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99 Member Publications for May

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The large GTPase Sey1/atlastin mediates lipid droplet- and FadL-dependent intracellular fatty acid metabolism of Legionella pneumophila.
1. Elife - published May 9, 2023
2. Hüsler D, Stauffer P, Keller B, Böck D, Steiner T, Ostrzinski A, Vormittag S, Striednig B, Swart AL, Letourneur F, Maaß S, Becher D, Eisenreich W, Pilhofer M, Hilbi H
HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways.
1. Cell Rep - published May 9, 2023
2. Monda JK, Ge X, Hunkeler M, Donovan KA, Ma MW, Jin CY, Leonard M, Fischer ES, Bennett EJ
Application of a quantitative framework to improve the accuracy of a bacterial infection model.
1. Proc Natl Acad Sci U S A - published May 9, 2023
2. Lewin GR, Kapur A, Cornforth DM, Duncan RP, Diggle FL, Moustafa DA, Harrison SA, Skaar EP, Chazin WJ, Goldberg JB, Bomberger JM, Whiteley M
Intestinal bile acids provide a surmountable barrier against C. difficile TcdB-induced disease pathogenesis.
1. Proc Natl Acad Sci U S A - published May 9, 2023
2. Icho S, Ward JS, Tam J, Kociolek LK, Theriot CM, Melnyk RA
Glioma immunotherapy enhancement and CD8-specific sialic acid cleavage by isocitrate dehydrogenase (IDH)-1.
1. Oncogene - published May 9, 2023
2. Cordner R, Jhun M, Panwar A, Wang H, Gull N, Murali R, McAbee JH, Mardiros A, Sanchez-Takei A, Mazer MW, Fan X, Jouanneau E, Yu JS, Black KL, Wheeler CJ
Structural basis for activation of CB1 by an endocannabinoid analog.
1. Nat Commun - published May 9, 2023
2. Krishna Kumar K, Robertson MJ, Thadhani E, Wang H, Suomivuori CM, Powers AS, Ji L, Nikas SP, Dror RO, Inoue A, Makriyannis A, Skiniotis G, Kobilka B
PARP1 and HPF1 team up to flag down DNA-repair machinery.
1. Nat Struct Mol Biol - published May 9, 2023
2. Rudolph J, Luger K
Designed Ankyrin Repeat Proteins provide insights into the structure and function of CagI and are potent inhibitors of CagA translocation by the Helicobacter pylori type IV secretion system.
1. PLoS Pathog - published May 8, 2023
2. Blanc M, Lettl C, Guérin J, Vieille A, Furler S, Briand-Schumacher S, Dreier B, Bergé C, Plückthun A, Vadon-Le Goff S, Fronzes R, Rousselle P, Fischer W, Terradot L
Using quotients as a mentor to facilitate the success of underrepresented trainees.
1. Pathog Dis - published May 8, 2023
2. Neikirk K, Barongan T, Rolle T, Lopez EG, Marshall A, Beasley HK, Crabtree A, Spencer EC, Shuler H, Martinez D, Murray S, Vang C, Jenkins F, Damo S, Vue Z
Lipid flipping in the omega-3 fatty-acid transporter.
1. Nat Commun - published May 8, 2023
2. Nguyen C, Lei HT, Lai LTF, Gallenito MJ, Mu X, Matthies D, Gonen T
Learning to evolve structural ensembles of unfolded and disordered proteins using experimental solution data.
1. J Chem Phys - published May 7, 2023
2. Zhang O, Haghighatlari M, Li J, Liu ZH, Namini A, Teixeira JMC, Forman-Kay JD, Head-Gordon T
Molecular basis of SARS-CoV-2 Omicron variant evasion from shared neutralizing antibody response.
1. Structure - published May 6, 2023
2. Patel A, Kumar S, Lai L, Chakravarthy C, Valanparambil R, Reddy ES, Gottimukkala K, Bajpai P, Raju DR, Edara VV, Davis-Gardner ME, Linderman S, Dixit K, Sharma P, Mantus G, Cheedarla N, Verkerke HP, Frank F, Neish AS, Roback JD, Davis CW, Wrammert J, Ahmed R, Suthar MS, Sharma A, Murali-Krishna K, Chandele A, Ortlund EA
Development of Novel Small-Molecule Activators of Pyruvate Kinase Muscle Isozyme 2, PKM2, to Reduce Photoreceptor Apoptosis.
