Cho W, Cheng Y, Manglik A, Beachy PA
Comparative roles of charge, π, and hydrophobic interactions in sequence-dependent phase separation of intrinsically disordered proteins.
1. Proc Natl Acad Sci U S A - published November 2, 2020
2. Das S, Lin YH, Vernon RM, Forman-Kay JD, Chan HS
Glycan Positioning Impacts HIV-1 Env Glycan-Shield Density, Function, and Recognition by Antibodies.
1. iScience - published November 2, 2020
2. Wei Q, Hargett AA, Knoppova B, Duverger A, Rawi R, Shen CH, Farney SK, Hall S, Brown R, Keele BF, Heath SL, Saag MS, Kutsch O, Chuang GY, Kwong PD, Moldoveanu Z, Raska M, Renfrow MB, Novak J
Progenitor identification and SARS-CoV-2 infection in human distal lung organoids.
1. Nature - published November 2, 2020
2. Salahudeen AA, Choi SS, Rustagi A, Zhu J, van Unen V, de la O SM, Flynn RA, Margalef-Català M, Santos AJM, Ju J, Batish A, Usui T, Zheng GXY, Edwards CE, Wagar LE, Luca V, Anchang B, Nagendran M, Nguyen K, Hart DJ, Terry JM, Belgrader P, Ziraldo SB, Mikkelsen TS, Harbury PB, Glenn JS, Garcia KC, Davis MM, Baric RS, Sabatti C, Amieva MR, Blish CA, Desai TJ, Kuo CJ
The flexible N-terminus of BchL autoinhibits activity through interaction with its [4Fe-4S] cluster and relieved upon ATP binding.
1. J Biol Chem - published November 2, 2020
2. Corless EI, Saad Imran SM, Watkins MB, Bacik JP, Mattice J, Patterson A, Danyal K, Soffe M, Kitelinger R, Seefeldt LC, Origanti SS, Bennett B, Bothner B, Ando N, Antony E
Structural asymmetry governs the assembly and GTPase activity of McrBC restriction complexes.
1. Nat Commun - published November 2, 2020
2. Niu Y, Suzuki H, Hosford CJ, Walz T, Chappie JS
From in vitro towards in situ: structure-based investigation of ABC exporters by electron paramagnetic resonance spectroscopy.
1. FEBS Lett - published November 2, 2020
2. Bordignon E, Seeger MA, Galazzo L, Meier G
A highly conserved glutamic acid in ALFY inhibits membrane binding to aid in aggregate clearance.
1. Traffic - published November 2, 2020
2. Reinhart EF, Litt NA, Katzenell S, Pellegrini M, Yamamoto A, Ragusa MJ
Are Financial Payments From the Pharmaceutical Industry Associated With Physician Prescribing? : A Systematic Review.
1. Ann Intern Med - published November 2, 2020
2. Mitchell AP, Trivedi NU, Gennarelli RL, Chimonas S, Tabatabai SM, Goldberg J, Diaz LA Jr, Korenstein D
Structural basis for multifunctional roles of human Ints3 C-terminal domain.
1. J Biol Chem - published November 2, 2020
2. Li J, Ma X, Banerjee S, Baruah S, Schnicker NJ, Roh E, Ma W, Liu K, Bode AM, Dong Z
SUCLA2 mutations cause global protein succinylation contributing to the pathomechanism of a hereditary mitochondrial disease.
1. Nat Commun - published November 2, 2020
2. Gut P, Matilainen S, Meyer JG, Pällijeff P, Richard J, Carroll CJ, Euro L, Jackson CB, Isohanni P, Minassian BA, Alkhater RA, Østergaard E, Civiletto G, Parisi A, Thevenet J, Rardin MJ, He W, Nishida Y, Newman JC, Liu X, Christen S, Moco S, Locasale JW, Schilling B, Suomalainen A, Verdin E
Combined Inhibition of Gαq and MEK Enhances Therapeutic Efficacy in Uveal Melanoma.
1. Clin Cancer Res - published November 2, 2020
2. Hitchman TD, Bayshtok G, Ceraudo E, Moore AR, Lee C, Jia R, Wang N, Pachai MR, Shoushtari AN, Francis JH, Guan Y, Chen J, Chang MT, Taylor BS, Sakmar TP, Huber T, Chi P, Chen Y
The sensitivity of qSOFA calculated at triage and during emergency department treatment to rapidly identify sepsis patients.
