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62 Member Publications for December

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Atomic models of the Toxoplasma cell invasion machinery.
1. Nat Struct Mol Biol - published December 9, 2025
2. Zeng J, Fu Y, Qian P, Huang W, Niu Q, Beatty WL, Brown A, Sibley LD, Zhang R
Puromycin-sensitive aminopeptidase acts as an inhibitory auxiliary subunit of volume-regulated anion channels and regulates cGAMP transport.
1. Mol Cell - published December 9, 2025
2. Zheng W, Hagino T, Wang H, Cheng HY, Koylass N, Chen KH, Wang H, Mani S, Mondal AK, Twomey EC, Qiu Z
Emerging structural insights into PRC2 function in development and disease.
1. Trends Biochem Sci - published December 9, 2025
2. Bhat MY, Liu X
Serendipity and the slime mold: a visual survey of high molecular-weight protein assemblies reveals the structure of the polyketide synthase Pks16.
1. Mol Cell Proteomics - published December 9, 2025
2. Hoogerbrugge G, Keatinge-Clay AT, Marcotte EM
Design, Synthesis, and Evaluation of Novel Inhibitors of Aminoglycoside-Resistance 16S Ribosomal RNA Methyltransferases.
1. ChemMedChem - published December 8, 2025
2. Deprez BE, Dey D, Zelinskaya N, Csatary EE, Yang QW, Nie M, Conn GL, Wuest WM
Multiplexed Analysis of Multicomponent Biomolecular Condensates without Any Tag.
1. J Am Chem Soc - published December 8, 2025
2. Pálfy G, Schmoll J, Pérez ME, Damberger FF, Han Y, Emmanouilidis L, Allain FH, Novakovic M
Unraveling the Potential of Small Molecule Heparin Glycomimetics in Neuroregenerative Therapeutics.
1. J Am Chem Soc - published December 8, 2025
2. Özkan M, Cellot G, Pawar S, Sardana D, Barravecchia I, Ballerini L, Angeloni D, Micera S, Stellacci F
A modular platform to display multiple hemagglutinin subtypes on a single immunogen.
1. Elife - published December 8, 2025
2. Thornlow Lamson D, Nait Mohamed FA, Vu M, Maurer DP, Ronsard L, Lingwood D, Schmidt AG
CD44 cross-linking promotes Plasmodium falciparum invasion.
1. Nat Commun - published December 7, 2025
2. Kongsomboonvech AK, Scally SW, Le Guen Y, Valissery P, Salinas ND, Cowman AF, Tolia NH, Egan ES
Metabolic engineering and late-stage functionalization expand the chemical space of the antimalarial premarineosin A.
1. Commun Chem - published December 5, 2025
2. McBride CM, McCauley M, Harris NR, Amin S, Curtis BJ, Verhey-Henke L, Teklemichael AA, Oliphant EN, Dranchak P, Lev KL, Qu F, Snodgrass HM, Lewis JC, Inglese J, Su XZ, Pereira F, Sherman DH
Exploitation of phage Carin-5's own DNA polymerase to sequence its T-hypermodified genome.
1. Sci Rep - published December 5, 2025
2. Sieskind R, Missoury S, Bonhomme F, Nogaret P, Lucas-Staat S, Monot M, Skurnik M, Baudoux AC, Delarue M
Non-Catalytic Inhibitors of the p38/MK2 Interface: Repurposing Approved Drugs to Target Neuroinflammation in Alzheimer's Disease.
1. J Med Chem - published December 5, 2025
2. Hu M, Li A, Fleming P, Gralla J, Negrón Terón K, Zhou Y, Miller EJ, Beyett TS, Wen Z, Du Y, Fu H, Ivanov AA
Postoperative delirium in patients with free flap reconstruction after head and neck tumor surgery: influencing factors for severity and onset time, and a prediction model.
1. BMC Oral Health - published December 4, 2025
2. Liu ZX, Yu ZL, Chen GL, Gong P
Discovery of a small molecule TLR3 agonist adjuvant.
