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128 Member Publications for January

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1H, 15N, and 13C backbone resonance assignments of the C4b-binding region from the S. aureus extracellular adherence protein.
1. Biomol NMR Assign - published January 9, 2021
2. Pal I, Mishra N, Herrera AI, Dubey A, Arthanari H, Geisbrecht BV, Prakash O
RADX controls RAD51 filament dynamics to regulate replication fork stability.
1. Mol Cell - published January 8, 2021
2. Adolph MB, Mohamed TM, Balakrishnan S, Xue C, Morati F, Modesti M, Greene EC, Chazin WJ, Cortez D
AXL is a candidate receptor for SARS-CoV-2 that promotes infection of pulmonary and bronchial epithelial cells.
1. Cell Res - published January 8, 2021
2. Wang S, Qiu Z, Hou Y, Deng X, Xu W, Zheng T, Wu P, Xie S, Bian W, Zhang C, Sun Z, Liu K, Shan C, Lin A, Jiang S, Xie Y, Zhou Q, Lu L, Huang J, Li X
Mechanism of filament formation in UPA-promoted CARD8 and NLRP1 inflammasomes.
1. Nat Commun - published January 8, 2021
2. Robert Hollingsworth L, David L, Li Y, Griswold AR, Ruan J, Sharif H, Fontana P, Orth-He EL, Fu TM, Bachovchin DA, Wu H
Structural basis for antibody inhibition of flavivirus NS1-triggered endothelial dysfunction.
1. Science - published January 8, 2021
2. Biering SB, Akey DL, Wong MP, Brown WC, Lo NTN, Puerta-Guardo H, Tramontini Gomes de Sousa F, Wang C, Konwerski JR, Espinosa DA, Bockhaus NJ, Glasner DR, Li J, Blanc SF, Juan EY, Elledge SJ, Mina MJ, Beatty PR, Smith JL, Harris E
Structure and dynamics of the drug-bound bacterial transporter EmrE in lipid bilayers.
1. Nat Commun - published January 8, 2021
2. Shcherbakov AA, Hisao G, Mandala VS, Thomas NE, Soltani M, Salter EA, Davis JH Jr, Henzler-Wildman KA, Hong M
Simple Secondary Amines Inhibit Growth of Gram-Negative Bacteria through Highly Selective Binding to Phenylalanyl-tRNA Synthetase.
1. J Am Chem Soc - published January 7, 2021
2. Baidin V, Owens TW, Lazarus MB, Kahne D
Bacterial Transcription Continues to Surprise: Activation by Alarmone-Mediated σ-Factor Tethering.
1. Mol Cell - published January 7, 2021
2. Saba J, Cao X, Landick R
General practitioners' deprescribing decisions in older adults with polypharmacy: a case vignette study in 31 countries.
1. BMC Geriatr - published January 7, 2021
2. Jungo KT, Mantelli S, Rozsnyai Z, Missiou A, Kitanovska BG, Weltermann B, Mallen C, Collins C, Bonfim D, Kurpas D, Petrazzuoli F, Dumitra G, Thulesius H, Lingner H, Johansen KL, Wallis K, Hoffmann K, Peremans L, Pilv L, Šter MP, Bleckwenn M, Sattler M, van der Ploeg M, Torzsa P, Kánská PB, Vinker S, Assenova R, Bravo RG, Viegas RPA, Tsopra R, Pestic SK, Gintere S, Koskela TH, Lazic V, Tkachenko V, Reeve E, Luymes C, Poortvliet RKE, Rodondi N, Gussekloo J, Streit S
Structural Basis for the Modulation of Human KCNQ4 by Small-Molecule Drugs.
1. Mol Cell - published January 7, 2021
2. Li T, Wu K, Yue Z, Wang Y, Zhang F, Shen H
Vaccination induces maturation in a mouse model of diverse unmutated VRC01-class precursors to HIV-neutralizing antibodies with >50% breadth.
1. Immunity - published January 7, 2021
2. Chen X, Zhou T, Schmidt SD, Duan H, Cheng C, Chuang GY, Gu Y, Louder MK, Lin BC, Shen CH, Sheng Z, Zheng MX, Doria-Rose NA, Joyce MG, Shapiro L, Tian M, Alt FW, Kwong PD, Mascola JR
Drug Design Strategies to Avoid Resistance in Direct-Acting Antivirals and Beyond.
1. Chem Rev - published January 7, 2021
2. Matthew AN, Leidner F, Lockbaum GJ, Henes M, Zephyr J, Hou S, Rao DN, Timm J, Rusere LN, Ragland DA, Paulsen JL, Prachanronarong K, Soumana DI, Nalivaika EA, Kurt Yilmaz N, Ali A, Schiffer CA
Primordial Protein Tails.
1. Mol Cell - published January 7, 2021
2. Brandman O, Frost A
Algorithmic robustness to preferred orientations in Single Particle Analysis by CryoEM.
1. J Struct Biol - published January 6, 2021
2. Sorzano COS, Semchonok D, Lin SC, Lo YC, Vilas JL, Jiménez-Moreno A, Gragera M, Vacca S, Maluenda D, Martínez M, Ramírez-Aportela E, Melero R, Cuervo A, Conesa JJ, Conesa P, Losana P, Caño LD, de la Morena JJ, Fonseca YC, Sánchez-García R, Strelak D, Fernández-Giménez E, de Isidro F, Herreros D, Kastritis PL, Marabini R, Bruce BD, Carazo JM
Structures of FHOD1-Nesprin1/2 complexes reveal alternate binding modes for the FH3 domain of formins.
