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104 Member Publications for February 2020

Heme peroxidase-Trapping intermediates by cryo neutron crystallography.
1. Methods Enzymol - published February 26, 2020
2. Kwon H, Schrader TE, Ostermann A, Blakeley MP, Raven EL, Moody PCE
Preface.
1. Methods Enzymol - published February 26, 2020
2. Moody PCE
Probiotics and oxytocin nasal spray as neuro-social-behavioral interventions for patients with autism spectrum disorders: a pilot randomized controlled trial protocol.
1. Pilot Feasibility Stud - published February 22, 2020
2. Kong XJ, Liu J, Li J, Kwong K, Koh M, Sukijthamapan P, Guo JJ, Sun ZJ, Song Y
Human parainfluenza virus type 3 expressing the respiratory syncytial virus pre-fusion F protein modified for virion packaging yields protective intranasal vaccine candidates.
1. PLoS One - published February 12, 2020
2. Liu X, Liang B, Liu X, Amaro-Carambot E, Surman S, Kwong PD, Graham BS, Collins PL, Munir S
Structure of an active human histone pre-mRNA 3'-end processing machinery.
1. Science - published February 7, 2020
2. Sun Y, Zhang Y, Aik WS, Yang XC, Marzluff WF, Walz T, Dominski Z, Tong L
Multi-state design of flexible proteins predicts sequences optimal for conformational change.
1. PLoS Comput Biol - published February 7, 2020
2. Sauer MF, Sevy AM, Crowe JE Jr, Meiler J
Molecular mechanisms of acquired resistance to MET tyrosine kinase inhibitors in patients with MET exon 14 mutant NSCLC.
1. Clin Cancer Res - published February 7, 2020
2. Recondo G, Bahcall M, Spurr LF, Che J, Ricciuti B, Leonardi GC, Lo YC, Li YY, Lamberti G, Nguyen T, Milan MSD, Venkatraman D, Umeton R, Paweletz CP, Albayrak A, Cherniack AD, Price KS, Fairclough SR, Nishino M, Sholl LM, Oxnard GR, Janne PA, Awad MM
Structural dynamics of the human COP9 signalosome revealed by cross-linking mass spectrometry and integrative modeling.
1. Proc Natl Acad Sci U S A - published February 7, 2020
2. Gutierrez C, Chemmama IE, Mao H, Yu C, Echeverria I, Block SA, Rychnovsky SD, Zheng N, Sali A, Huang L
Water as a good solvent for unfolded proteins: Folding and collapse are fundamentally different.
1. J Mol Biol - published February 7, 2020
2. Clark PL, Plaxco KW, Sosnick TR
Characterization of the c10orf76-PI4KB complex and its necessity for Golgi PI4P levels and enterovirus replication.
1. EMBO Rep - published February 5, 2020
2. McPhail JA, Lyoo H, Pemberton JG, Hoffmann RM, van Elst W, Strating JRPM, Jenkins ML, Stariha JTB, Powell CJ, Boulanger MJ, Balla T, van Kuppeveld FJM, Burke JE
Influences of Nanoparticles Characteristics on the Cellular Responses: The Example of Iron Oxide and Macrophages.
1. Nanomaterials (Basel) - published February 5, 2020
2. Dalzon B, Torres A, Reymond S, Gallet B, Saint-Antonin F, Collin-Faure V, Moriscot C, Fenel D, Schoehn G, Aude-Garcia C, Rabilloud T
Reducing Aspergillus fumigatus Virulence through Targeted Dysregulation of the Conidiation Pathway.
1. mBio - published February 4, 2020
2. Stewart JIP, Fava VM, Kerkaert JD, Subramanian AS, Gravelat FN, Lehoux M, Howell PL, Cramer RA, Sheppard DC
Experimental Phasing of MicroED Data Using Radiation Damage.
1. Structure - published February 4, 2020
2. Martynowycz MW, Hattne J, Gonen T
Mammalian Retromer Is an Adaptable Scaffold for Cargo Sorting from Endosomes.
1. Structure - published February 4, 2020
2. Kendall AK, Xie B, Xu P, Wang J, Burcham R, Frazier MN, Binshtein E, Wei H, Graham TR, Nakagawa T, Jackson LP
Allosteric Activation of PI3Kα Results in Dynamic Access to Catalytically Competent Conformations.
1. Structure - published February 4, 2020
2. Chakrabarti M, Gabelli SB, Amzel LM
Reaction of Vinyl Aziridines with Arynes: Synthesis of Benzazepines and Branched Allyl Fluorides.
1. Chemistry - published February 3, 2020
2. Kaldas SJ, Kran E, Mück-Lichtenfeld C, Yudin AK, Studer A
Exocyst structural changes associated with activation of tethering downstream of Rho/Cdc42 GTPases.
