Member Publications

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25 Member Publications for April

Previous Month

Single-molecule dissection of CFTR folding defects and pharmacological rescue.
1. Proc Natl Acad Sci U S A - published April 7, 2026
2. Kim SA, Levring J, Chen J, Yoon TY
Structures of folding intermediates on BAM show diverse substrates fold by a conserved mechanism.
1. Proc Natl Acad Sci U S A - published April 7, 2026
2. Thomson BD, Marquez MD, Rawson S, Dos Santos TMA, Harrison SC, Kahne D
Leveraging Kinase Drugs for Neurosciences: Discovery of Selective, CNS-Penetrant Reversible Bruton's Tyrosine Kinase Inhibitors as Therapeutics for Neuroinflammation.
1. J Med Chem - published April 7, 2026
2. Hopkins BT, Marx IE, Vandeveer HG, Nevalainen M, Basile R, Bajrami B, Choi CK, Grater RJ, Gu C, Hoemberger M, Kadakia E, Kapadnis SK, Liu Y, Ma B, Magee T, Metrick CM, Mingueneau M, Muste CA, Parker Harp CR, Prince RJ, Santoro JC, Schulz J, Sciabola S, Tang H, Wang T, Meissner R, Bohnert T
Charged molecular glue discovery enabled by targeted degron display.
1. Nat Chem Biol - published April 6, 2026
2. Zhuang Z, Byun WS, Chrustowicz J, Kozicka Z, Li VL, Abeja DM, Donovan KA, Sepic S, You I, Słabicki M, Fischer ES, Hinshaw SM, Ebert BL, Schulman BA, Gray NS
DPY30 is an epigenetic decoupler linking replication stress to immunoediting in pancreatic cancer.
1. Cancer Res - published April 6, 2026
2. Citron F, Cecchetto L, Granato E, Ho IL, Liu Z, Balestrieri C, Yen EY, Perelli L, Zhang L, Castillo Montanez LA, Dyke CA, Shah R, Attanasio S, Srinivasan S, Roy S, Kwon HJ, Blazanin N, Chen Y, Chen KC, Chen Z, Scognamiglio I, Pham N, Jiang S, Pan J, Leung CS, Wang L, Gao S, Carugo A, Wang H, Yao W, Tonon G, Bonini MC, Zal MA, Jeter C, Tainer JA, Heffernan TP, Giuliani V, Lissanu Y, Genovese G, Di Pilato M, Viale A, Schlacher K, Draetta GF
Mechanisms of human mitochondrial leaderless mRNA translation initiation.
1. Nat Commun - published April 4, 2026
2. Shen S, Xu Y, Kober DL, Wang J
Multimerizing transcription factors FOXP3 and AIRE as chromatin architectural regulators.
1. Nat Immunol - published April 3, 2026
2. Leng F, Huoh YS, Hur S
Nonlinear stiffness of NompC gating spring and its implication in mechanotransduction.
1. Sci Adv - published April 3, 2026
2. Wang Y, Jin P, Kumar A, Jan L, Cheng Y, Jan YN, Zhang Y
Claudins interact with LILRB immune inhibitory receptors to promote myeloid immunosuppression in cancer.
1. Sci Immunol - published April 3, 2026
2. Liu X, Huang R, Ku Z, Xie J, Chen H, He Y, Lou Q, Zhang C, Yang X, Lewis C, Homsi J, Gupta A, Dong L, Chen K, Tu A, Du L, Yu H, Hu Q, Fang M, Li B, Khan AEMA, Simith C, John S, Xu L, Zhang N, An Z, Zhang CC
Molecular mechanisms of immune evasion by host protein glycosylation of a bacterial immunogen used in nucleic acid vaccines.
1. J Biol Chem - published April 2, 2026
2. Cinar MS, Adams TM, Nawaz Z, Demir ES, Demirturk ME, Keelaghan AP, Nazaar SM, Roberts BR, Ozdilek A, Avci FY
Intratumoral T(reg) cell ablation elicits NK cell-mediated control of CD8 T cell-resistant tumors.
1. Sci Immunol - published April 1, 2026
2. Zhang C, Chien C, Jurgaitytė E, Sakiyama K, Bockman A, Jo Y, Lee S, Silveria S, Andrews E, Mende A, Zhang L, Garcia KC, Wagner A, DuPage M, Raulet D
Mechanism of lipid-dependent cold sensitivity in a model ion channel.
1. Nat Commun - published April 1, 2026
2. Li CC, Nimigean CM
SRC-mediated phosphorylation of UBC9 regulates inflammatory and metabolic signaling in alcohol-associated liver disease.
1. Sci Adv - published April 1, 2026
2. Chandla S, Lim Y, Floris A, Mazarei M, Yang X, Tsuchiya T, Dagar M, Darmawan A, Justo M, Murali R, Gangi A, Tomasi I, Mavila N, Ramani K, Tomasi ML