1. Structure - published January 6, 2021
2. Lim SM, Cruz VE, Antoku S, Gundersen GG, Schwartz TU
Design of biologically active binary protein 2D materials.
1. Nature - published January 6, 2021
2. Ben-Sasson AJ, Watson JL, Sheffler W, Johnson MC, Bittleston A, Somasundaram L, Decarreau J, Jiao F, Chen J, Mela I, Drabek AA, Jarrett SM, Blacklow SC, Kaminski CF, Hura GL, De Yoreo JJ, Kollman JM, Ruohola-Baker H, Derivery E, Baker D
Crystal structure of a tick-borne flavivirus RNA-dependent RNA polymerase suggests a host adaptation hotspot in RNA viruses.
1. Nucleic Acids Res - published January 6, 2021
2. Yang J, Jing X, Yi W, Li XD, Yao C, Zhang B, Zheng Z, Wang H, Gong P
Seesaw conformations of Npl4 in the human p97 complex and the inhibitory mechanism of a disulfiram derivative.
1. Nat Commun - published January 5, 2021
2. Pan M, Zheng Q, Yu Y, Ai H, Xie Y, Zeng X, Wang C, Liu L, Zhao M
Cold sensitivity of the SARS-CoV-2 spike ectodomain.
1. Nat Struct Mol Biol - published January 5, 2021
2. Edwards RJ, Mansouri K, Stalls V, Manne K, Watts B, Parks R, Janowska K, Gobeil SMC, Kopp M, Li D, Lu X, Mu Z, Deyton M, Oguin TH 3rd, Sprenz J, Williams W, Saunders KO, Montefiori D, Sempowski GD, Henderson R, Munir Alam S, Haynes BF, Acharya P
Can video games enhance surgical skills acquisition for medical students? A systematic review.
1. Surgery - published January 5, 2021
2. Gupta A, Lawendy B, Goldenberg MG, Grober E, Lee JY, Perlis N
Functional Genomics Identify Distinct and Overlapping Genes Mediating Resistance to Different Classes of Heterobifunctional Degraders of Oncoproteins.
1. Cell Rep - published January 5, 2021
2. Shirasaki R, Matthews GM, Gandolfi S, de Matos Simoes R, Buckley DL, Raja Vora J, Sievers QL, Brüggenthies JB, Dashevsky O, Poarch H, Tang H, Bariteau MA, Sheffer M, Hu Y, Downey-Kopyscinski SL, Hengeveld PJ, Glassner BJ, Dhimolea E, Ott CJ, Zhang T, Kwiatkowski NP, Laubach JP, Schlossman RL, Richardson PG, Culhane AC, Groen RWJ, Fischer ES, Vazquez F, Tsherniak A, Hahn WC, Levy J, Auclair D, Licht JD, Keats JJ, Boise LH, Ebert BL, Bradner JE, Gray NS, Mitsiades CS
The Glo3 GAP crystal structure supports the molecular niche model for ArfGAPs in COPI coats.
1. Adv Biol Regul - published January 5, 2021
2. Xie B, Jung C, Chandra M, Engel A, Kendall AK, Jackson LP
Necator americanus Ancylostoma Secreted Protein-2 (Na-ASP-2) Binds an Ascaroside (ascr#3) in Its Fatty Acid Binding Site.
1. Front Chem - published January 4, 2021
2. El Atab O, Darwiche R, Truax NJ, Schneiter R, Hull KG, Romo D, Asojo OA
TLR3 controls constitutive IFN-β antiviral immunity in human fibroblasts and cortical neurons.
1. J Clin Invest - published January 4, 2021
2. Gao D, Ciancanelli MJ, Zhang P, Harschnitz O, Bondet V, Hasek M, Chen J, Mu X, Itan Y, Cobat A, Sancho-Shimizu V, Bigio B, Lorenzo L, Ciceri G, McAlpine J, Anguiano E, Jouanguy E, Chaussabel D, Meyts I, Diamond MS, Abel L, Hur S, Smith GA, Notarangelo L, Duffy D, Studer L, Casanova JL, Zhang SY
A general chemical crosslinking strategy for structural analyses of weakly interacting proteins applied to preTCR-pMHC complexes.
1. J Biol Chem - published January 4, 2021
2. Mizsei R, Li X, Chen WN, Szabo M, Wang JH, Wagner G, Reinherz EL, Mallis RJ
Intracellular immune sensing promotes inflammation via gasdermin D-driven release of a lectin alarmin.
1. Nat Immunol - published January 4, 2021
2. Russo AJ, Vasudevan SO, Méndez-Huergo SP, Kumari P, Menoret A, Duduskar S, Wang C, Pérez Sáez JM, Fettis MM, Li C, Liu R, Wanchoo A, Chandiran K, Ruan J, Vanaja SK, Bauer M, Sponholz C, Hudalla GA, Vella AT, Zhou B, Deshmukh SD, Rabinovich GA, Rathinam VA
Structural basis for voltage-sensor trapping of the cardiac sodium channel by a deathstalker scorpion toxin.
1. Nat Commun - published January 4, 2021
2. Jiang D, Tonggu L, Gamal El-Din TM, Banh R, Pomès R, Zheng N, Catterall WA
Structural and functional characterization of the Spo11 core complex.