1. J Cell Biol - published February 3, 2020
2. Rossi G, Lepore D, Kenner L, Czuchra AB, Plooster M, Frost A, Munson M, Brennwald P
The full-length structure of Thermus scotoductus OLD defines the ATP hydrolysis properties and catalytic mechanism of Class 1 OLD family nucleases.
1. Nucleic Acids Res - published February 3, 2020
2. Schiltz CJ, Adams MC, Chappie JS
RNA polymerase mutations cause cephalosporin resistance in clinical Neisseria gonorrhoeae isolates.
1. Elife - published February 3, 2020
2. Palace SG, Wang Y, Rubin DHF, Welsh MA, Mortimer TD, Cole K, Eyre DW, Walker S, Grad YH
A thermophilic phage uses a small terminase protein with a fixed helix-turn-helix geometry.
1. J Biol Chem - published February 3, 2020
2. Hayes JA, Hilbert BJ, Gaubitz C, Stone NP, Kelch BA
Potent Zika and dengue cross-neutralizing antibodies induced by Zika vaccination in a dengue-experienced donor.
1. Nat Med - published February 3, 2020
2. Dussupt V, Sankhala RS, Gromowski GD, Donofrio G, De La Barrera RA, Larocca RA, Zaky W, Mendez-Rivera L, Choe M, Davidson E, McCracken MK, Brien JD, Abbink P, Bai H, Bryan AL, Bias CH, Berry IM, Botero N, Cook T, Doria-Rose NA, Escuer AGI, Frimpong JA, Geretz A, Hernandez M, Hollidge BS, Jian N, Kabra K, Leggat DJ, Liu J, Pinto AK, Rutvisuttinunt W, Setliff I, Tran U, Townsley S, Doranz BJ, Rolland M, McDermott AB, Georgiev IS, Thomas R, Robb ML, Eckels KH, Barranco E, Koren M, Smith DR, Jarman RG, George SL, Stephenson KE, Barouch DH, Modjarrad K, Michael NL, Joyce MG, Krebs SJ
HSF1 phase transition mediates stress adaptation and cell fate decisions.
1. Nat Cell Biol - published February 3, 2020
2. Gaglia G, Rashid R, Yapp C, Joshi GN, Li CG, Lindquist SL, Sarosiek KA, Whitesell L, Sorger PK, Santagata S
Neuronal L-Type Calcium Channel Signaling to the Nucleus Requires a Novel CaMKIIα-Shank3 Interaction.
1. J Neurosci - published February 3, 2020
2. Perfitt TL, Wang X, Dickerson MT, Stephenson JR, Nakagawa T, Jacobson DA, Colbran RJ
Analysis of a Therapeutic Antibody Cocktail Reveals Determinants for Cooperative and Broad Ebolavirus Neutralization.
1. Immunity - published February 3, 2020
2. Gilchuk P, Murin CD, Milligan JC, Cross RW, Mire CE, Ilinykh PA, Huang K, Kuzmina N, Altman PX, Hui S, Gunn BM, Bryan AL, Davidson E, Doranz BJ, Turner HL, Alkutkar T, Flinko R, Orlandi C, Carnahan R, Nargi R, Bombardi RG, Vodzak ME, Li S, Okoli A, Ibeawuchi M, Ohiaeri B, Lewis GK, Alter G, Bukreyev A, Saphire EO, Geisbert TW, Ward AB, Crowe JE Jr
Metabolite therapy guided by liquid biopsy proteomics delays retinal neurodegeneration.
1. EBioMedicine - published February 3, 2020
2. Wert KJ, Velez G, Kanchustambham VL, Shankar V, Evans LP, Sengillo JD, Zare RN, Bassuk AG, Tsang SH, Mahajan VB
DHHC20 Palmitoyl-Transferase Reshapes the Membrane to Foster Catalysis.
1. Biophys J - published February 2, 2020
2. Stix R, Song J, Banerjee A, Faraldo-Gómez JD
Structure and Mechanism of a Cyclic Trinucleotide-Activated Bacterial Endonuclease Mediating Bacteriophage Immunity.
1. Mol Cell - published February 2, 2020
2. Lau RK, Ye Q, Birkholz EA, Berg KR, Patel L, Mathews IT, Watrous JD, Ego K, Whiteley AT, Lowey B, Mekalanos JJ, Kranzusch PJ, Jain M, Pogliano J, Corbett KD
Clickable Galactose Analogues for Imaging Glycans in Developing Zebrafish.
1. ACS Chem Biol - published February 2, 2020
2. Daughtry JL, Cao W, Ye J, Baskin JM
POLARIS: Path of Least Action Analysis on Energy Landscapes.
