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67 Member Publications for November

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Synaptobrevin-2 disease variants reveal spatial constraints within the presynaptic active zone.
1. Proc Natl Acad Sci U S A - published November 4, 2025
2. Guzikowski NJ, Bagatelas ED, Shin OH, Khan YA, Esquivies L, Alten B, Brunger AT, Kavalali ET
LRP8 is an entry receptor for tick-borne encephalitis viruses.
1. Proc Natl Acad Sci U S A - published November 4, 2025
2. Li P, Hui S, Chong Z, Escaffre O, Nguyen MN, Muraro SP, Janova H, Ma H, Cao S, Kaszuba T, Imbiakha B, Palakurty S, Pearson ML, Price DA, Amarasinghe GK, Leung DW, Rossi SL, Freiberg AN, Fremont DH, Diamond MS
Corrigendum to "Structural Basis of Drug Recognition by the Multidrug Transporter ABCG2". [J. Mol. Biol. 433 (2021) 166980].
1. J Mol Biol - published November 4, 2025
2. Kowal J, Ni D, Jackson SM, Manolaridis I, Stahlberg H, Locher KP
Generation of antigen-specific paired-chain antibodies using large language models.
1. Cell - published November 4, 2025
2. Wasdin PT, Johnson NV, Janke AK, Held S, Marinov TM, Jordaan G, Gillespie RA, Vandenabeele L, Pantouli F, Powers OC, Vukovich MJ, Holt CM, Kim J, Hansman G, Logue J, Chu HY, Andrews SF, Kanekiyo M, Sautto GA, Ross TM, Sheward DJ, McLellan JS, Abu-Shmais AA, Georgiev IS
The monoclonal antibody AZD5148 confers broad protection against TcdB-diverse Clostridioides difficile strains in mice.
1. PLoS Pathog - published November 3, 2025
2. Peritore-Galve FC, Kroh HK, Shupe JA, Ehni AG, Cano Rodríguez R, Kordus SL, Washington MK, Knippel RJ, Stanley AM, Gamson A, Tkaczyk C, Lacy DB
The path to equitable respiratory syncytial virus prevention for infants: challenges and opportunities for global implementation.
1. Lancet Glob Health - published November 3, 2025
2. Shaaban FL, Groenendijk RW, Baral R, Caballero MT, Crowe JE Jr, Englund JA, Esteban I, Hirve S, Jit M, Kalergis AM, Karron RA, Lukacs N, Martinon-Torres F, Mejias A, Nair H, Nisar MI, Nyiro JU, Pecenka C, Sparrow E, Srikantiah P, Thwaites RS, Zar HJ, Bont LJ
Targeting ACE2 with a camelid antibody inhibits SARS-CoV-2 binding and has protective effects in vivo.
1. Nat Commun - published November 2, 2025
2. Blachier S, Vaney MC, Conquet L, Staropoli I, Fernández I, Giraud E, Arbabian A, Michel V, Szilagyi F, Guez S, Boucharlat A, Chiaravalli J, Tran-Rajau J, Dufour E, Haouz A, Petres S, Planas D, Montagutelli X, Agou F, Lafaye P, Ayme G, Schwartz O, Rey FA, Enninga J, Brelot A
Phage SSB detection by retron Eco8 msDNA unleashes nuclease-mediated immunity.
1. Mol Cell - published November 2, 2025
2. Yu C, Wang C, Forman T, Xie J, Major S, Fang MX, Voyer JE, Pogliano J, Fu TM
ER protein CLCC1 promotes nuclear envelope fusion in herpesviral and host processes.
1. Nat Commun - published November 2, 2025
2. Dai B, Sperl AW, Polack L, Mejia I, Dame H, Huynh T, Deveney C, Lavoie N, Lee C, Doench JG, Daugherty MD, Heldwein EE
The dynamic and heterogeneous composition of biomolecular condensates and its functional relevance.
1. Nat Rev Mol Cell Biol - published November 2, 2025
2. Chin Sang C, Upadhyay S, Nosella ML, Forman-Kay JD, Lee HO
Hepatocyte mitochondrial NAD(+) content is limiting for liver regeneration.