1. Pharmaceuticals (Basel) - published May 6, 2023
2. Wubben TJ, Chaudhury S, Watch BT, Stuckey JA, Weh E, Fernando R, Goswami M, Pawar M, Rech JC, Besirli CG
Unusual substructure conformations observed in crystal structures of a dicistrovirus RNA-dependent RNA polymerase suggest contribution of the N-terminal extension in proper folding.
1. Virol Sin - published May 6, 2023
2. Fang X, Lu G, Deng Y, Yang S, Hou C, Gong P
Circulating tumor DNA reveals mechanisms of lorlatinib resistance in patients with relapsed/refractory ALK-driven neuroblastoma.
1. Nat Commun - published May 5, 2023
2. Berko ER, Witek GM, Matkar S, Petrova ZO, Wu MA, Smith CM, Daniels A, Kalna J, Kennedy A, Gostuski I, Casey C, Krytska K, Gerelus M, Pavlick D, Ghazarian S, Park JR, Marachelian A, Maris JM, Goldsmith KC, Radhakrishnan R, Lemmon MA, Mossé YP
Dieter Wolf (1941-2023): a life dedicated to understanding protein quality control and the ubiquitin-proteasome system.
1. EMBO J - published May 5, 2023
2. Varshavsky A, Finley D, Goldberg AL, Rapoport TA, Pfirrmann T
Molecular basis of translation termination at noncanonical stop codons in human mitochondria.
1. Science - published May 5, 2023
2. Saurer M, Leibundgut M, Nadimpalli HP, Scaiola A, Schönhut T, Lee RG, Siira SJ, Rackham O, Dreos R, Lenarčič T, Kummer E, Gatfield D, Filipovska A, Ban N
Rational optimization of siRNA to ensure strand bias in the interaction with the RNA-induced silencing complex.
1. Chem Commun (Camb) - published May 5, 2023
2. Datta D, Theile CS, Wassarman K, Qin J, Racie T, Schmidt K, Jiang Y, Sigel R, Janas MM, Egli M, Manoharan M
Acyl-CoA thioesterase 12 suppresses YAP-mediated hepatocarcinogenesis by limiting glycerolipid biosynthesis.
1. Cancer Lett - published May 5, 2023
2. He H, Sugiyama A, Snyder NW, Teneche MG, Liu X, Maner-Smith KM, Goessling W, Hagen SJ, Ortlund EA, Najafi-Shoushtari SH, Acuña M, Cohen DE
HIV-2 Immature Particle Morphology Provides Insights into Gag Lattice Stability and Virus Maturation.
1. J Mol Biol - published May 5, 2023
2. Talledge N, Yang H, Shi K, Coray R, Yu G, Arndt WG, Meng S, Baxter GC, Mendonça LM, Castaño-Díez D, Aihara H, Mansky LM, Zhang W
Structure-based mechanisms of 2'3'-cGAMP intercellular transport in the cGAS-STING immune pathway.
1. Trends Immunol - published May 4, 2023
2. Xie W, Patel DJ
Interrupting Endocrine Therapy to Attempt Pregnancy after Breast Cancer.
1. N Engl J Med - published May 4, 2023
2. Partridge AH, Niman SM, Ruggeri M, Peccatori FA, Azim HA Jr, Colleoni M, Saura C, Shimizu C, Sætersdal AB, Kroep JR, Mailliez A, Warner E, Borges VF, Amant F, Gombos A, Kataoka A, Rousset-Jablonski C, Borstnar S, Takei J, Lee JE, Walshe JM, Ruíz-Borrego M, Moore HCF, Saunders C, Bjelic-Radisic V, Susnjar S, Cardoso F, Smith KL, Ferreiro T, Ribi K, Ruddy K, Kammler R, El-Abed S, Viale G, Piccart M, Korde LA, Goldhirsch A, Gelber RD, Pagani O, International Breast Cancer Study Group, POSITIVE Trial Collaborators
Viral persistence, reactivation, and mechanisms of long COVID.
