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CCP4

  • Description

    (Collaborative Computational Project, Number 4) a collection of programs and associated data and software libraries used for macromolecular structure determination by X-ray crystallography.

    All SBGrid members must complete the CCP4 license and return the executed document directly to The Science and Technology Facilities Council as specified on the CCP4 licensing page located here: http://www.ccp4.ac.uk/ccp4license.php.

  • Usage Notes

    Subprograms webinars are also available at the following links:

    BLEND https://www.youtube.com/watch?v=icEaCTiqW60.
    CRANK2 https://www.youtube.com/watch?v=aLvrIsaUW1k.
    AMPLE https://www.youtube.com/watch?v=_gLbqAIUuZM.

  • Primary Citation*

    M. D. Winn, C. C. Ballard, K. D. Cowtan, E. J. Dodson, P. Emsley, P. R. Evans, R. M. Keegan, E. B. Krissinel, A. G. Leslie, A. McCoy, S. J. McNicholas, G. N. Murshudov, N. S. Pannu, E. A. Potterton, H. R. Powell, R. J. Read, A. Vagin, and K. S. Wilson. 2011. Overview of the CCP4 suite and current developments. Acta crystallographica Section D: Biological crystallography. 67(4): 235-242.

    • *Full citation information available through

    Citation Note

    Any publication arising from use of the CCP4 software suite should include both references to the specific programs used (see subprograms) and the primary citation for the CCP4 suite. Additional citations can be found on the CCP4 website

  • Categories

    Crystallography, Structural Biology

  • Default Versions

    Linux 64 7.0
    OS X INTEL 7.0

  • Other Available Versions

    Linux 32 5.0.2_1
    Linux 32 6.0.2
    Linux 32 6.1.13
    Linux 32 6.2.0
    Linux 32 6.3.0
    Linux 64 6.5
    OS X INTEL 6.5
    OS X INTEL 6.5.020
    powermac 5.0.2
    powermac 6.0.2
    powermac 6.1.13
    powermac 6.1.3

  • Developers

    Eleanor Dodson, Phil Evans, Ronan Keegan, Randy Read.

  • Tales

    Unstructured

    Unstructured

    Sit down in front of a newly installed copy of CCP4 today, and you will find approximately 250 computer programs for solving protein structures. The list of programs includes several with catchy names, such as beast (for molecular replacement), dimple (for ligand identification in difference maps), crank (for experimental phasing) and buccaneer (for model building), and some cryptic, such as seqwt and npo. Nearly two dozen applications support file manipulations and format conversions. Still more are riders-on, either deprecated or unsupported.

    The seeming mishmash is so by design. "CCP4 has always been a very loose collaboration," says Phil Evans, a structural biologist at the Medical Research Council Laboratory of Molecular Biology in Cambridge, UK, and one of the earliest members of the team that created CCP4 in 1979 ...

    Read More.
    Stop, Collaborate and Listen

    Stop, Collaborate and Listen

    Back in the mid-1970s, the British government funded several collaborative computing projects. Among them (14 in all) was Collaborative Computing Project 4, known by structural biologists as CCP4. "The idea was that computers were so expensive, you'd probably only have one in London and maybe one in Manchester, so everybody would have to collaborate on using the hardware and developing software," says Eleanor Dodson, Professor Emeritus at the York Structural Biology Laboratory and a contributor to CCP4 from the beginning.

    By then, Dodson had already been involved in structural biology for over a decade. With just a bachelor's degree, she began working in the lab of protein crystallography pioneer and Nobel Laureate Dorothy Hodgkin, who solved structures for penicillin, Vitamin B12 and insulin. "Dorothy needed a ...

    Read More.
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