1. Nat Struct Mol Biol - published January 4, 2021
2. Claeys Bouuaert C, Tischfield SE, Pu S, Mimitou EP, Arias-Palomo E, Berger JM, Keeney S
Binding and transport of SFPQ-RNA granules by KIF5A/KLC1 motors promotes axon survival.
1. J Cell Biol - published January 4, 2021
2. Fukuda Y, Pazyra-Murphy MF, Silagi ES, Tasdemir-Yilmaz OE, Li Y, Rose L, Yeoh ZC, Vangos NE, Geffken EA, Seo HS, Adelmant G, Bird GH, Walensky LD, Marto JA, Dhe-Paganon S, Segal RA
A phage-encoded anti-activator inhibits quorum sensing in Pseudomonas aeruginosa.
1. Mol Cell - published January 4, 2021
2. Shah M, Taylor VL, Bona D, Tsao Y, Stanley SY, Pimentel-Elardo SM, McCallum M, Bondy-Denomy J, Howell PL, Nodwell JR, Davidson AR, Moraes TF, Maxwell KL
Apobec1 complementation factor overexpression promotes hepatic steatosis, fibrosis, and hepatocellular cancer.
1. J Clin Invest - published January 4, 2021
2. Blanc V, Riordan JD, Soleymanjahi S, Nadeau JH, Nalbantoglu I, Xie Y, Molitor EA, Madison BB, Brunt EM, Mills JC, Rubin DC, Ng IO, Ha Y, Roberts LR, Davidson NO
Structural basis of cytoplasmic NaV1.5 and NaV1.4 regulation.
1. J Gen Physiol - published January 4, 2021
2. Nathan S, Gabelli SB, Yoder JB, Srinivasan L, Aldrich RW, Tomaselli GF, Ben-Johny M, Amzel LM
Malaria parasites use a soluble RhopH complex for erythrocyte invasion and an integral form for nutrient uptake.
1. Elife - published January 4, 2021
2. Schureck MA, Darling JE, Merk A, Shao J, Daggupati G, Srinivasan P, Olinares PDB, Rout MP, Chait BT, Wollenberg K, Subramaniam S, Desai SA
Translocation of Proteins through a Distorted Lipid Bilayer.
1. Trends Cell Biol - published January 3, 2021
2. Wu X, Rapoport TA
TLR3-Activated Monocyte-Derived Dendritic Cells Trigger Progression from Acute Viral Infection to Chronic Disease in the Lung.
1. J Immunol - published January 2, 2021
2. Wang X, Wu K, Keeler SP, Mao D, Agapov EV, Zhang Y, Holtzman MJ
Structures of monomeric and dimeric PRC2:EZH1 reveal flexible modules involved in chromatin compaction.
1. Nat Commun - published January 2, 2021
2. Grau D, Zhang Y, Lee CH, Valencia-Sánchez M, Zhang J, Wang M, Holder M, Svetlov V, Tan D, Nudler E, Reinberg D, Walz T, Armache KJ
Heterogeneity and clonal evolution of acquired PARP inhibitor resistance in TP53- and BRCA1-deficient cells.
1. Cancer Res - published January 2, 2021
2. Färkkilä A, Rodríguez A, Oikkonen J, Gulhan DC, Nguyen H, Domínguez J, Ramos S, Mills CE, Perez-Villatoro F, Lazaro JB, Zhou J, Clairmont CS, Moreau LA, Park PJ, Sorger PK, Hautaniemi S, Frias S, D'Andrea AD
NAD(H) phosphates mediate tetramer assembly of human C-terminal binding protein (CtBP).
1. J Biol Chem - published January 2, 2021
2. Nichols JC, Schiffer CA, Royer WE Jr
Identification of SARS-CoV-2 spike mutations that attenuate monoclonal and serum antibody neutralization.
1. Cell Host Microbe - published January 2, 2021
2. Liu Z, VanBlargan LA, Bloyet LM, Rothlauf PW, Chen RE, Stumpf S, Zhao H, Errico JM, Theel ES, Liebeskind MJ, Alford B, Buchser WJ, Ellebedy AH, Fremont DH, Diamond MS, Whelan SPJ
Loss of wild type KRAS in KRAS^MUT lung adenocarcinoma is associated with cancer mortality and confers sensitivity to FASN inhibitors.
1. Lung Cancer - published January 2, 2021
2. Liu Y, Gao GF, Minna JD, Williams NS, Westover KD
Protein cysteine palmitoylation in immunity and inflammation.
1. FEBS J - published January 2, 2021
2. Lin H
The Eya1 Phosphatase Mediates Shh-Driven Symmetric Cell Division of Cerebellar Granule Cell Precursors.
1. Dev Neurosci - published January 2, 2021
2. Merk DJ, Zhou P, Cohen SM, Pazyra-Murphy MF, Hwang GH, Rehm KJ, Alfaro J, Reid CM, Zhao X, Park E, Xu PX, Chan JA, Eck MJ, Nazemi KJ, Harwell CC, Segal RA
A host receptor enables type 1 pilus-mediated pathogenesis of Escherichia coli pyelonephritis.
1. PLoS Pathog - published January 2, 2021
2. McLellan LK, McAllaster MR, Kim AS, Tóthová Ľ, Olson PD, Pinkner JS, Daugherty AL, Hreha TN, Janetka JW, Fremont DH, Hultgren SJ, Virgin HW, Hunstad DA
¹H, ¹³C and ¹⁵N backbone chemical shift assignments of SARS-CoV-2 nsp3a.