1. Elife - published May 4, 2023
2. Chen B, Julg B, Mohandas S, Bradfute SB, RECOVER Mechanistic Pathways Task Force
A Comprehensive Approach to Sample Preparation for Electron Microscopy and the Assessment of Mitochondrial Morphology in Tissue and Cultured Cells.
1. Adv Biol (Weinh) - published May 4, 2023
2. Hinton A Jr, Katti P, Christensen TA, Mungai M, Shao J, Zhang L, Trushin S, Alghanem A, Jaspersen A, Geroux RE, Neikirk K, Biete M, Lopez EG, Shao B, Vue Z, Vang L, Beasley HK, Marshall AG, Stephens D, Damo S, Ponce J, Bleck CKE, Hicsasmaz I, Murray SA, Edmonds RAC, Dajles A, Koo YD, Bacevac S, Salisbury JL, Pereira RO, Glancy B, Trushina E, Abel ED
Echinomycin as a promising therapeutic agent against KSHV-related malignancies.
1. J Hematol Oncol - published May 4, 2023
2. Chen J, Lin Z, Song J, Plaisance-Bonstaff K, James J, Mu S, Post SR, Dai L, Qin Z
Author Correction: CFTR function, pathology and pharmacology at single-molecule resolution.
1. Nature - published May 4, 2023
2. Levring J, Terry DS, Kilic Z, Fitzgerald G, Blanchard SC, Chen J
Swertia L.: A comprehensive review of its genetic relationship, chemical compositions, pharmacological effects, toxicities, and applications.
1. Phytother Res - published May 4, 2023
2. Guo S, Du Q, Xing N, Qin J, Liu X, Li R, Wang S, Zhang Y
Ligand and G-protein selectivity in the κ-opioid receptor.
1. Nature - published May 3, 2023
2. Han J, Zhang J, Nazarova AL, Bernhard SM, Krumm BE, Zhao L, Lam JH, Rangari VA, Majumdar S, Nichols DE, Katritch V, Yuan P, Fay JF, Che T
Bacterial NLR-related proteins protect against phage.
1. Cell - published May 3, 2023
2. Kibby EM, Conte AN, Burroughs AM, Nagy TA, Vargas JA, Whalen LA, Aravind L, Whiteley AT
Structural insights into HIV-1 polyanion-dependent capsid lattice formation revealed by single particle cryo-EM.
1. Proc Natl Acad Sci U S A - published May 2, 2023
2. Highland CM, Tan A, Ricaña CL, Briggs JAG, Dick RA
Structural basis for the self-recognition of sDSCAM in Chelicerata.
1. Nat Commun - published May 2, 2023
2. Cheng J, Yu Y, Wang X, Zheng X, Liu T, Hu D, Jin Y, Lai Y, Fu TM, Chen Q
Mechanism of the Multistep Catalytic Cycle of 6-Hydroxynicotinate 3-Monooxygenase Revealed by Global Kinetic Analysis.
1. Biochemistry - published May 2, 2023
2. Perkins SW, Hlaing MZ, Hicks KA, Rajakovich LJ, Snider MJ
Comparative Biochemical Studies of Disease-Associated Human Dicer Mutations on Processing of a Pre-microRNA and snoRNA.
1. Biochemistry - published May 2, 2023
2. Torrez RM, Nagaraja S, Menon A, Chang L, Ohi MD, Garner AL
Hidradenitis suppurativa patient-reported influences on COVID-19 vaccine acceptance and hesitancy.
1. Br J Dermatol - published May 2, 2023
2. Williams JC, Alhusayen R, Guilbault S, Ingram JR, Lowes MA, Yannuzzi CA, Naik HB
Mutations in α-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases.
1. Mol Neurodegener - published May 2, 2023
2. Sampognaro PJ, Arya S, Knudsen GM, Gunderson EL, Sandoval-Perez A, Hodul M, Bowles K, Craik CS, Jacobson MP, Kao AW
(1)H, (13)C, (15)N backbone chemical shift assignments of the extended ARID domain in human AT-rich interactive domain protein 5a (Arid5a).