1. J Chem Inf Model - published February 2, 2020
2. Seitz E, Frank J
Protein-Protein Modeling Using Cryo-EM Restraints.
1. Methods Mol Biol - published February 2, 2020
2. Trellet M, van Zundert G, Bonvin AMJJ
Comparison of Cross-Regulation by Different OTUB1:E2 Complexes.
1. Biochemistry - published February 2, 2020
2. Que LT, Morrow ME, Wolberger C
Benzothiourea Derivatives Target the Secretory Pathway of the Human Fungal Pathogen Cryptococcus neoformans.
1. ACS Infect Dis - published February 2, 2020
2. Beattie SR, Schnicker NJ, Murante T, Kettimuthu K, Williams NS, Gakhar L, Krysan DJ
X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release.
1. Nat Commun - published February 2, 2020
2. Gotfryd K, Boesen T, Mortensen JS, Khelashvili G, Quick M, Terry DS, Missel JW, LeVine MV, Gourdon P, Blanchard SC, Javitch JA, Weinstein H, Loland CJ, Nissen P, Gether U
Angiotensin and biased analogs induce structurally distinct active conformations within a GPCR.
1. Science - published February 2, 2020
2. Wingler LM, Skiba MA, McMahon C, Staus DP, Kleinhenz ALW, Suomivuori CM, Latorraca NR, Dror RO, Lefkowitz RJ, Kruse AC
Biochemical Analysis of a Sugar 4,6-Dehydratase from Acanthamoeba polyphaga Mimivirus.
1. Protein Sci - published February 2, 2020
2. Ferek JD, Thoden JB, Holden HM
New Frontiers in Drug Discovery: Academia Meets Industry at the International Helmholtz Drug Discovery Conference (HDDC).
1. ChemMedChem - published February 2, 2020
2. Göttlicher M, Sattler M, Brönstrup M
Preclinical Development of a Fusion Peptide Conjugate as an HIV Vaccine Immunogen.
1. Sci Rep - published February 2, 2020
2. Ou L, Kong WP, Chuang GY, Ghosh M, Gulla K, O'Dell S, Varriale J, Barefoot N, Changela A, Chao CW, Cheng C, Druz A, Kong R, McKee K, Rawi R, Sarfo EK, Schön A, Shaddeau A, Tsybovsky Y, Verardi R, Wang S, Wanninger TG, Xu K, Yang GJ, Zhang B, Zhang Y, Zhou T, VRC Production Program., Arnold FJ, Doria-Rose NA, Lei QP, Ryan ET, Vann WF, Mascola JR, Kwong PD
Re-examining how Munc13-1 facilitates opening of syntaxin-1.
1. Protein Sci - published February 2, 2020
2. Magdziarek M, Bolembach AA, Stepien KP, Quade B, Liu X, Rizo J
What Will Computational Modeling Approaches Have to Say in the Era of Atomistic Cryo-EM Data?
1. J Chem Inf Model - published February 2, 2020
2. Fraser JS, Lindorff-Larsen K, Bonomi M
Navigating the structure of COMPASS.
1. Elife - published February 2, 2020
2. Luger K, Markert JW
The photo-catalysed thiol-ene reaction: a new tag to yield fast, selective and irreversible paramagnetic tagging of proteins.
1. Chemphyschem - published February 2, 2020
2. Denis M, Softley C, Giuntini S, Gentili M, Ravera E, Parigi G, Fragai M, Popowicz G, Sattler M, Luchinat C, Cerofolini L, Nativi C
Aedes aegypti Odorant Binding Protein 22 selectively binds fatty acids through a conformational change in its C-terminal tail.
1. Sci Rep - published February 2, 2020
2. Wang J, Murphy EJ, Nix JC, Jones DNM
Agonist-selective recruitment of engineered protein probes and of GRK2 by opioid receptors in living cells.
1. Elife - published February 2, 2020
2. Stoeber M, Jullié D, Li J, Chakraborty S, Majumdar S, Lambert NA, Manglik A, von Zastrow M
Structure and physiological function of the human KCNQ1 channel voltage sensor intermediate state.
1. Elife - published February 2, 2020
2. Taylor KC, Kang PW, Hou P, Yang ND, Kuenze G, Smith JA, Shi J, Huang H, White KM, Peng D, George AL, Meiler J, McFeeters RL, Cui J, Sanders CR
Family-wide Structural and Biophysical Analysis of Binding Interactions among Non-clustered δ-Protocadherins.
1. Cell Rep - published February 2, 2020
2. Harrison OJ, Brasch J, Katsamba PS, Ahlsen G, Noble AJ, Dan H, Sampogna RV, Potter CS, Carragher B, Honig B, Shapiro L
Revisiting the Relationship Between Hospital Case Volume and Outcomes in Abdominally Based Free Flap Breast Reconstruction.
