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112 Member Publications for March

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Isoforms of Cathepsin B1 in Neurotropic Schistosomula of Trichobilharzia regenti Differ in Substrate Preferences and a Highly Expressed Catalytically Inactive Paralog Binds Cystatin.
1. Front Cell Infect Microbiol - published March 17, 2020
2. Dvořáková H, Leontovyč R, Macháček T, O'Donoghue AJ, Šedo O, Zdráhal Z, Craik CS, Caffrey CR, Horák P, Mikeš L
Hematopoietic Cell Transplantation in Patients With Primary Immune Regulatory Disorders (PIRD): A Primary Immune Deficiency Treatment Consortium (PIDTC) Survey.
1. Front Immunol - published March 11, 2020
2. Chan AY, Leiding JW, Liu X, Logan BR, Burroughs LM, Allenspach EJ, Skoda-Smith S, Uzel G, Notarangelo LD, Slatter M, Gennery AR, Smith AR, Pai SY, Jordan MB, Marsh RA, Cowan MJ, Dvorak CC, Craddock JA, Prockop SE, Chandrakasan S, Kapoor N, Buckley RH, Parikh S, Chellapandian D, Oshrine BR, Bednarski JJ, Cooper MA, Shenoy S, Davila Saldana BJ, Forbes LR, Martinez C, Haddad E, Shyr DC, Chen K, Sullivan KE, Heimall J, Wright N, Bhatia M, Cuvelier GDE, Goldman FD, Meyts I, Miller HK, Seidel MG, Vander Lugt MT, Bacchetta R, Weinacht KG, Andolina JR, Caywood E, Chong H, de la Morena MT, Aquino VM, Shereck E, Walter JE, Dorsey MJ, Seroogy CM, Griffith LM, Kohn DB, Puck JM, Pulsipher MA, Torgerson TR
Sedimentation Yields Long-Term Stable Protein Samples as Shown by Solid-State NMR.
1. Front Mol Biosci - published March 11, 2020
2. Wiegand T, Lacabanne D, Torosyan A, Boudet J, Cadalbert R, Allain FH, Meier BH, Böckmann A
Visualizing the protons in a metalloenzyme electron proton transfer pathway.
1. Proc Natl Acad Sci U S A - published March 9, 2020
2. Kwon H, Basran J, Devos JM, Suardíaz R, van der Kamp MW, Mulholland AJ, Schrader TE, Ostermann A, Blakeley MP, Moody PCE, Raven EL
Deep mutational scanning reveals the structural basis for α-synuclein activity.
1. Nat Chem Biol - published March 9, 2020
2. Newberry RW, Leong JT, Chow ED, Kampmann M, DeGrado WF
Flexible linkers in CaMKII control the balance between activating and inhibitory autophosphorylation.
1. Elife - published March 9, 2020
2. Bhattacharyya M, Lee YK, Muratcioglu S, Qiu B, Nyayapati P, Schulman H, Groves JT, Kuriyan J
Intestinal bile acids directly modulate the structure and function of C. difficile TcdB toxin.
1. Proc Natl Acad Sci U S A - published March 9, 2020
2. Tam J, Icho S, Utama E, Orrell KE, Gómez-Biagi RF, Theriot CM, Kroh HK, Rutherford SA, Lacy DB, Melnyk RA
Intraoperative Cardiac Arrest During Adult Liver Transplantation: Incidence and Risk Factor Analysis From 7 Academic Centers in the United States.
1. Anesth Analg - published March 9, 2020
2. Smith NK, Zerillo J, Kim SJ, Efune GE, Wang C, Pai SL, Chadha R, Kor TM, Wetzel DR, Hall MA, Burton KK, Fukazawa K, Hill B, Spad MA, Wax DB, Lin HM, Liu X, Odeh J, Torsher L, Kindscher JD, Mandell MS, Sakai T, DeMaria S Jr
Diffuse X-ray scattering from correlated motions in a protein crystal.
1. Nat Commun - published March 9, 2020
2. Meisburger SP, Case DA, Ando N
HIV-1 fusion inhibitors targeting the membrane-proximal external region of Env spikes.
1. Nat Chem Biol - published March 9, 2020
2. Xiao T, Frey G, Fu Q, Lavine CL, Scott DA, Seaman MS, Chou JJ, Chen B
What Could Go Wrong? A Practical Guide to Single-Particle Cryo-EM: From Biochemistry to Atomic Models.
1. J Chem Inf Model - published March 9, 2020
2. Cianfrocco MA, Kellogg EH
Structural coordination of polymerization and crosslinking by a SEDS-bPBP peptidoglycan synthase complex.
