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95 Member Publications for February

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Histone 3 lysine 9 dimethylation by the G9a-GLP heterodimer requires intranucleosomal product reading.
1. bioRxiv - published February 5, 2026
2. Yousefi F, Simental EA, Du Y, Whedon S, Trnka MJ, Darling D, Jia S, Panning B, Cole PA, Halic M, Al-Sady B
Personalized Ultra-Fractionated Stereotactic Adaptive Radiotherapy (PULSAR) for Patients with Lung Tumors and Severe Pulmonary Disease.
1. J Clin Med - published February 5, 2026
2. Westover KD, Li R, Tanner S, Aliru M, Lin MH, Cai B, Parsons D, Visak J, Gonzalez Y, Gill A, Zhang Y, Badiyan SN, Iyengar P, Timmerman R
The SETD2 L1609P mutation found in leukemia disrupts methyltransferase activity and reduces histone H3K36 trimethylation.
1. J Biol Chem - published February 5, 2026
2. Michail C, Berthelet J, Mechaly AE, Bui LC, Yang H, Cai D, Al Mahi A, Xie A, Bisio V, Sirri V, Dupret JM, Guidez F, Xu X, Joly N, Regad L, Viguier M, Deshayes F, Dulphy N, Green MR, Haouz A, Lima FR
Ligand Binding Dynamics of Ion Channels and GPCRs Using Single-Molecule Fluorescence.
1. Annu Rev Biophys - published February 5, 2026
2. Chowdhury SR, Goldsmith RH, Chanda B
Editorial: Molecular and physiological mechanisms driving phytoremediation.
1. Front Plant Sci - published February 5, 2026
2. Noori A, Sharifan H, Rodríguez-Seijo A
Deposition of CENP-A Cse4 is enhanced by mutations in the AAA+ ATPase domain of ATAD2 Yta7.
1. Genetics - published February 5, 2026
2. Kaur N, Cho C, Samel-Pommerencke A, Shahnejat-Bushehri S, Poßling A, Kuznecova J, Song JJ, Ehrenhofer-Murray AE
NMR, a tool for biology.
1. Structure - published February 5, 2026
2. Izadi-Pruneyre N, Nilges M
Isolation and characterization of broadly-neutralizing anti-HCMV-gB antibodies from human donors using a prefusion-stabilized HCMV gB variant.
1. PLoS Pathog - published February 5, 2026
2. McClave MK, Wan YH, White EM, Gálvez Martínez B, Karimian Shamsabadi M, Aldridge N, Poudel B, Sperl AW, McGuire AT, Heldwein EE
Single-molecule tracking of DNMT1 in living cells reveals its cell cycle dynamics and its redistribution upon drug treatment.
1. Nucleic Acids Res - published February 5, 2026
2. Lee ES, Tommer ER, Rothman PB, Middleton SV, Youmans DT, Cech TR
The interaction of XPG with TFIIH through p62 and XPD is required for the completion of nucleotide excision repair.
1. Nucleic Acids Res - published February 5, 2026
2. Kim M, Jeong E, Park J, D'Souza A, Tsai MS, Yan C, Ivanov I, Chazin WJ, Kim HS, Schärer OD
Programmable genome editing in human cells using RNA-guided bridge recombinases.
1. Science - published February 5, 2026
2. Pelea O, Tálas A, Carrera JF, Mathis N, van de Venn L, Yeh CD, Kulcsár PI, Marquart KF, Weber Y, Gerecke SE, Harvey-Seutcheu IF, Mailänder D, Pfleiderer MM, Chanez C, Corn JE, Schwank G, Jinek M
KRAS4a and KRAS4b show distinct lipid-dependent regulation of RAS-RAF membrane dynamics.
1. J Biol Chem - published February 4, 2026
2. Georgouli K, Tempkin JOB, Stanton LG, Oppelstrup T, Shrestha R, Carpenter TS, Aydin F, Zhang X, Bhatia H, Yang Y, Van QN, Bonilla PA, Gulten G, Goswami D, Di Natale F, Chavez JR, Moon JY, Dharuman G, Hengartner NW, Simanshu DK, Tran TH, Nguyen K, Stanley CB, Van Essen B, Bremer PT, Lightstone FC, Stephen AG, Glosli JN, Gnanakaran S, Turbyville TJ, McCormick F, Nissley DV, Streitz FH, Ingólfsson HI
A multivalent adaptor mechanism drives the nuclear import of proteasomes.
