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118 Member Publications for June

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Large Nanodiscs: A Potential Game Changer in Structural Biology of Membrane Protein Complexes and Virus Entry.
1. Front Bioeng Biotechnol - published June 30, 2020
2. Padmanabha Das KM, Shih WM, Wagner G, Nasr ML
Structure-Based Design of Nipah Virus Vaccines: A Generalizable Approach to Paramyxovirus Immunogen Development.
1. Front Immunol - published June 30, 2020
2. Loomis RJ, Stewart-Jones GBE, Tsybovsky Y, Caringal RT, Morabito KM, McLellan JS, Chamberlain AL, Nugent ST, Hutchinson GB, Kueltzo LA, Mascola JR, Graham BS
Differential dynamics of early stages of platelet adhesion and spreading on collagen IV- and fibrinogen-coated surfaces.
1. F1000Res - published June 23, 2020
2. Horev MB, Zabary Y, Zarka R, Sorrentino S, Medalia O, Zaritsky A, Geiger B
Combination of Antifungal Drugs and Protease Inhibitors Prevent Candida albicans Biofilm Formation and Disrupt Mature Biofilms.
1. Front Microbiol - published June 12, 2020
2. Lohse MB, Gulati M, Craik CS, Johnson AD, Nobile CJ
Coarse-grained (hybrid) integrative modeling of biomolecular interactions.
1. Comput Struct Biotechnol J - published June 10, 2020
2. Roel-Touris J, Bonvin AMJJ
An ECF-type transporter scavenges heme to overcome iron-limitation in Staphylococcus lugdunensis.
1. Elife - published June 9, 2020
2. Jochim A, Adolf L, Belikova D, Schilling NA, Setyawati I, Chin D, Meyers S, Verhamme P, Heinrichs DE, Slotboom DJ, Heilbronner S
Homogeneous Oligomers of Pro-apoptotic BAX Reveal Structural Determinants of Mitochondrial Membrane Permeabilization.
1. Mol Cell - published June 9, 2020
2. Hauseman ZJ, Harvey EP, Newman CE, Wales TE, Bucci JC, Mintseris J, Schweppe DK, David L, Fan L, Cohen DT, Herce HD, Mourtada R, Ben-Nun Y, Bloch NB, Hansen SB, Wu H, Gygi SP, Engen JR, Walensky LD
Structure and Characterization of a Covalent Inhibitor of Src Kinase.
1. Front Mol Biosci - published June 9, 2020
2. Gurbani D, Du G, Henning NJ, Rao S, Bera AK, Zhang T, Gray NS, Westover KD
Small Molecule Sensors Targeting the Bacterial Cell Wall.
1. ACS Infect Dis - published June 9, 2020
2. Parker MFL, Flavell RR, Luu JM, Rosenberg OS, Ohliger MA, Wilson DM
Molecular basis for the distinct cellular functions of the Lsm1-7 and Lsm2-8 complexes.
1. RNA - published June 9, 2020
2. Montemayor EJ, Virta JM, Hayes SM, Nomura Y, Brow DA, Butcher SE
Identifying the role of PrimPol in TDF-induced toxicity and implications of its loss of function mutation in an HIV+ patient.
1. Sci Rep - published June 9, 2020
2. Duong VN, Zhou L, Martínez-Jiménez MI, He L, Cosme M, Blanco L, Paintsil E, Anderson KS
Slow Receptor Binding of the Noncytopathic HIV-2UC1 Envs Is Balanced by Long-Lived Activation State and Efficient Fusion Activity.
1. Cell Rep - published June 9, 2020
2. Harris M, Ratnapriya S, Chov A, Cervera H, Block A, Gu C, Talledge N, Mansky LM, Sodroski J, Herschhorn A
Bi-allelic missense disease-causing variants in RPL3L associate neonatal dilated cardiomyopathy with muscle-specific ribosome biogenesis.
1. Hum Genet - published June 8, 2020
2. Ganapathi M, Argyriou L, Martínez-Azorín F, Morlot S, Yigit G, Lee TM, Auber B, von Gise A, Petrey DS, Thiele H, Cyganek L, Sabater-Molina M, Ahimaz P, Cabezas-Herrera J, Sorlí-García M, Zibat A, Siegelin MD, Burfeind P, Buchovecky CM, Hasenfuss G, Honig B, Li Y, Iglesias AD, Wollnik B
Mutant-Selective Allosteric EGFR Degraders are Effective Against a Broad Range of Drug-Resistant Mutations.
1. Angew Chem Int Ed Engl - published June 8, 2020
2. Jang J, To C, De Clercq DJH, Park E, Ponthier CM, Shin BH, Mushajiang M, Nowak RP, Fischer ES, Eck MJ, Jänne PA, Gray NS
Near-atomic structures of the BBSome reveal the basis for BBSome activation and binding to GPCR cargoes.
1. Elife - published June 8, 2020
2. Yang S, Bahl K, Chou HT, Woodsmith J, Stelzl U, Walz T, Nachury MV
ARIA digital anamorphosis: Digital transformation of health and care in airway diseases from research to practice.