1. Nat Microbiol - published March 9, 2020
2. Sjodt M, Rohs PDA, Gilman MSA, Erlandson SC, Zheng S, Green AG, Brock KP, Taguchi A, Kahne D, Walker S, Marks DS, Rudner DZ, Bernhardt TG, Kruse AC
2mISCU interacts with NFU1, and ISCU[4Fe-4S] transfers its Fe-S cluster to NFU1 leading to the production of holo-NFU1.
1. J Struct Biol - published March 6, 2020
2. Cai K, Frederick RO, Markley JL
Spotlight on the Ballet of Proteins: The Structural Dynamic Properties of Proteins Illuminated by Solution NMR.
1. Int J Mol Sci - published March 6, 2020
2. Tokunaga Y, Viennet T, Arthanari H, Takeuchi K
Response and mechanisms of resistance to larotrectinib and selitrectinib in metastatic undifferentiated sarcoma harboring oncogenic fusion of NTRK1.
1. JCO Precis Oncol - published March 6, 2020
2. Hemming ML, Nathenson MJ, Lin JR, Mei S, Du Z, Malik K, Marino-Enriquez A, Jagannathan JP, Sorger PK, Bertagnolli M, Sicinska E, Demetri GD, Santagata S
Biochemical and structural insights into how amino acids regulate pyruvate kinase muscle isoform 2.
1. J Biol Chem - published March 6, 2020
2. Nandi S, Dey M
A New Humanized Mouse Model Mimics Humans in Lacking α-Gal Epitopes and Secreting Anti-Gal Antibodies.
1. J Immunol - published March 6, 2020
2. Saleh FM, Chandra PK, Lin D, Robinson JE, Izadpanah R, Mondal D, Bollensdorff C, Alt EU, Zhu Q, Marasco WA, Braun SE, Abdel-Motal UM
Detection and Quantification of the Anti-Obesity Drug Celastrol in Murine Liver and Brain.
1. Neurochem Int - published March 6, 2020
2. De Angelis M, Schriever SC, Kyriakou E, Sattler M, Messias AC, Schramm KW, Pfluger PT
Photoinduced damage of AsLOV2 domain is accompanied by increased singlet oxygen production due to flavin dissociation.
1. Sci Rep - published March 5, 2020
2. Petrenčáková M, Filandr F, Hovan A, Yassaghi G, Man P, Kožár T, Schwer MS, Jancura D, Plückthun A, Novák P, Miškovský P, Bánó G, Sedlák E
Alpaca (Vicugna pacos), the first nonprimate species with a phosphoantigen-reactive Vγ9Vδ2 T cell subset.
1. Proc Natl Acad Sci U S A - published March 5, 2020
2. Fichtner AS, Karunakaran MM, Gu S, Boughter CT, Borowska MT, Starick L, Nöhren A, Göbel TW, Adams EJ, Herrmann T
Multiplexed capture of spatial configuration and temporal dynamics of locus-specific 3D chromatin by biotinylated dCas9.
1. Genome Biol - published March 5, 2020
2. Liu X, Chen Y, Zhang Y, Liu Y, Liu N, Botten GA, Cao H, Orkin SH, Zhang MQ, Xu J
Development of a novel minimally invasive technique to washout necrotic bone marrow content from epiphyseal bone: A preliminary cadaveric bone study.
1. Orthop Traumatol Surg Res - published March 4, 2020
2. Alves do Monte F, Sung Park M, Gokani V, Singhal M, Ma C, Aruwajoye OO, Niese B, Liu X, Kim HKW
Avoiding Drug Resistance by Substrate Envelope-Guided Design: Toward Potent and Robust HCV NS3/4A Protease Inhibitors.
1. mBio - published March 3, 2020
2. Matthew AN, Zephyr J, Nageswara Rao D, Henes M, Kamran W, Kosovrasti K, Hedger AK, Lockbaum GJ, Timm J, Ali A, Kurt Yilmaz N, Schiffer CA
Extensive GTPase crosstalk regulates Golgi trafficking and maturation.
1. Curr Opin Cell Biol - published March 3, 2020
2. Thomas LL, Fromme JC
Structure-Based Design of Prefusion-Stabilized Filovirus Glycoprotein Trimers.
1. Cell Rep - published March 3, 2020
2. Rutten L, Gilman MSA, Blokland S, Juraszek J, McLellan JS, Langedijk JPM
Bacillus anthracis Responds to Targocil-Induced Envelope Damage through EdsRS Activation of Cardiolipin Synthesis.
1. mBio - published March 3, 2020
2. Laut CL, Perry WJ, Metzger AL, Weiss A, Stauff DL, Walker S, Caprioli RM, Skaar EP
Effect of Health Education on Healthcare-Seeking Behavior of Migrant Workers in China.
1. Int J Environ Res Public Health - published March 3, 2020
2. Li X, Yang H, Wang H, Liu X
High-resolution structures of TRPV channels: unveiling a functionally diverse group of ion channels.