1. Nat Metab - published November 2, 2025
2. Mukherjee S, Velázquez Aponte RA, Perry CE, Lee WD, Janssen KA, Niere M, Adzika GK, Lu MJ, Chan HR, Zou X, Chen B, Bye N, Xiao T, Yook JS, Salik O, Frederick DW, Gaspar RB, Doan KV, Davis JG, Rabinowitz JD, Wallace DC, Snyder NW, Kajimura S, Cambronne XA, Ziegler M, Baur JA
Multi-proteomics reveals integrated metabolic and regulatory networks for xylan catabolism in Streptomyces sp. SirexAA-E.
1. Microbiol Spectr - published November 2, 2025
2. Nagano T, Ohashi K, Banko P, Kumar V, Hori C, Fox BG, Takasuka TE
Advances in biomarker discovery for peripartum cardiomyopathy: current status and future directions.
1. Expert Rev Cardiovasc Ther - published November 2, 2025
2. Pretorius E, Sai SRAV, Barnet A, Kodogo V, Sliwa K, Chakafana G, Zininga T
Broad anti-sarbecovirus responses elicited by a single administration of mosaic-8 RBD-nanoparticle vaccine prepared using atomic layer deposition.
1. iScience - published November 2, 2025
2. Cohen AA, Keeffe JR, Rorick AV, Rho S, Priso Fils AC, Manasyan L, Gao H, Gnanapragasam PNP, Funke HH, Randolph TW, Garcea RL, Bjorkman PJ
DIRAS3-derived cyclic peptides disrupt KRAS-RAF interaction and KRAS nanoclustering, suppressing KRAS-driven pancreatic and ovarian tumors.
1. iScience - published November 2, 2025
2. Gray JP, Bildik G, Kim HN, Sutton MN, Wang J, Osuji AO, Batistatou N, Yang H, Mao W, Tan Z, Gasmi-Seabrook GMC, Liu J, Hancock JF, Marshall CB, Kritzer JA, Ikura M, Bast RC Jr, Millward SW, Lu Z
A periplasmic zinc capture protein enhances the resistance of Neisseria gonorrhoeae to nutritional immunity.
1. Proc Natl Acad Sci U S A - published November 2, 2025
2. Liyayi IK, Bera AK, Perera YR, Ferdausi N, Bhatia I, Noinaj N, Chazin WJ, Cornelissen CN, Criss AK
Structural basis for Lamassu-based antiviral immunity and its evolution from DNA repair machinery.
1. Proc Natl Acad Sci U S A - published November 2, 2025
2. Haudiquet M, Chakravarti A, Zhang Z, Ramirez JL, Herrero Del Valle A, Olinares PDB, Lavenir R, Ahmed MA, de la Cruz MJ, Chait BT, Sternberg SH, Bernheim A, Patel DJ
Directed evolution of a beta-lactamase samples a wide variety of conformational states.
1. Protein Sci - published November 1, 2025
2. Sun J, Timmer M, Brünle S, Boyle AL, Ubbink M
Structural basis of DNA-dependent coactivator recruitment by the tuft cell master regulator POU2F3.
1. Cell Rep - published November 1, 2025
2. Alpsoy A, Ipsaro JJ, Skopelitis D, Pal S, Chung FS, Carpenter S, Desmarais JJ, Wu XS, Chang K, DiMare MT, Harten E, Bergman S, Kinney JB, Engelman JA, Bhang HC, Joshua-Tor L, Vakoc CR
Structure of the transcriptional co-activator SAGA complex, including the histone acetyltransferase module.
1. Mol Cell - published November 1, 2025
2. Mattoo RUH, Chen DH, Bushnell DA, Tamir S, Kornberg RD
The Mac1 ADP-ribosylhydrolase is a therapeutic target for SARS-CoV-2.
