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44 Member Publications for August

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Novel interaction interfaces mediate the interaction between the NEIL1 DNA glycosylase and mitochondrial transcription factor A.
1. Front Cell Dev Biol - published August 8, 2022
2. Sharma N, Thompson MK, Arrington JF, Terry DM, Chakravarthy S, Prevelige PE, Prakash A
Multistep loading of a DNA sliding clamp onto DNA by replication factor C.
1. Elife - published August 8, 2022
2. Schrecker M, Castaneda JC, Devbhandari S, Kumar C, Remus D, Hite RK
Autoantibody mimicry of hormone action at the thyrotropin receptor.
1. Nature - published August 8, 2022
2. Faust B, Billesbølle CB, Suomivuori CM, Singh I, Zhang K, Hoppe N, Pinto AFM, Diedrich JK, Muftuoglu Y, Szkudlinski MW, Saghatelian A, Dror RO, Cheng Y, Manglik A
mRNA booster vaccination protects aged mice against the SARS-CoV-2 Omicron variant.
1. Commun Biol - published August 6, 2022
2. Nanishi E, McGrath ME, O'Meara TR, Barman S, Yu J, Wan H, Dillen CA, Menon M, Seo HS, Song K, Xu AZ, Sebastian L, Brook B, Bosco AN, Borriello F, Ernst RK, Barouch DH, Dhe-Paganon S, Levy O, Frieman MB, Dowling DJ
Immediate and Sustained Effects of Cobalt and Zinc-Containing Pigments on Macrophages.
1. Front Immunol - published August 5, 2022
2. Devcic J, Dussol M, Collin-Faure V, Pérard J, Fenel D, Schoehn G, Carrière M, Rabilloud T, Dalzon B
BCL10 Mutations Define Distinct Dependencies Guiding Precision Therapy for DLBCL.
1. Cancer Discov - published August 5, 2022
2. Xia M, David L, Teater M, Gutierrez J, Wang X, Meydan C, Lytle A, Slack GW, Scott DW, Morin RD, Onder O, Elenitoba-Johnson KSJ, Zamponi N, Cerchietti L, Lu T, Philippar U, Fontan L, Wu H, Melnick AM
Structure-based evolutionary relationship between IscB and Cas9.
1. Cell Res - published August 5, 2022
2. Jia N, Patel DJ
Modulation of pre-mRNA structure by hnRNP proteins regulates alternative splicing of MALT1.
1. Sci Adv - published August 5, 2022
2. Jones AN, Graß C, Meininger I, Geerlof A, Klostermann M, Zarnack K, Krappmann D, Sattler M
The TPR domain of PgaA is a multifunctional scaffold that binds PNAG and modulates PgaB-dependent polymer processing.
1. PLoS Pathog - published August 5, 2022
2. Pfoh R, Subramanian AS, Huang J, Little DJ, Forman A, DiFrancesco BR, Balouchestani-Asli N, Kitova EN, Klassen JS, Pomès R, Nitz M, Howell PL
Coupling to short linear motifs creates versatile PME-1 activities in PP2A holoenzyme demethylation and inhibition.
1. Elife - published August 4, 2022
2. Li Y, Balakrishnan VK, Rowse M, Wu CG, Bravos AP, Yadav VK, Ivarsson Y, Strack S, Novikova IV, Xing Y
Inhibition of H1 and H5 Influenza A Virus Entry by Diverse Macrocyclic Peptides Targeting the Hemagglutinin Stem Region.
1. ACS Chem Biol - published August 4, 2022
2. Pascha MN, Thijssen V, Egido JE, Linthorst MW, van Lanen JH, van Dongen DAA, Hopstaken AJP, van Kuppeveld FJM, Snijder J, de Haan CAM, Jongkees SAK
A Review of Clinical Efficacy Data Supporting Emergency Use Authorization for COVID-19 Therapeutics and Lessons for Future Pandemics.
1. Clin Transl Sci - published August 4, 2022
2. Yoo SH, Kim L, Lu M, Nagoshi K, Namchuk MN
PEX5 translocation into and out of peroxisomes drives matrix protein import.
1. Mol Cell - published August 4, 2022
2. Skowyra ML, Rapoport TA
The SOS response-associated peptidase (SRAP) domain of YedK catalyzes ring opening of abasic sites and reversal of its DNA-protein crosslink.
1. J Biol Chem - published August 4, 2022
2. Paulin KA, Cortez D, Eichman BF
Rotavirus VP4 Epitope of a Broadly Neutralizing Human Antibody Defined by Its Structure Bound with an Attenuated-Strain Virion.
1. J Virol - published August 4, 2022
2. Jenni S, Li Z, Wang Y, Bessey T, Salgado EN, Schmidt AG, Greenberg HB, Jiang B, Harrison SC
Characterization of N-terminal RYR2 variants outside CPVT1 hotspot regions using patient iPSCs reveal pathogenesis and therapeutic potential.