1. Nat Commun - published February 4, 2026
2. Brunner HL, Kalis RW, Grundmann L, Hodáková Z, Koskova Z, Grishkovskaya I, de Almeida M, Hinterndorfer M, Knaudt H, Höfflin S, Andersch F, Kotisch H, Dickmanns A, Cuylen-Haering S, Zuber J, Haselbach D
Metabolic engineering of doxorubicin biosynthesis through P450-redox partner optimization and structural analysis of DoxA.
1. Nat Commun - published February 4, 2026
2. Koroleva A, Artukka E, Yamada K, Newmister SA, Harte RJ, Boesger H, Londen M, Sanders JN, Tirkkonen H, Kannisto M, Kuin RCM, Hulst M, Wang R, Leskinen E, Barillec M, Niemi J, van Wezel GP, Neefjes J, Nybo SE, Houk KN, Sherman DH, Kim RQ, Metsä-Ketelä M
Controlling spatial structure in minimal microbial communities by sequential capillary assembly.
1. Lab Chip - published February 4, 2026
2. Boggon C, Wong JPH, Sahoo A, Zinkernagel AS, Seeger MA, Secchi E, Isa L
A clinical-stage oncology compound selectively targets drug-resistant cancers.
1. bioRxiv - published February 3, 2026
2. Long K, Bhattacharjee D, Newman-Stonebraker SH, Suhr S, Mercado BQ, Scheib E, Tighe A, Romero L, Thompson SL, Sausville EL, John KM, Julian L, Mishra S, Klingbeil O, Gupta P, Bhatt U, Gao AC, Ricardo S, Vakoc CR, Bornhauser BC, Corsello SM, Taylor SS, Chen J, Holland PL, Sheltzer JM
Regulation of virion production by the ORF8 signal peptide across SARS-CoV-2 variants.
1. bioRxiv - published February 3, 2026
2. Khalid MM, Chen IP, Soveg FS, Taha TY, Tabata T, Suryawanshi RK, Syed AM, Ciling A, McCavitt-Malvido M, Schulze-Gahmen U, Hayashi J, Kim IJ, Fong SW, Batra J, Kumar GR, Renia L, Ng LF, Krogan NJ, Doudna JA, Verdin E, Ott M
Clinical characteristics, echocardiographic findings, and 6-month outcomes in Ugandan women with peripartum cardiomyopathy.
1. ESC Heart Fail - published February 3, 2026
2. Nabbaale J, Sliwa K, Nakimuli A, Chakafana G, Zhang W, Lwabi P, Omagino J, Lubega S, Sebatta E, Kayima J, Okello E
Identification of a potent V3 glycan site broadly neutralizing antibody targeting an N332(gp120) glycan-independent epitope.
1. Nat Immunol - published February 3, 2026
2. Gieselmann L, DeLaitsch AT, Rohde M, Radford C, Worczinski J, Ashurov A, Ahmadov E, Burger JA, Havenar-Daughton C, Deshpande S, Giovannoni F, Corti D, Kreer C, Ercanoglu MS, Schommers P, Georgiev IS, West AP Jr, Knüfer J, Stumpf R, Kroidl A, Geldmacher C, Maganga L, William W, Ntinginya NE, Hoelscher M, Yang Z, Wei Q, Renfrow MB, Green TJ, Novak J, van Gils MJ, Gristick HB, Gruell H, Bloom JD, Seaman MS, Bjorkman PJ, Klein F
Recurrent resistance mutations to lirafugratinib inform treatment sequencing in FGFR2-driven tumors.
1. Clin Cancer Res - published February 3, 2026
2. Facchinetti F, Hollebecque A, Barbé R, Jang DM, Alonso-De-Castro B, Brayé F, Bigot L, Nobre C, Da Silva A, Méteau M, Delavigne M, Soares M, Italiano A, Rodriguez J, Mosele F, Beshiri K, Ducreux M, Boilève A, Nikolaev S, Alonso-Garcia I, Vasseur D, Smolenschi C, Bourien H, Cotteret S, Samaniego J, Bernard E, Nicotra C, Ngo-Camus M, Nakazawa S, Tselikas L, Badoual C, André F, Eck MJ, Olaussen KA, Loriot Y, Friboulet L
The BK channel-NS1619 agonist complex reveals molecular insights into allosteric activation gating.