1. Sci Rep - published November 2, 2020
2. Perman SM, Mikkelsen ME, Goyal M, Ginde A, Bhardwaj A, Drumheller B, Sante SC, Agarwal AK, Gaieski DF
Multi-wavelength, handheld laser speckle imaging for skin evaluation.
1. Skin Res Technol - published November 2, 2020
2. Zieger M, Kaatz M, Springer S, Riesenberg R, Wuttig A, Kanka M, Stanca S, Reble C, Khazaka G, Sieg R, De Gregorio M, Sattler M, Fischer F
Discovery of Marburg virus neutralizing antibodies from virus-naïve human antibody repertoires using large-scale structural predictions.
1. Proc Natl Acad Sci U S A - published November 2, 2020
2. Bozhanova NG, Sangha AK, Sevy AM, Gilchuk P, Huang K, Nargi RS, Reidy JX, Trivette A, Carnahan RH, Bukreyev A, Crowe JE Jr, Meiler J
Automated Design by Structure-Based Stabilization and Consensus Repair to Achieve Prefusion-Closed Envelope Trimers in a Wide Variety of HIV Strains.
1. Cell Rep - published November 2, 2020
2. Rawi R, Rutten L, Lai YT, Olia AS, Blokland S, Juraszek J, Shen CH, Tsybovsky Y, Verardi R, Yang Y, Zhang B, Zhou T, Chuang GY, Kwong PD, Langedijk JPM
Structural and mechanistic basis of the EMC-dependent biogenesis of distinct transmembrane clients.
1. Elife - published November 2, 2020
2. Miller-Vedam LE, Bräuning B, Popova KD, Schirle Oakdale NT, Bonnar JL, Prabu JR, Boydston EA, Sevillano N, Shurtleff MJ, Stroud RM, Craik CS, Schulman BA, Frost A, Weissman JS
Deep learning model predicts water interaction sites on the surface of proteins using limited-resolution data.
1. Chem Commun (Camb) - published November 2, 2020
2. Zaucha J, Softley CA, Sattler M, Frishman D, Popowicz GM
Protein Side-Chain-DNA Contacts Probed by Fast Magic-Angle Spinning NMR.
1. J Phys Chem B - published November 2, 2020
2. Lacabanne D, Boudet J, Malär AA, Wu P, Cadalbert R, Salmon L, Allain FH, Meier BH, Wiegand T
Direct Tumor Killing and Immunotherapy through Anti-SerpinB9 Therapy.
1. Cell - published November 2, 2020
2. Jiang L, Wang YJ, Zhao J, Uehara M, Hou Q, Kasinath V, Ichimura T, Banouni N, Dai L, Li X, Greiner DL, Shultz LD, Zhang X, Sun ZJ, Curtin I, Vangos NE, Yeoh ZC, Geffken EA, Seo HS, Liu ZX, Heffron GJ, Shah K, Dhe-Paganon S, Abdi R
Concurrent Dexamethasone Limits the Clinical Benefit of Immune Checkpoint Blockade in Glioblastoma.
1. Clin Cancer Res - published November 2, 2020
2. Iorgulescu JB, Gokhale PC, Speranza MC, Eschle BK, Poitras MJ, Wilkens MK, Soroko KM, Chhoeu C, Knott A, Gao Y, Lim-Fat MJ, Baker GJ, Bonal DM, Nguyen QD, Grant GRL, Ligon KL, Sorger PK, Chiocca EA, Anderson AC, Kirschmeier PT, Sharpe AH, Freeman GJ, Reardon DA
Clonal Hematopoiesis Before, During, and After Human Spaceflight.
1. Cell Rep - published November 2, 2020
2. Trinchant NM, MacKay MJ, Chin C, Afshinnekoo E, Foox J, Meydan C, Butler D, Mozsary C, Vernice NA, Darby C, Schatz MC, Bailey SM, Melnick AM, Guzman M, Bolton K, Braunstein LZ, Garrett-Bakelman F, Levine RL, Hassane D, Mason CE
Cholesterol 25-hydroxylase suppresses SARS-CoV-2 replication by blocking membrane fusion.