1. Biomol NMR Assign - published May 2, 2023
2. von Ehr J, Korn SM, Weiß L, Schlundt A
The membrane electric field regulates the PIP(2)-binding site to gate the KCNQ1 channel.
1. Proc Natl Acad Sci U S A - published May 2, 2023
2. Mandala VS, MacKinnon R
Cilia-associated wound repair mediated by IFT88 in retinal pigment epithelium.
1. Sci Rep - published May 2, 2023
2. Ning K, Bhuckory MB, Lo CH, Sendayen BE, Kowal TJ, Chen M, Bansal R, Chang KC, Vollrath D, Berbari NF, Mahajan VB, Hu Y, Sun Y
Allnighter pseudokinase-mediated feedback links proteostasis and sleep in Drosophila.
1. Nat Commun - published May 2, 2023
2. Shekhar S, Moehlman AT, Park B, Ewnetu M, Tracy C, Titos I, Pawłowski K, Tagliabracci VS, Krämer H
Suppression of the human malic enzyme 2 modifies energy metabolism and inhibits cellular respiration.
1. Commun Biol - published May 2, 2023
2. Hsieh JY, Chen KC, Wang CH, Liu GY, Ye JA, Chou YT, Lin YC, Lyu CJ, Chang RY, Liu YL, Li YH, Lee MR, Ho MC, Hung HC
Generation and Repair of Postreplication Gaps in Escherichia coli.
1. Microbiol Mol Biol Rev - published May 2, 2023
2. Cox MM, Goodman MF, Keck JL, van Oijen A, Lovett ST, Robinson A
Biochemical and structural insight into the chemical resistance and cofactor specificity of the formate dehydrogenase from Starkeya novella.
1. FEBS J - published May 2, 2023
2. Partipilo M, Whittaker JJ, Pontillo N, Coenradij J, Herrmann A, Guskov A, Slotboom DJ
Activity-based directed evolution of a membrane editor in mammalian cells.
1. Nat Chem - published May 2, 2023
2. Tei R, Bagde SR, Fromme JC, Baskin JM
The adhesion GPCRs CELSR1-3 and LPHN3 engage G proteins via distinct activation mechanisms.
1. Cell Rep - published May 2, 2023
2. Bui DLH, Roach A, Li J, Bandekar SJ, Orput E, Raghavan R, Araç D, Sando RC
A multi-specific, multi-affinity antibody platform neutralizes sarbecoviruses and confers protection against SARS-CoV-2 in vivo.
1. Sci Transl Med - published May 2, 2023
2. Burn Aschner C, Muthuraman K, Kucharska I, Cui H, Prieto K, Nair MS, Wang M, Huang Y, Christie-Holmes N, Poon B, Lam J, Sultana A, Kozak R, Mubareka S, Rubinstein JL, Rujas E, Treanor B, Ho DD, Jetha A, Julien JP
Pyruvate Kinase M (PKM) binds ribosomes in a poly-ADP ribosylation dependent manner to induce translational stalling.
1. Nucleic Acids Res - published May 2, 2023
2. Kejiou NS, Ilan L, Aigner S, Luo E, Tonn T, Ozadam H, Lee M, Cole GB, Rabano I, Rajakulendran N, Yee BA, Najafabadi HS, Moraes TF, Angers S, Yeo GW, Cenik C, Palazzo AF
Unraveling attributes of COVID-19 vaccine acceptance and uptake in the U.S.: a large nationwide study.
1. Sci Rep - published May 2, 2023
2. McCabe SD, Hammershaimb EA, Cheng D, Shi A, Shyr D, Shen S, Cole LD, Cataldi JR, Allen W, Probasco R, Silbermann B, Zhang F, Marsh R, Travassos MA, Lin X
Ubiquitin receptor PSMD4/Rpn10 is a novel therapeutic target in multiple myeloma.
1. Blood - published May 2, 2023
2. Du T, Song Y, Ray A, Wan X, Yao Y, Samur MK, Shen C, Penailillo J, Sewastianik T, Tai YT, Fulciniti M, Munshi NC, Wu H, Carrasco RD, Chauhan D, Anderson KC
A general and efficient approach to synthesize the phosphoramidites of 5'-(18)O labeled purine nucleosides.