1. Elife - published November 1, 2025
2. Suryawanshi RK, Jaishankar P, Correy GJ, Rachman MM, O'Leary PC, Taha TY, Matsui Y, Zapatero-Belinchón FJ, McCavitt-Malvido M, Doruk YU, Stevens MGV, Diolaiti ME, Jogalekar MP, Chen H, Richards AL, Kongpracha P, Bali S, Montano M, Rosecrans J, Matthay M, Togo T, Gonciarz RL, Gopalkrishnan S, Neitz RJ, Krogan NJ, Swaney DL, Shoichet BK, Ott M, Renslo AR, Ashworth A, Fraser JS
CD40 Drives Tumor Growth in Non-Small Cell Lung Cancer via non-canonical Immune-Independent Mechanisms.
1. Cancer Lett - published November 1, 2025
2. Liu Y, Prasad CB, Qiu Z, Singh D, Bean N, Honne S, Zhang X, Yan C, Li Z, Kim B, Wang QE, Zhang J
Repulsions instruct synaptic partner matching in an olfactory circuit.
1. Nature - published November 1, 2025
2. Li Z, Lyu C, Xu C, Hu Y, Luginbuhl DJ, Caspi-Lebovic AB, Priest JM, Özkan E, Luo L
Structural Biology Enabling Drug Discovery.
1. J Med Chem - published November 1, 2025
2. Heppner DE, Bigi-Botterill SV, Riley AP, Chibale K, Lindsley CW
Doxorubicin recognition and transport by the MATE multidrug transporter NorM from Vibrio cholerae.
1. J Mol Biol - published November 1, 2025
2. Hsieh PY, Romane K, Kowal J, Locher KP, van Veen HW
Structural basis of regulated N-glycosylation at the secretory translocon.
1. Nature - published November 1, 2025
2. Yamsek M, Ma M, Jha R, Wan Y, Li Q, Zhong F, DeLong K, Ji Z, Rohatgi R, Keenan RJ
CpoS-Inc interactions facilitate host cell modulation during Chlamydia trachomatis infection.
1. Infect Immun - published November 1, 2025
2. Tijerina X, Jabeena C, Faris R, Xu Z, Smith P, Schnicker NJ, Weber MM
Enrichment-Free, Targeted Covalent Drug Discovery in Live Cells.
1. ACS Chem Biol - published November 1, 2025
2. Dong KD, Yu Q, Yang K, Wong BJ, Yue H, Fu S, Whitehouse RL, Fischer ES, Gygi SP
Temporal photoproximity labeling of ligand-activated EGFR neighborhoods using MultiMap.
1. Nat Chem Biol - published November 1, 2025
2. Lin Z, Ngo W, Chou YT, Wu H, Susa KJ, Jun YW, Bivona TG, Doudna JA, Wells JA
[Rehospitalizations after tracheostomy tube insertion in pediatrics: a quantitative retrospective cross-sectional study].
1. Pflege - published November 1, 2025
2. Caflisch A, Waldboth V, Seliner B
Frame-Shifted Synthesis of Oligoheterocycles as a Platform for Molecular Design.
1. Angew Chem Int Ed Engl - published November 1, 2025
2. Bastick KAC, Griesbach CE, Huang BZ, Cordell MJ, Ou YD, Aspuru-Guzik A, Yudin AK
Filament formation and NAD processing by noncanonical human FAM118 sirtuins.
1. Nat Struct Mol Biol - published November 1, 2025
2. Baretić D, Missoury S, Patel K, Martinez M, Coste F, Zhu K, Smith R, Kopasz AG, Lu Y, Bigot N, Chapuis C, Riou R, Đukić N, Goffinont S, Pressoir V, Patačko S, Timinszky G, Delarue M, Castaing B, Ahel D, Mikoč A, Huet S, Ahel I, Suskiewicz MJ
Recurrent evolution of selfishness from an essential tRNA synthetase in Caenorhabditis tropicalis.
1. Nat Ecol Evol - published November 1, 2025
2. Tikanova P, Ross JJ, Hagmüller A, Pühringer F, Pliota P, Krogull D, Stefania V, Hunold M, Koreshova A, Koller A, Ostapchuk I, Okweri J, Gokcezade J, Duchek P, Dong G, Ben-David E, Burga A
Author Correction: Redox regulation of m(6)A methyltransferase METTL3 in β-cells controls the innate immune response in type 1 diabetes.
