an automated structure solution pipeline built around the heavy-atom refinement and phasing program SHARP, the substructure determination program SHELXD, the density modification program SOLOMON and the model building programs BUCCANEER and ARP/wARP. It allows fully automated structure solution by experimental phasing, from merged reflection data to an initial model, without any user intervention.
SHARP/autoSHARP is installed on our server at Harvard Medical School. Please email firstname.lastname@example.org to gain access.
autoSHARP is also available from the command-line or through the CCP4i interface if users install the software in their home lab. This software in included for all academic labs automatically, but users must request a license at https://www.globalphasing.com/sharp/ then copy the license file to /programs/local/autosharp/autosharp_license. Once the license file is in place the software will start working.
G. Bricogne, C. Vonrhein, C. Flensburg, M. Schiltz, and W. Paciorek. 2003. Generation, representation and flow of phase information in structure determination: recent developments in and around SHARP 2.0. Acta Crystallogr D Biol Crystallogr. 59(11): 2023-2030.
(Note: Use this citation for SHARP.)
C. Vonrhein, E. Blanc, P. Roversi, and G. Bricogne. 2007. Automated structure solution with autoSHARP. Methods Mol Biol. 364: 215-230.
(Note: Use this citation for autoSHARP.)
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Eric Blanc, Gerard Bricogne, Claus Flensberg, Wlodek Paciorek, Pietro Roversi, Marc Schiltz, Clemens Vonrhein.