1. Nucleosides Nucleotides Nucleic Acids - published May 2, 2023
2. Li NS, Dai Q, Weissman B, Harris ME, Piccirilli JA
Deoxyguanosine-Linked Bifunctional Inhibitor of SAMHD1 dNTPase Activity and Nucleic Acid Binding.
1. ACS Chem Biol - published May 2, 2023
2. Egleston M, Dong L, Howlader AH, Bhat S, Orris B, Bianchet MA, Greenberg MM, Stivers JT
(1)H, (13)C and (15)N backbone and sidechain assignment of the Burkholderia mallei acyl carrier protein.
1. Biomol NMR Assign - published May 2, 2023
2. Matosin S, Fischer PD, Droemer MA, Baggs E, Chowdhury AS, Tavares I, Ficarro SB, Warner LR, Arthanari H, Nagarajan R
Membrane protein isolation and structure determination in cell-derived membrane vesicles.
1. Proc Natl Acad Sci U S A - published May 2, 2023
2. Tao X, Zhao C, MacKinnon R
Interaction with single-stranded DNA-binding protein (SSB) modulates Escherichia coli RadD DNA repair activities.
1. J Biol Chem - published May 2, 2023
2. Osorio Garcia MA, Wood EA, Keck JL, Cox MM
In diverse conditions, intrinsic chromatin condensates have liquid-like material properties.
1. Proc Natl Acad Sci U S A - published May 2, 2023
2. Gibson BA, Blaukopf C, Lou T, Chen L, Doolittle LK, Finkelstein I, Narlikar GJ, Gerlich DW, Rosen MK
Structural Basis of DNA Binding by the WhiB-Like Transcription Factor WhiB3 in Mycobacterium tuberculosis.
1. J Biol Chem - published May 2, 2023
2. Wan T, Horová M, Khetrapal V, Li S, Jones C, Schacht A, Sun X, Zhang L
Stacked binding of a PET ligand to Alzheimer's tau paired helical filaments.
1. Nat Commun - published May 2, 2023
2. Merz GE, Chalkley MJ, Tan SK, Tse E, Lee J, Prusiner SB, Paras NA, DeGrado WF, Southworth DR
EMC chaperone-Ca(V) structure reveals an ion channel assembly intermediate.
1. Nature - published May 1, 2023
2. Chen Z, Mondal A, Ali FA, Jang S, Niranjan S, Montaño JL, Zaro BW, Minor DL Jr
DARPins bind their cytosolic targets after having been translocated through the protective antigen pore of anthrax toxin.
1. Sci Rep - published May 1, 2023
2. Becker L, Plückthun A
Forward genetic screening using fundus spot scale identifies an essential role for Lipe in murine retinal homeostasis.
1. Commun Biol - published May 1, 2023
2. Yuksel S, Aredo B, Zegeye Y, Zhao CX, Tang M, Li X, Hulleman JD, Gautron L, Ludwig S, Moresco EMY, Butovich IA, Beutler BA, Ufret-Vincenty RL
A chikungunya virus-like particle vaccine induces broadly neutralizing and protective antibodies against alphaviruses in humans.
1. Sci Transl Med - published May 1, 2023
2. Raju S, Adams LJ, Earnest JT, Warfield K, Vang L, Crowe JE Jr, Fremont DH, Diamond MS
Publisher Correction: The NK cell receptor NKp46 recognizes ecto-calreticulin on ER-stressed cells.
1. Nature - published May 1, 2023
2. Sen Santara S, Lee DJ, Crespo Â, Hu JJ, Walker C, Ma X, Zhang Y, Chowdhury S, Meza-Sosa KF, Lewandrowski M, Zhang H, Rowe M, McClelland A, Wu H, Junqueira C, Lieberman J
Enhanced stability of the SARS CoV-2 spike glycoprotein following modification of an alanine cavity in the protein core.