1. Nat Commun - published December 4, 2025
2. Lee B, Dong D, Nanishi E, Awad JM, Abedi KZ, Saito Y, Borriello F, Barman S, Brook B, Kelly A, Menon M, Marques-Mourlet C, Gupta MV, Lister I, Oh C, Lyskawa K, Goetz M, Walker K, Cheng WK, Brightman SE, Sharma P, O'Meara TR, Chew K, Vieira D, Ryff K, Sweitzer C, Thomas S, van Haren SD, Pettengill M, Seo HS, Dhe-Paganon S, Zhang W, Levy O, Dowling DJ
The specificity and structure of DNA cross-linking by the gut bacterial genotoxin colibactin.
1. Science - published December 4, 2025
2. Carlson ES, Haslecker R, Lecchi C, Aguilar Ramos MA, Vennelakanti V, Honaker L, Stornetta A, Millán ES, Johnson BA, Kulik HJ, Balbo S, Villalta PW, D'Souza VM, Balskus EP
A bypass gateway from cholesterol to sex steroid biosynthesis circumnavigates CYP17A1.
1. Nat Commun - published December 4, 2025
2. Zhu Z, Chung YM, Alyamani M, Dai Y, McCarty KD, Roberts E, Sinha S, Li J, Li X, Gad EM, Zhou Z, Shi J, Burgess RA, Hargrove TY, Lepesheva GI, Guengerich FP, Auchus RJ, Sharifi N
A fin-loop-like structure in GPX4 underlies neuroprotection from ferroptosis.
1. Cell - published December 4, 2025
2. Lorenz SM, Wahida A, Bostock MJ, Seibt T, Santos Dias Mourão A, Levkina A, Trümbach D, Soudy M, Emler D, Rothammer N, Woo MS, Sonner JK, Novikova M, Henkelmann B, Aldrovandi M, Kaemena DF, Mishima E, Vermonden P, Zong Z, Cheng D, Nakamura T, Ito J, Doll S, Proneth B, Bürkle E, Rizzollo F, Escamilla Ayala A, Napolitano V, Kolonko-Adamska M, Gaussmann S, Merl-Pham J, Hauck S, Pertek A, Orschmann T, van San E, Vanden Berghe T, Hass D, Maida A, Frenz JM, Pedrera L, Dolga A, Kraiger M, Hrabé de Angelis M, Fuchs H, Ebert G, Lenberg J, Friedman J, Scale C, Agostinis P, Zimprich A, Vogt-Weisenhorn D, Garrett L, Hölter SM, Wurst W, Glaab E, Lewerenz J, Popper B, Sieben C, Steinacker P, Zischka H, Garcia-Saez AJ, Tietze A, Ramesh SK, Ayton S, Vincendeau M, Friese MA, Wigby K, Sattler M, Mann M, Ingold I, Jayavelu AK, Popowicz GM, Conrad M
Rethinking what pLDDT really tells us about protein flexibility.
1. Structure - published December 4, 2025
2. Riccabona JR, Loeffler JR, Schoeder CT, Meiler J, Ward AB, Fernandez-Quintero M
Post-vaccination SARS-CoV-2 neutralizing antibodies in pregnant women receiving biologics for inflammatory bowel disease.
1. PLoS One - published December 3, 2025
2. Leet DE, Jin J, Craik CS, Kattah MG, Long MD, Mahadevan U
Fission yeast Tpt1 is composed of tandem RNA 2'-phosphotransferase and Yae1 domains, both of which are essential for viability.
1. RNA - published December 3, 2025
2. Sarkar A, Schwer B, Shuman S
Differential Effects of Sodium on Agonist-Induced Conformational Transitions and Signaling at μ and κ Opioid Receptors.
1. Biochemistry - published December 3, 2025
2. Kuijer MB, Fulton CJ, Albert TL, Knobloch P, Wang J, Krumm BE, Che T, Varga BR, Majumdar S, Katritch V, Gumpper RH, Kenakin T, Huang XP, Roth BL
A system for high-throughput axonal imaging of induced pluripotent stem cell-derived human i(3)Neurons.