1. Biomol NMR Assign - published January 2, 2021
2. Salvi N, Bessa LM, Guseva S, Camacho-Zarco A, Maurin D, Perez LM, Malki A, Hengesbach M, Korn SM, Schlundt A, Schwalbe H, Blackledge M
Atomistic and Thermodynamic Analysis of N6-Methyladenosine (m⁶A) Recognition by the Reader Domain of YTHDC1.
1. J Chem Theory Comput - published January 2, 2021
2. Li Y, Bedi RK, Wiedmer L, Sun X, Huang D, Caflisch A
Molecular determinants and mechanism for antibody cocktail preventing SARS-CoV-2 escape.
1. Nat Commun - published January 2, 2021
2. Ku Z, Xie X, Davidson E, Ye X, Su H, Menachery VD, Li Y, Yuan Z, Zhang X, Muruato AE, I Escuer AG, Tyrell B, Doolan K, Doranz BJ, Wrapp D, Bates PF, McLellan JS, Weiss SR, Zhang N, Shi PY, An Z
Comparison of Subgenomic and Total RNA in SARS-CoV-2 Challenged Rhesus Macaques.
1. J Virol - published January 2, 2021
2. Dagotto G, Mercado NB, Martinez DR, Hou YJ, Nkolola JP, Carnahan RH, Crowe JE Jr, Baric RS, Barouch DH
Pharmacological and genetic perturbation establish SIRT5 as a promising target in breast cancer.
1. Oncogene - published January 2, 2021
2. Abril YLN, Fernandez IR, Hong JY, Chiang YL, Kutateladze DA, Zhao Q, Yang M, Hu J, Sadhukhan S, Li B, He B, Remick B, Bai JJ, Mullmann J, Wang F, Maymi V, Dhawan R, Auwerx J, Southard T, Cerione RA, Lin H, Weiss RS
Altered structure and dynamics of pathogenic cytochrome c variants correlate with increased apoptotic activity.
1. Biochem J - published January 2, 2021
2. Fellner M, Parakra R, McDonald KO, Kass I, Jameson GNL, Wilbanks SM, Ledgerwood EC
Structural basis for transcription complex disruption by the Mfd translocase.
1. Elife - published January 2, 2021
2. Kang JY, Llewellyn E, Chen J, Olinares PDB, Brewer J, Chait BT, Campbell EA, Darst SA
Analysis of SteraMist ionized hydrogen peroxide technology in the sterilization of N95 respirators and other PPE.
1. Sci Rep - published January 2, 2021
2. Cramer AK, Plana D, Yang H, Carmack MM, Tian E, Sinha MS, Krikorian D, Turner D, Mo J, Li J, Gupta R, Manning H, Bourgeois FT, Yu SH, Sorger PK, LeBoeuf NR
JARID2 and AEBP2 regulate PRC2 in the presence of H2AK119ub1 and other histone modifications.
1. Science - published January 2, 2021
2. Kasinath V, Beck C, Sauer P, Poepsel S, Kosmatka J, Faini M, Toso D, Aebersold R, Nogales E
Competitive Microtubule Binding of PEX14 Coordinates Peroxisomal Protein Import and Motility.
1. J Mol Biol - published January 2, 2021
2. Reuter M, Kooshapur H, Suda JG, Gaussmann S, Neuhaus A, Brühl L, Bharti P, Jung M, Schliebs W, Sattler M, Erdmann R
Interplay between hevin, SPARC, and MDGAs: modulators of neurexin-neuroligin transsynaptic bridges.
1. Structure - published January 2, 2021
2. Fan S, Gangwar SP, Machius M, Rudenko G
¹H, ¹³C and ¹⁵N chemical shift assignment of the stem-loop 5a from the 5'-UTR of SARS-CoV-2.
1. Biomol NMR Assign - published January 2, 2021
2. Schnieders R, Peter SA, Banijamali E, Riad M, Altincekic N, Bains JK, Ceylan B, Fürtig B, Grün JT, Hengesbach M, Hohmann KF, Hymon D, Knezic B, Oxenfarth A, Petzold K, Qureshi NS, Richter C, Schlagnitweit J, Schlundt A, Schwalbe H, Stirnal E, Sudakov A, Vögele J, Wacker A, Weigand JE, Wirmer-Bartoschek J, Wöhnert J
A novel AKR1C3 specific prodrug TH3424 with potent anti-tumor activity in liver cancer.
1. Clin Pharmacol Ther - published January 2, 2021
2. He P, Wang C, Wang Y, Wang C, Zhou C, Cao D, Li J, Bushnell DA, Li Q, Kornberg RD, Xie W, Wang Z
Membrane binding and homodimerization of Atg16 via two distinct protein regions is essential for autophagy in yeast.
1. J Mol Biol - published January 2, 2021
2. Popelka H, Reinhart EF, Padma Metur S, Leary KA, Ragusa MJ, Klionsky DJ
Mammalian cell proliferation requires noncatalytic functions of O-GlcNAc transferase.
1. Proc Natl Acad Sci U S A - published January 2, 2021
2. Levine ZG, Potter SC, Joiner CM, Fei GQ, Nabet B, Sonnett M, Zachara NE, Gray NS, Paulo JA, Walker S
In-depth and 3-dimensional exploration of the budding yeast phosphoproteome.