1. Nat Cell Biol - published November 1, 2025
2. De Jesus DF, Zhang Z, Brown NK, Li X, Xiao L, Hu J, Gaffrey MJ, Fogarty G, Kahraman S, Wei J, Basile G, Rana TM, Mathews C, Powers AC, Parent AV, Atkinson MA, Dhe-Paganon S, Eizirik DL, Qian WJ, He C, Kulkarni RN
Structures of human organellar SPFH protein complexes.
1. Nat Commun - published November 1, 2025
2. Gao J, Sherpa D, Kupko N, Chino H, Zeng J, Shao S
Structure-based discovery of sulfamoyl-ethyl-4-oxo-3,4-dihydro-7H-pyrrolo[2,3-d]pyrimidine amides and sulfonamides as potent B-Cell Lymphoma 6 (BCL6)-BTB inhibitors.
1. Bioorg Med Chem Lett - published November 1, 2025
2. Mamai A, Morshed MM, Prakesch M, Poda G, Subramanian P, Chau AM, Watson IDG, Joseph B, Wilson B, Morin JA, Marcellus R, Theriault B, Mohammed M, Abibi A, Chan M, Kiyota T, Aman A, Subramaniam R, Strathdee C, Winston J, O'Meara J, Kuntz D, Pomroy N, Uehling D, Isaac M, Privé GG, Al-Awar R
Oral delivery of Silybin via HA-DOCA-functionalized zein nanocolloids for amelioration of liver fibrosis.
1. Int J Biol Macromol - published November 1, 2025
2. Wen L, Wu J, Zhao Y, Sun Z, Liang C, Liu X, Luo J, Li X
Dynamics driving the precursor in NifEN scaffold during nitrogenase FeMo-cofactor assembly.
1. Nat Chem Biol - published November 1, 2025
2. Payá Tormo L, Nguyen TQ, Fyfe C, Basbous H, Dobrzyńska K, Echavarri-Erasun C, Martin L, Caserta G, Legrand P, Thorn A, Amara P, Schoehn G, Cherrier MV, Rubio LM, Nicolet Y
Degrons and degradation signals beyond short linear motifs.
1. Nat Chem Biol - published November 1, 2025
2. Wang B, Zheng N
Novel Wide-Spectrum Virucidal Lipid Nanoparticles.
1. Small - published November 1, 2025
2. Martins YA, Bondeelle L, Zwygart AC, de Lima TM, Souza JP, Tee HK, Chahud F, Neto EA, Stellacci F, Lopez RFV, Tapparel C
Pharmacological suppression of lactate mitigates postoperative cognitive dysfunction.
1. Exp Neurol - published November 1, 2025
2. Wang W, Song W, Gong P, Bu X, Zhang L, Zhao B
CD21 primes extrafollicular differentiation of autoreactive B cells in a TLR7-driven lupus model.
1. Sci Immunol - published November 1, 2025
2. Zhu DY, Maurer DP, Castrillon C, Deng Y, Mohamed FAN, Ma M, Tang D, Min-Debartolo J, Higginson-Scott N, Buhlmann J, Schmidt AG, Lingwood D, Carroll MC
Essential and dispensable domains of DivIVA for walled growth in filamentous Actinomycetota.
1. Open Biol - published November 1, 2025
2. Lubbers M, Bajramović B, Ongenae V, Willemse J, de Bruin D, Mulder N, Zhang L, Vriesendorp B, Barona-Gomez F, Briegel A, van Wezel GP, Flärdh K, Claessen D
ALLOSTERIC REGULATION OF PROSTAGLANDIN ENDOPEROXIDE H(2) SYNTHASES.
1. J Biol Chem - published November 1, 2025
2. Dong L, Malkowski MG
Structural Insights into De Novo Promoter Escape by Mycobacterium tuberculosis RNA Polymerase.