1. Allergy - published June 8, 2020
2. Bousquet J, Anto JM, Bachert C, Haahtela T, Zuberbier T, Czarlewski W, Bedbrook A, Bosnic-Anticevich S, Walter Canonica G, Cardona V, ElisioCosta, Cruz AA, Erhola M, Fokkens WJ, Fonseca JA, Illario M, CarlosIvancevich J, Jutel M, Klimek L, PiotrKuna, Kvedariene V, Le L, Larenas-Linnemann D, Laune D, Lourenço OM, Melén E, Mullol J, Niedoszytko M, Odemyr M, Okamoto Y, Papadopoulos NG, Patella V, Pfaar O, Pham-Thi N, Rolland C, Samolinski B, Sheikh A, Sofiev M, SuppliUlrik C, Todo-Bom A, Tomazic PV, Toppila-Salmi S, Tsiligianni I, Valiulis A, Valovirta E, Ventura MT, Walker S, Williams S, Yorgancioglu A, Agache I, Akdis CA, Almeida R, Ansotegui IJ, Annesi-Maesano I, Arnavielhe S, Basagaña X, Bateman E, Bédard A, Bedolla-Barajas M, Becker S, Bennoor KS, Benveniste S, Bergmann KC, Bewick M, Bialek S, Billo N, Bindslev-Jensen C, Bjermer L, Blain H, Bonini M, Bonniaud P, Bosse I, Bouchard J, Boulet LP, Bourret R, Boussery K, Braido F, Briedis V, Briggs A, Brightling CE, JanBrozek, Brusselle G, Brussino L, Buhl R, Buonaiuto R, Calderon MA, Camargos P, Camuzat T, Caraballo L, Carriazo AM, Carr W, Cartier C, Casale T, Cecchi L, Cepeda Sarabia AM, Chavannes N, Chkhartishvili E, Chu DK, Cingi C, Correia de Sousa J, Costa DJ, Courbis AL, Custovic A, Cvetkosvki B, D'Amato G, da Silva J, Dantas C, Dokic D, Dauvilliers Y, De Feo G, De Vries G, Devillier P, Di Capua S, Dray G, Dubakiene R, Durham SR, Dykewicz M, Ebisawa M, Gaga M, El-Gamal Y, Heffler E, Emuzyte R, Farrell J, Fauquert JL, Fiocchi A, Fink-Wagner A, Fontaine JF, Fuentes Perez JM, Gemicioğlu B, Gamkrelidze A, Garcia-Aymerich J, Gevaert P, Gomez M, González Diaz S, Gotua M, Guldemond NA, Guzmán MA, Hajjam J, Huerta Villalobos YR, Humbert M, Iaccarino G, Ierodiakonou D, TomohisaIinuma, Jassem E, Joos G, Jung KS, Kaidashev I, Kalayci O, Kardas P, Keil T, Khaitov M, Khaltaev N, Kleine-Tebbe J, Kouznetsov R, Kowalski ML, Kritikos V, Kull I, La Grutta S, Leonardini L, Ljungberg H, Lieberman P, Lipworth B, Lodrup Carlsen KC, Lopes-Pereira C, Loureiro CC, Louis R, Mair A, Mahboub B, Makris M, Malva J, Manning P, Marshall GD, Masjedi MR, Maspero JF, Carreiro-Martins P, Makela M, Mathieu-Dupas E, Maurer M, De Manuel Keenoy E, Melo-Gomes E, Meltzer EO, Menditto E, Mercier J, Micheli Y, Miculinic N, Mihaltan F, Milenkovic B, Mitsias D, Moda G, Mogica-Martinez MD, Mohammad Y, Montefort S, Monti R, Morais-Almeida M, Mösges R, Münter L, Muraro A, Murray R, Naclerio R, Napoli L, Namazova-Baranova L, Neffen H, Nekam K, Neou A, Nordlund B, Novellino E, Nyembue D, O'Hehir R, Ohta K, Okubo K, Onorato GL, Ouedraogo S, Palamarchuk J, Pali-Schöll I, Panzner P, Park HS, Passalacqua G, Pépin JL, Paulino E, Phillips J, Picard R, Pinnock H, Plavec D, Popov TA, Portejoie F, Price D, Prokopakis EP, Psarros F, Pugin B, Puggioni F, Quinones-Delgado P, Raciborski F, Rajabian-Söderlund R, Regateiro FS, Reitsma S, Rivero-Yeverino D, Roberts G, Roche N, Rodriguez-Zagal E, Rolland C, Roller-Wirnsberger RE, Rosario N, Romano A, Rottem M, Ryan D, Salimäki J, Sanchez-Borges MM, Sastre J, Scadding GK, Scheire S, Schmid-Grendelmeier P, Schünemann HJ, Serpa F, Shamji M, Sisul JC, Sofiev M, Solé D, Somekh D, Sooronbaev T, Sova M, Spertini F, Spranger O, Stellato C, Stelmach R, Thibaudon M, To T, MondherToumi, Usmani O, Valero A, Valenta R, Valentin-Rostan M, van der Kleij R, Van Eerd M, Vandenplas O, Vasankari T, Vaz Carneiro A, Vezzani G, Viart F, Viegi G, Wallace D, Wagenmann M, Wang Y, Waserman S, Wickman M, Williams DM, Wong G, Wroczynski P, Yiallouros PK, Yusuf OM, Zar HJ, Zeng S, Zernotti ME, Zhang L, Zhong NS, Zidarn M
Pat1 increases the range of decay factors and RNA bound by the Lsm1-7 complex.
1. RNA - published June 8, 2020
2. Lobel JH, Gross JD
Structure and mechanism of DHHC protein acyltransferases.
1. J Mol Biol - published June 6, 2020
2. Stix R, Lee CJ, Faraldo-Gómez JD, Banerjee A
Mode of action of teixobactins in cellular membranes.
1. Nat Commun - published June 5, 2020
2. Shukla R, Medeiros-Silva J, Parmar A, Vermeulen BJA, Das S, Paioni AL, Jekhmane S, Lorent J, Bonvin AMJJ, Baldus M, Lelli M, Veldhuizen EJA, Breukink E, Singh I, Weingarth M
Comment on "RNA-guided DNA insertion with CRISPR-associated transposases".