1. Proc Natl Acad Sci U S A - published November 2, 2020
2. Zang R, Case JB, Yutuc E, Ma X, Shen S, Gomez Castro MF, Liu Z, Zeng Q, Zhao H, Son J, Rothlauf PW, Kreutzberger AJB, Hou G, Zhang H, Bose S, Wang X, Vahey MD, Mani K, Griffiths WJ, Kirchhausen T, Fremont DH, Guo H, Diwan A, Wang Y, Diamond MS, Whelan SPJ, Ding S
Antibody-guided structure-based vaccines.
1. Semin Immunol - published November 2, 2020
2. Kwong PD, DeKosky BJ, Ulmer JB
Tumor microenvironment-targeted nanoparticles loaded with bortezomib and ROCK inhibitor improve efficacy in multiple myeloma.
1. Nat Commun - published November 2, 2020
2. Federico C, Alhallak K, Sun J, Duncan K, Azab F, Sudlow GP, de la Puente P, Muz B, Kapoor V, Zhang L, Yuan F, Markovic M, Kotsybar J, Wasden K, Guenthner N, Gurley S, King J, Kohnen D, Salama NN, Thotala D, Hallahan DE, Vij R, DiPersio JF, Achilefu S, Azab AK
Structure of the bacterial cellulose ribbon and its assembly-guiding cytoskeleton by electron cryotomography.
1. J Bacteriol - published November 1, 2020
2. Nicolas WJ, Ghosal D, Tocheva EI, Meyerowitz EM, Jensen GJ
Heparin-mediated dimerization of follistatin.
1. Exp Biol Med (Maywood) - published November 1, 2020
2. Walker RG, Kattamuri C, Goebel EJ, Zhang F, Hammel M, Tainer JA, Linhardt RJ, Thompson TB
Biochemical patterns of antibody polyreactivity revealed through a bioinformatics-based analysis of CDR loops.
1. Elife - published November 1, 2020
2. Boughter CT, Borowska MT, Guthmiller JJ, Bendelac A, Wilson PC, Roux B, Adams EJ
Structure-function analysis of microRNA 3'-end trimming by Nibbler.
1. Proc Natl Acad Sci U S A - published November 1, 2020
2. Xie W, Sowemimo I, Hayashi R, Wang J, Burkard TR, Brennecke J, Ameres SL, Patel DJ
Identification of highly selective covalent inhibitors by phage display.
1. Nat Biotechnol - published November 1, 2020
2. Chen S, Lovell S, Lee S, Fellner M, Mace PD, Bogyo M
The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase.
1. Proc Natl Acad Sci U S A - published November 1, 2020
2. Lilic M, Chen J, Boyaci H, Braffman N, Hubin EA, Herrmann J, Müller R, Mooney R, Landick R, Darst SA, Campbell EA
Enhancing the signal-to-noise ratio and generating contrast for cryo-EM images with convolutional neural networks.
1. IUCrJ - published November 1, 2020
2. Palovcak E, Asarnow D, Campbell MG, Yu Z, Cheng Y
High-resolution cryo-EM using beam-image shift at 200 keV.
1. IUCrJ - published November 1, 2020
2. Cash JN, Kearns S, Li Y, Cianfrocco MA
qFit 3: Protein and ligand multiconformer modeling for X-ray crystallographic and single-particle cryo-EM density maps.
1. Protein Sci - published November 1, 2020
2. Riley BT, Wankowicz SA, de Oliveira SHP, van Zundert GCP, Hogan DW, Fraser JS, Keedy DA, van den Bedem H
Single-molecule and in silico dissection of the interaction between Polycomb repressive complex 2 and chromatin.
1. Proc Natl Acad Sci U S A - published November 1, 2020
2. Leicher R, Ge EJ, Lin X, Reynolds MJ, Xie W, Walz T, Zhang B, Muir TW, Liu S
RCSB Protein Data Bank: powerful new tools for exploring 3D structures of biological macromolecules for basic and applied research and education in fundamental biology, biomedicine, biotechnology, bioengineering and energy sciences.