1. Mol Biol Cell - published December 3, 2025
2. Whittaker SAC, McKenna ED, Sarbanes SL, Fernandopulle MS, Ward ME, Roll-Mecak A
Translational activators align mRNAs at the small mitoribosomal subunit for translation initiation.
1. Nat Struct Mol Biol - published December 3, 2025
2. Bridgers JB, Carlström A, Sherpa D, Couvillion MT, Rovšnik U, Gao J, Wan B, Shao S, Ott M, Churchman LS
Selective decoupling of IgG1 binding to viral Fc receptors restores antibody-mediated NK cell activation against HCMV.
1. Cell Rep - published December 3, 2025
2. Qerqez AN, Hoffmann K, Lee AG, Pareek S, Hager K, Mishra AK, Delidakis G, Bentley K, Kerr-Jones L, Cabrera M, Nguyen T, Göttler RL, Chowdhury A, Kolb PL, Hengel H, Georgiou G, McLellan JS, Stanton RJ, Nguyen AW, Maynard JA
The far extracellular CUB domain of the adhesion GPCR ADGRG6/GPR126 is a key regulator of receptor signaling.
1. Proc Natl Acad Sci U S A - published December 2, 2025
2. Bandekar SJ, Dintzner EE, Leon K, Kordon SP, Slezak T, Cechova K, Vafabakhsh R, Araç D
ATG2 is a triglyceride transfer protein.
1. Proc Natl Acad Sci U S A - published December 2, 2025
2. Korfhage JL, Elhan H, Wan N, Lu Y, Kauffmann L, Pilli G, Fuller DM, Rios AM, Reinisch KM, Maddipati KR, Thiam AR, Melia TJ
Karyopherins remodel the dynamic organization of the nuclear pore complex transport barrier.
1. Nat Cell Biol - published December 2, 2025
2. Kozai T, Fernandez-Martinez J, Kapinos LE, Gallardo P, van Eeuwen T, Saladin M, Eliasian R, Mazur A, Zhang W, Tempkin J, Panatala R, Delgado-Izquierdo M, Escribano-Marin R, Feng Q, Lin C, Sali A, Chait BT, Raveh B, Veenhoff LM, Rout MP, Lim RYH
Enhanced S-Palmitoylated Protein Detection by Mild Nonionic Detergent in Proteomic Workflow.
1. J Am Soc Mass Spectrom - published December 2, 2025
2. Kim H, Issara-Amphorn J, Yoon S, Banerjee A, Nita-Lazar A
The Expanding Histone Universe: Histone-Based DNA Organization in Noneukaryotic Organisms.
1. Annu Rev Biophys - published December 2, 2025
2. Villalta A, Weerawarana SR, Nosella ML, Hamel NL, Luger K
Parallel stopped-flow interrogation of diverse biological systems at the single-molecule scale.
1. Nat Methods - published December 2, 2025
2. Kiselev R, Brady RA, Modak A, Cruz-Navarrete FA, Alejo JL, Terry DS, Altman RB, Asher WB, Javitch JA, Blanchard SC
Autoregulation of the MET receptor tyrosine kinase by its intracellular juxtamembrane domain.
1. Biochem J - published December 1, 2025
2. Linossi EM, Espinoza CA, Estevam GO, Fraser JS, Jura N
Asymmetrically glycosylated IgG1 antibodies are universal and drive human disease.
1. Nat Commun - published December 1, 2025
2. Azzam T, Bournazos S, Gunduz H, Adams T, Flowers MW, Niejadlik EG, Duong V, Brown TJ, Roberts AM, Sastre DE, Avci FY, Lam WA, Cantaert T, Roberts BR, Diamond B, Ravetch JV, Du JJ, Sundberg EJ
Structural insights into GM4951 as a lipid droplet GTPase regulating hepatic lipid metabolism.