1. Ann Plast Surg - published February 2, 2020
2. Chattha A, Chen AD, Muste J, Cohen JB, Lee BT, Lin SJ
Sensing Actin Dynamics through Adherens Junctions.
1. Cell Rep - published February 2, 2020
2. Indra I, Troyanovsky RB, Shapiro L, Honig B, Troyanovsky SM
Mechanism of Crosstalk between the LSD1 Demethylase and HDAC1 Deacetylase in the CoREST Complex.
1. Cell Rep - published February 2, 2020
2. Song Y, Dagil L, Fairall L, Robertson N, Wu M, Ragan TJ, Savva CG, Saleh A, Morone N, Kunze MBA, Jamieson AG, Cole PA, Hansen DF, Schwabe JWR
Dynamics at the serine loop underlie differential affinity of cryptochromes for CLOCK:BMAL1 to control circadian timing.
1. Elife - published February 2, 2020
2. Fribourgh JL, Srivastava A, Sandate CR, Michael AK, Hsu PL, Rakers C, Nguyen LT, Torgrimson MR, Parico GCG, Tripathi S, Zheng N, Lander GC, Hirota T, Tama F, Partch CL
Mind the gap: Expediting gender parity in MD-PhD admissions.
1. JCI Insight - published February 2, 2020
2. Rowell TR, Redd RA, Neuberg DS, Walensky LD
Metabolic Changes in Synaptosomes in an Animal Model of Schizophrenia Revealed by 1H and 1H,13C NMR Spectroscopy.
1. Metabolites - published February 2, 2020
2. Barnett BR, Fathi F, Falco Cobra P, Yi SY, Anderson JM, Eghbalnia HR, Markley JL, Yu JJ
NMT1 and NMT2 are lysine myristoyltransferases regulating the ARF6 GTPase cycle.
1. Nat Commun - published February 2, 2020
2. Kosciuk T, Price IR, Zhang X, Zhu C, Johnson KN, Zhang S, Halaby SL, Komaniecki GP, Yang M, DeHart CJ, Thomas PM, Kelleher NL, Fromme JC, Lin H
Mutational signature in colorectal cancer caused by genotoxic pks+ E. coli.
1. Nature - published February 2, 2020
2. Pleguezuelos-Manzano C, Puschhof J, Huber AR, van Hoeck A, Wood HM, Nomburg J, Gurjao C, Manders F, Dalmasso G, Stege PB, Paganelli FL, Geurts MH, Beumer J, Mizutani T, Miao Y, van der Linden R, van Elst S, Genomics England Research Consortium., Garcia KC, Top J, Willems RJL, Giannakis M, Bonnet R, Quirke P, Meyerson M, Cuppen E, van Boxtel R, Clevers H
Publisher Correction: Cryo-EM structure of the human MLL1 core complex bound to the nucleosome.
1. Nat Commun - published February 2, 2020
2. Park SH, Ayoub A, Lee YT, Xu J, Kim H, Zheng W, Zhang B, Sha L, An S, Zhang Y, Cianfrocco MA, Su M, Dou Y, Cho US
Structures of the ATP-fueled ClpXP proteolytic machine bound to protein substrate.
1. Elife - published February 2, 2020
2. Fei X, Bell TA, Jenni S, Stinson BM, Baker TA, Harrison SC, Sauer RT
Estimating the Allele-Specific Expression of SNVs From 10× Genomics Single-Cell RNA-Sequencing Data.
1. Genes (Basel) - published February 2, 2020
2. M PN, Liu H, Bousounis P, Spurr L, Alomran N, Ibeawuchi H, Sein J, Reece-Stremtan D, Horvath A
Structural analyses of the group A flavin-dependent monooxygenase PieE reveal a sliding FAD cofactor conformation bridging OUT and IN conformations.
1. J Biol Chem - published February 2, 2020
2. Manenda MS, Picard MÈ, Zhang L, Cyr N, Zhu X, Barma J, Pascal JM, Couture M, Zhang C, Shi R
Structure of the processive human Pol δ holoenzyme.
1. Nat Commun - published February 2, 2020
2. Lancey C, Tehseen M, Raducanu VS, Rashid F, Merino N, Ragan TJ, Savva CG, Zaher MS, Shirbini A, Blanco FJ, Hamdan SM, De Biasio A
Correction: McCarthy, C.; et al. Developing Picornaviruses for Cancer Therapy. Cancers 2019, 11, 685.
1. Cancers (Basel) - published February 2, 2020
2. McCarthy C, Jayawardena N, Burga LN, Bostina M
Structures of Gα Proteins in Complex with Their Chaperone Reveal Quality Control Mechanisms.