1. Science - published June 5, 2020
2. Rice PA, Craig NL, Dyda F
Diverse nucleosome site-selectivity among histone deacetylase complexes.
1. Elife - published June 5, 2020
2. Wang ZA, Millard CJ, Lin CL, Gurnett JE, Wu M, Lee K, Fairall L, Schwabe JWR, Cole PA
Visualizing group II intron dynamics between the first and second steps of splicing.
1. Nat Commun - published June 5, 2020
2. Manigrasso J, Chillón I, Genna V, Vidossich P, Somarowthu S, Pyle AM, De Vivo M, Marcia M
Phosphorylation barcode-dependent signal bias of the dopamine D1 receptor.
1. Proc Natl Acad Sci U S A - published June 5, 2020
2. Kaya AI, Perry NA, Gurevich VV, Iverson TM
Publisher Correction: Methylation deficiency disrupts biological rhythms from bacteria to humans.
1. Commun Biol - published June 4, 2020
2. Fustin JM, Ye S, Rakers C, Kaneko K, Fukumoto K, Yamano M, Versteven M, Grünewald E, Cargill SJ, Tamai TK, Xu Y, Jabbur ML, Kojima R, Lamberti ML, Yoshioka-Kobayashi K, Whitmore D, Tammam S, Howell PL, Kageyama R, Matsuo T, Stanewsky R, Golombek DA, Johnson CH, Kakeya H, van Ooijen G, Okamura H
Approaches to modulate the chronic wound environment using localized nucleic acid delivery.
1. Adv Wound Care (New Rochelle) - published June 4, 2020
2. Berger AG, Chou JJ, Hammond PT
The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K.
1. Nature - published June 3, 2020
2. Słabicki M, Kozicka Z, Petzold G, Li YD, Manojkumar M, Bunker RD, Donovan KA, Sievers QL, Koeppel J, Suchyta D, Sperling AS, Fink EC, Gasser JA, Wang LR, Corsello SM, Sellar RS, Jan M, Gillingham D, Scholl C, Fröhling S, Golub TR, Fischer ES, Thomä NH, Ebert BL
Structural basis for the recognition of transiently structured AU-rich elements by Roquin.
1. Nucleic Acids Res - published June 3, 2020
2. Binas O, Tants JN, Peter SA, Janowski R, Davydova E, Braun J, Niessing D, Schwalbe H, Weigand JE, Schlundt A
Biophysical Properties of HP1-Mediated Heterochromatin.
1. Cold Spring Harb Symp Quant Biol - published June 3, 2020
2. Sanulli S, Gross JD, Narlikar GJ
A requirement for an active proton delivery network supports a Compound I mediated C-C bond cleavage in CYP51 catalysis.
1. J Biol Chem - published June 3, 2020
2. Hargrove TY, Wawrzak Z, Guengerich FP, Lepesheva GI
Discovering How Heme Controls Genome Function Through Heme-omics.
1. Cell Rep - published June 3, 2020
2. Liao R, Zheng Y, Liu X, Zhang Y, Seim G, Tanimura N, Wilson GM, Hematti P, Coon JJ, Fan J, Xu J, Keles S, Bresnick EH
Noncanonical inhibition of caspase-3 by a nuclear microRNA confers endothelial protection by autophagy in atherosclerosis.
1. Sci Transl Med - published June 3, 2020
2. Santovito D, Egea V, Bidzhekov K, Natarelli L, Mourão A, Blanchet X, Wichapong K, Aslani M, Brunßen C, Horckmans M, Hristov M, Geerlof A, Lutgens E, Daemen MJAP, Hackeng T, Ries C, Chavakis T, Morawietz H, Naumann R, von Hundelshausen P, Steffens S, Duchêne J, Megens RTA, Sattler M, Weber C
Bisphosphonate-Based Molecules as Potential New Antiparasitic Drugs.
1. Molecules - published June 3, 2020
2. Branco Santos JC, de Melo JA, Maheshwari S, de Medeiros WMTQ, de Freitas Oliveira JW, Moreno CJ, Mario Amzel L, Gabelli SB, Sousa Silva M
A Combination of Human Broadly Neutralizing Antibodies against Hepatitis B Virus HBsAg with Distinct Epitopes Suppresses Escape Mutations.
1. Cell Host Microbe - published June 3, 2020
2. Wang Q, Michailidis E, Yu Y, Wang Z, Hurley AM, Oren DA, Mayer CT, Gazumyan A, Liu Z, Zhou Y, Schoofs T, Yao KH, Nieke JP, Wu J, Jiang Q, Zou C, Kabbani M, Quirk C, Oliveira T, Chhosphel K, Zhang Q, Schneider WM, Jahan C, Ying T, Horowitz J, Caskey M, Jankovic M, Robbiani DF, Wen Y, de Jong YP, Rice CM, Nussenzweig MC
KRASQ61H preferentially signals through MAPK in a RAF dimer-dependent manner in non-small cell lung cancer.
1. Cancer Res - published June 3, 2020
2. Zhou ZW, Ambrogio C, Bera AK, Li Q, Li XX, Li L, Son J, Gondi S, Li J, Campbell E, Jin H, Okoro JJ, Xu CX, Janne PA, Westover KD
Structure of Human ATG9A, the Only Transmembrane Protein of the Core Autophagy Machinery.
1. Cell Rep - published June 3, 2020
2. Guardia CM, Tan XF, Lian T, Rana MS, Zhou W, Christenson ET, Lowry AJ, Faraldo-Gómez JD, Bonifacino JS, Jiang J, Banerjee A
Turning up the heat on HIV-1.