Cetacean coronavirus spikes highlight S glycoprotein structural plasticity.
1. PLoS Pathog - published April 1, 2026
2. Hulswit RJG, Shamorkina TM, van der Lee J, Rosman F, Wetzels LS, van Kuppeveld FJM, Snijder J, Bosch BJ, Hurdiss DL
Pulmonary neuroendocrine cell-derived exosomes regulate iron homeostasis and oxidative stress in lung neurons.
1. Sci Adv - published April 1, 2026
2. Thakur A, Zhang K, Chen J, Mei S, Chen J, Verdiell A, Jacobs E, Mulder L, Whitford A, Iyaswamy A, Chen YW, Cliffe A, Esser-Kahn A, Chen B, Lian Q, Solway J, Xing S, Chen HJ
Structure basis for C-C chemokine receptor 4 modulation by orthosteric and allosteric antagonists.
1. Proc Natl Acad Sci U S A - published April 1, 2026
2. Zhou N, Wang R, Chen B, Qi X
Antagonism by the type VI secretion system of Bacteroides fragilis is controlled by a TetR family regulator and released small molecule.
1. Proc Natl Acad Sci U S A - published April 1, 2026
2. Tuzlak L, Pappas TE, Coyne MJ, Sheahan ML, Burgo V, Rice PA, Comstock LE
Structural and mechanistic basis of ADAR1-mediated RNA editing and immune regulation.
1. Cell Insight - published April 1, 2026
2. Deng X, Elsharkawy M, Gao Y
Automated workflows for strategy computation and data collection at synchrotron beamlines.
1. Acta Crystallogr D Struct Biol - published April 1, 2026
2. Fogh RH, Keller P, Flensburg C, Vonrhein C, Paciorek W, Carter L, Bricogne G
Glucocorticoids elevate clear cell renal cell carcinoma sensitivity to HIF-2α inhibitors by suppressing H4K12 lactylation.
1. Signal Transduct Target Ther - published April 1, 2026
2. Zhang K, He L, Wang Y, Qin S, Yu C, Zheng E, Zhang Z, Xu Y, Chen X, Liu Y, Liu X, Guan S, Xia L, Suo F, Pei F, Du J, Su Y, Li Y, Wu Y, Zhou X, Zhou J, Cai L, Tang X, Zhang Z, Shang Y, Zhang Q, Gong K, Sun L
A µ-opioid receptor superagonist analgesic with minimal adverse effects.
1. Nature - published April 1, 2026
2. Gomez JL, Ventriglia EN, Frangos ZJ, Sulima A, Robertson MJ, Sacco MD, Budinich RC, Giosan IM, Xie T, Solis O, Tischer AE, Bossert JM, Caldwell KE, Bonbrest H, Essmann A, Garçon-Poca ZM, Choi S, Noya MR, Limiac F, Arce A, Glatfelter GC, Robinson M, Chen L, Mullarkey AA, Brademan DR, Enten G, Dunne W, Quiroz C, Schoenborn I, Lee CB, Rais R, Holt DP, Dannals RF, Shi L, Hüttenhain R, Ferré S, Kiyatkin E, Bonaventura J, Shaham Y, Zachariou V, Baumann MH, Skiniotis G, Rice KC, Michaelides M
Multiplexed antigen panel analysis identifies B cell phenotype and receptor genetic contributions to antibody breadth.
1. Immunity - published April 1, 2026
2. Wirz OF, Kotagiri P, Haraguchi E, Röltgen K, Hunter M, Craig E, Afaghani J, Lee JY, Nielsen SCA, Hoh RA, Pursell T, Arunachalam PS, Manohar M, Chang I, Schuetz JP, Lam B, Fernandes A, Do E, Smith D, Ha B, Liao L, Najeeb J, Otrelo-Cardoso AR, Ho C, Wohlstadter JN, Sigal GB, Jardetzky TS, Scott SA, Van Slyck S, Davis MM, Pulendran B, Minshull J, Pinsky BA, Nadeau KC, Niemann CU, Yang F, Boyd SD
A luciferase-based hRBC-NSG mouse model to evaluate anti-CelTOS transmission-blocking antibodies against P. falciparum.
1. Malar J - published April 1, 2026
2. Xu S, Roth AE, Thomson-Luque R, Salinas N, Barnes S, Herman C, Tolia NH, Adams JH
CGM23 corresponds to a pan-coronavirus lipopeptide inhibitor potently inhibiting virion fusion.
1. iScience - published April 1, 2026
2. Matsui Y, Schwarzer R, Montano M, Helmy EW, Suryawanshi RK, Taha TY, Wang Y, Angel Y, Adler M, Sassano MF, Jo H, Tarran R, Ott M, Greene WC
Proteome-wide prediction of interactions between structured domains and peptide motifs reveals functionally coherent subnetworks.
1. Proc Natl Acad Sci U S A - published April 1, 2026
2. Saha A, Tang CL, Murray D, Honig B