1. Nat Commun - published December 1, 2025
2. Raj R, Jiang Y, Jha RK, Moresco EMY, Joshi H, Zhang Z, Beutler B
General trends in the calnexin-dependent expression and pharmacological rescue of clinical CFTR variants.
1. Elife - published December 1, 2025
2. Tedman A, Olson JA, Kim M, Foye C, Jackson JJ, McDonald EF, McKee AG, Noguera K, Kuntz CP, Meiler J, Oliver KE, Plate L, Schlebach JP
Structural and immunological characterization of the H3 influenza hemagglutinin during antigenic drift.
1. Nat Commun - published December 1, 2025
2. de Paiva Froes Rocha R, Tomris I, Bowman CA, Stevens E, Kantorow J, Plitt CM, Peng W, Oeverdieck S, Galdino Andrade T, Ferguson JA, Jung DD, Marques RE, Herfst S, Snijder J, Chakraborty S, Torrents de la Peña A, Berndsen ZT, de Vries RP, Ward AB
Evolution of the RNA alternative decay cis element into a high-affinity target for the immunomodulatory protein Roquin.
1. RNA Biol - published December 1, 2025
2. Tants JN, Friedrich K, Neumann J, Schlundt A
PfCSP-ferritin nanoparticle malaria vaccine antigen formulated with aluminum-salt and CpG 1018® adjuvants: Preformulation characterization, antigen-adjuvant interactions, and mouse immunogenicity studies.
1. Hum Vaccin Immunother - published December 1, 2025
2. Hickey JM, Sharma N, Fairlamb M, Doering J, Adewunmi Y, Prieto K, Costa G, Wizel B, Levashina EA, Mantis NJ, Julien JP, Joshi SB, Volkin DB
The crystal structure of the toxin EspC from enteropathogenic Escherichia coli reveals the mechanism that governs host cell entry and cytotoxicity.
1. Gut Microbes - published December 1, 2025
2. Pilapitiya AU, Hor L, Pan J, Wijeyewickrema LC, Pike RN, Leyton DL, Paxman JJ, Heras B
Building a potent TREM2 agonistic, biparatopic, common light chain antibody.
1. MAbs - published December 1, 2025
2. da Silva Almeida A, Geddie ML, Bhate A, Quan C, Arndt JW, Jiao Y, Santoro JC, Noiman L, Vijayakumar R, Sanchez-Salazar J, Datta A, Antognetti G, Hartana CA, Wang XF, Smith BA, Bartlett D, Duncan D, Liu CC, Otero Gutierrez K, Cameron TO, Koirala S, Cooke HA
Relationship between baseline right ventricular systolic function and left ventricular recovery at six-months of follow up among women with peripartum cardiomyopathy in Uganda.
1. Int J Cardiol Heart Vasc - published December 1, 2025
2. Nabbaale J, Okello E, Nakimuli A, Chakafana G, Sliwa K
SINE compounds activate exportin 1 degradation through an allosteric mechanism.
1. Nat Chem Biol - published December 1, 2025
2. Wing CE, Fung HYJ, Kwanten B, Cagatay T, Niesman AB, Jacquemyn M, Gharghabi M, Permentier B, Shakya B, Nandi R, Ready JM, Kashyap T, Shacham S, Landesman Y, Lapalombella R, Daelemans D, Chook YM
CryoSift: an accessible and automated CNN-driven tool for cryo-EM 2D class selection.
1. Acta Crystallogr F Struct Biol Commun - published December 1, 2025
2. Schäfer JH, Calza A, Hom K, Damodar P, Peng R, Bogdanović N, Lander GC, Stagg SM, Cianfrocco MA
Gluing the allosteric way.
1. Nat Chem Biol - published December 1, 2025
2. Schneider LA, Bendel AM, Baur R, Thomä NH
DNA topoisomerase I acts as supercoiling sensor for bacterial transcription elongation.