1. PLoS Pathog - published May 1, 2023
2. Poumbourios P, Langer C, Boo I, Zakir T, Center RJ, Akerman A, Milogiannakis V, Aggarwal A, Johnstone BA, Ha J, Coulibaly F, Turville SG, Drummer HE
Mechanism of glycoform specificity and in vivo protection by an anti-afucosylated IgG nanobody.
1. Nat Commun - published May 1, 2023
2. Gupta A, Kao KS, Yamin R, Oren DA, Goldgur Y, Du J, Lollar P, Sundberg EJ, Ravetch JV
Biochemical and HDX Mass Spectral Characterization of the SARS-CoV-2 Nsp1 Protein.
1. Biochemistry - published May 1, 2023
2. Mishra N, Kant R, Leung DW, Gross ML, Amarasinghe GK
An acetylation-mediated chromatin switch governs H3K4 methylation read-write capability.
1. Elife - published May 1, 2023
2. Jain K, Marunde MR, Burg JM, Gloor SL, Joseph FM, Poncha KF, Gillespie ZB, Rodriguez KL, Popova IK, Hall NW, Vaidya A, Howard SA, Taylor HF, Mukhsinova L, Onuoha UC, Patteson EF, Cooke SW, Taylor BC, Weinzapfel EN, Cheek MA, Meiners MJ, Fox GC, Namitz KEW, Cowles MW, Krajewski K, Sun ZW, Cosgrove MS, Young N, Keogh MC, Strahl BD
Integrated network pharmacology, transcriptomics and metabolomics analysis to reveal the mechanism of salt Eucommia cortex in the treatment of chronic kidney disease mineral bone disorders via the PPARG/AMPK signaling pathway.
1. J Ethnopharmacol - published May 1, 2023
2. Shen J, Liu YP, Wang Q, Chen H, Hu Y, Guo X, Liu X, Li Y
Systemic Lupus Erythematosus Women with Lupus Nephritis in Pregnancy Therapeutic Challenge (SWITCH): The Systemic Lupus International Collaborating Clinics experience.
1. Ann Rheum Dis - published May 1, 2023
2. Lee JE, Mendel A, Askanase A, Bae SC, Buyon JP, Clarke AE, Costedoat-Chalumeau N, Fortin PR, Gladman DD, Ramsey-Goldman R, Hanly JG, Inanç M, Isenberg DA, Mak A, Mosca M, Petri M, Rahman A, Sanchez-Guerrero J, Urowitz M, Wallace DJ, Bernatsky S, Vinet É
Processive kinetics in the three-step lanosterol 14α-demethylation reaction catalyzed by human cytochrome P450 51A1.
1. J Biol Chem - published May 1, 2023
2. McCarty KD, Sullivan ME, Tateishi Y, Hargrove TY, Lepesheva GI, Guengerich FP
A single inactivating amino acid change in the SARS-CoV-2 NSP3 Mac1 domain attenuates viral replication and pathogenesis in vivo.
1. bioRxiv - published May 1, 2023
2. Taha TY, Suryawanshi RK, Chen IP, Correy GJ, O'Leary PC, Jogalekar MP, McCavitt-Malvido M, Diolaiti ME, Kimmerly GR, Tsou CL, Martinez-Sobrido L, Krogan NJ, Ashworth A, Fraser JS, Ott M
Blockade of TRPV channels by intracellular spermine.
1. J Gen Physiol - published May 1, 2023
2. Maksaev G, Yuan P, Nichols CG
HIV-1 protease inhibitors with a P1 phosphonate modification maintain potency against drug-resistant variants by increased interactions with flap residues.
1. Eur J Med Chem - published May 1, 2023
2. Lockbaum GJ, Rusere LN, Henes M, Kosovrasti K, Rao DN, Spielvogel E, Lee SK, Nalivaika EA, Swanstrom R, Yilmaz NK, Schiffer CA, Ali A
An ancient defense mechanism: Conservation of gasdermin-mediated pyroptosis.
1. PLoS Biol - published May 1, 2023
2. Wang C, Ruan J
Global age-structured spatial modeling for emerging infectious diseases like COVID-19.