1. Protein Sci - published March 3, 2020
2. van Goor MK, de Jager L, Cheng Y, van der Wijst J
A newly identified Leishmania IF4E-interacting protein, Leish4E-IP2, modulates the activity of cap-binding protein paralogs.
1. Nucleic Acids Res - published March 3, 2020
2. Tupperwar N, Meleppattu S, Shrivastava R, Baron N, Gilad A, Wagner G, Léger-Abraham M, Shapira M
An ultralong CDRH2 in HCV neutralizing antibody demonstrates structural plasticity of antibodies against E2 glycoprotein.
1. Elife - published March 3, 2020
2. Flyak AI, Ruiz SE, Salas J, Rho S, Bailey JR, Bjorkman PJ
New approach for membrane protein reconstitution into peptidiscs and basis for their adaptability to different proteins.
1. Elife - published March 3, 2020
2. Angiulli G, Dhupar HS, Suzuki H, Wason IS, Duong Van Hoa F, Walz T
An investigation of transmission control measures during the first 50 days of the COVID-19 epidemic in China.
1. Science - published March 3, 2020
2. Tian H, Liu Y, Li Y, Wu CH, Chen B, Kraemer MUG, Li B, Cai J, Xu B, Yang Q, Wang B, Yang P, Cui Y, Song Y, Zheng P, Wang Q, Bjornstad ON, Yang R, Grenfell BT, Pybus OG, Dye C
Molecular basis of the multifaceted functions of human leucyl-tRNA synthetase in protein synthesis and beyond.
1. Nucleic Acids Res - published March 3, 2020
2. Liu RJ, Long T, Li H, Zhao J, Li J, Wang M, Palencia A, Lin J, Cusack S, Wang ED
Cryo-EM structures of the ATP release channel pannexin 1.
1. Nat Struct Mol Biol - published March 3, 2020
2. Deng Z, He Z, Maksaev G, Bitter RM, Rau M, Fitzpatrick JAJ, Yuan P
VRC34-Antibody Lineage Development Reveals How a Required Rare Mutation Shapes the Maturation of a Broad HIV-Neutralizing Lineage.
1. Cell Host Microbe - published March 3, 2020
2. Shen CH, DeKosky BJ, Guo Y, Xu K, Gu Y, Kilam D, Ko SH, Kong R, Liu K, Louder MK, Ou L, Zhang B, Chao CW, Corcoran MM, Feng E, Huang J, Normandin E, O'Dell S, Ransier A, Rawi R, Sastry M, Schmidt SD, Wang S, Wang Y, Chuang GY, Doria-Rose NA, Lin B, Zhou T, Boritz EA, Connors M, Douek DC, Karlsson Hedestam GB, Sheng Z, Shapiro L, Mascola JR, Kwong PD
Targeting the PI5P4K Lipid Kinase Family in Cancer Using Covalent Inhibitors.
1. Cell Chem Biol - published March 3, 2020
2. Sivakumaren SC, Shim H, Zhang T, Ferguson FM, Lundquist MR, Browne CM, Seo HS, Paddock MN, Manz TD, Jiang B, Hao MF, Krishnan P, Wang DG, Yang TJ, Kwiatkowski NP, Ficarro SB, Cunningham JM, Marto JA, Dhe-Paganon S, Cantley LC, Gray NS
PINK1-dependent phosphorylation of Serine111 within the SF3 motif of Rab GTPases impairs effector interactions and LRRK2 mediated phosphorylation at Threonine72.
1. Biochem J - published March 3, 2020
2. Vieweg S, Mulholland K, Brauning B, Kacharia N, Lai YC, Toth R, Singh PK, Volpi I, Sattler M, Groll M, Itzen A, Muqit MMK
Activity of Fructose-1, 6-bisphosphatase from Campylobacter jejuni.
1. Biochem Cell Biol - published March 3, 2020
2. Ayna A, Moody PCE
Factor VIII exhibits chaperone-dependent and glucose-regulated reversible amyloid formation in the endoplasmic reticulum.
1. Blood - published March 3, 2020
2. Poothong J, Pottekat A, Siriin M, Campos AR, Paton AW, Paton JC, Lagunas-Acosta J, Chen Z, Swift M, Volkmann N, Hanein D, Yong J, Kaufman RJ
Deriving Immune Modulating Drugs from Viruses-A New Class of Biologics.
1. J Clin Med - published March 3, 2020
2. Yaron JR, Zhang L, Guo Q, Burgin M, Schutz LN, Awo E, Wise L, Krause KL, Ildefonso CJ, Kwiecien JM, Juby M, Rahman MM, Chen H, Moyer RW, Alcami A, McFadden G, Lucas AR
Calmodulin disrupts plasma membrane localization of farnesylated KRAS4b by sequestering its lipid moiety.