1. EMBO Rep - published January 2, 2021
2. Lanz MC, Yugandhar K, Gupta S, Sanford EJ, Faça VM, Vega S, Joiner AMN, Fromme JC, Yu H, Smolka MB
Interactions of APOBEC3s with DNA and RNA.
1. Curr Opin Struct Biol - published January 2, 2021
2. Maiti A, Hou S, Schiffer CA, Matsuo H
General Purpose Structure-Based Drug Discovery Neural Network Score Functions with Human-Interpretable Pharmacophore Maps.
1. J Chem Inf Model - published January 2, 2021
2. Brown BP, Mendenhall J, Geanes AR, Meiler J
Opposing immune and genetic mechanisms shape oncogenic programs in synovial sarcoma.
1. Nat Med - published January 2, 2021
2. Jerby-Arnon L, Neftel C, Shore ME, Weisman HR, Mathewson ND, McBride MJ, Haas B, Izar B, Volorio A, Boulay G, Cironi L, Richman AR, Broye LC, Gurski JM, Luo CC, Mylvaganam R, Nguyen L, Mei S, Melms JC, Georgescu C, Cohen O, Buendia-Buendia JE, Segerstolpe A, Sud M, Cuoco MS, Labes D, Gritsch S, Zollinger DR, Ortogero N, Beechem JM, Petur Nielsen G, Chebib I, Nguyen-Ngoc T, Montemurro M, Cote GM, Choy E, Letovanec I, Cherix S, Wagle N, Sorger PK, Haynes AB, Mullen JT, Stamenkovic I, Rivera MN, Kadoch C, Wucherpfennig KW, Rozenblatt-Rosen O, Suvà ML, Riggi N, Regev A
Broad and potent activity against SARS-like viruses by an engineered human monoclonal antibody.
1. Science - published January 2, 2021
2. Rappazzo CG, Tse LV, Kaku CI, Wrapp D, Sakharkar M, Huang D, Deveau LM, Yockachonis TJ, Herbert AS, Battles MB, O'Brien CM, Brown ME, Geoghegan JC, Belk J, Peng L, Yang L, Hou Y, Scobey TD, Burton DR, Nemazee D, Dye JM, Voss JE, Gunn BM, McLellan JS, Baric RS, Gralinski LE, Walker LM
Palbociclib renders human papilloma virus-negative head and neck squamous cell carcinoma vulnerable to the senolytic agent navitoclax.
1. Mol Cancer Res - published January 2, 2021
2. Gadsden NJ, Fulcher CD, Li D, Shrivastava N, Thomas C, Segall JE, Prystowsky MB, Schlecht NF, Gavathiotis E, Ow TJ
Unique structural solution from a V_H3-30 antibody targeting the hemagglutinin stem of influenza A viruses.
1. Nat Commun - published January 2, 2021
2. Harshbarger WD, Deming D, Lockbaum GJ, Attatippaholkun N, Kamkaew M, Hou S, Somasundaran M, Wang JP, Finberg RW, Zhu QK, Schiffer CA, Marasco WA
Mechanism of membrane-curvature generation by ER-tubule shaping proteins.
1. Nat Commun - published January 2, 2021
2. Wang N, Clark LD, Gao Y, Kozlov MM, Shemesh T, Rapoport TA
DDX58(RIG-I)-related disease is associated with tissue-specific interferon pathway activation.
1. J Med Genet - published January 2, 2021
2. Prasov L, Bohnsack BL, El Husny AS, Tsoi LC, Guan B, Kahlenberg JM, Almeida E, Wang H, Cowen EW, De Jesus AA, Jani P, Billi AC, Moroi SE, Wasikowski R, Almeida I, Almeida LN, Kok F, Garnai SJ, Mian SI, Chen MY, Warner BM, Ferreira CR, Goldbach-Mansky R, Hur S, Brooks BP, Richards JE, Hufnagel RB, Gudjonsson JE
Newcastle Disease Virus-Like Particles Displaying Prefusion-Stabilized SARS-CoV-2 Spikes Elicit Potent Neutralizing Responses.
1. Vaccines (Basel) - published January 2, 2021
2. Yang Y, Shi W, Abiona OM, Nazzari A, Olia AS, Ou L, Phung E, Stephens T, Tsybovsky Y, Verardi R, Wang S, Werner A, Yap C, Ambrozak D, Bylund T, Liu T, Nguyen R, Wang L, Zhang B, Zhou T, Chuang GY, Graham BS, Mascola JR, Corbett KS, Kwong PD
Polyclonal epitope mapping reveals temporal dynamics and diversity of human antibody responses to H5N1 vaccination.
1. Cell Rep - published January 2, 2021
2. Han J, Schmitz AJ, Richey ST, Dai YN, Turner HL, Mohammed BM, Fremont DH, Ellebedy AH, Ward AB
Detection of Bacterial Membrane Vesicles by NOD-Like Receptors.
1. Int J Mol Sci - published January 2, 2021
2. Johnston EL, Heras B, Kufer TA, Kaparakis-Liaskos M
Epithelial IL-33 appropriates exosome trafficking for secretion in chronic airway disease.