1. Proc Natl Acad Sci U S A - published June 3, 2020
2. Chen IP, Ott M
Relationship of CT densitometry to lung physiological parameters and health status in alpha-1 antitrypsin deficiency: initial report of a centralised database of the NIHR rare diseases translational research collaborative.
1. BMJ Open - published June 3, 2020
2. Crossley D, Stockley J, Bolton CE, Hopkinson NS, Mahadeva R, Steiner M, Wilkinson T, Hurst JR, Gooptu B, Stockley RA
A conserved RNA degradation complex required for spreading and epigenetic inheritance of heterochromatin.
1. Elife - published June 3, 2020
2. Shipkovenska G, Durango A, Kalocsay M, Gygi SP, Moazed D
Deploying Big Data to Crack the Genotype to Phenotype Code.
1. Integr Comp Biol - published June 3, 2020
2. Westerman EL, Bowman SEJ, Davidson B, Davis MC, Larson ER, Sanford C
Role of nanoscale antigen organization on B-cell activation probed using DNA origami.
1. Nat Nanotechnol - published June 2, 2020
2. Veneziano R, Moyer TJ, Stone MB, Wamhoff EC, Read BJ, Mukherjee S, Shepherd TR, Das J, Schief WR, Irvine DJ, Bathe M
Spectroscopic Investigation of Cysteamine Dioxygenase.
1. Biochemistry - published June 2, 2020
2. Fernandez RL, Dillon SL, Stipanuk MH, Fox BG, Brunold TC
Ribonucleotide Reductases: Structure, Chemistry, and Metabolism Suggest New Therapeutic Targets.
1. Annu Rev Biochem - published June 2, 2020
2. Greene BL, Kang G, Cui C, Bennati M, Nocera DG, Drennan CL, Stubbe J
Moyamoya disease factor RNF213 is a giant E3 ligase with a dynein-like core and a distinct ubiquitin-transfer mechanism.
1. Elife - published June 2, 2020
2. Ahel J, Lehner A, Vogel A, Schleiffer A, Meinhart A, Haselbach D, Clausen T
A single-cell landscape of high-grade serous ovarian cancer.
1. Nat Med - published June 2, 2020
2. Izar B, Tirosh I, Stover EH, Wakiro I, Cuoco MS, Alter I, Rodman C, Leeson R, Su MJ, Shah P, Iwanicki M, Walker SR, Kanodia A, Melms JC, Mei S, Lin JR, Porter CBM, Slyper M, Waldman J, Jerby-Arnon L, Ashenberg O, Brinker TJ, Mills C, Rogava M, Vigneau S, Sorger PK, Garraway LA, Konstantinopoulos PA, Liu JF, Matulonis U, Johnson BE, Rozenblatt-Rosen O, Rotem A, Regev A
Gating of human TRPV3 in a lipid bilayer.
1. Nat Struct Mol Biol - published June 2, 2020
2. Deng Z, Maksaev G, Rau M, Xie Z, Hu H, Fitzpatrick JAJ, Yuan P
Rapid Elaboration of Fragments into Leads by X-ray Crystallographic Screening of Parallel Chemical Libraries (REFiLX).
1. J Med Chem - published June 2, 2020
2. Bentley MR, Ilyichova OV, Wang G, Williams ML, Sharma G, Alwan WS, Whitehouse RL, Mohanty B, Scammells PJ, Heras B, Martin JL, Totsika M, Capuano B, Doak BC, Scanlon MJ
Structures of metabotropic GABAB receptor.
1. Nature - published June 2, 2020
2. Papasergi-Scott MM, Robertson MJ, Seven AB, Panova O, Mathiesen JM, Skiniotis G
Correction for Softley et al., "Structure and Molecular Recognition Mechanism of IMP-13 Metallo-β-Lactamase".
1. Antimicrob Agents Chemother - published June 2, 2020
2. Softley CA, Zak KM, Bostock MJ, Fino R, Zhou RX, Kolonko M, Mejdi-Nitiu R, Meyer H, Sattler M, Popowicz GM
Structural basis for capsid recruitment and coat formation during HSV-1 nuclear egress.
1. Elife - published June 2, 2020
2. Draganova EB, Zhang J, Zhou ZH, Heldwein EE
CD300LF polymorphisms of inbred mouse strains confer resistance to murine norovirus infection in a cell type-dependent manner.
1. J Virol - published June 2, 2020
2. Furlong K, Biering SB, Choi J, Wilen CB, Orchard RC, Wobus CE, Nelson CA, Fremont DH, Baldridge MT, Randall G, Hwang S
Recognition of physiological phosphorylation sites by p21-activated kinase 4.
1. J Struct Biol - published June 2, 2020
2. Chetty AK, Sexton JA, Hak Ha B, Turk BE, Boggon TJ
Discovery of MFH290: A Potent and Highly Selective Covalent Inhibitor for Cyclin-Dependent Kinase 12/13.
1. J Med Chem - published June 2, 2020
2. Liu Y, Hao M, Leggett AL, Gao Y, Ficarro SB, Che J, He Z, Olson CM, Marto JA, Kwiatkowski NP, Zhang T, Gray NS
Structure of human GABAB receptor in an inactive state.
1. Nature - published June 2, 2020
2. Park J, Fu Z, Frangaj A, Liu J, Mosyak L, Shen T, Slavkovich VN, Ray KM, Taura J, Cao B, Geng Y, Zuo H, Kou Y, Grassucci R, Chen S, Liu Z, Lin X, Williams JP, Rice WJ, Eng ET, Huang RK, Soni RK, Kloss B, Yu Z, Javitch JA, Hendrickson WA, Slesinger PA, Quick M, Graziano J, Yu H, Fiehn O, Clarke OB, Frank J, Fan QR
Recognition of Semaphorin Proteins by P. sordellii Lethal Toxin Reveals Principles of Receptor Specificity in Clostridial Toxins.