1. Sci Signal - published March 3, 2020
2. Grant BMM, Enomoto M, Back SI, Lee KY, Gebregiworgis T, Ishiyama N, Ikura M, Marshall CB
Lamin A/C Assembly Defects in LMNA-Congenital Muscular Dystrophy Is Responsible for the Increased Severity of the Disease Compared with Emery-Dreifuss Muscular Dystrophy.
1. Cells - published March 3, 2020
2. Bertrand AT, Brull A, Azibani F, Benarroch L, Chikhaoui K, Stewart CL, Medalia O, Ben Yaou R, Bonne G
A potent photoreactive general anesthetic with novel binding site selectivity for GABAA receptors.
1. Eur J Med Chem - published March 2, 2020
2. Shalabi AR, Yu Z, Zhou X, Jounaidi Y, Chen H, Dai J, Kent DE, Feng HJ, Forman SA, Cohen JB, Bruzik KS, Miller KW
The transcription factor NFAT5 limits infection-induced type I interferon responses.
1. J Exp Med - published March 2, 2020
2. Huerga Encabo H, Traveset L, Argilaguet J, Angulo A, Nistal-Villán E, Jaiswal R, Escalante CR, Gekas C, Meyerhans A, Aramburu J, López-Rodríguez C
Dynamics of Auxilin 1 and GAK in clathrin-mediated traffic.
1. J Cell Biol - published March 2, 2020
2. He K, Song E, Upadhyayula S, Dang S, Gaudin R, Skillern W, Bu K, Capraro BR, Rapoport I, Kusters I, Ma M, Kirchhausen T
Selectively Disrupting m6A-Dependent Protein-RNA Interactions with Fragments.
1. ACS Chem Biol - published March 2, 2020
2. Bedi RK, Huang D, Wiedmer L, Li Y, Dolbois A, Wojdyla JA, Sharpe ME, Caflisch A, Sledz P
Conformational control of small GTPases by AMPylation.
1. Proc Natl Acad Sci U S A - published March 2, 2020
2. Barthelmes K, Ramcke E, Kang HS, Sattler M, Itzen A
A multi-level similarity measure for the retrieval of the common CT imaging signs of lung diseases.
1. Med Biol Eng Comput - published March 2, 2020
2. Ma L, Liu X, Fei B
bioPROTACs as versatile modulators of intracellular therapeutic targets including proliferating cell nuclear antigen (PCNA).
1. Proc Natl Acad Sci U S A - published March 2, 2020
2. Lim S, Khoo R, Peh KM, Teo J, Chang SC, Ng S, Beilhartz GL, Melnyk RA, Johannes CW, Brown CJ, Lane DP, Henry B, Partridge AW
Heteromeric three-stranded coiled coils designed using a Pb(II)(Cys)3 template mediated strategy.
1. Nat Chem - published March 2, 2020
2. Tolbert AE, Ervin CS, Ruckthong L, Paul TJ, Jayasinghe-Arachchige VM, Neupane KP, Stuckey JA, Prabhakar R, Pecoraro VL
Structural elucidation of the Clostridioides difficile transferase toxin reveals a single-site binding mode for the enzyme.
1. Proc Natl Acad Sci U S A - published March 2, 2020
2. Sheedlo MJ, Anderson DM, Thomas AK, Lacy DB
Stepwise Promoter Melting by Bacterial RNA Polymerase.
1. Mol Cell - published March 2, 2020
2. Chen J, Chiu C, Gopalkrishnan S, Chen AY, Olinares PDB, Saecker RM, Winkelman JT, Maloney MF, Chait BT, Ross W, Gourse RL, Campbell EA, Darst SA
Regulation of the RNA and DNA nuclease activities required for Pyrococcus furiosus Type III-B CRISPR-Cas immunity.
1. Nucleic Acids Res - published March 2, 2020
2. Foster K, Grüschow S, Bailey S, White MF, Terns MP
Therapeutic modulation of phagocytosis in glioblastoma can activate both innate and adaptive antitumour immunity.
1. Nat Commun - published March 2, 2020
2. von Roemeling CA, Wang Y, Qie Y, Yuan H, Zhao H, Liu X, Yang Z, Yang M, Deng W, Bruno KA, Chan CK, Lee AS, Rosenfeld SS, Yun K, Johnson AJ, Mitchell DA, Jiang W, Kim BYS
Clostridioides difficile infection damages colonic stem cells via TcdB, impairing epithelial repair and recovery from disease.
1. Proc Natl Acad Sci U S A - published March 2, 2020
2. Mileto SJ, Jardé T, Childress KO, Jensen JL, Rogers AP, Kerr G, Hutton ML, Sheedlo MJ, Bloch SC, Shupe JA, Horvay K, Flores T, Engel R, Wilkins S, McMurrick PJ, Lacy DB, Abud HE, Lyras D
NELL2-Robo3 complex structure reveals mechanisms of receptor activation for axon guidance.