1. JCI Insight - published January 2, 2021
2. Katz-Kiriakos E, Steinberg DF, Kluender CE, Osorio OA, Newsom-Stewart C, Baronia A, Byers DE, Holtzman MJ, Katafiasz D, Bailey KL, Brody SL, Miller MJ, Alexander-Brett J
Crystal Structure of SARS-CoV-2 Main Protease in Complex with the Non-Covalent Inhibitor ML188.
1. Viruses - published January 2, 2021
2. Lockbaum GJ, Reyes AC, Lee JM, Tilvawala R, Nalivaika EA, Ali A, Kurt Yilmaz N, Thompson PR, Schiffer CA
Intractable COVID-19 and Prolonged SARS-CoV-2 Replication in a CAR-T-cell Therapy Recipient: A Case Study.
1. Clin Infect Dis - published January 2, 2021
2. Hensley MK, Bain WG, Jacobs J, Nambulli S, Parikh U, Cillo A, Staines B, Heaps A, Sobolewski MD, Rennick LJ, Macatangay BJC, Klamar-Blain C, Kitsios GD, Methé B, Somasundaram A, Bruno T, Cardello C, Shan F, Workman C, Ray P, Ray A, Lee J, Sethi R, Schwarzmann WE, Ladinsky MS, Bjorkman PJ, Vignali DA, Duprex WP, Agha ME, Mellors JW, McCormick KD, Morris A, Haidar G
Drugging the 'undruggable' MYCN oncogenic transcription factor: Overcoming previous obstacles to impact childhood cancers.
1. Cancer Res - published January 2, 2021
2. Wolpaw AJ, Bayliss R, Büchel G, Dang CV, Eilers M, Gustafson WC, Hansen GM, Jura N, Knapp S, Lemmon MA, Levens D, Maris JM, Marmorstein R, Metallo SJ, Park JR, Penn LZ, Rape M, Roussel MF, Shokat KM, Tansey WP, Verba KA, Vos SM, Weiss WA, Wolf E, Mossé YP
Early hemodynamic assessment using NICOM in patients at risk of developing Sepsis immediately after emergency department triage.
1. Scand J Trauma Resusc Emerg Med - published January 2, 2021
2. Chukwulebe SB, Gaieski DF, Bhardwaj A, Mulugeta-Gordon L, Shofer FS, Dean AJ
Dynamics of the HD regulatory subdomain of PARP-1; substrate access and allostery in PARP activation and inhibition.
1. Nucleic Acids Res - published January 2, 2021
2. Ogden TEH, Yang JC, Schimpl M, Easton LE, Underwood E, Rawlins PB, McCauley MM, Langelier MF, Pascal JM, Embrey KJ, Neuhaus D
The Card1 nuclease provides defence during type-III CRISPR immunity.
1. Nature - published January 1, 2021
2. Rostøl JT, Xie W, Kuryavyi V, Maguin P, Kao K, Froom R, Patel DJ, Marraffini LA
Statistically correcting dynamical electron scattering improves the refinement of protein nanocrystals, including charge refinement of coordinated metals.
1. Acta Crystallogr D Struct Biol - published January 1, 2021
2. Blum TB, Housset D, Clabbers MTB, van Genderen E, Bacia-Verloop M, Zander U, McCarthy AA, Schoehn G, Ling WL, Abrahams JP
Selective Aster inhibitors distinguish vesicular and nonvesicular sterol transport mechanisms.
1. Proc Natl Acad Sci U S A - published January 1, 2021
2. Xiao X, Kim Y, Romartinez-Alonso B, Sirvydis K, Ory DS, Schwabe JWR, Jung ME, Tontonoz P
Tuning MPL signaling to influence hematopoietic stem cell differentiation and inhibit essential thrombocythemia progenitors.
1. Proc Natl Acad Sci U S A - published January 1, 2021
2. Cui L, Moraga I, Lerbs T, Van Neste C, Wilmes S, Tsutsumi N, Trotman-Grant AC, Gakovic M, Andrews S, Gotlib J, Darmanis S, Enge M, Quake S, Hitchcock IS, Piehler J, Garcia KC, Wernig G
Structure of SARS-CoV-2 ORF8, a rapidly evolving immune evasion protein.
1. Proc Natl Acad Sci U S A - published January 1, 2021
2. Flower TG, Buffalo CZ, Hooy RM, Allaire M, Ren X, Hurley JH
Proteostasis of Islet Amyloid Polypeptide: A Molecular Perspective of Risk Factors and Protective Strategies for Type II Diabetes.
1. Chem Rev - published January 1, 2021
2. Milardi D, Gazit E, Radford SE, Xu Y, Gallardo RU, Caflisch A, Westermark GT, Westermark P, Rosa C, Ramamoorthy A
Mutations causing Lopes-Maciel-Rodan Syndrome are huntingtin hypomorphs.
1. Hum Mol Genet - published January 1, 2021
2. Jung R, Lee Y, Barker D, Correia K, Shin B, Loupe J, Collins RL, Lucente D, Ruliera J, Gillis T, Mysore JS, Rodan L, Picker J, Lee JM, Howland D, Lee R, Kwak S, MacDonald ME, Gusella JF, Seong IS
A trimeric human angiotensin-converting enzyme 2 as an anti-SARS-CoV-2 agent.
1. Nat Struct Mol Biol - published January 1, 2021
2. Xiao T, Lu J, Zhang J, Johnson RI, McKay LGA, Storm N, Lavine CL, Peng H, Cai Y, Rits-Volloch S, Lu S, Quinlan BD, Farzan M, Seaman MS, Griffiths A, Chen B
Exploring the Evolutionary History of Kinetic Stability in the α-Lytic Protease Family.