1. Nucleic Acids Res - published November 1, 2020
2. Burley SK, Bhikadiya C, Bi C, Bittrich S, Chen L, Crichlow GV, Christie CH, Dalenberg K, Di Costanzo L, Duarte JM, Dutta S, Feng Z, Ganesan S, Goodsell DS, Ghosh S, Green RK, Guranović V, Guzenko D, Hudson BP, Lawson CL, Liang Y, Lowe R, Namkoong H, Peisach E, Persikova I, Randle C, Rose A, Rose Y, Sali A, Segura J, Sekharan M, Shao C, Tao YP, Voigt M, Westbrook JD, Young JY, Zardecki C, Zhuravleva M
Gating by ionic strength and safety check by cyclic-di-AMP in the ABC transporter OpuA.
1. Sci Adv - published November 1, 2020
2. Sikkema HR, van den Noort M, Rheinberger J, de Boer M, Krepel ST, Schuurman-Wolters GK, Paulino C, Poolman B
RNA helicases are hubs that orchestrate exosome-dependent 3'-5' decay.
1. Curr Opin Struct Biol - published November 1, 2020
2. Weick EM, Lima CD
Requisite Chromatin Remodeling for Myeloid and Erythroid Lineage Differentiation from Erythromyeloid Progenitors.
1. Cell Rep - published November 1, 2020
2. Wu J, Krchma K, Lee HJ, Prabhakar S, Wang X, Zhao H, Xing X, Seong RH, Fremont DH, Artyomov MN, Wang T, Choi K
Lipocalin Blc is a potential heme-binding protein.
1. FEBS Lett - published November 1, 2020
2. Bozhanova NG, Calcutt MW, Beavers WN, Brown BP, Skaar EP, Meiler J
Amidine Functionality As a Conformational Probe of Cyclic Peptides.
1. Org Lett - published November 1, 2020
2. Huh S, Appavoo SD, Yudin AK
LDLRAD3 is a receptor for Venezuelan equine encephalitis virus.
1. Nature - published November 1, 2020
2. Ma H, Kim AS, Kafai NM, Earnest JT, Shah AP, Case JB, Basore K, Gilliland TC, Sun C, Nelson CA, Thackray LB, Klimstra WB, Fremont DH, Diamond MS
Small-molecule-induced polymerization triggers degradation of BCL6.
1. Nature - published November 1, 2020
2. Słabicki M, Yoon H, Koeppel J, Nitsch L, Roy Burman SS, Di Genua C, Donovan KA, Sperling AS, Hunkeler M, Tsai JM, Sharma R, Guirguis A, Zou C, Chudasama P, Gasser JA, Miller PG, Scholl C, Fröhling S, Nowak RP, Fischer ES, Ebert BL
Mechanism of Lamellar Body Formation by Lung Surfactant Protein B.
1. Mol Cell - published November 1, 2020
2. Sever N, Miličić G, Bodnar NO, Wu X, Rapoport TA
Bridging a DNA Break to Leave a Poly(ADP-Ribose) Mark on Chromatin.
1. Mol Cell - published November 1, 2020
2. Rouleau-Turcotte É, Pascal JM
Native Mass Spectrometry-Based Screening for Optimal Sample Preparation in Single-Particle Cryo-EM.
1. Structure - published November 1, 2020
2. Olinares PDB, Kang JY, Llewellyn E, Chiu C, Chen J, Malone B, Saecker RM, Campbell EA, Darst SA, Chait BT
Simultaneous Inhibition of SIRT2 Deacetylase and Defatty-Acylase Activities via a PROTAC Strategy.
1. ACS Med Chem Lett - published November 1, 2020
2. Hong JY, Jing H, Price IR, Cao J, Bai JJ, Lin H
Lower respiratory tract myeloid cells harbor SARS-CoV-2 and display an inflammatory phenotype.
1. Chest - published November 1, 2020
2. Bain WG, Peñaloza HF, Ladinsky MS, van der Geest R, Sullivan M, Ross M, Kitsios GD, Methe B, McVerry BJ, Morris A, Watson AM, Watkins SC, St Croix CM, Stolz DB, Bjorkman PJ, Lee JS
Inhibition of urease, a Ni-enzyme: the reactivity of a key thiol with mono- and di-substituted catechols elucidated by kinetic, structural and theoretical studies.
1. Angew Chem Int Ed Engl - published November 1, 2020
2. Mazzei L, Contaldo U, Musiani F, Cianci M, Bagnolini G, Roberti M, Ciurli S
Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth.