1. Cell - published June 2, 2020
2. Lee H, Beilhartz GL, Kucharska I, Raman S, Cui H, Lam MHY, Liang H, Rubinstein JL, Schramek D, Julien JP, Melnyk RA, Taipale M
The MiDAC histone deacetylase complex is essential for embryonic development and has a unique multivalent structure.
1. Nat Commun - published June 2, 2020
2. Turnbull RE, Fairall L, Saleh A, Kelsall E, Morris KL, Ragan TJ, Savva CG, Chandru A, Millard CJ, Makarova OV, Smith CJ, Roseman AM, Fry AM, Cowley SM, Schwabe JWR
A Potently Neutralizing Antibody Protects Mice against SARS-CoV-2 Infection.
1. J Immunol - published June 2, 2020
2. Alsoussi WB, Turner JS, Case JB, Zhao H, Schmitz AJ, Zhou JQ, Chen RE, Lei T, Rizk AA, McIntire KM, Winkler ES, Fox JM, Kafai NM, Thackray LB, Hassan AO, Amanat F, Krammer F, Watson CT, Kleinstein SH, Fremont DH, Diamond MS, Ellebedy AH
Pharmacological disruption of the Notch transcription factor complex.
1. Proc Natl Acad Sci U S A - published June 2, 2020
2. Lehal R, Zaric J, Vigolo M, Urech C, Frismantas V, Zangger N, Cao L, Berger A, Chicote I, Loubéry S, Choi SH, Koch U, Blacklow SC, Palmer HG, Bornhauser B, González-Gaitán M, Arsenijevic Y, Zoete V, Aster JC, Bourquin JP, Radtke F
Beyond protein structure determination with MicroED.
1. Curr Opin Struct Biol - published June 2, 2020
2. Nguyen C, Gonen T
PelX is a UDP-N-acetylglucosamine C4-epimerase involved in Pel polysaccharide-dependent biofilm formation.
1. J Biol Chem - published June 2, 2020
2. Marmont LS, Whitfield GB, Pfoh R, Williams RJ, Randall TE, Ostaszewski A, Razvi E, Groves RA, Robinson H, Nitz M, Parsek MR, Lewis IA, Whitney JC, Harrison J, Howell PL
Fibroblast-tumor cell signaling limits HER2 kinase therapy response via activation of MTOR and antiapoptotic pathways.
1. Proc Natl Acad Sci U S A - published June 2, 2020
2. Zervantonakis IK, Poskus MD, Scott AL, Selfors LM, Lin JR, Dillon DA, Pathania S, Sorger PK, Mills GB, Brugge JS
Quantitative analysis of yeast MAPK signaling networks and crosstalk using a microfluidic device.
1. Lab Chip - published June 2, 2020
2. Lee B, Jeong SG, Jin SH, Mishra R, Peter M, Lee CS, Lee SS
Subnanometer structures of HIV-1 envelope trimers on aldrithiol-2-inactivated virus particles.
1. Nat Struct Mol Biol - published June 2, 2020
2. Li Z, Li W, Lu M, Bess J Jr, Chao CW, Gorman J, Terry DS, Zhang B, Zhou T, Blanchard SC, Kwong PD, Lifson JD, Mothes W, Liu J
Structural Insights into Pseudokinase Domains of Receptor Tyrosine Kinases.
1. Mol Cell - published June 2, 2020
2. Sheetz JB, Mathea S, Karvonen H, Malhotra K, Chatterjee D, Niininen W, Perttilä R, Preuss F, Suresh K, Stayrook SE, Tsutsui Y, Radhakrishnan R, Ungureanu D, Knapp S, Lemmon MA
Broad neutralization of SARS-related viruses by human monoclonal antibodies.
1. Science - published June 1, 2020
2. Wec AZ, Wrapp D, Herbert AS, Maurer DP, Haslwanter D, Sakharkar M, Jangra RK, Dieterle ME, Lilov A, Huang D, Tse LV, Johnson NV, Hsieh CL, Wang N, Nett JH, Champney E, Burnina I, Brown M, Lin S, Sinclair M, Johnson C, Pudi S, Bortz R 3rd, Wirchnianski AS, Laudermilch E, Florez C, Fels JM, O'Brien CM, Graham BS, Nemazee D, Burton DR, Baric RS, Voss JE, Chandran K, Dye JM, McLellan JS, Walker LM
The GTPase-activating protein p120RasGAP has an evolutionarily conserved "FLVR-unique" SH2 domain.
1. J Biol Chem - published June 1, 2020
2. Jaber Chehayeb R, Wang J, Stiegler AL, Boggon TJ
Discovery of 3-({5-Chloro-1-[3-(methylsulfonyl)propyl]-1H-indol-2-yl}methyl)-1-(2,2,2-trifluoroethyl)-1,3-dihydro-2H-imidazo[4,5-c]pyridin-2-one (JNJ-53718678), a Potent and Orally Bioavailable Fusion Inhibitor of Respiratory Syncytial Virus.
1. J Med Chem - published June 1, 2020
2. Vendeville S, Tahri A, Hu L, Demin S, Cooymans L, Vos A, Kwanten L, Van den Berg J, Battles MB, McLellan JS, Koul A, Raboisson P, Roymans D, Jonckers THM
FOXO1 promotes HIV latency by suppressing ER stress in T cells.