1. Proc Natl Acad Sci U S A - published February 3, 2026
2. Gonzalez-Sanabria N, Contreras GF, Rojas M, Duarte Y, Gonzalez-Nilo FD, Perozo E, Latorre R
Integrated mutational landscape analysis of endometrial stromal sarcoma.
1. Proc Natl Acad Sci U S A - published February 3, 2026
2. Hartwich TMP, Choi S, Hwang A, Bellone S, Palmieri L, Seo H, Kim T, Hong J, Krakstad C, Trovik J, Stefansson IM, Haugland HK, Greenman M, Ettorre V, Ottum S, Demirkiran C, Yang-Hartwich Y, Buza N, Hui P, Lopez S, Cormio G, Ramunno M, Zito A, Perrone E, Fagotti A, Fanfani F, Santoro A, Ravaggi A, Bignotti E, Odicino F, Ardighieri L, Ratner E, Angioli R, Perrone G, Luvero D, Conca B, Choi J, Schlessinger J, Santin AD
Intercalated bacterial biofilms are intrinsic internal components of calcium-based kidney stones.
1. Proc Natl Acad Sci U S A - published February 3, 2026
2. Schmidt WC, Mousavi A, Li J, Yang R, Gonzalez Marin G, Schreiber HL 4th, Hammann RES, Obernuefemann CLP, Bergeron K, Klim A, Wong D, Du K, Hultgren SJ, Chen Q, Celestian A, Wong GCL, Scotland KB
Coordination of cell organelles to promote metabolon formation.
1. Proc Natl Acad Sci U S A - published February 3, 2026
2. Sha Z, Pedley AM, Iles TD, Zhang S, Staub JR, Zhou R, Benkovic SJ
RNA polymerase I inhibitor CX-5461 suppresses cervical cancer cell growth by inducing DNA damage and mitotic catastrophe and enhances cisplatin sensitivity.
1. Biochem Pharmacol - published February 2, 2026
2. Liu X, Xu T, Wu J, Zhou B, Wen J, Zhang Y, Cui B, Chiang CM, Wang J
DNA translocation by the CMG helicase: the helical inchworm model.
1. Biochem Soc Trans - published February 2, 2026
2. Batra S, Allwein B, Wang YL, Hite RK, Remus D
Characterisation of Encephalitozoon cuniculi α-actinin.
1. Mol Biochem Parasitol - published February 2, 2026
2. Sandblad L, Backman L
The structure of the full catalytic cycle of Vibrio cholerae NFeoB.
1. J Mol Biol - published February 2, 2026
2. Magante K, Armstrong CM, Lee M, Smith AT
The annotated blueprint: integrated functional genomic resources for a model tetraploid wheat Triticum turgidum cv Kronos.
1. New Phytol - published February 2, 2026
2. Seong K, Kumar R, Prigozhin DM, Lunde C, Cherubino Ribeiro TH, Bélanger S, Hsieh JA, Tang M, Meyers BC, Krasileva KV
A small molecule inhibitor of ARF GTPase protein 1 limits liver and colon cancer cell growth and metastasis.
1. Cell Death Dis - published February 2, 2026
2. Peng H, Chhimwal J, Fan W, Wang J, Barbier-Torres L, Sinha S, Chatterjee A, Zhang Y, Tomasi ML, Mato JM, Murali R, Lu SC
Structure and dynamics of a multidomain nitric oxide synthase regulated by a C2 domain.
1. Sci Adv - published February 2, 2026
2. Nair D, Crane BR
Cryogenic electron tomography by the numbers: Charting underexplored lineages in structural cell biology.
1. Proc Natl Acad Sci U S A - published February 2, 2026
2. Ansell TB, Berrios L, G Peay K, D Dahlberg P
Transmembrane proteins mediate basal complex assembly and individual daughter cell formation in malaria parasites.
1. Sci Adv - published February 2, 2026
2. Back PS, Wagner E, Llopis PM, de Oliveira RG, Mottinelli M, Ferrins L, Dvorin JD
Circadian ADCY3 Ser107Pro variant bridges difficulty awakening in the morning and adiposity.