1. Nat Commun - published March 2, 2020
2. Pak JS, DeLoughery ZJ, Wang J, Acharya N, Park Y, Jaworski A, Özkan E
Water envelope has a critical impact on the design of protein-protein interaction inhibitors.
1. Chem Commun (Camb) - published March 2, 2020
2. Ratkova EL, Dawidowski M, Napolitano V, Dubin G, Fino R, Ostertag MS, Sattler M, Popowicz G, Tetko IV
Next-Generation Sequencing of the Intrahepatic Antibody Repertoire Delineates a Unique B-Cell Response in HBV-Associated Acute Liver Failure.
1. J Viral Hepat - published March 2, 2020
2. Chen Z, Shen CH, Engle RE, Zamboni F, Kwong PD, Purcell RH, Farci P
An H3K9 methylation dependent protein interaction regulates the non-enzymatic function of a putative histone demethylase.
1. Elife - published March 2, 2020
2. Raiymbek G, An S, Khurana N, Gopinath S, Larkin A, Biswas S, Trievel RC, Cho US, Ragunathan K
Structural Analysis of Cj1427, an Essential NAD-Dependent Dehydrogenase for the Biosynthesis of the Heptose Residues in the Capsular Polysaccharides of Campylobacter jejuni.
1. Biochemistry - published March 2, 2020
2. Huddleston JP, Anderson TK, Spencer KD, Thoden JB, Raushel FM, Holden HM
PROTAC-mediated degradation of class I histone deacetylase enzymes in corepressor complexes.
1. Chem Commun (Camb) - published March 2, 2020
2. Smalley JP, Adams GE, Millard CJ, Song Y, Norris JKS, Schwabe JWR, Cowley SM, Hodgkinson JT
Structure and molecular recognition mechanism of IMP-13 metallo-β-lactamase.
1. Antimicrob Agents Chemother - published March 2, 2020
2. Softley CA, Zak KM, Bostock MJ, Fino R, Zhou RX, Kolonko M, Mejdi-Nitiu R, Meyer H, Sattler M, Popowicz GM
Is There an Association Between COVID-19 Mortality and the Renin-Angiotensin System-a Call for Epidemiologic Investigations.
1. Clin Infect Dis - published March 2, 2020
2. Hanff TC, Harhay MO, Brown TS, Cohen JB, Mohareb AM
Inter-organelle lipid transfer: a channel model for Vps13 and chorein-N motif proteins.
1. Curr Opin Cell Biol - published March 2, 2020
2. Lees JA, Reinisch KM
Selective USP7 inhibition elicits cancer cell killing through a p53-dependent mechanism.
1. Sci Rep - published March 2, 2020
2. Schauer NJ, Liu X, Magin RS, Doherty LM, Chan WC, Ficarro SB, Hu W, Roberts RM, Iacob RE, Stolte B, Giacomelli AO, Perera S, McKay K, Boswell SA, Weisberg EL, Ray A, Chauhan D, Dhe-Paganon S, Anderson KC, Griffin JD, Li J, Hahn WC, Sorger PK, Engen JR, Stegmaier K, Marto JA, Buhrlage SJ
A combination of two human monoclonal antibodies limits fetal damage by Zika virus in macaques.
1. Proc Natl Acad Sci U S A - published March 2, 2020
2. Van Rompay KKA, Coffey LL, Kapoor T, Gazumyan A, Keesler RI, Jurado A, Peace A, Agudelo M, Watanabe J, Usachenko J, Singapuri A, Immareddy R, Ardeshir A, Stuart JB, Bournazos S, Ravetch JV, Balderes PJ, Lorenz IC, Esswein SR, Keeffe JR, Bjorkman PJ, Wang Q, Rice CM, MacDonald MR, Nussenzweig MC, Robbiani DF
Activation and self-inactivation mechanisms of the cyclic oligoadenylate-dependent CRISPR ribonuclease Csm6.
1. Nat Commun - published March 2, 2020
2. Garcia-Doval C, Schwede F, Berk C, Rostøl JT, Niewoehner O, Tejero O, Hall J, Marraffini LA, Jinek M
Modulation of androgen receptor DNA binding activity through direct interaction with the ETS transcription factor ERG.
1. Proc Natl Acad Sci U S A - published March 2, 2020
2. Wasmuth EV, Hoover EA, Antar A, Klinge S, Chen Y, Sawyers CL
Cryo-EM Structures of Human Drosha and DGCR8 in Complex with Primary MicroRNA.
1. Mol Cell - published March 2, 2020
2. Partin AC, Zhang K, Jeong BC, Herrell E, Li S, Chiu W, Nam Y
Arabinofuranose-derived positron-emission tomography radiotracers for detection of pathogenic microorganisms.