1. Science - published November 1, 2020
2. Roark RS, Li H, Williams WB, Chug H, Mason RD, Gorman J, Wang S, Lee FH, Rando J, Bonsignori M, Hwang KK, Saunders KO, Wiehe K, Moody MA, Hraber PT, Wagh K, Giorgi EE, Russell RM, Bibollet-Ruche F, Liu W, Connell J, Smith AG, DeVoto J, Murphy AI, Smith J, Ding W, Zhao C, Chohan N, Okumura M, Rosario C, Ding Y, Lindemuth E, Bauer AM, Bar KJ, Ambrozak D, Chao CW, Chuang GY, Geng H, Lin BC, Louder MK, Nguyen R, Zhang B, Lewis MG, Raymond D, Doria-Rose NA, Schramm CA, Douek DC, Roederer M, Kepler TB, Kelsoe G, Mascola JR, Kwong PD, Korber BT, Harrison SC, Haynes BF, Hahn BH, Shaw GM
Real-Time Conformational Dynamics of SARS-CoV-2 Spikes on Virus Particles.
1. Cell Host Microbe - published November 1, 2020
2. Lu M, Uchil PD, Li W, Zheng D, Terry DS, Gorman J, Shi W, Zhang B, Zhou T, Ding S, Gasser R, Prévost J, Beaudoin-Bussières G, Anand SP, Laumaea A, Grover JR, Liu L, Ho DD, Mascola JR, Finzi A, Kwong PD, Blanchard SC, Mothes W
High-Throughput Image Cytometry Detection Method for CAR-T Transduction, Cell Proliferation, and Cytotoxicity Assays.
1. Cytometry A - published November 1, 2020
2. Wang Y, Chan LL, Grimaud M, Fayed A, Zhu Q, Marasco WA
Structural Basis for High-Affinity Trapping of the Na_V1.7 Channel in Its Resting State by Tarantula Toxin.
1. Mol Cell - published November 1, 2020
2. Wisedchaisri G, Tonggu L, Gamal El-Din TM, McCord E, Zheng N, Catterall WA
Structure of an affinity-matured inhibitory recombinant fab against urokinase plasminogen activator reveals basis of potency and specificity.
1. Biochim Biophys Acta Proteins Proteom - published November 1, 2020
2. Sevillano N, Bohn MF, Zimanyi M, Chen Y, Petzold C, Gupta S, Ralston CY, Craik CS
Identification of a novel leptin receptor (LEPR) variant and proof of functional relevance directing treatment decisions in patients with morbid obesity.
1. Metabolism - published November 1, 2020
2. Voigtmann F, Wolf P, Landgraf K, Stein R, Kratzsch J, Schmitz S, Jamra RA, Blüher M, Meiler J, Beck-Sickinger AG, Kiess W, Körner A
Comparing the Efficacy of Cancer Therapies between Subgroups in Basket Trials.
1. Cell Syst - published November 1, 2020
2. Palmer AC, Plana D, Sorger PK
Transmembrane Polar Relay Drives the Allosteric Regulation for ABCG5/G8 Sterol Transporter.
1. Int J Mol Sci - published November 1, 2020
2. Xavier BM, Zein AA, Venes A, Wang J, Lee JY
A Prospective Randomized Controlled Trial of Irrigation "Bag Squeeze" to Manage Pain for Patients Undergoing Flexible Cystoscopy.
1. J Urol - published November 1, 2020
2. Berajoui MB, Aditya I, Herrera-Caceres J, Qaoud Y, Lajkosz K, Ajib K, Glase Z, Wagner H, Hersey K, Kenk M, Hamilton RJ, Kulkarni GS, Zlotta AR, Lee JY, Perlis N, Finelli A, Fleshner NE
Androgen Signaling Regulates SARS-CoV-2 Receptor Levels and Is Associated with Severe COVID-19 Symptoms in Men.
1. Cell Stem Cell - published November 1, 2020
2. Samuel RM, Majd H, Richter MN, Ghazizadeh Z, Zekavat SM, Navickas A, Ramirez JT, Asgharian H, Simoneau CR, Bonser LR, Koh KD, Garcia-Knight M, Tassetto M, Sunshine S, Farahvashi S, Kalantari A, Liu W, Andino R, Zhao H, Natarajan P, Erle DJ, Ott M, Goodarzi H, Fattahi F
A CRISPR Screen Reveals Resistance Mechanisms to CD3-Bispecific Antibody Therapy.