1. Nat Struct Mol Biol - published December 1, 2025
2. Vidmar V, Borde C, Bruno L, Miropolskaya N, Takacs M, Batisse C, Saint-André C, Zhu C, Espéli O, Lamour V, Weixlbaumer A
A protective and heterosubtypic antibody lineage targeting the influenza A virus neuraminidase active site.
1. J Clin Invest - published December 1, 2025
2. Sornberger TA, Wolters RM, Gilchuk IM, Myers L, Binshtein E, Irving R, Chen EC, Gilchuk P, Nargi RS, Sutton RE, Howard BN, Handal LS, Trivette A, Webb KE, Kona C, Villalobos E, Williamson LE, Crowe JE Jr, Zost SJ
RAD51 D-loop structures reveal the mechanism of eukaryotic RAD51-mediated strand exchange.
1. Nat Commun - published December 1, 2025
2. Luo SC, Yang CH, Yeh HY, Lin CW, Yeh MC, Chi P, Ho MC
CD8(+) T cell stemness precedes post-intervention control of HIV viremia.
1. Nature - published December 1, 2025
2. Kiani Z, Urbach JM, Wisner H, Olatotse MJ, Chang DY, Acklin JA, Piechocka-Trocha A, Bonheur N, Khatri A, Lichterfeld M, Gunst JD, Søgaard OS, Caskey M, Nussenzweig MC, Walker BD, Collins DR
Correlates of HIV-1 control after combination immunotherapy.
1. Nature - published December 1, 2025
2. Peluso MJ, Sandel DA, Deitchman AN, Kim SJ, Dalhuisen T, Tummala HP, Tibúrcio R, Zemelko L, Borgo GM, Singh SS, Schwartz K, Deswal M, Williams MC, Hoh R, Shimoda M, Narpala S, Serebryannyy L, Khalili M, Vendrame E, SenGupta D, Whitmore LS, Tisoncik-Go J, Gale M Jr, Koup RA, Mullins JI, Felber BK, Pavlakis GN, Reeves JD, Petropoulos CJ, Glidden DV, Spitzer MH, Gama L, Caskey M, Nussenzweig MC, Chew KW, Henrich TJ, Yukl SA, Cohn LB, Deeks SG, Rutishauser RL
IMPDH and GTP Metabolism in Cancer: Mechanisms, Regulation, and Translational Scope.
1. Cancer Sci - published December 1, 2025
2. Ogawa-Iio A, Takeuchi K, Shigemi K, Genoveso MJ, Niitsu H, Koh I, Ota Y, Yamane K, Hinoi T, Osaka N, Oshima M, Ishikawa T, Mizuno T, Natsumeda M, Tateishi K, Hashizume R, Osuka S, Goyama S, Yasuda T, Senda T, Sasaki AT
Cross-species interactome analysis uncovers a conserved selective autophagy mechanism for protein quality control in plants.
1. Dev Cell - published December 1, 2025
2. Sánchez de Medina Hernández V, Nava-García MM, Bianchi A, Clavel M, Papareddy RK, Benchalel L, Andreev VI, Mathur V, Mohseni A, García-León M, Gao P, de la Concepción JC, Picchianti L, Grujic N, Kobylinska R, Abdrakhmanov A, Duvergé H, Anand G, Leibrock N, Ma J, Raffeiner M, Crawford TS, Argirò L, Matuszkiewicz M, Wun CL, Kanne JV, Meinhart A, Roitinger E, Bäurle I, Kang BH, Petersen M, Üstün S, Kulathu Y, Clausen T, Ramundo S, Dagdas Y
SRC at the Crossroads of KRAS Inhibitor Resistance: Mechanisms and Therapeutic Opportunities.
1. Cancer Lett - published December 1, 2025
2. Tian H, Zhao D, Zhou Z, Kim A, Huang H, Lee YJ, Qu Z, Kang R, Zeh HJ, Westover KD, Song X
The Specification and Functional Maturation of Sub-Cerebral Projection Neurons Derived from Human Induced Pluripotent Stem Cells.