1. Nat Microbiol - published June 1, 2020
2. Vallejo-Gracia A, Chen IP, Perrone R, Besnard E, Boehm D, Battivelli E, Tezil T, Krey K, Raymond KA, Hull PA, Walter M, Habrylo I, Cruz A, Deeks S, Pillai S, Verdin E, Ott M
Competitive Antagonism of Etomidate Action by Diazepam: In Vitro GABAA Receptor and In Vivo Zebrafish Studies.
1. Anesthesiology - published June 1, 2020
2. McGrath M, Hoyt H, Pence A, Jayakar SS, Zhou X, Forman SA, Cohen JB, Miller KW, Raines DE
Structure of the RECK CC domain, an evolutionary anomaly.
1. Proc Natl Acad Sci U S A - published June 1, 2020
2. Chang TH, Hsieh FL, Smallwood PM, Gabelli SB, Nathans J
Rationally Designed Covalent BCL6 Inhibitor That Targets a Tyrosine Residue in the Homodimer Interface.
1. ACS Med Chem Lett - published June 1, 2020
2. Teng M, Ficarro SB, Yoon H, Che J, Zhou J, Fischer ES, Marto JA, Zhang T, Gray NS
A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies.
1. Cell - published June 1, 2020
2. Hassan AO, Case JB, Winkler ES, Thackray LB, Kafai NM, Bailey AL, McCune BT, Fox JM, Chen RE, Alsoussi WB, Turner JS, Schmitz AJ, Lei T, Shrihari S, Keeler SP, Fremont DH, Greco S, McCray PB Jr, Perlman S, Holtzman MJ, Ellebedy AH, Diamond MS
Discovery of Potent Small-Molecule Inhibitors of MLL Methyltransferase.
1. ACS Med Chem Lett - published June 1, 2020
2. Chern TR, Liu L, Petrunak E, Stuckey JA, Wang M, Bernard D, Zhou H, Lee S, Dou Y, Wang S
Quantitative Autofluorescence Following Gene Therapy With Voretigene Neparvovec.
1. JAMA Ophthalmol - published June 1, 2020
2. Levi SR, Oh JK, de Carvalho JRL Jr, Mahajan VB, Tsang SH, Sparrow JR
Convergent antibody responses to SARS-CoV-2 in convalescent individuals.
1. Nature - published June 1, 2020
2. Robbiani DF, Gaebler C, Muecksch F, Lorenzi JCC, Wang Z, Cho A, Agudelo M, Barnes CO, Gazumyan A, Finkin S, Hägglöf T, Oliveira TY, Viant C, Hurley A, Hoffmann HH, Millard KG, Kost RG, Cipolla M, Gordon K, Bianchini F, Chen ST, Ramos V, Patel R, Dizon J, Shimeliovich I, Mendoza P, Hartweger H, Nogueira L, Pack M, Horowitz J, Schmidt F, Weisblum Y, Michailidis E, Ashbrook AW, Waltari E, Pak JE, Huey-Tubman KE, Koranda N, Hoffman PR, West AP Jr, Rice CM, Hatziioannou T, Bjorkman PJ, Bieniasz PD, Caskey M, Nussenzweig MC
Crosstalk and spatiotemporal regulation between stress-induced MAP kinase pathways and pheromone signaling in budding yeast.
1. Cell Cycle - published June 1, 2020
2. Van Drogen F, Dard N, Pelet S, Lee SS, Mishra R, Srejić N, Peter M
An 'Arms Race' between the Nonsense-mediated mRNA Decay Pathway and Viral Infections.
1. Semin Cell Dev Biol - published June 1, 2020
2. Leon K, Ott M
Concurrent chemo-radiotherapy with proton therapy: reduced toxicity with comparable oncological outcomes vs photon chemo-radiotherapy.
1. Br J Cancer - published June 1, 2020
2. Baumann BC, Hallahan DE, Michalski JM, Perez CA, Metz JM
Personal Protective Equipment for COVID-19: Distributed Fabrication and Additive Manufacturing.
1. Am J Public Health - published June 1, 2020
2. Sinha MS, Bourgeois FT, Sorger PK
A quantitative inventory of yeast P body proteins reveals principles of composition and specificity.
1. Elife - published June 1, 2020
2. Xing W, Muhlrad D, Parker R, Rosen MK
Serial scanning electron microscopy of anti-PKHD1L1 immuno-gold labeled mouse hair cell stereocilia bundles.
1. Sci Data - published June 1, 2020
2. Ivanchenko MV, Cicconet M, Jandal HA, Wu X, Corey DP, Indzhykulian AA
Rationale for targeting Complement in COVID-19.
1. EMBO Mol Med - published June 1, 2020
2. Polycarpou A, Howard M, Farrar CA, Greenlaw R, Fanelli G, Wallis R, Klavinskis LS, Sacks S
The Covalent SNAP Tag for Protein Display Quantification and Low-pH Protein Engineering.
1. J Biotechnol - published June 1, 2020
2. Jin W, Madan B, Mussman BK, Hailemariam AT, Fahad AS, Wolfe JR, Kwon YD, Zhang B, Shapiro L, Kwong PD, DeKosky BJ
A Library of Nucleotide Analogues Terminate RNA Synthesis Catalyzed by Polymerases of Coronaviruses that Cause SARS and COVID-19.
1. Antiviral Res - published June 1, 2020
2. Jockusch S, Tao C, Li X, Anderson TK, Chien M, Kumar S, Russo JJ, Kirchdoerfer RN, Ju J
Structure, dynamics and phase separation of measles virus RNA replication machinery.
1. Curr Opin Virol - published June 1, 2020
2. Guseva S, Milles S, Jensen MR, Schoehn G, Ruigrok RW, Blackledge M
Identification of a potent and selective covalent Pin1 inhibitor.