1. Cancer Immunol Res - published November 1, 2020
2. Liu SQ, Grantham A, Landry C, Granda B, Chopra R, Chakravarthy S, Deutsch S, Vogel M, Russo K, Seiss K, Tschantz WR, Rejtar T, Ruddy DA, Hu T, Aardalen K, Wagner JP, Dranoff G, D'Alessio JA
Engineered chemotaxis core signaling units indicate a constrained kinase-off state.
1. Sci Signal - published November 1, 2020
2. Muok AR, Chua TK, Srivastava M, Yang W, Maschmann Z, Borbat PP, Chong J, Zhang S, Freed JH, Briegel A, Crane BR
Lipoteichoic acid polymer length is determined by competition between free starter units.
1. Proc Natl Acad Sci U S A - published November 1, 2020
2. Hesser AR, Schaefer K, Lee W, Walker S
Structural Insight into the DNA Binding Function of Transcription Factor ERF.
1. Biochemistry - published November 1, 2020
2. Hou C, McCown C, Ivanov DN, Tsodikov OV
Rapid Induction of the Unfolded Protein Response and Apoptosis by Estrogen Mimic TTC-352 for the Treatment of Endocrine-Resistant Breast Cancer.
1. Mol Cancer Ther - published November 1, 2020
2. Abderrahman B, Maximov PY, Curpan RF, Fanning SW, Hanspal JS, Fan P, Foulds CE, Chen Y, Malovannaya A, Jain A, Xiong R, Greene GL, Tonetti DA, Thatcher GRJ, Jordan VC
Crystal structures of ORFV125 provide insight into ORF virus mediated inhibition of apoptosis.
1. Biochem J - published November 1, 2020
2. Suraweera CD, Hinds MG, Kvansakul M
A Structural Basis for Lithium and Substrate Binding of an Inositide Phosphatase.
1. J Biol Chem - published November 1, 2020
2. Dollins DE, Xiong JP, Endo-Streeter S, Anderson DE, Bansal VS, Ponder JW, Ren Y, York JD
Structural basis of ion transport and inhibition in ferroportin.
1. Nat Commun - published November 1, 2020
2. Pan Y, Ren Z, Gao S, Shen J, Wang L, Xu Z, Yu Y, Bachina P, Zhang H, Fan X, Laganowsky A, Yan N, Zhou M
Assessment of Outcomes After Stopping Tyrosine Kinase Inhibitors Among Patients With Chronic Myeloid Leukemia: A Nonrandomized Clinical Trial.
1. JAMA Oncol - published November 1, 2020
2. Atallah E, Schiffer CA, Radich JP, Weinfurt KP, Zhang MJ, Pinilla-Ibarz J, Kota V, Larson RA, Moore JO, Mauro MJ, Deininger MWN, Thompson JE, Oehler VG, Wadleigh M, Shah NP, Ritchie EK, Silver RT, Cortes J, Lin L, Visotcky A, Baim A, Harrell J, Helton B, Horowitz M, Flynn KE
Secondary structure determination of conserved SARS-CoV-2 RNA elements by NMR spectroscopy.
1. Nucleic Acids Res - published November 1, 2020
2. Wacker A, Weigand JE, Akabayov SR, Altincekic N, Bains JK, Banijamali E, Binas O, Castillo-Martinez J, Cetiner E, Ceylan B, Chiu LY, Davila-Calderon J, Dhamotharan K, Duchardt-Ferner E, Ferner J, Frydman L, Fürtig B, Gallego J, Grün JT, Hacker C, Haddad C, Hähnke M, Hengesbach M, Hiller F, Hohmann KF, Hymon D, de Jesus V, Jonker H, Keller H, Knezic B, Landgraf T, Löhr F, Luo L, Mertinkus KR, Muhs C, Novakovic M, Oxenfarth A, Palomino-Schätzlein M, Petzold K, Peter SA, Pyper DJ, Qureshi NS, Riad M, Richter C, Saxena K, Schamber T, Scherf T, Schlagnitweit J, Schlundt A, Schnieders R, Schwalbe H, Simba-Lahuasi A, Sreeramulu S, Stirnal E, Sudakov A, Tants JN, Tolbert BS, Vögele J, Weiß L, Wirmer-Bartoschek J, Wirtz Martin MA, Wöhnert J, Zetzsche H
Characterization of the ExoU activation mechanism using EPR and integrative modeling.