1. Stem Cells Dev - published December 1, 2025
2. Jordan Z, Singh A, Kattapong-Graber S, Goswami S, Sanjana NE, Zuccaro E, Zhang F, Eggan K, Hsieh J, Hermann BP, Hebert JM, Maroof AM
PROFILING THE TRPV4 ANKYRIN REPEAT DOMAIN INTERACTOME AND ITS DISRUPTION BY NEUROMUSCULAR DISEASE-CAUSING MUTATIONS.
1. J Biol Chem - published December 1, 2025
2. Loder AK, Kosmanopoulos GP, Aisenberg WH, Cox E, Meeker AR, Blackshaw S, Gaudet R, Hellmich UA, McCray BA, Sumner CJ, Sullivan JM
Postpartum lipid dysregulation in African American women who experienced cardiometabolic complications of pregnancy.
1. iScience - published December 1, 2025
2. Maner-Smith K, Chen CY, Hou Z, Gulbin XL, Ahn J, Ortlund EA, Dunlop AL, Ferranti E
A dendritic guidance receptor functions in both ligand dependent and independent modes.
1. PLoS Genet - published December 1, 2025
2. Reddy AR, Machera SJ, Cook ZT, Deng H, Nawrocka WI, Özkan E, Shen K
Vinyl ether maleic acid block copolymers: a versatile platform for tunable self-assembled lipid nanodiscs and membrane protein characterization.
1. Polym Chem - published December 1, 2025
2. Shah MZ, Okorafor E, Rotich NC, Henoch Q, Thapa Acharya R, Page RC, Lorigan GA, Konkolewicz D
Genome-replicating HC-AdV: A novel high-capacity adenoviral vector class featuring enhanced in situ payload expression.
1. Mol Ther Methods Clin Dev - published December 1, 2025
2. Kolibius J, Weiss F, Freitag PC, Plückthun A
Provider perceptions and experiences integrating depression treatment into chronic healthcare services in Neno District, Malawi: a qualitative study.
1. BMC Health Serv Res - published December 1, 2025
2. Kamwiyo M, Mwale O, Mpinga K, Kayira W, Johnson I, Ruderman T, Matanje B, Kasambara K, Houde A, Isaacs R, Needham C, Wagner G, Kulisewa K, Udedi M, McBain RK
Decreased cytoplasmic crowding via inhibition of ribosome biogenesis can trigger Candida albicans filamentous growth.
1. Nat Microbiol - published December 1, 2025
2. Serrano A, Puerner C, Chevalier L, Plumb E, Elferich J, Diggs S, Sinn LR, Grigorieff N, Ralser M, Delarue M, Bassilana M, Arkowitz RA
Potent neutralization by antibodies targeting the MPXV A28 protein.
1. Nat Commun - published December 1, 2025
2. Yefet R, Battini L, Hubert M, Rakayev K, Guivel-Benhassine F, Rattner N, Porrot F, Abramovitz L, Ostashinsky G, Ben-Shalom N, Postal J, Polonsky K, Ralph-Altman M, Sweed S, Korner T, Friedel N, Hagin D, Sprecher E, Fishelson Z, Kobiler O, Adler-Abramovich L, Schwartz O, Guardado-Calvo P, Freund NT
Antigen-agnostic identification of poxvirus broadly neutralizing antibodies targeting OPG153.
1. Sci Transl Med - published December 1, 2025
2. Paciello I, Rundlet EJ, Zhou L, Realini G, Perrone F, Pierleoni G, Troisi M, Postal J, Guivel-Benhassine F, Porrot F, Mullins CM, Moschese D, Cossu MV, Sabaini F, Accordini S, Gianesini N, Passarelli Mantovani R, Panza F, Fabbiani M, Tumbarello M, Antinori S, Castilletti C, Montagnani F, Schwartz O, Rappuoli R, McLellan JS, Andreano E
The molecular mechanism of fluoride export by the eukaryotic fluoride channel FEX.
1. Nat Commun - published December 1, 2025
2. Kang CY, An M, Heidari S, Torabifard H, Ohi MD, Stockbridge RB