1. Nat Chem Biol - published June 1, 2020
2. Pinch BJ, Doctor ZM, Nabet B, Browne CM, Seo HS, Mohardt ML, Kozono S, Lian X, Manz TD, Chun Y, Kibe S, Zaidman D, Daitchman D, Yeoh ZC, Vangos NE, Geffken EA, Tan L, Ficarro SB, London N, Marto JA, Buratowski S, Dhe-Paganon S, Zhou XZ, Lu KP, Gray NS
TiPARP forms nuclear condensates to degrade HIF-1α and suppress tumorigenesis.
1. Proc Natl Acad Sci U S A - published June 1, 2020
2. Zhang L, Cao J, Dong L, Lin H
The length of lipoteichoic acid polymers controls Staphylococcus aureus cell size and envelope integrity.
1. J Bacteriol - published June 1, 2020
2. Hesser AR, Matano LM, Vickery CR, Wood BM, Santiago AG, Morris HG, Do T, Losick R, Walker S
Phenotypic variance in Calpain-5 retinal degeneration.
1. Am J Ophthalmol Case Rep - published June 1, 2020
2. Tang PH, Chemudupati T, Wert KJ, Folk JC, Mahajan M, Tsang SH, Bassuk AG, Mahajan VB
Asymptomatic COVID-19 positive patient suspected on FDG-PET/CT.
1. Nucl Med Commun - published June 1, 2020
2. Castanheira J, Mascarenhas Gaivão A, Mairos Teixeira S, Pereira PJ, Costa DC
A structurally minimized yet fully active insulin based on cone-snail venom insulin principles.
1. Nat Struct Mol Biol - published June 1, 2020
2. Xiong X, Menting JG, Disotuar MM, Smith NA, Delaine CA, Ghabash G, Agrawal R, Wang X, He X, Fisher SJ, MacRaild CA, Norton RS, Gajewiak J, Forbes BE, Smith BJ, Safavi-Hemami H, Olivera B, Lawrence MC, Chou DH
The RING Domain of RING Finger 12 Efficiently Builds Degradative Ubiquitin Chains.
1. J Mol Biol - published June 1, 2020
2. Middleton AJ, Zhu J, Day CL
Proteomic analysis of intermediate uveitis suggests myeloid cell recruitment and implicates IL-23 as a therapeutic target.
1. Am J Ophthalmol Case Rep - published June 1, 2020
2. Sepah YJ, Velez G, Tang PH, Yang J, Chemudupati T, Li AS, Nguyen QD, Bassuk AG, Mahajan VB
SARS-CoV-2 mRNA Vaccine Development Enabled by Prototype Pathogen Preparedness.
1. bioRxiv - published June 1, 2020
2. Corbett KS, Edwards D, Leist SR, Abiona OM, Boyoglu-Barnum S, Gillespie RA, Himansu S, Schäfer A, Ziwawo CT, DiPiazza AT, Dinnon KH, Elbashir SM, Shaw CA, Woods A, Fritch EJ, Martinez DR, Bock KW, Minai M, Nagata BM, Hutchinson GB, Bahl K, Garcia-Dominguez D, Ma L, Renzi I, Kong WP, Schmidt SD, Wang L, Zhang Y, Stevens LJ, Phung E, Chang LA, Loomis RJ, Altaras NE, Narayanan E, Metkar M, Presnyak V, Liu C, Louder MK, Shi W, Leung K, Yang ES, West A, Gully KL, Wang N, Wrapp D, Doria-Rose NA, Stewart-Jones G, Bennett H, Nason MC, Ruckwardt TJ, McLellan JS, Denison MR, Chappell JD, Moore IN, Morabito KM, Mascola JR, Baric RS, Carfi A, Graham BS
CRISPR-Directed Therapeutic Correction at the NCF1 Locus Is Challenged by Frequent Incidence of Chromosomal Deletions.
1. Mol Ther Methods Clin Dev - published June 1, 2020
2. Wrona D, Pastukhov O, Pritchard RS, Raimondi F, Tchinda J, Jinek M, Siler U, Reichenbach J
MHC-II alleles shape the CDR3 repertoires of conventional and regulatory naïve CD4+ T cells.
1. Proc Natl Acad Sci U S A - published June 1, 2020
2. Logunova NN, Kriukova VV, Shelyakin PV, Egorov ES, Pereverzeva A, Bozhanova NG, Shugay M, Shcherbinin DS, Pogorelyy MV, Merzlyak EM, Zubov VN, Meiler J, Chudakov DM, Apt AS, Britanova OV
N-Myristoyltransferase as a Glycine and Lysine Myristoyltransferase in Cancer, Immunity, and Infections.
1. ACS Chem Biol - published June 1, 2020
2. Kosciuk T, Lin H
Recognition of nuclear export signals by CRM1 carrying the oncogenic E571K mutation.
1. Mol Biol Cell - published June 1, 2020
2. Baumhardt JM, Walker JS, Lee Y, Shakya B, Brautigam CA, Lapalombella R, Grishin N, Chook YM
Production of Recombinant Transmembrane Proteins from Mammalian Cells for Biochemical and Structural Analyses.
1. Curr Protoc Cell Biol - published June 1, 2020
2. Puthenveetil R, Lee CJ, Banerjee A
CRISPR-Cas12a exploits R-loop asymmetry to form double-strand breaks.
1. Elife - published June 1, 2020
2. Cofsky JC, Karandur D, Huang CJ, Witte IP, Kuriyan J, Doudna JA
Shedding-resistant HIV-1 envelope glycoproteins adopt downstream conformations that remain responsive to conformation-preferring ligands.
1. J Virol - published June 1, 2020
2. Lu M, Ma X, Reichard N, Terry DS, Arthos J, Smith AB 3rd, Sodroski JG, Blanchard SC, Mothes W
Paramagnetic NMR in drug discovery.