1. Sci Rep - published November 1, 2020
2. Tessmer MH, DeCero SA, Del Alamo D, Riegert MO, Meiler J, Frank DW, Feix JB
Nanobubble-controlled nanofluidic transport.
1. Sci Adv - published November 1, 2020
2. Rabinowitz J, Whittier E, Liu Z, Jayant K, Frank J, Shepard K
Mithramycin 2'-Oximes with Improved Selectivity, Pharmacokinetics, and Ewing Sarcoma Antitumor Efficacy.
1. J Med Chem - published November 1, 2020
2. Liu Y, Eckenrode JM, Zhang Y, Zhang J, Hayden RC, Kyomuhangi A, Ponomareva LV, Cui Z, Rohr J, Tsodikov OV, Van Lanen SG, Shaaban KA, Leggas M, Thorson JS
RCSB Protein Data Bank: Architectural advances towards integrated searching and efficient access to macromolecular structure data from the PDB archive.
1. J Mol Biol - published November 1, 2020
2. Rose Y, Duarte JM, Lowe R, Segura J, Bi C, Bhikadiya C, Chen L, Rose AS, Bittrich S, Burley SK, Westbrook JD
Flavonol-mediated stabilization of PIN efflux complexes regulates polar auxin transport.
1. EMBO J - published November 1, 2020
2. Teale WD, Pasternak T, Dal Bosco C, Dovzhenko A, Kratzat K, Bildl W, Schwörer M, Falk T, Ruperti B, V Schaefer J, Shahriari M, Pilgermayer L, Li X, Lübben F, Plückthun A, Schulte U, Palme K
The 3.2-Å resolution structure of human mTORC2.
1. Sci Adv - published November 1, 2020
2. Scaiola A, Mangia F, Imseng S, Boehringer D, Berneiser K, Shimobayashi M, Stuttfeld E, Hall MN, Ban N, Maier T
Cellular context of IL-33 expression dictates impact on anti-helminth immunity.
1. Sci Immunol - published November 1, 2020
2. Hung LY, Tanaka Y, Herbine K, Pastore C, Singh B, Ferguson A, Vora N, Douglas B, Zullo K, Behrens EM, Li Hui Tan T, Kohanski MA, Bryce P, Lin C, Kambayashi T, Reed DR, Brown BL, Cohen NA, Herbert DR
Structure of the human core transcription-export complex reveals a hub for multivalent interactions.
1. Elife - published November 1, 2020
2. Pühringer T, Hohmann U, Fin L, Pacheco-Fiallos B, Schellhaas U, Brennecke J, Plaschka C
Talin-activated vinculin interacts with branched actin networks to initiate bundles.
1. Elife - published November 1, 2020
2. Boujemaa-Paterski R, Martins B, Eibauer M, Beals CT, Geiger B, Medalia O
County-level CO₂ emissions and sequestration in China during 1997-2017.
1. Sci Data - published November 1, 2020
2. Chen J, Gao M, Cheng S, Hou W, Song M, Liu X, Liu Y, Shan Y
Atypical chemoreceptor arrays accommodate high membrane curvature.
1. Nat Commun - published November 1, 2020
2. Muok AR, Ortega DR, Kurniyati K, Yang W, Maschmann ZA, Sidi Mabrouk A, Li C, Crane BR, Briegel A
Simulations of Proposed Mechanisms of FtsZ-Driven Cell Constriction.
1. J Bacteriol - published November 1, 2020
2. Nguyen LT, Oikonomou CM, Jensen GJ
Senescent cells promote tissue NAD⁺ decline during ageing via the activation of CD38⁺ macrophages.
1. Nat Metab - published November 1, 2020
2. Covarrubias AJ, Kale A, Perrone R, Lopez-Dominguez JA, Pisco AO, Kasler HG, Schmidt MS, Heckenbach I, Kwok R, Wiley CD, Wong HS, Gibbs E, Iyer SS, Basisty N, Wu Q, Kim IJ, Silva E, Vitangcol K, Shin KO, Lee YM, Riley R, Ben-Sahra I, Ott M, Schilling B, Scheibye-Knudsen M, Ishihara K, Quake SR, Newman J, Brenner C, Campisi J, Verdin E