1. Stem Cell Reports - published August 3, 2022
2. Stutzman MJ, Kim CSJ, Tester DJ, Hamrick SK, Dotzler SM, Giudicessi JR, Miotto MC, Gc JB, Frank J, Marks AR, Ackerman MJ
Blockade of the Adenylate Cyclase Toxin Synergizes with Opsonizing Antibodies to Protect Mice against Bordetella pertussis.
1. mBio - published August 3, 2022
2. DiVenere AM, Amengor D, Silva RP, Goldsmith JA, McLellan JS, Maynard JA
¹⁵N-Detected TROSY NMR experiments to study large disordered proteins in high-field magnets.
1. Chem Commun (Camb) - published August 3, 2022
2. Dubey A, Viennet T, Chhabra S, Takeuchi K, Seo HC, Bermel W, Frueh DP, Arthanari H
Role of a "Magic" Methyl: 2'-Deoxy-2'-α-F-2'-β-C-methyl Pyrimidine Nucleotides Modulate RNA Interference Activity through Synergy with 5'-Phosphate Mimics and Mitigation of Off-Target Effects.
1. J Am Chem Soc - published August 3, 2022
2. Guenther DC, Mori S, Matsuda S, Gilbert JA, Willoughby JLS, Hyde S, Bisbe A, Jiang Y, Agarwal S, Madaoui M, Janas MM, Charisse K, Maier MA, Egli M, Manoharan M
A mitotic chromatin phase transition prevents perforation by microtubules.
1. Nature - published August 3, 2022
2. Schneider MWG, Gibson BA, Otsuka S, Spicer MFD, Petrovic M, Blaukopf C, Langer CCH, Batty P, Nagaraju T, Doolittle LK, Rosen MK, Gerlich DW
The transcription factor FoxP3 can fold into two dimerization states with divergent implications for regulatory T cell function and immune homeostasis.
1. Immunity - published August 3, 2022
2. Leng F, Zhang W, Ramirez RN, Leon J, Zhong Y, Hou L, Yuki K, van der Veeken J, Rudensky AY, Benoist C, Hur S
Teixobactin kills bacteria by a two-pronged attack on the cell envelope.
1. Nature - published August 3, 2022
2. Shukla R, Lavore F, Maity S, Derks MGN, Jones CR, Vermeulen BJA, Melcrová A, Morris MA, Becker LM, Wang X, Kumar R, Medeiros-Silva J, van Beekveld RAM, Bonvin AMJJ, Lorent JH, Lelli M, Nowick JS, MacGillavry HD, Peoples AJ, Spoering AL, Ling LL, Hughes DE, Roos WH, Breukink E, Lewis K, Weingarth M
A conserved sequence motif in the E. coli soluble FAD-containing pyridine nucleotide transhydrogenase is important for reaction efficiency.
1. J Biol Chem - published August 3, 2022
2. Partipilo M, Yang G, Mascotti ML, Wijma HJ, Slotboom DJ, Fraaije MW
Omicron mutations enhance infectivity and reduce antibody neutralization of SARS-CoV-2 virus-like particles.
1. Proc Natl Acad Sci U S A - published August 2, 2022
2. Syed AM, Ciling A, Taha TY, Chen IP, Khalid MM, Sreekumar B, Chen PY, Kumar GR, Suryawanshi R, Silva I, Milbes B, Kojima N, Hess V, Shacreaw M, Lopez L, Brobeck M, Turner F, Spraggon L, Tabata T, Ott M, Doudna JA
Golgi stress induces SIRT2 to counteract Shigella infection via defatty-acylation.
1. Nat Commun - published August 2, 2022
2. Wang M, Zhang Y, Komaniecki GP, Lu X, Cao J, Zhang M, Yu T, Hou D, Spiegelman NA, Yang M, Price IR, Lin H
Structural basis of mRNA maturation: Time to put it together.
1. Curr Opin Struct Biol - published August 2, 2022
2. Vorländer MK, Pacheco-Fiallos B, Plaschka C
Dynamics of integrin α5β1, fibronectin, and their complex reveal sites of interaction and conformational change.
1. J Biol Chem - published August 2, 2022
2. Su Y, Iacob RE, Li J, Engen JR, Springer TA
Antibody binding increases the flexibility of the prion protein.
1. Biochim Biophys Acta Proteins Proteom - published August 2, 2022
2. Ilie IM, Caflisch A
Shelterin is a dimeric complex with extensive structural heterogeneity.
1. Proc Natl Acad Sci U S A - published August 2, 2022
2. Zinder JC, Olinares PDB, Svetlov V, Bush MW, Nudler E, Chait BT, Walz T, de Lange T
A lipopolysaccharide-dependent phage infects a pseudomonad phytopathogen and can evolve to evade phage resistance.