1. J Labelled Comp Radiopharm - published March 2, 2020
2. Kalita M, Parker MFL, Luu JM, Stewart MN, Blecha JE, VanBrocklin HF, Evans MJ, Flavell RR, Rosenberg OS, Ohliger MA, Wilson DM
Identification of the Cargo-Binding Site in the Human Karyopherin RanBP5.
1. J Mol Biol - published March 2, 2020
2. Swale C, Da Costa B, Sedano L, Garzoni F, McCarthy AA, Berger I, Bieniossek C, Ruigrok RWH, Delmas B, Crépin T
Two Distinct Structures of Membrane-associated Homodimers of GTP- and GDP-bound KRAS4B Revealed by Paramagnetic Relaxation Enhancement.
1. Angew Chem Int Ed Engl - published March 2, 2020
2. Lee KY, Fang Z, Enomoto M, Seabrook GG, Zheng L, Koide S, Ikura M, Marshall CB
Effects of underfeeding and oral vancomycin on gut microbiome and nutrient absorption in humans.
1. Nat Med - published March 2, 2020
2. Basolo A, Hohenadel M, Ang QY, Piaggi P, Heinitz S, Walter M, Walter P, Parrington S, Trinidad DD, von Schwartzenberg RJ, Turnbaugh PJ, Krakoff J
Structure of a trapped radical transfer pathway within a ribonucleotide reductase holocomplex.
1. Science - published March 2, 2020
2. Kang G, Taguchi AT, Stubbe J, Drennan CL
Development of Potent, Selective Surrogate WNT Molecules and Their Application in Defining Frizzled Requirements.
1. Cell Chem Biol - published March 1, 2020
2. Chen H, Lu C, Ouyang B, Zhang H, Huang Z, Bhatia D, Lee SJ, Shah D, Sura A, Yeh WC, Li Y
Selecting for Altered Substrate Specificity Reveals the Evolutionary Flexibility of ATP-Binding Cassette Transporters.
1. Curr Biol - published March 1, 2020
2. Srikant S, Gaudet R, Murray AW
Drug sensitivity and allele-specificity of first-line osimertinib resistance EGFR mutations.
1. Cancer Res - published March 1, 2020
2. Starrett JH, Guernet AA, Cuomo ME, Poels KE, van Alderwerelt van Rosenburgh IK, Nagelberg A, Farnsworth D, Price KS, Khan H, Ashtekar KD, Gaefele M, Ayeni D, Stewart TF, Kuhlmann A, Kaech S, Unni AM, Homer R, Lockwood WW, Michor F, Goldberg SB, Lemmon MA, Smith PD, Cross DA, Politi K
E. coli production process yields stable dengue 1 virus-sized particles (VSPs).
1. Vaccine - published March 1, 2020
2. Hirsch J, Faber BW, Crowe JE Jr, Verstrepen B, Cornelissen G
Nonsynonymous SNPs in LPA homologous to plasminogen deficiency mutants represent novel null apo(a) alleles.
1. J Lipid Res - published March 1, 2020
2. Morgan BM, Brown AN, Deo N, Harrop TWR, Taiaroa G, Mace PD, Wilbanks SM, Merriman TR, Williams MJA, McCormick SPA
Structure-based mechanism of preferential complex formation by apoptosis signal-regulating kinases.
1. Sci Signal - published March 1, 2020
2. Trevelyan SJ, Brewster JL, Burgess AE, Crowther JM, Cadell AL, Parker BL, Croucher DR, Dobson RCJ, Murphy JM, Mace PD
Current approaches for integrating solution NMR spectroscopy and small angle scattering to study the structure and dynamics of biomolecular complexes.
1. J Mol Biol - published March 1, 2020
2. Delhommel F, Gabel F, Sattler M
Author Correction: An allosteric network in spastin couples multiple activities required for microtubule severing.
1. Nat Struct Mol Biol - published March 1, 2020
2. Sandate CR, Szyk A, Zehr EA, Lander GC, Roll-Mecak A
ALIXE: a phase-combination tool for fragment-based molecular replacement.
1. Acta Crystallogr D Struct Biol - published March 1, 2020
2. Millán C, Jiménez E, Schuster A, Diederichs K, Usón I
Site-Dependent Cysteine Lipidation Potentiates the Activation of Proapoptotic BAX.
1. Cell Rep - published March 1, 2020
2. Cohen DT, Wales TE, McHenry MW, Engen JR, Walensky LD
An asymmetric sheath controls flagellar supercoiling and motility in the leptospira spirochete.
1. Elife - published March 1, 2020
2. Gibson KH, Trajtenberg F, Wunder EA, Brady MR, San Martin F, Mechaly A, Shang Z, Liu J, Picardeau M, Ko A, Buschiazzo A, Sindelar CV
ZupT Facilitates Clostridioides difficile Resistance to Host-Mediated Nutritional Immunity.