1. Cell Rep - published February 2, 2020
2. Seven AB, Hilger D, Papasergi-Scott MM, Zhang L, Qu Q, Kobilka BK, Tall GG, Skiniotis G
FBXL5 Regulates IRP2 Stability in Iron Homeostasis via an Oxygen-Responsive [2Fe2S] Cluster.
1. Mol Cell - published February 2, 2020
2. Wang H, Shi H, Rajan M, Canarie ER, Hong S, Simoneschi D, Pagano M, Bush MF, Stoll S, Leibold EA, Zheng N
Systematic Review of Patient-Reported Outcomes following Surgical Treatment of Lymphedema.
1. Cancers (Basel) - published February 2, 2020
2. Coriddi M, Dayan J, Sobti N, Nash D, Goldberg J, Klassen A, Pusic A, Mehrara B
Sensing Living Bacteria in Vivo Using d-Alanine-Derived 11C Radiotracers.
1. ACS Cent Sci - published February 2, 2020
2. Parker MFL, Luu JM, Schulte B, Huynh TL, Stewart MN, Sriram R, Yu MA, Jivan S, Turnbaugh PJ, Flavell RR, Rosenberg OS, Ohliger MA, Wilson DM
Preclinical testing of AAV9-PHP.B for transgene expression in the non-human primate cochlea.
1. Hear Res - published February 2, 2020
2. Ivanchenko MV, Hanlon KS, Devine MK, Tenneson K, Emond F, Lafond JF, Kenna MA, Corey DP, Maguire CA
Viral vectors for gene delivery to the inner ear.
1. Hear Res - published February 2, 2020
2. Maguire CA, Corey DP
LightDock goes information-driven.
1. Bioinformatics - published February 1, 2020
2. Roel-Touris J, Bonvin AMJJ, Jiménez-García B
Longitudinal Antibody Responses in People Who Inject Drugs Infected With Similar Human Immunodeficiency Virus Strains.
1. J Infect Dis - published February 1, 2020
2. Redd AD, Doria-Rose NA, Weiner JA, Nason M, Seivers M, Schmidt SD, Laeyendecker O, Martens C, Bruno D, Keele BF, Raju N, Georgiev IS, Lamers SL, Astemborski J, Kirk GD, Mascola JR, Ackerman ME, Mehta SH, Quinn TC
Comprehensive Transcriptome Profiling of Cryptic CBFA2T3-GLIS2 Fusion-Positive AML Defines Novel Therapeutic Options: A COG and TARGET Pediatric AML Study.
1. Clin Cancer Res - published February 1, 2020
2. Smith JL, Ries RE, Hylkema T, Alonzo TA, Gerbing RB, Santaguida MT, Eidenschink Brodersen L, Pardo L, Cummings CL, Loeb KR, Le Q, Imren S, Leonti AR, Gamis AS, Aplenc R, Kolb EA, Farrar JE, Triche TJ Jr, Nguyen C, Meerzaman D, Loken MR, Oehler VG, Bolouri H, Meshinchi S
Evolutionary classification of CRISPR-Cas systems: a burst of class 2 and derived variants.
1. Nat Rev Microbiol - published February 1, 2020
2. Makarova KS, Wolf YI, Iranzo J, Shmakov SA, Alkhnbashi OS, Brouns SJJ, Charpentier E, Cheng D, Haft DH, Horvath P, Moineau S, Mojica FJM, Scott D, Shah SA, Siksnys V, Terns MP, Venclovas Č, White MF, Yakunin AF, Yan W, Zhang F, Garrett RA, Backofen R, van der Oost J, Barrangou R, Koonin EV
Integrated Stress Response Inhibitor Reverses Sex-Dependent Behavioral and Cell-Specific Deficits after Mild Repetitive Head Trauma.
1. J Neurotrauma - published February 1, 2020
2. Krukowski K, Nolan A, Frias ES, Grue K, Becker M, Ureta G, Delgado L, Bernales S, Sohal VS, Walter P, Rosi S
Unhooking of an interstrand cross-link at DNA fork structures by the DNA glycosylase NEIL3.
1. DNA Repair (Amst) - published February 1, 2020
2. Imani Nejad M, Housh K, Rodriguez AA, Haldar T, Kathe S, Wallace SS, Eichman BF, Gates KS
Structure-Guided Design of a Peptide Lock for Modular Peptide Binders.
1. ACS Chem Biol - published February 1, 2020
2. Ernst P, Zosel F, Reichen C, Nettels D, Schuler B, Plückthun A
Elongation factor-Tu can repetitively engage aminoacyl-tRNA within the ribosome during the proofreading stage of tRNA selection.