1. Environ Microbiol - published August 1, 2022
2. Warring SL, Malone LM, Jayaraman J, Easingwood RA, Rigano LA, Frampton RA, Visnovsky SB, Addison SM, Hernandez L, Pitman AR, Lopez Acedo E, Kleffmann T, Templeton MD, Bostina M, Fineran PC
Discovery of a drug to treat airway mucus hypersecretion.
1. Clin Transl Med - published August 1, 2022
2. Dickey BF, Lai Y, Frick M, Brunger AT
Emerging roles of spliceosome in cancer and immunity.
1. Protein Cell - published August 1, 2022
2. Yang H, Beutler B, Zhang D
Highly protective antimalarial antibodies via precision library generation and yeast display screening.
1. J Exp Med - published August 1, 2022
2. Banach BB, Tripathi P, Da Silva Pereira L, Gorman J, Nguyen TD, Dillon M, Fahad AS, Kiyuka PK, Madan B, Wolfe JR, Bonilla B, Flynn B, Francica JR, Hurlburt NK, Kisalu NK, Liu T, Ou L, Rawi R, Schön A, Shen CH, Teng IT, Zhang B, Pancera M, Idris AH, Seder RA, Kwong PD, DeKosky BJ
Structural insights into the human PA28-20S proteasome enabled by efficient tagging and purification of endogenous proteins.
1. Proc Natl Acad Sci U S A - published August 1, 2022
2. Zhao J, Makhija S, Zhou C, Zhang H, Wang Y, Muralidharan M, Huang B, Cheng Y
Engineered IL13 variants direct specificity of IL13Rα2-targeted CAR T cell therapy.
1. Proc Natl Acad Sci U S A - published August 1, 2022
2. Stern LA, Gholamin S, Moraga I, Yang X, Saravanakumar S, Cohen JR, Starr R, Aguilar B, Salvary V, Hibbard JC, Kalbasi A, Shepphird JK, O'Hearn J, Garcia KC, Brown CE
Monoclonal antibodies binding data for SARS-CoV-2 proteins.
1. Data Brief - published August 1, 2022
2. Mishra N, Teyra J, Boytz R, Miersch S, Merritt TN, Cardarelli L, Gorelik M, Mihalic F, Jemth P, Davey RA, Sidhu SS, Leung DW, Amarasinghe GK
Oropouche orthobunyavirus infection is mediated by the cellular host factor Lrp1.
1. Proc Natl Acad Sci U S A - published August 1, 2022
2. Schwarz MM, Price DA, Ganaie SS, Feng A, Mishra N, Hoehl RM, Fatma F, Stubbs SH, Whelan SPJ, Cui X, Egawa T, Leung DW, Amarasinghe GK, Hartman AL
Interactions between mTORC2 core subunits Rictor and mSin1 dictate selective and context-dependent phosphorylation of substrate kinases SGK1 and Akt.
1. J Biol Chem - published August 1, 2022
2. Yu Z, Chen J, Takagi E, Wang F, Saha B, Liu X, Joubert LM, Gleason CE, Jin M, Li C, Nowotny C, Agard D, Cheng Y, Pearce D
Crystal structures of glutamyl-tRNA synthetase from Elizabethkingia anopheles and E. meningosepticum.
1. Acta Crystallogr F Struct Biol Commun - published August 1, 2022
2. Brooks L, Subramanian S, Dranow DM, Mayclin SJ, Myler PJ, Asojo OA
A Homozygous Missense Variant in KRT25 Underlying Overlapping Phenotype with Woolly Hair and Dental Anomalies.
1. J Invest Dermatol - published August 1, 2022
2. Raza R, Chhabra G, Bilal M, Ndiaye MA, Liaqat K, Nawaz S, Sgro JY, Rayment I, Ahmad W, Ahmad N
Molecular analysis and essentiality of Aro1 shikimate biosynthesis multi-enzyme in Candida albicans.
1. Life Sci Alliance - published August 1, 2022
2. Stogios PJ, Liston SD, Semper C, Quade B, Michalska K, Evdokimova E, Ram S, Otwinowski Z, Borek D, Cowen LE, Savchenko A
Room-temperature serial synchrotron crystallography of Drosophila cryptochrome.
1. Acta Crystallogr D Struct Biol - published August 1, 2022
2. Schneps CM, Ganguly A, Crane BR
The crystal structure of CbpD clarifies substrate-specificity motifs in chitin-active lytic polysaccharide monooxygenases.
1. Acta Crystallogr D Struct Biol - published August 1, 2022
2. Dade CM, Douzi B, Cambillau C, Ball G, Voulhoux R, Forest KT
The Innate Immune Protein Calprotectin Interacts With and Encases Biofilm Communities of Pseudomonas aeruginosa and Staphylococcus aureus.
1. Front Cell Infect Microbiol - published August 1, 2022
2. Baishya J, Everett JA, Chazin WJ, Rumbaugh KP, Wakeman CA