1. mSphere - published March 1, 2020
2. Zackular JP, Knippel RJ, Lopez CA, Beavers WN, Maxwell CN, Chazin WJ, Skaar EP
Comparing serial X-ray crystallography and microcrystal electron diffraction (MicroED) as methods for routine structure determination from small macromolecular crystals.
1. IUCrJ - published March 1, 2020
2. Wolff AM, Young ID, Sierra RG, Brewster AS, Martynowycz MW, Nango E, Sugahara M, Nakane T, Ito K, Aquila A, Bhowmick A, Biel JT, Carbajo S, Cohen AE, Cortez S, Gonzalez A, Hino T, Im D, Koralek JD, Kubo M, Lazarou TS, Nomura T, Owada S, Samelson AJ, Tanaka T, Tanaka R, Thompson EM, van den Bedem H, Woldeyes RA, Yumoto F, Zhao W, Tono K, Boutet S, Iwata S, Gonen T, Sauter NK, Fraser JS, Thompson MC
Long-Acting BMS-378806 Analogues Stabilize the State-1 Conformation of the Human Immunodeficiency Virus (HIV-1) Envelope Glycoproteins.
1. J Virol - published March 1, 2020
2. Zou S, Zhang S, Gaffney A, Ding H, Lu M, Grover JR, Farrell M, Nguyen HT, Zhao C, Anang S, Zhao M, Mohammadi M, Blanchard SC, Abrams C, Madani N, Mothes W, Kappes JC, Smith AB 3rd, Sodroski J
Drug Screen Identifies Leflunomide for Treatment of Inflammatory Bowel Disease Caused by TTC7A Deficiency.
1. Gastroenterology - published March 1, 2020
2. Jardine S, Anderson S, Babcock S, Leung G, Pan J, Dhingani N, Warner N, Guo C, Siddiqui I, Kotlarz D, Dowling JJ, Melnyk RA, Snapper SB, Klein C, Thiagarajah JR, Muise AM
The crystal structure of the catalytic domain of tau tubulin kinase 2 in complex with a small-molecule inhibitor.
1. Acta Crystallogr F Struct Biol Commun - published March 1, 2020
2. Marcotte DJ, Spilker KA, Wen D, Hesson T, Patterson TA, Kumar PR, Chodaparambil JV
Specificity and affinity of the N-terminal residues in staphylocoagulase in binding to prothrombin.
1. J Biol Chem - published March 1, 2020
2. Maddur AA, Kroh HK, Aschenbrenner ME, Gibson BH, Panizzi P, Sheehan JH, Meiler J, Bock PE, Verhamme IM
Formation of pre-pore complexes of pneumolysin is accompanied by a decrease in short-range order of lipid molecules throughout vesicle bilayers.
1. Sci Rep - published March 1, 2020
2. Faraj BHA, Collard L, Cliffe R, Blount LA, Lonnen R, Wallis R, Andrew PW, Hudson AJ
Small-molecule inhibitors of METTL3, the major human epitranscriptomic writer.
1. ChemMedChem - published March 1, 2020
2. Bedi RK, Huang D, Eberle SA, Wiedmer L, Caflisch A, Śledź P
Chimeric siRNAs with chemically modified pentofuranose and hexopyranose nucleotides: altritol-nucleotide (ANA) containing GalNAc-siRNA conjugates: in vitro and in vivo RNAi activity and resistance to 5'-exonuclease.
1. Nucleic Acids Res - published March 1, 2020
2. Kumar P, Degaonkar R, Guenther DC, Abramov M, Schepers G, Capobianco M, Jiang Y, Harp J, Kaittanis C, Janas MM, Castoreno A, Zlatev I, Schlegel MK, Herdewijn P, Egli M, Manoharan M
A transient α-helix in the N-terminal RNA recognition motif of polypyrimidine tract binding protein senses RNA secondary structure.
1. Nucleic Acids Res - published March 1, 2020
2. Maris C, Jayne S, Damberger FF, Beusch I, Dorn G, Ravindranathan S, Allain FH
Conformational dynamics modulate the catalytic activity of the molecular chaperone Hsp90.
1. Nat Commun - published March 1, 2020
2. Mader SL, Lopez A, Lawatscheck J, Luo Q, Rutz DA, Gamiz-Hernandez AP, Sattler M, Buchner J, Kaila VRI
Molecular basis for catabolism of the abundant metabolite trans-4-hydroxy-L-proline by a microbial glycyl radical enzyme.
1. Elife - published March 1, 2020
2. Backman LR, Huang YY, Andorfer MC, Gold B, Raines RT, Balskus EP, Drennan CL
Probing biophysical sequence constraints within the transmembrane domains of rhodopsin by deep mutational scanning.