1. J Biomol NMR - published June 1, 2020
2. Softley CA, Bostock MJ, Popowicz GM, Sattler M
Structural Insights into the Mechanism of the Radical SAM Carbide Synthase NifB, a Key Nitrogenase Cofactor Maturating Enzyme.
1. J Am Chem Soc - published June 1, 2020
2. Fajardo AS, Legrand P, Payá-Tormo LA, Martin L, Pellicer Martı Nez MT, Echavarri-Erasun C, Vernède X, Rubio LM, Nicolet Y
Human XPG nuclease structure, assembly, and activities with insights for neurodegeneration and cancer from pathogenic mutations.
1. Proc Natl Acad Sci U S A - published June 1, 2020
2. Tsutakawa SE, Sarker AH, Ng C, Arvai AS, Shin DS, Shih B, Jiang S, Thwin AC, Tsai MS, Willcox A, Her MZ, Trego KS, Raetz AG, Rosenberg D, Bacolla A, Hammel M, Griffith JD, Cooper PK, Tainer JA
Phase 3 Trial of RNAi Therapeutic Givosiran for Acute Intermittent Porphyria.
1. N Engl J Med - published June 1, 2020
2. Balwani M, Sardh E, Ventura P, Peiró PA, Rees DC, Stölzel U, Bissell DM, Bonkovsky HL, Windyga J, Anderson KE, Parker C, Silver SM, Keel SB, Wang JD, Stein PE, Harper P, Vassiliou D, Wang B, Phillips J, Ivanova A, Langendonk JG, Kauppinen R, Minder E, Horie Y, Penz C, Chen J, Liu S, Ko JJ, Sweetser MT, Garg P, Vaishnaw A, Kim JB, Simon AR, Gouya L, ENVISION Investigators.
LEM2 phase separation promotes ESCRT-mediated nuclear envelope reformation.
1. Nature - published June 1, 2020
2. von Appen A, LaJoie D, Johnson IE, Trnka MJ, Pick SM, Burlingame AL, Ullman KS, Frost A
Synthesis and structure activity relationships of DCLK1 kinase inhibitors based on a 5,11-dihydro-6H-benzo[e]pyrimido[5,4-b][1,4]diazepin-6-one scaffold.
1. J Med Chem - published June 1, 2020
2. Ferguson FM, Liu Y, Harshbarger W, Huang L, Wang J, Deng X, Capuzzi SJ, Muratov EN, Tropsha A, Muthuswamy S, Westover KD, Gray NS
Structure of a D2 dopamine receptor-G-protein complex in a lipid membrane.
1. Nature - published June 1, 2020
2. Yin J, Chen KM, Clark MJ, Hijazi M, Kumari P, Bai XC, Sunahara RK, Barth P, Rosenbaum DM
Structure of a nascent membrane protein as it folds on the BAM complex.
1. Nature - published June 1, 2020
2. Tomasek D, Rawson S, Lee J, Wzorek JS, Harrison SC, Li Z, Kahne D
Structural basis for divergent C-H hydroxylation selectivity in two Rieske oxygenases.
1. Nat Commun - published June 1, 2020
2. Lukowski AL, Liu J, Bridwell-Rabb J, Narayan ARH
Structure and mechanism of the mitochondrial Ca2+ uniporter holocomplex.
1. Nature - published June 1, 2020
2. Fan M, Zhang J, Tsai CW, Orlando BJ, Rodriguez M, Xu Y, Liao M, Tsai MF, Feng L
Author Correction: A structurally minimized yet fully active insulin based on cone-snail venom insulin principles.
1. Nat Struct Mol Biol - published June 1, 2020
2. Xiong X, Menting JG, Disotuar MM, Smith NA, Delaine CA, Ghabash G, Agrawal R, Wang X, He X, Fisher SJ, MacRaild CA, Norton RS, Gajewiak J, Forbes BE, Smith BJ, Safavi-Hemami H, Olivera B, Lawrence MC, Chou DH
Structural basis for the O-acetyltransferase function of the extracytoplasmic domain of OatA from Staphylococcus aureus.
1. J Biol Chem - published June 1, 2020
2. Jones CS, Sychantha D, Howell PL, Clarke AJ
Targeting MET Dysregulation in Cancer.
1. Cancer Discov - published June 1, 2020
2. Recondo G, Che J, Jänne PA, Awad MM
Targeted protein degradation as a powerful research tool in basic biology and drug target discovery.
1. Nat Struct Mol Biol - published June 1, 2020
2. Wu T, Yoon H, Xiong Y, Dixon-Clarke SE, Nowak RP, Fischer ES
The protein kinase Akt acts as a coat adaptor in endocytic recycling.
1. Nat Cell Biol - published June 1, 2020
2. Hsu JW, Bai M, Li K, Yang JS, Chu N, Cole PA, Eck MJ, Li J, Hsu VW
Structural Enzymology of Nitrogenase Enzymes.
1. Chem Rev - published June 1, 2020
2. Einsle O, Rees DC
Photoaffinity labeling identifies an intersubunit steroid-binding site in heteromeric GABA type A (GABAA) receptors.
1. J Biol Chem - published June 1, 2020
2. Jayakar SS, Chiara DC, Zhou X, Wu B, Bruzik KS, Miller KW, Cohen JB
A constricted opening in Kir channels does not impede potassium conduction.
1. Nat Commun - published June 1, 2020
2. Black KA, He S, Jin R, Miller DM, Bolla JR, Clarke OB, Johnson P, Windley M, Burns CJ, Hill AP, Laver D, Robinson CV, Smith BJ, Gulbis JM