1. Biochemistry - published January 1, 2021
2. Nixon CF, Lim SA, Sailer ZR, Zheludev IN, Gee CL, Kelch BA, Harms MJ, Marqusee S
Structural vaccinology of malaria transmission-blocking vaccines.
1. Expert Rev Vaccines - published January 1, 2021
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Targeted disruption of pi-pi stacking in Malaysian banana lectin reduces mitogenicity while preserving antiviral activity.
1. Sci Rep - published January 1, 2021
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Structural biology in the fight against COVID-19.
1. Nat Struct Mol Biol - published January 1, 2021
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Mosaic nanoparticles elicit cross-reactive immune responses to zoonotic coronaviruses in mice.
1. Science - published January 1, 2021
2. Cohen AA, Gnanapragasam PNP, Lee YE, Hoffman PR, Ou S, Kakutani LM, Keeffe JR, Wu HJ, Howarth M, West AP, Barnes CO, Nussenzweig MC, Bjorkman PJ
Functional refolding of the penetration protein on a non-enveloped virus.
1. Nature - published January 1, 2021
2. Herrmann T, Torres R, Salgado EN, Berciu C, Stoddard D, Nicastro D, Jenni S, Harrison SC
Real-time observation of Cas9 postcatalytic domain motions.
1. Proc Natl Acad Sci U S A - published January 1, 2021
2. Wang Y, Mallon J, Wang H, Singh D, Hyun Jo M, Hua B, Bailey S, Ha T
Comprehensive in vivo secondary structure of the SARS-CoV-2 genome reveals novel regulatory motifs and mechanisms.
1. Mol Cell - published January 1, 2021
2. Huston NC, Wan H, Strine MS, de Cesaris Araujo Tavares R, Wilen CB, Pyle AM
Chaperone-mediated autophagy sustains haematopoietic stem-cell function.
1. Nature - published January 1, 2021
2. Dong S, Wang Q, Kao YR, Diaz A, Tasset I, Kaushik S, Thiruthuvanathan V, Zintiridou A, Nieves E, Dzieciatkowska M, Reisz JA, Gavathiotis E, D'Alessandro A, Will B, Cuervo AM
Fungal-Selective Resorcylate Aminopyrazole Hsp90 Inhibitors: Optimization of Whole-Cell Anticryptococcal Activity and Insights into the Structural Origins of Cryptococcal Selectivity.
1. J Med Chem - published January 1, 2021
2. Marcyk PT, LeBlanc EV, Kuntz DA, Xue A, Ortiz F, Trilles R, Bengtson S, Kenney TMG, Huang DS, Robbins N, Williams NS, Krysan DJ, Privé GG, Whitesell L, Cowen LE, Brown LE
ENRICH: A fast method to improve the quality of flexible macromolecular reconstructions.
1. Prog Biophys Mol Biol - published January 1, 2021
2. Kazemi M, Sorzano COS, Carazo JM, Georges AD, Abrishami V, Vargas J
Identification of fidelity-governing factors in human recombinases DMC1 and RAD51 from cryo-EM structures.
1. Nat Commun - published January 1, 2021
2. Luo SC, Yeh HY, Lan WH, Wu YM, Yang CH, Chang HY, Su GC, Lee CY, Wu WJ, Li HW, Ho MC, Chi P, Tsai MD
Mithramycin and Analogs for Overcoming Cisplatin Resistance in Ovarian Cancer.
1. Biomedicines - published January 1, 2021
2. Schweer D, McCorkle JR, Rohr J, Tsodikov OV, Ueland F, Kolesar J
Cryo-EM structure of the B cell co-receptor CD19 bound to the tetraspanin CD81.
1. Science - published January 1, 2021
2. Susa KJ, Rawson S, Kruse AC, Blacklow SC
Phosphorylation-dependent regulation of messenger RNA transcription, processing and translation within biomolecular condensates.
1. Curr Opin Cell Biol - published January 1, 2021
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HAND1 and BARX1 act as transcriptional and anatomic determinants of malignancy in gastrointestinal stromal tumor.
1. Clin Cancer Res - published January 1, 2021
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Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia.
1. J Hematol Oncol - published January 1, 2021
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A high-throughput cell-based assay pipeline for the preclinical development of bacterial DsbA inhibitors as antivirulence therapeutics.
1. Sci Rep - published January 1, 2021
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Structural basis for placental malaria mediated by Plasmodium falciparum VAR2CSA.
1. Nat Microbiol - published January 1, 2021
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Structure and activation mechanism of the yeast RNA Pol II CTD kinase CTDK-1 complex.
1. Proc Natl Acad Sci U S A - published January 1, 2021
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Lactoferrin receptors in Gram-negative bacteria: an evolutionary perspective.
1. Biochem Cell Biol - published January 1, 2021
2. Ostan NKH, Moraes TF, Schryvers AB
Rosetta design with co-evolutionary information retains protein function.
1. PLoS Comput Biol - published January 1, 2021
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Evolution of antibody immunity to SARS-CoV-2.
1. Nature - published January 1, 2021
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Atomic structures of respiratory complex III₂, complex IV, and supercomplex III₂-IV from vascular plants.
1. Elife - published January 1, 2021
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Structural basis for non-radical catalysis by TsrM, a radical SAM methylase.