1. Proc Natl Acad Sci U S A - published February 1, 2020
2. Morse JC, Girodat D, Burnett BJ, Holm M, Altman RB, Sanbonmatsu KY, Wieden HJ, Blanchard SC
Structural Elucidation of Peptide Binding to KLHL-12, a Substrate Specific Adapter Protein in a Cul3-Ring E3 Ligase Complex.
1. Biochemistry - published February 1, 2020
2. Zhao B, Payne WG, Sai J, Lu Z, Olejniczak ET, Fesik SW
Replication-Based Rearrangements Are a Common Mechanism for SNCA Duplication in Parkinson's Disease.
1. Mov Disord - published February 1, 2020
2. Seo SH, Bacolla A, Yoo D, Koo YJ, Cho SI, Kim MJ, Seong MW, Kim HJ, Kim JM, Tainer JA, Park SS, Kim JY, Jeon B
De novo protein design, a retrospective.
1. Q Rev Biophys - published February 1, 2020
2. Korendovych IV, DeGrado WF
Human PLD structures enable drug design and characterization of isoenzyme selectivity.
1. Nat Chem Biol - published February 1, 2020
2. Metrick CM, Peterson EA, Santoro JC, Enyedy IJ, Murugan P, Chen T, Michelsen K, Cullivan M, Spilker KA, Kumar PR, May-Dracka TL, Chodaparambil JV
Development of a covalent inhibitor of gut bacterial bile salt hydrolases.
1. Nat Chem Biol - published February 1, 2020
2. Adhikari AA, Seegar TCM, Ficarro SB, McCurry MD, Ramachandran D, Yao L, Chaudhari SN, Ndousse-Fetter S, Banks AS, Marto JA, Blacklow SC, Devlin AS
Retroelement origins of pre-mRNA splicing.
1. Wiley Interdiscip Rev RNA - published February 1, 2020
2. Haack DB, Toor N
Dynamic surveillance of tamoxifen-resistance in ER-positive breast cancer by CAIX-targeted ultrasound imaging.
1. Cancer Med - published February 1, 2020
2. Li Y, Chen X, Zhou Z, Li Q, Westover KD, Wang M, Liu J, Zhang S, Zhang J, Xu B, Wei X
The cryo-EM structure of a pannexin 1 reveals unique motifs for ion selection and inhibition.
1. Elife - published February 1, 2020
2. Michalski K, Syrjanen JL, Henze E, Kumpf J, Furukawa H, Kawate T
The small molecule BI-2852 induces a nonfunctional dimer of KRAS.
1. Proc Natl Acad Sci U S A - published February 1, 2020
2. Tran TH, Alexander P, Dharmaiah S, Agamasu C, Nissley DV, McCormick F, Esposito D, Simanshu DK, Stephen AG, Balius TE
Basis for metabolite-dependent Cullin-RING ligase deneddylation by the COP9 signalosome.
1. Proc Natl Acad Sci U S A - published February 1, 2020
2. Lin H, Zhang X, Liu L, Fu Q, Zang C, Ding Y, Su Y, Xu Z, He S, Yang X, Wei X, Mao H, Cui Y, Wei Y, Zhou C, Du L, Huang N, Zheng N, Wang T, Rao F
Structure of an Inner Membrane Protein Required for PhoPQ-Regulated Increases in Outer Membrane Cardiolipin.
1. mBio - published February 1, 2020
2. Fan J, Petersen EM, Hinds TR, Zheng N, Miller SI
Reply to Tran et al.: Dimeric KRAS protein-protein interaction stabilizers.
1. Proc Natl Acad Sci U S A - published February 1, 2020
2. Kessler D, Gollner A, Gmachl M, Mantoulidis A, Martin LJ, Zoephel A, Mayer M, Covini D, Fischer S, Gerstberger T, Gmaschitz T, Goodwin C, Greb P, Häring D, Hela W, Hoffmann J, Karolyi-Oezguer J, Knesl P, Kornigg S, Koegl M, Kousek R, Lamarre L, Moser F, Munico-Martinez S, Peinsipp C, Phan J, Rinnenthal J, Sai J, Salamon C, Scherbantin Y, Schipany K, Schnitzer R, Schrenk A, Sharps B, Siszler G, Sun Q, Waterson A, Wolkerstorfer B, Zeeb M, Pearson M, Fesik SW, McConnell DB
Physiological and Pathological Roles of RAD52 at DNA Replication Forks.
1. Cancers (Basel) - published February 1, 2020
2. Malacaria E, Honda M, Franchitto A, Spies M, Pichierri P
HCMV glycoprotein B nucleoside-modified mRNA vaccine elicits antibody responses with greater durability and breadth than MF59-adjuvanted gB protein immunization.