1. iScience - published February 2, 2026
2. Tchio C, Maher M, Moth C, Meiler J, Lane JM, Taylor HA, Williams JS, Saxena R
Conformational ensembles of the magnesium channel CorA reveal structural basis for channel gating.
1. Proc Natl Acad Sci U S A - published February 2, 2026
2. Erramilli SK, Nosol K, Pietrzak-Lichwa K, Schmandt N, Li T, Tokarz P, Hou J, Zhao M, Perozo E, Kossiakoff AA
Da-Bu-Yin-Wan rescues cognitive deficits in aging and Alzheimer's disease models by Wnt/β-catenin-dependent restoration of lysosomal acidification.
1. Phytomedicine - published February 2, 2026
2. Zhang H, Zhang H, Zhao M, Luo W, Chen S, Wang P, Liu X, Xu S
Electromotility can be disassociated from gating charge movement in outer hair cells of conditional alpha2 spectrin knockout mice.
1. J Biol Chem - published February 2, 2026
2. Bai JP, Stankewich MC, Yang J, Tan W, Zuo Z, Song Q, Khan S, Wang L, Morrow JS, Santos-Sacchi J, Navaratnam DS
Cytochrome nanowires under electron microscopy.
1. Emerg Top Life Sci - published February 2, 2026
2. Petersen HA, Hochbaum AI, Bond DR, Wang F
Author Correction: The human ciliopathy protein RSG1 links the CPLANE complex to transition zone architecture.
1. Nat Commun - published February 2, 2026
2. Vazquez N, Lee C, Valenzuela I, Phan TP, Derderian C, Chávez M, Mooney NA, Demeter J, Aziz-Zanjani MO, Cusco I, Codina M, Martínez-Gil N, Valverde D, Solarat C, Bruel AL, Thauvin-Robinet C, Steichen E, Filges I, Joset P, De Geyter J, Vaidyanathan K, Gardner TP, Toriyama M, Marcotte EM, Drew K, Roberson EC, Jackson PK, Reiter JF, Tizzano EF, Wallingford JB
Mechanistic insights and in vivo HIV suppression by the BRD4-targeting small molecule ZL0580.
1. PLoS Pathog - published February 2, 2026
2. Kumar N, Ma Z, Long F, Bonam SR, Lai HT, Wu SY, Chen H, Hazell NC, Bei J, Liu X, Chen Y, Wei Z, Chiang CM, Zhou J, Hu H
ER remodelling is a feature of ageing and depends on ER-phagy.
1. Nat Cell Biol - published February 2, 2026
2. Donahue EKF, Hepowit NL, Ruark EM, Mulligan AG, Keuchel B, Urban ND, Peng L, Stephens S, Johnson DJ, Wallace NS, Jackson LP, Ellisman MH, Arrojo E Drigo R, Folkmann AW, Truttmann MC, MacGurn JA, Burkewitz K
Regulation of tension-dependent localization of LATS1 and LATS2 to adherens junctions.
1. PLoS One - published February 2, 2026
2. De Silva C, Kelch BA, McCollum D
The CspC:CspA heterodimer transduces germinant and co-germinant signals during Clostridioides difficile spore germination.
1. PLoS Biol - published February 2, 2026
2. McNellis ME, González-Del Pino G, Serrano-Jiménez JA, Forster ER, Stoica AI, Heldwein EE, Shen A
Adding Context to the Declining Board Pass Rate in Emergency Medicine.
1. AEM Educ Train - published February 1, 2026
2. Burns B, Jordan J, Smith JL, Hopson LR
MRAP2 potentiates GPCR signaling by conserved mechanisms that are disrupted by obesity-associated genetic variants.
1. Cell Rep - published February 1, 2026
2. Jamaluddin A, Wyatt RA, Broichhagen J, Levitz J, Gorvin CM
Wnt signaling pathway: Therapeutic target of natural products for cancer therapy.
1. Pharmacol Ther - published February 1, 2026
2. Fang W, Luo W, Hu J, He Z, Liu X, Tang X, Li Y, Ming T, Li Y, He Y, Xu H
Scaling Genomic Reanalysis to Unlock Diagnoses and Transform Rare Disease Care.