1. Nat Chem Biol - published January 1, 2021
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Structure of SRSF1 RRM1 bound to RNA reveals an unexpected bimodal mode of interaction and explains its involvement in SMN1 exon7 splicing.
1. Nat Commun - published January 1, 2021
2. Cléry A, Krepl M, Nguyen CKX, Moursy A, Jorjani H, Katsantoni M, Okoniewski M, Mittal N, Zavolan M, Sponer J, Allain FH
Impact of WIN site inhibitor on the WDR5 interactome.
1. Cell Rep - published January 1, 2021
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Daptomycin resistance in Enterococcus faecium can be delayed by disruption of the LiaFSR stress response pathway.
1. Antimicrob Agents Chemother - published January 1, 2021
2. Prater AG, Mehta HH, Beabout K, Supandy A, Miller WR, Tran TT, Arias CA, Shamoo Y
Publisher Correction: Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques.
1. Nature - published January 1, 2021
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Murine intrarectal instillation of purified recombinant C. difficile toxins enables mechanistic studies of pathogenesis.
1. Infect Immun - published January 1, 2021
2. Markham NO, Bloch SC, Shupe JA, Laubacher EN, Thomas AK, Kroh HK, Childress KO, Peritore-Galve FC, Washington MK, Coffey RJ, Lacy DB
SARS-CoV-2 Infection Severity Is Linked to Superior Humoral Immunity against the Spike.
1. mBio - published January 1, 2021
2. Guthmiller JJ, Stovicek O, Wang J, Changrob S, Li L, Halfmann P, Zheng NY, Utset H, Stamper CT, Dugan HL, Miller WD, Huang M, Dai YN, Nelson CA, Hall PD, Jansen M, Shanmugarajah K, Donington JS, Krammer F, Fremont DH, Joachimiak A, Kawaoka Y, Tesic V, Madariaga ML, Wilson PC
Choroid plexus NKCC1 mediates cerebrospinal fluid clearance during mouse early postnatal development.
1. Nat Commun - published January 1, 2021
2. Xu H, Fame RM, Sadegh C, Sutin J, Naranjo C, Della Syau, Cui J, Shipley FB, Vernon A, Gao F, Zhang Y, Holtzman MJ, Heiman M, Warf BC, Lin PY, Lehtinen MK
Structural basis for self-cleavage prevention by tag:anti-tag pairing complementarity in type VI Cas13 CRISPR systems.
1. Mol Cell - published January 1, 2021
2. Wang B, Zhang T, Yin J, Yu Y, Xu W, Ding J, Patel DJ, Yang H
p.E152K-STIM1 mutation deregulates Ca²⁺ signaling contributing to chronic pancreatitis.
1. J Cell Sci - published January 1, 2021
2. Burgos M, Philippe R, Antigny F, Buscaglia P, Masson E, Mukherjee S, Dubar P, Le Maréchal C, Campeotto F, Lebonvallet N, Frieden M, Llopis J, Domingo B, Stathopulos PB, Ikura M, Brooks W, Guida W, Chen JM, Ferec C, Capiod T, Mignen O
Unveiling the polarity of actin filaments by cryo-electron tomography.
1. Structure - published January 1, 2021
2. Martins B, Sorrentino S, Chung WL, Tatli M, Medalia O, Eibauer M
2.5Å-resolution structure of the human CDK-activating kinase bound to the clinical inhibitor ICEC0942.
1. Biophys J - published January 1, 2021
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Cdc42 functions as a regulatory node for tumour-derived microvesicle biogenesis.
1. J Extracell Vesicles - published January 1, 2021
2. Wang J, Zhuang X, Greene KS, Si H, Antonyak MA, Druso JE, Wilson KF, Cerione RA, Feng Q, Wang H
Structural Analysis of Neutralizing Epitopes of the SARS-CoV-2 Spike to Guide Therapy and Vaccine Design Strategies.
1. Viruses - published January 1, 2021
2. Finkelstein MT, Mermelstein AG, Parker Miller E, Seth PC, Stancofski ED, Fera D
A Peek Inside the Machines of Bacterial Nucleotide Excision Repair.
1. Int J Mol Sci - published January 1, 2021
2. Kraithong T, Hartley S, Jeruzalmi D, Pakotiprapha D
Calcineurin: A star is reborn.
1. Cell Calcium - published January 1, 2021
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Discovery of a Pyrimidothiazolodiazepinone as a Potent and Selective Focal Adhesion Kinase (FAK) Inhibitor.
1. ACS Med Chem Lett - published January 1, 2021
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Mechanism of C-type inactivation in the hERG potassium channel.
1. Sci Adv - published January 1, 2021
2. Li J, Shen R, Reddy B, Perozo E, Roux B
Complexes of the neurotensin receptor 1 with small-molecule ligands reveal structural determinants of full, partial, and inverse agonism.
1. Sci Adv - published January 1, 2021
2. Deluigi M, Klipp A, Klenk C, Merklinger L, Eberle SA, Morstein L, Heine P, Mittl PRE, Ernst P, Kamenecka TM, He Y, Vacca S, Egloff P, Honegger A, Plückthun A
EphrinB2 clustering by Nipah virus G is required to activate and trap F intermediates at supported lipid bilayer-cell interfaces.
1. Sci Adv - published January 1, 2021
2. Wong JJ, Chen Z, Chung JK, Groves JT, Jardetzky TS