1. J Virol - published February 1, 2020
2. Nelson CS, Jenks JA, Pardi N, Goodwin M, Roark H, Edwards W, McLellan JS, Pollara J, Weissman D, Permar SR
Modulation of post-traumatic immune response using the IL-1 receptor antagonist anakinra for improved visual outcomes.
1. J Neurotrauma - published February 1, 2020
2. Evans LP, Woll AW, Wu S, Todd BP, Hehr NN, Hedberg-Buenz A, Anderson MG, Newell EA, Ferguson PJ, Mahajan VB, Harper MM, Bassuk AG
Miro: A molecular switch at the center of mitochondrial regulation.
1. Protein Sci - published February 1, 2020
2. Eberhardt EL, Ludlam AV, Tan Z, Cianfrocco MA
A nanobody targeting the LIN28:let-7 interaction fragment of TUT4 blocks uridylation of let-7.
1. Proc Natl Acad Sci U S A - published February 1, 2020
2. Yu C, Wang L, Rowe RG, Han A, Ji W, McMahon C, Baier AS, Huang YC, Marion W, Pearson DS, Kruse AC, Daley GQ, Wu H, Sliz P
Polynuclear Ruthenium Amines Inhibit K2P Channels via a "Finger in the Dam" Mechanism.
1. Cell Chem Biol - published February 1, 2020
2. Pope L, Lolicato M, Minor DL Jr
Dominant mutations of the Notch ligand Jagged1 cause peripheral neuropathy.
1. J Clin Invest - published February 1, 2020
2. Sullivan JM, Motley WW, Johnson JO, Aisenberg WH, Marshall KL, Barwick KE, Kong L, Huh JS, Saavedra-Rivera PC, McEntagart MM, Marion MH, Hicklin LA, Modarres H, Baple EL, Farah MH, Zuberi AR, Lutz CM, Gaudet R, Traynor BJ, Crosby AH, Sumner CJ
Shared genetic risk between eating disorder- and substance-use-related phenotypes: Evidence from genome-wide association studies.
1. Addict Biol - published February 1, 2020
2. Munn-Chernoff MA, Johnson EC, Chou YL, Coleman JRI, Thornton LM, Walters RK, Yilmaz Z, Baker JH, Hübel C, Gordon S, Medland SE, Watson HJ, Gaspar HA, Bryois J, Hinney A, Leppä VM, Mattheisen M, Ripke S, Yao S, Giusti-Rodríguez P, Hanscombe KB, Adan RAH, Alfredsson L, Ando T, Andreassen OA, Berrettini WH, Boehm I, Boni C, Boraska Perica V, Buehren K, Burghardt R, Cassina M, Cichon S, Clementi M, Cone RD, Courtet P, Crow S, Crowley JJ, Danner UN, Davis OSP, de Zwaan M, Dedoussis G, Degortes D, DeSocio JE, Dick DM, Dikeos D, Dina C, Dmitrzak-Weglarz M, Docampo E, Duncan LE, Egberts K, Ehrlich S, Escaramís G, Esko T, Estivill X, Farmer A, Favaro A, Fernández-Aranda F, Fichter MM, Fischer K, Föcker M, Foretova L, Forstner AJ, Forzan M, Franklin CS, Gallinger S, Giegling I, Giuranna J, Gonidakis F, Gorwood P, Gratacos Mayora M, Guillaume S, Guo Y, Hakonarson H, Hatzikotoulas K, Hauser J, Hebebrand J, Helder SG, Herms S, Herpertz-Dahlmann B, Herzog W, Huckins LM, Hudson JI, Imgart H, Inoko H, Janout V, Jiménez-Murcia S, Julià A, Kalsi G, Kaminská D, Karhunen L, Karwautz A, Kas MJH, Kennedy JL, Keski-Rahkonen A, Kiezebrink K, Kim YR, Klump KL, Knudsen GPS, La Via MC, Le Hellard S, Levitan RD, Li D, Lilenfeld L, Lin BD, Lissowska J, Luykx J, Magistretti PJ, Maj M, Mannik K, Marsal S, Marshall CR, Mattingsdal M, McDevitt S, McGuffin P, Metspalu A, Meulenbelt I, Micali N, Mitchell K, Monteleone AM, Monteleone P, Nacmias B, Navratilova M, Ntalla I, O'Toole JK, Ophoff RA, Padyukov L, Palotie A, Pantel J, Papezova H, Pinto D, Rabionet R, Raevuori A, Ramoz N, Reichborn-Kjennerud T, Ricca V, Ripatti S, Ritschel F, Roberts M, Rotondo A, Rujescu D, Rybakowski F, Santonastaso P, Scherag A, Scherer SW, Schmidt U, Schork