1. Sci Adv - published March 1, 2020
2. Penn WD, McKee AG, Kuntz CP, Woods H, Nash V, Gruenhagen TC, Roushar FJ, Chandak M, Hemmerich C, Rusch DB, Meiler J, Schlebach JP
Detection of Transport Intermediates in the Peptidoglycan Flippase MurJ Identifies Residues Essential for Conformational Cycling.
1. J Am Chem Soc - published March 1, 2020
2. Rubino FA, Mollo A, Kumar S, Butler EK, Ruiz N, Walker S, Kahne DE
MAML1-dependent Notch responsive genes exhibit differing co-factor requirements for transcriptional activation.
1. Mol Cell Biol - published March 1, 2020
2. Rogers JM, Guo B, Egan ED, Aster JC, Adelman K, Blacklow SC
Structure-Activity Relationship Study of Covalent Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors.
1. ACS Med Chem Lett - published March 1, 2020
2. Manz TD, Sivakumaren SC, Yasgar A, Hall MD, Davis MI, Seo HS, Card JD, Ficarro SB, Shim H, Marto JA, Dhe-Paganon S, Sasaki AT, Boxer MB, Simeonov A, Cantley LC, Shen M, Zhang T, Ferguson FM, Gray NS
GTP hydrolysis is modulated by Arg34 in the RASopathy-associated KRASP34R.
1. Birth Defects Res - published March 1, 2020
2. Bera AK, Lu J, Lu C, Li L, Gondi S, Yan W, Nelson A, Zhang G, Westover KD
Interleukin-2 druggability is modulated by global conformational transitions controlled by a helical capping switch.
1. Proc Natl Acad Sci U S A - published March 1, 2020
2. De Paula VS, Jude KM, Nerli S, Glassman CR, Garcia KC, Sgourakis NG
Modeling cancer genomic data in yeast reveals selection against ATM function during tumorigenesis.
1. PLoS Genet - published March 1, 2020
2. Hohl M, Mojumdar A, Hailemariam S, Kuryavyi V, Ghisays F, Sorenson K, Chang M, Taylor BS, Patel DJ, Burgers PM, Cobb JA, Petrini JHJ
A systematic re-examination of processing of MHCI-bound antigenic peptide precursors by ER aminopeptidase 1.
1. J Biol Chem - published March 1, 2020
2. Mavridis G, Arya R, Domnick A, Zoidakis J, Makridakis M, Vlahou A, Mpakali A, Lelis A, Georgiadis D, Tampé R, Papakyriakou A, Stern LJ, Stratikos E
An autoinhibitory intramolecular interaction proof-reads RNA recognition by the essential splicing factor U2AF2.
1. Proc Natl Acad Sci U S A - published March 1, 2020
2. Kang HS, Sánchez-Rico C, Ebersberger S, Sutandy FXR, Busch A, Welte T, Stehle R, Hipp C, Schulz L, Buchbender A, Zarnack K, König J, Sattler M
Non-Coding Variants Connect Enhancer Dysregulation with Nuclear Receptor Signaling in Hematopoietic Malignancies.
1. Cancer Discov - published March 1, 2020
2. Li K, Zhang Y, Liu X, Liu Y, Gu Z, Cao H, Dickerson KE, Chen M, Chen W, Shao Z, Ni M, Xu J
Pathogenic Nocardia: A diverse genus of emerging pathogens or just poorly recognized?
1. PLoS Pathog - published March 1, 2020
2. Mehta HH, Shamoo Y
Optimizing the refinement of merohedrally twinned P61 HIV-1 protease-inhibitor cocrystal structures.
1. Acta Crystallogr D Struct Biol - published March 1, 2020
2. Lockbaum GJ, Leidner F, Royer WE, Kurt Yilmaz N, Schiffer CA
Structural evidence for a latch mechanism regulating access to the active site of SufS-family cysteine desulfurases.
1. Acta Crystallogr D Struct Biol - published March 1, 2020
2. Dunkle JA, Bruno MR, Frantom PA
Ddi1 is a ubiquitin-dependent protease.
1. Proc Natl Acad Sci U S A - published March 1, 2020
2. Yip MCJ, Bodnar NO, Rapoport TA
Immunogenomic profiling determines responses to combined PARP and PD-1 inhibition in ovarian cancer.
1. Nat Commun - published March 1, 2020
2. Färkkilä A, Gulhan DC, Casado J, Jacobson CA, Nguyen H, Kochupurakkal B, Maliga Z, Yapp C, Chen YA, Schapiro D, Zhou Y, Graham JR, Dezube BJ, Munster P, Santagata S, Garcia E, Rodig S, Lako A, Chowdhury D, Shapiro GI, Matulonis UA, Park PJ, Hautaniemi S, Sorger PK, Swisher EM, D'Andrea AD, Konstantinopoulos PA