1. PNAS Nexus - published May 1, 2023
2. Xiao Y, Zhou J, Cheng Q, Yang J, Chen B, Zhang T, Xu L, Xu B, Ren Z, Liu Z, Shen C, Wang C, Liu H, Li X, Li R, Yu L, Guan D, Zhang W, Wang J, Hou L, Deng K, Bai Y, Xu B, Dou D, Gong P
A Fluorescence Polarization Assay for Macrodomains Facilitates the Identification of Potent Inhibitors of the SARS-CoV-2 Macrodomain.
1. ACS Chem Biol - published May 1, 2023
2. Anmangandla A, Jana S, Peng K, Wallace SD, Bagde SR, Drown BS, Xu J, Hergenrother PJ, Fromme JC, Lin H
Croquemort elicits activation of the immune deficiency pathway in ticks.
1. Proc Natl Acad Sci U S A - published May 1, 2023
2. O'Neal AJ, Singh N, Rolandelli A, Laukaitis HJ, Wang X, Shaw DK, Young BD, Narasimhan S, Dutta S, Snyder GA, Samaddar S, Marnin L, Butler LR, Mendes MT, Cabrera Paz FE, Valencia LM, Sundberg EJ, Fikrig E, Pal U, Weber DJ, Pedra JHF
Targeting thiol isomerase activity with zafirlukast to treat ovarian cancer from the bench to clinic.
1. FASEB J - published May 1, 2023
2. Gelzinis JA, Szahaj MK, Bekendam RH, Wurl SE, Pantos MM, Verbetsky CA, Dufresne A, Shea M, Howard KC, Tsodikov OV, Garneau-Tsodikova S, Zwicker JI, Kennedy DR
Structure of WNT inhibitor adenomatosis polyposis coli down-regulated 1 (APCDD1), a cell-surface lipid-binding protein.
1. Proc Natl Acad Sci U S A - published May 1, 2023
2. Hsieh FL, Chang TH, Gabelli SB, Nathans J
The human E3 ligase RNF185 is a regulator of the SARS-CoV-2 envelope protein.
1. iScience - published May 1, 2023
2. Zou C, Yoon H, Park PMC, Patten JJ, Pellman J, Carreiro J, Tsai JM, Li YD, Roy Burman SS, Donovan KA, Gasser J, Sperling AS, Nowak RP, Fischer ES, Davey RA, Ebert BL, Słabicki M
7SK methylation by METTL3 promotes transcriptional activity.
1. Sci Adv - published May 1, 2023
2. Perez-Pepe M, Desotell AW, Li H, Li W, Han B, Lin Q, Klein DE, Liu Y, Goodarzi H, Alarcón CR
Spin-gapless van der Waals heterostructure for spin gating through magnetic injection devices.
1. Phys Chem Chem Phys - published May 1, 2023
2. Zhang X, Gong P, Liu F, Zhu S
Complete non-proline backbone resonance assignments of the S. aureus neutrophil serine protease inhibitor, EapH1.
1. Biomol NMR Assign - published May 1, 2023
2. Mishra N, Pal I, Herrera AI, Dubey A, Arthanari H, Geisbrecht BV, Prakash O
Dodecamer assembly of a metazoan AAA(+) chaperone couples substrate extraction to refolding.
1. Sci Adv - published May 1, 2023
2. Gupta A, Lentzsch AM, Siegel A, Yu Z, Chio US, Cheng Y, Shan SO
Selective SARS-CoV2 BA.2 escape of antibody Fc/Fc-receptor interactions.
1. iScience - published May 1, 2023
2. Bartsch YC, Cizmeci D, Kang J, Gao H, Shi W, Chandrashekar A, Collier AY, Chen B, Barouch DH, Alter G
Replication fork binding triggers structural changes in the PriA helicase that govern DNA replication restart in E. coli.
1. Nat Commun - published May 1, 2023
2. Duckworth AT, Ducos PL, McMillan SD, Satyshur KA, Blumenthal KH, Deorio HR, Larson JA, Sandler SJ, Grant T, Keck JL
Thermally controlled intein splicing of engineered DNA polymerases provides a robust and generalizable solution for accurate and sensitive molecular diagnostics.
1. Nucleic Acids Res - published May 1, 2023
2. Wang Y, Shi Y, Hellinga HW, Beese LS
About hysteresis in Shaker: Response to note by Villalba-Galea.