1. HGG Adv - published February 1, 2026
2. Rockowitz S, Shao W, French C, Truong TK, Hagen J, McGonigle R, Geltzeiler A, Sheidley B, Smith L, D'Gama AM, Irons M, Chou J, Stoler J, Kritzer A, Rodan L, Shimamura A, Bodamer O, Sacharow S, Soul JS, Srivastava S, Kennedy AR, Abu-El-Haija A, Lai A, Olson H, Juusola J, Ryan E, Friedman B, Singh A, Li C, Mallik R, Strickland G, Prinzing G, Mo A, O'Donnell-Luria A, Bolton J, Boone PM, Brucker W, Duyzend M, Mahida S, Miller DT, Omorodion J, Petit J, Picker J, Poduri A, Carlston C, Wojcik MH, Sliz P, Chung WK
Cell-free genomics reveals fundamental regulatory principles of the Mycobacterium tuberculosis transcription cycle.
1. Mol Cell - published February 1, 2026
2. Froom R, Wolfe MB, Eckartt KN, Mooney RA, Delbeau M, Lilic M, Jaramillo Cartagena A, Rock JM, Darst SA, Landick R, Campbell EA
Rewiring STAT signaling from the cell surface with Trikine immunotherapeutics.
1. Science - published February 1, 2026
2. Rodriguez GE, Zhao Y, Nishiga Y, Peprah F, Shen J, Abhiraman GC, Ogishi M, Zhang C, Saco J, Waghray D, Serasanambati M, Torres L, Simone BW, Su L, Wilson SC, Yang A, Sun Q, Picton L, Saxton RA, Bhandarkar V, Lee MJ, Andrews E, Jiang H, Obenaus M, Yen M, Atajanova T, Blish CA, Spranger S, Wherry EJ, Kirane A, Ribas A, Raulet DH, Kalbasi A, Dougan SK, Dougan M, Sage J, Garcia KC
Structural Characterization of Glycolytic Enzymes from Trypanosoma cruzi.
1. Mol Biochem Parasitol - published February 1, 2026
2. Austin K, Obachi VA, Muzenda FL, Moetlediwa MT, Agyei C, Craig T, Abendroth J, Edwards T, Nguyen M, Tran N, Staker B, Subramanian S, Myler P, Zininga T, Govender KK, Chakafana G
Large Library Docking for Polypharmacology.
1. J Med Chem - published February 1, 2026
2. Wu Y, Vigneron S, Braz J, Srinivasan K, Fink EA, Huang XP, Xu X, Huebner H, Kim JY, Wang J, Pfeiffer T, Sakamoto K, Radchenko DS, Rodriguiz RM, Moroz YS, Irwin JJ, Gmeiner P, Billesboelle C, Roth BL, Basbaum AI, Manglik A, Wetsel WC, Shoichet BK
Diverse Cyanopeptides Follow Distinct Temporal Succession Patterns in Freshwater Harmful Algal Blooms.
1. ISME J - published February 1, 2026
2. Hart LN, Errera R, Godwin C, Loftin KA, Laughrey ZR, Katona LR, Johnson EC, Cory RM, Kiledal EA, Den Uyl P, Kharbush JJ, Sherman DH, Dick GJ
Giant DNA viruses encode a hallmark translation initiation complex of eukaryotic life.
1. Cell - published February 1, 2026
2. Fels JM, Hill AB, Han R, Garcia JM, Bisio H, Abergel C, Kranzusch PJ, Lee ASY
The Development of Canonical Proportion as a Function of Community, Multilingualism, and Target Language's Syllable Complexity.
1. J Child Lang - published February 1, 2026
2. Tey KJ, Walker S, Seidl A, Scaff C, Peurey L, Kelleher BL, Havard W, Hamrick L, Grosjean P, Cychosz M, Colleran H, Casillas M, Bergelson E, Hitczenko K, Cristia A
Caveolar Compartmentalization of Pacemaker Signaling Ensures Stable Sinoatrial Rhythmicity Which Is Disrupted in Heart Failure.
1. JACC Clin Electrophysiol - published February 1, 2026
2. Lang D, Ni H, Medvedev RY, Liu F, Alvarez-Baron CP, Tyan L, Turner DGP, Warden A, Morotti S, Schrauth TA, Chanda B, Kamp TJ, Robertson GA, Grandi E, Glukhov AV
BacPROTAC-induced protein degradation as a new antibiotic concept.
1. Trends Biochem Sci - published February 1, 2026
2. Junker S, Clausen T
Membrane composition-dependent patterning of Rho and F-actin in an artificial cell cortex.