1. Nat Commun - published November 1, 2025
2. Brewer J, Delbeau M, Zoullas WB, Darst SA, Campbell EA
Physical and functional interaction of Lrrc56 and Odad3 is required for deployment of axonemal dyneins in vertebrate multiciliated cells.
1. Dis Model Mech - published November 1, 2025
2. Reyes-Nava NG, Lee C, Papoulas O, Hong J, Marcotte EM, Wallingford JB
William J. Rutter 1927-2025.
1. Nat Biotechnol - published November 1, 2025
2. Craik CS
Design and synthesis of novel 4-aryl-2-benzoyl-imidazoles as colchicine binding site inhibitors.
1. Eur J Med Chem - published November 1, 2025
2. Albadari N, Xie Y, Wang Q, Miller DJ, Gruntz JQ, Oldham ML, Chen H, Ma D, Wu Z, Miller DD, Li W
PCNA is a nucleotide exchange factor for the clamp loader ATPase complex.
1. Proc Natl Acad Sci U S A - published November 1, 2025
2. Pajak J, Landeck JT, Liu X, Anand K, Litvak S, Kelch BA
Oligomeric cystatin C supports the immunosuppressive activity of myeloid cells through interaction with inhibitory receptors.
1. Signal Transduct Target Ther - published November 1, 2025
2. Zhang C, He Y, Liu X, Xie J, Fang M, Yang X, Huang R, Lou Q, Li B, Gupta A, Lewis C, Diamond MI, Zhang N, An Z, Zhang CC
Spermatozoa lacking TEX51 display hypofertility and defects in morphology.
1. Commun Biol - published November 1, 2025
2. Dupuis S, Le Beulze M, Vance TDR, Pierre R, Lee JE, Ziyyat A, Barbaux S
MicroRNA-142 improves IL1RAP CAR-T cell activity in acute myeloid leukemia.
1. J Hematol Oncol - published November 1, 2025
2. Harada K, Zhao D, Park M, Chen F, Xu Y, Zhang Y, Zhou Y, Parcutela B, Jewel Y, Munoz A, Amanam I, Nguyen LXT, Chen J, Ghoda L, Forman SJ, Williams JC, Zhang B, Marcucci G
Monkeypox Virus Is Inhibited by Nucleoside Analogues Including the Acyclic Phosphonates Adefovir and Tenofovir In Vitro.
1. J Med Virol - published November 1, 2025
2. Lee J, Zhang H, Boggs EA, Kilcullen J, Moriarty M, Du Y, Fu H, Lan S, Hutson CL, Satheshkumar PS, Tedbury PR, Sarafianos SG
Magellon - an extensible platform for cryo-EM data visualization, management and processing.
1. IUCrJ - published November 1, 2025
2. Khoshbin B, Damodar P, Garje RR, Schotanus FH, Nair N, Wei L, Schäfer JH, Lander GC, Cianfrocco MA, Stagg SM
Prefusion structure, evasion and neutralization of HSV-1 glycoprotein B.
1. Nat Microbiol - published November 1, 2025
2. Roark RS, Schaub AJ, Shi W, Wang M, Bahna FA, Becker JE, Biju A, Chong S, Du H, Guo Y, Hong H, Katsamba PS, Mannepalli SM, Olia AS, Ou L, Rubin SK, Sabo Y, Suleiman M, Wells ML, Zhang B, Cheng C, Glasgow A, Ho DD, Huang Y, Pierson TC, Rawi R, Zhou T, Shapiro L, Kwong PD
Conformational regulation of two essential activators of bacterial cell elongation.
1. Proc Natl Acad Sci U S A - published November 1, 2025
2. Gilman MSA, Shlosman I, Guerra DDS, Domecillo M, Fivenson EM, Bourett C, Bernhardt TG, Polizzi NF, Loparo JJ, Kruse AC
Sticking around: σ factor dynamics and implications for transcription elongation.
1. Proc Natl Acad Sci U S A - published November 1, 2025
2. Mooney RA, Landick R
High-affinity omalizumab variants with optimized disruptive potency prevent anaphylaxis in vivo.