1. J Gen Physiol - published May 1, 2023
2. Chanda B, Cowgill J
The structure of fly Teneurin-m reveals an asymmetric self-assembly that allows expansion into zippers.
1. EMBO Rep - published May 1, 2023
2. Li J, Bandekar SJ, Araç D
Publisher Correction: Structure of anhydrotetracycline-bound Tet(X6) reveals the mechanism for inhibition of type 1 tetracycline destructases.
1. Commun Biol - published May 1, 2023
2. Kumar H, Williford EE, Blake KS, Virgin-Downey B, Dantas G, Wencewicz TA, Tolia NH
APOE expression and secretion are modulated by mitochondrial dysfunction.
1. Elife - published May 1, 2023
2. Wynne ME, Ogunbona O, Lane AR, Gokhale A, Zlatic SA, Xu C, Wen Z, Duong DM, Rayaprolu S, Ivanova A, Ortlund EA, Dammer EB, Seyfried NT, Roberts BR, Crocker A, Shanbhag V, Petris M, Senoo N, Kandasamy S, Claypool SM, Barrientos A, Wingo A, Wingo TS, Rangaraju S, Levey AI, Werner E, Faundez V
Gβγ activates PIP2 hydrolysis by recruiting and orienting PLCβ on the membrane surface.
1. Proc Natl Acad Sci U S A - published May 1, 2023
2. Falzone ME, MacKinnon R
Structure of a eukaryotic cholinephosphotransferase-1 reveals mechanisms of substrate recognition and catalysis.
1. Nat Commun - published May 1, 2023
2. Wang L, Zhou M
Ligand dependent interaction between PC-TP and PPARδ mitigates diet-induced hepatic steatosis in male mice.
1. Nat Commun - published May 1, 2023
2. Druzak SA, Tardelli M, Mays SG, El Bejjani M, Mo X, Maner-Smith KM, Bowen T, Cato ML, Tillman MC, Sugiyama A, Xie Y, Fu H, Cohen DE, Ortlund EA
TET2, tumor control, and CAR T cell hyperproliferation.
1. Trends Cancer - published May 1, 2023
2. Dash B, Hogan PG
Dynamic conformational switching underlies TFIIH function in transcription and DNA repair and impacts genetic diseases.
1. Nat Commun - published May 1, 2023
2. Yu J, Yan C, Dodd T, Tsai CL, Tainer JA, Tsutakawa SE, Ivanov I
Stimulation of antitumor immunity by FoxP3-targeting PROTAC.
1. Biomed Pharmacother - published May 1, 2023
2. Wang Y, Zhang Y, Su S, Tamukong P, Murali R, Kim HL
Structural basis for breadth development in the HIV-1 V3-glycan targeting DH270 antibody clonal lineage.
1. Nat Commun - published May 1, 2023
2. Henderson R, Zhou Y, Stalls V, Wiehe K, Saunders KO, Wagh K, Anasti K, Barr M, Parks R, Alam SM, Korber B, Haynes BF, Bartesaghi A, Acharya P
Discovery and Characterization of Antibody Probes of Module 2 of the 6-Deoxyerythronolide B Synthase.
1. Biochemistry - published May 1, 2023
2. Guzman KM, Cogan DP, Brodsky KL, Soohoo AM, Li X, Sevillano N, Mathews II, Nguyen KP, Craik CS, Khosla C
Pan-sarbecovirus prophylaxis with human anti-ACE2 monoclonal antibodies.
1. Nat Microbiol - published May 1, 2023
2. Zhang F, Jenkins J, de Carvalho RVH, Nakandakari-Higa S, Chen T, Abernathy ME, Baharani VA, Nyakatura EK, Andrew D, Lebedeva IV, Lorenz IC, Hoffmann HH, Rice CM, Victora GD, Barnes CO, Hatziioannou T, Bieniasz PD
Leveraging a Structural Blueprint to Rationally Engineer the Rieske Oxygenase TsaM.
1. Biochemistry - published May 1, 2023
2. Tian J, Garcia AA, Donnan PH, Bridwell-Rabb J