1. Mol Biol Cell - published February 1, 2026
2. Schwarz GJ, Suber JR, Andhare D, Ragusa MJ, Landino J
Mucosal vaccination clears Clostridioides difficile colonization.
1. Nature - published February 1, 2026
2. Thomas AK, Peritore-Galve FC, Ehni AG, Lança BBC, Coggin J, Brady EJ, Yoder SM, Shrem R, Rodríguez RC, Kroh HK, Gibson-Corley KN, Kay Washington M, Olivares-Villagómez D, Creech CB, Nicholson MR, Spiller BW, Lacy DB
Design of a Targeted Covalent Probe to Interrogate the DNA Polymerase Activity of Polθ.
1. ACS Med Chem Lett - published February 1, 2026
2. Bubenik M, Mader P, Orlicky S, Perryman AL, Hamel M, Godbout C, Falgueyret JP, Kurinov I, Wong C, Gingras AC, Mamane Y, Zinda M, Morris SJ, Gallant M, Sfeir A, Black WC, Durocher D, Zimmermann M, Sicheri F
Altered Levels of Known Allergens in Cultured Primary Bovine Myoblasts for Cultivated Meat.
1. J Agric Food Chem - published February 1, 2026
2. Trlin HJF, Bennie RZ, Ogilvie OJ, Oh JK, Jin A, America AHP, Schols HA, de Ram C, Bastiaan-Net S, Boudewijn A, Maes E, Kleter G, Domigan LJ, Dobson RCJ
Discovery of Isohexide Bisglycolamides as Inhibitors of the Integrated Stress Response.
1. ACS Med Chem Lett - published February 1, 2026
2. Colandrea VJ, Joshi-Pangu A, Nolte RT, Bledsoe RK, Ward P, Glancy J, Kowalski MD, Huff CA, Desai S, Nagilla R, Laping NJ, Axten JM, Evans KA
Mechanistic Insights into Unary Peptide-Membrane Interactions Enable Stable Encapsulation and Trigger-Responsive Peptidyl Liposomes.
1. J Am Chem Soc - published February 1, 2026
2. Gao HD, Hong JL, Jian CB, Chen TH, Chang NC, Meeroekyai S, He RY, Liao YT, Wang CH, Su CJ, Jeng US, Ho MC, Chen YJ, Lee HM
Nucleotide signals coordinate activation and inhibition of bacterial immunity.
1. Nature - published February 1, 2026
2. Yamaguchi S, Fernandez SG, Wassarman DR, Lüders M, Schwede F, Kranzusch PJ
Structural heterogeneity of apolipoprotein B-100.
1. FEBS J - published February 1, 2026
2. Dearborn AD, Remaley AT, Marcotrigiano J
Harnessing evolution: leveraging bacterial isoprenoid pathway diversity toward improved bioengineering strategies.
1. J Bacteriol - published February 1, 2026
2. Qabar CM, Marshall BA, Landick R, Cox JS
Structural basis for recognition of Rift Valley fever virus Gn protein by a human neutralizing monoclonal antibody with a kappa light chain.
1. PLoS Pathog - published February 1, 2026
2. Paesen GC, Chapman NS, Westover JB, McMillen CM, Kuzmina NA, Dews EA, Myers L, Stass R, Montgomery JM, Bukreyev A, Hartman AL, Gowen BB, Crowe JE Jr, Bowden TA
High-throughput ligand diversification to discover chemical inducers of proximity.
1. Nat Chem Biol - published February 1, 2026
2. Shaum JB, Muñoz I Ordoño M, Steen EA, Wenge DV, Cheong H, Janowski J, Hunkeler M, Bilotta EM, Rutter ZJ, Barta PA, Thornhill AM, Milosevich N, Hargis LM, Bishop TR, Carter TR, da Camara B, Hinterndorfer M, Dada L, He WJ, Offensperger F, Furihata H, Schweber SR, Hatton C, Wen Y, Cravatt BF, Engle KM, Donovan KA, Melillo B, Kitamura S, Ciulli A, Armstrong SA, Fischer ES, Winter GE, Erb MA
Structural and functional mechanisms underlying activation gate dynamics and IFM motif accessibility in human Na(v)1.5.