1. J Allergy Clin Immunol - published November 1, 2025
2. Brigger D, Guntern P, Pennington LF, van Brummelen R, Jardetzky TS, Eggel A
Publisher Correction: Radiation-induced amphiregulin drives tumour metastasis.
1. Nature - published November 1, 2025
2. Piffkó A, Yang K, Panda A, Heide J, Tesak K, Wen C, Zawieracz K, Wang L, Naccasha EZ, Bugno J, Fu Y, Chen D, Donle L, Lengyel E, Tilley DG, Mack M, Rock RS, Chmura SJ, Vokes EE, He C, Pitroda SP, Liang HL, Weichselbaum RR
A Structural Perspective on Insect Gustatory Receptors.
1. Chem Senses - published November 1, 2025
2. Gomes JV, Reilly RA, Butterwick JA
Glycan-reactive antibodies isolated from human HIV-1 vaccine trial participants show broad pathogen cross-reactivity.
1. J Virol - published November 1, 2025
2. Jamieson PJ, Shen X, Abu-Shmais AA, Wasdin PT, Janowska K, Edwards RJ, Scapellato G, Bukenya M, Bass LE, Richardson SI, Manamela NP, Liu S, Barr M, Adams L, Paola Velez-Castro C, McCarthy C, Alexander CA, Gillespie RA, Mimms J, Suryadevara N, Sornberger TA, Zost SJ, Parks R, Flaherty S, Janke AK, Howard BN, Suresh YP, Ruprecht RM, Crowe JE Jr, Carnhan RH, Bailey JR, Kanekiyo M, Lingwood D, Haynes BF, Moore PL, Bonami RH, Tomaras GD, Archarya P, Montefiori DC, Kalams SA, Lu S, Georgiev IS
Zero-shot segmentation using embeddings from a protein language model identifies functional regions in the human proteome.
1. PLoS Comput Biol - published November 1, 2025
2. Sangster AG, Dufault C, Qu H, Le D, Forman-Kay JD, Moses AM
Alterations in Cardiovascular Parameters in 5xFAD Murine Model.
1. Cell Biochem Funct - published November 1, 2025
2. Marshall AG, Stephens D, Neikirk K, Masenga SK, Shao B, Crabtree A, Vue Z, Beasley HK, Garza-Lopez E, Scudese E, Rodriguez BI, Le H, Damo S, Taffet GE, Ochayi OM, McMillan R, Afolabi JM, Exil V, Oliver A, Sharma V, Martin P, Gaye A, Harris C, Tomeau B, Bell L, Hamilton M, Gillyard T, Webster R, Jackson M, Prakash P, Frierson S, Dash C, Mungai M, Kirabo A, Gaddy JA, Wandira N, Hinton A Jr, Reddy AK
A composite motif in calcimembrin/C16orf74 dictates multimeric dephosphorylation by calcineurin.
1. Nat Commun - published November 1, 2025
2. Bradburn DA, Reis JC, Moreno RY, Qayyum S, Viennet T, Arthanari H, Cyert MS
ONECUT2: A Validated Drug Target and Lineage Plasticity Driver in Prostate Cancer and Other Malignancies.
1. Endocr Relat Cancer - published November 1, 2025
2. Freeman MR, Perez LM, Yang Q, Qian C, Murali R, Rotinen M, Posadas EM, Di Vizio D, Freedland SJ, You S
Breaking Barriers: Respiratory Viral Strategies Targeting the Host's Nuclear Pore Complex and Nuclear Transport Pathways.
1. Mol Biol Cell - published November 1, 2025
2. Udi Y, Aitchison JD, Rout MP, Obado S
Cryo-EM structure of bacteriophage Bas63 reveals structural conservation and diversity in the Felixounavirus genus.
1. Sci Adv - published November 1, 2025
2. Hodgkinson-Bean J, Ayala R, McJarrow-Keller K, Cassin L, Rutter GL, Crowe AJM, Wolf M, Bostina M