1. Nat Commun - published February 1, 2026
2. Biswas R, López-Serrano AL, Purohit A, Ramirez-Navarro A, Huang HL, Cheng X, Heissler SM, Deschênes I, Chinthalapudi K
PARP1-HPF1 structure and dynamics on nicked DNA suggest a mechanism for acute and localized ADP-ribosylation.
1. Nat Commun - published February 1, 2026
2. Sverzhinsky A, Xue H, Langelier MF, Muniz Corrêa MV, Del Mundo J, Classen S, Hammel M, Rothenberg E, Pascal JM
Supercoiled DNA recognition and cleavage control in topoisomerase VI.
1. Nat Commun - published February 1, 2026
2. Richman DE, Wendorff TJ, Rashid F, Beck C, Yan Q, Johnson HR, Eckerty RA, Fogg JM, Baker ML, Zechiedrich L, Berger JM
Clustering and a conformational switch drive activation of the mammalian receptor tyrosine kinase ROS1.
1. Nat Commun - published February 1, 2026
2. Li H, Zhang J, Li T, Wang Y, Alarcón CR, Klein DE
14-3-3ζ interacts with DNA-binding domain of FOXO3a and competitively dissociates DNA by dual-motif tethering.
1. Nat Commun - published February 1, 2026
2. Enomoto S, Kuwayama T, Nakatsuka S, Yokogawa M, Kawatsu K, Nakamura R, Kimura T, Tanabe M, Senda T, Saito J, Saya H, Osawa M
Direct from the seed: an atomic resolution protein structure by ab initio MicroED.
1. Nat Commun - published February 1, 2026
2. Vasireddy PCR, Low-Beer T, Spoth KA, Acehan D, Crawley MR, Martynowycz MW
Dual recruitment of two CCM2 molecules to KRIT1 suppresses KLF4 expression.
1. Nat Commun - published February 1, 2026
2. Huet-Calderwood C, Fisher OS, Das S, Su VL, Boggon TJ, Calderwood DA
BamA self-insertion drives inner-to-outer membrane remodelling in diderm Firmicutes.
1. Nat Commun - published February 1, 2026
2. Beskrovnaya P, Hashimi A, Sexton DL, Nikas GE, Tocheva EI
Small-Molecule Drug Discovery Targeting RNAs: Hope or Hype?
1. J Med Chem - published February 1, 2026
2. Kang C, Nguyen HT, Heppner DE, Yu B, Xu W
Towards Understanding the Drivers of Antibody-Antigen Binding.
1. Biophys J - published February 1, 2026
2. Khan O, Kankkunen M, Shaker M, Chow H, Moustakas N, Allegra-Berger S, Lazou M, Vajda S, Joseph-McCarthy D
Lysine Targeting Group-Transfer Chimeras for Proximity Induction.
1. Angew Chem Int Ed Engl - published February 1, 2026
2. Singh S, Tran K, Karaj E, Mondal B, Tian W, Siriwongsup S, Sindi SH, Dhawa U, Pal K, Shoba VM, Shi S, Lian A, Mou J, Han M, Singh P, Polizzi NF, Choudhary A
Structural ontogeny of protein-protein interactions.
1. Science - published February 1, 2026
2. Yang A, Jiang H, Jude KM, Akpinaroglu D, Allenspach S, Li AJ, Bowden J, Perez CP, Liu L, Huang PS, Kortemme T, Listgarten J, Garcia KC
Activation of TMEM175 lysosomal ion channels by CysLT1 receptor antagonists.
1. Am J Physiol Cell Physiol - published February 1, 2026
2. Li K, Satpute Janve V, Le SD, Days EL, Bauer JA, Lazarenko RM, Gulsevin A, Denton JS
Lipid nanoparticle GM-CSF replacement for autoimmune pulmonary alveolar proteinosis.
1. Proc Natl Acad Sci U S A - published February 1, 2026
2. Lian L, Jang B, Huayamares SG, Shakked A, Gentry K, Zenhausern R, Radmand A, Schrader Echeverri E, Parihar VC, Guerrero-Ferreira RC, Calkins R, Vanover D, Santangelo PJ, Kim H, Dahlman JE
CSN5i-3 is an orthosteric molecular glue inhibitor of COP9 signalosome.
1. Nature - published February 1, 2026
2. Shi H, Wang X, Yu C, Mao H, Jiao F, Braitbard M, Shor B, Zhang Z, Hinds TR, Cao S, Fan E, Schneidman-Duhovny D, Huang L, Zheng N
Computational Evolution of Anti-PD-1 Antibodies Induces Structural Refolding for High-Affinity Interactions.
1. Biochemistry - published February 1, 2026
2. Shi Y, Kim Y, Liu P, Wang J, Tang S, Batista VS
Metabolic control of innate immune activation in TET2-mutant clonal hematopoiesis.
1. Cell Chem Biol - published February 1, 2026
2. Kim PG, Hergott CB, Miller AP, Deik A, Boileau M, Bullock K, Pierce KA, Choy AH, Shin W, McConkey M, Loke J, Ryback BA, Trinh MN, Rutter JC, Yue H, Yoon H, Park P, Roy Burman SS, Vander Heiden MG, Fischer ES, Armstrong SA, Clish C, Ebert BL
Degraders of the dengue virus capsid protein exhibit differentiated pharmacology relative to capsid inhibitors.
1. Nat Commun - published February 1, 2026
2. Chakravarty A, Wang LN, Golden RP, Li Z, Donovan KA, Afanzar O, Zhang Y, Fischer ES, Gray NS, Yang PL
Structural Insights into PFAS-β-Lactoglobulin-Binding Mechanism Mediating PFAS Toxicity.
1. Biochemistry - published February 1, 2026
2. Verma S, Singh A, Ramirez Orozco RS, Vukovic L, Narayan M, Kumar P
Listening to the quiescence of single STIM1 dimers.
1. Proc Natl Acad Sci U S A - published February 1, 2026
2. Hogan PG
Genomic and Effector-Based Insights Into Austropuccinia psidii-Host Interactions Informing RNAi and Resistance Development.
1. Mol Plant Pathol - published February 1, 2026
2. Sullivan JV, Eccersall SE, Smith GR, Dobson RCJ, Meisrimler CN
Polyphyletic screen defines distinct classes of plant-derived natural products that oppose tauopathy.
1. Life Sci Alliance - published February 1, 2026
2. Shepard CD, Chang X, Seidler PM, Curran SP
HYPK-Related Neurodevelopmental Syndrome: Case Report of Intellectual Disability, Developmental Delay, and Dysmorphic Features.
1. Clin Genet - published February 1, 2026
2. Patel R, Makwana R, Marchi E, Fan Z, Falsey E, Menendez B, Giampietro P, Wentzensen IM, Hsieh TC, Shan SO, Lyon GJ
Cryo-EM reveals an ensemble of cytochrome P450 reductase conformations in solution.
1. Protein Sci - published February 1, 2026
2. Lepesheva GI, Hargrove TY, Ren Y
Guiding AlphaFold predictions with experimental knowledge to inform dynamics and interactions with VAIRO.
1. Protein Sci - published February 1, 2026
2. Triviño J, Jiménez E, Grininger C, Caballero I, Medina A, Castellví A, Petrillo G, Govantes F, Sagmeister T, Alcorlo M, Hermoso JA, Sammito MD, Diederichs K, Pavkov-Keller T, Usón I
Case Series of Histopathological Findings in Chronic Kidney Disease: Insights From the Kidney Precision Medicine Project.
1. Kidney Med - published February 1, 2026
2. Limonte CP, Aw S, Alpers CE, Barisoni L, Berry B, Brosius FC, Campbell KN, Herlitz LC, Laszik Z, McMahon G, Mottl A, Nachman P, Nam Y, Poggio EE, Randhawa PS, Rosas SE, Stillman IE, Taliercio JJ, Torrealba J, Tuttle K, Vazquez M, de Boer IH, Henderson J, Kidney Precision Medicine Project
Sample purification and characterization of the α- and β-crustacyanin pigments from the American lobster for crystallographic and cryo-EM studies.
1. Acta Crystallogr F Struct Biol Commun - published February 1, 2026
2. Cedri MC, Bansia H, Amici A, Collet T, Moretti P, McCarthy AA, Mueller-Dieckmann C, Raffaelli N, Wang T, des Georges A, Cianci M
ADAM15 Is a Potential Biomarker for Pan-Cancer Prognosis and Immunotherapy: Validation in HCC and COAD.
1. IUBMB Life - published February 1, 2026
2. Guo W, Liu Y, Ma W, Fan L, Chen B, Wang J