NJ, Schosser A, Seitz J, Slachtova L, Slagboom PE, Slof-Op't Landt MCT, Slopien A, Sorbi S, Świątkowska B, Szatkiewicz JP, Tachmazidou I, Tenconi E, Tortorella A, Tozzi F, Treasure J, Tsitsika A, Tyszkiewicz-Nwafor M, Tziouvas K, van Elburg AA, van Furth EF, Wagner G, Walton E, Widen E, Zeggini E, Zerwas S, Zipfel S, Bergen AW, Boden JM, Brandt H, Crawford S, Halmi KA, Horwood LJ, Johnson C, Kaplan AS, Kaye WH, Mitchell J, Olsen CM, Pearson JF, Pedersen NL, Strober M, Werge T, Whiteman DC, Woodside DB, Grove J, Henders AK, Larsen JT, Parker R, Petersen LV, Jordan J, Kennedy MA, Birgegård A, Lichtenstein P, Norring C, Landén M, Mortensen PB, Polimanti R, McClintick JN, Adkins AE, Aliev F, Bacanu SA, Batzler A, Bertelsen S, Biernacka JM, Bigdeli TB, Chen LS, Clarke TK, Degenhardt F, Docherty AR, Edwards AC, Foo JC, Fox L, Frank J, Hack LM, Hartmann AM, Hartz SM, Heilmann-Heimbach S, Hodgkinson C, Hoffmann P, Hottenga JJ, Konte B, Lahti J, Lahti-Pulkkinen M, Lai D, Ligthart L, Loukola A, Maher BS, Mbarek H, McIntosh AM, McQueen MB, Meyers JL, Milaneschi Y, Palviainen T, Peterson RE, Ryu E, Saccone NL, Salvatore JE, Sanchez-Roige S, Schwandt M, Sherva R, Streit F, Strohmaier J, Thomas N, Wang JC, Webb BT, Wedow R, Wetherill L, Wills AG, Zhou H, Boardman JD, Chen D, Choi DS, Copeland WE, Culverhouse RC, Dahmen N, Degenhardt L, Domingue BW, Frye MA, Gäbel W, Hayward C, Ising M, Keyes M, Kiefer F, Koller G, Kramer J, Kuperman S, Lucae S, Lynskey MT, Maier W, Mann K, Männistö S, Müller-Myhsok B, Murray AD, Nurnberger JI, Preuss U, Räikkönen K, Reynolds MD, Ridinger M, Scherbaum N, Schuckit MA, Soyka M, Treutlein J, Witt SH, Wodarz N, Zill P, Adkins DE, Boomsma DI, Bierut LJ, Brown SA, Bucholz KK, Costello EJ, de Wit H, Diazgranados N, Eriksson JG, Farrer LA, Foroud TM, Gillespie NA, Goate AM, Goldman D, Grucza RA, Hancock DB, Harris KM, Hesselbrock V, Hewitt JK, Hopfer CJ, Iacono WG, Johnson EO, Karpyak VM, Kendler KS, Kranzler HR, Krauter K, Lind PA, McGue M, MacKillop J, Madden PAF, Maes HH, Magnusson PKE, Nelson EC, Nöthen MM, Palmer AA, Penninx BWJH, Porjesz B, Rice JP, Rietschel M, Riley BP, Rose RJ, Shen PH, Silberg J, Stallings MC, Tarter RE, Vanyukov MM, Vrieze S, Wall TL, Whitfield JB, Zhao H, Neale BM, Wade TD, Heath AC, Montgomery GW, Martin NG, Sullivan PF, Kaprio J, Breen G, Gelernter J, Edenberg HJ, Bulik CM, Agrawal A
The structure of the cohesin ATPase elucidates the mechanism of SMC-kleisin ring opening.
1. Nat Struct Mol Biol - published February 1, 2020
2. Muir KW, Li Y, Weis F, Panne D
Impact of the Protein Data Bank on antineoplastic approvals.
1. Drug Discov Today - published February 1, 2020
2. Westbrook JD, Soskind R, Hudson BP, Burley SK
Urinary tract infections: microbial pathogenesis, host-pathogen interactions and new treatment strategies.
1. Nat Rev Microbiol - published February 1, 2020
2. Klein RD, Hultgren SJ
Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation.
1. Science - published February 1, 2020
2. Wrapp D, Wang N, Corbett KS, Goldsmith JA, Hsieh CL, Abiona O, Graham BS, McLellan JS
An Evolutionary Insertion in the Mxra8 Receptor-Binding Site Confers Resistance to Alphavirus Infection and Pathogenesis.
1. Cell Host Microbe - published February 1, 2020
2. Kim AS, Zimmerman O, Fox JM, Nelson CA, Basore K, Zhang R, Durnell L, Desai C, Bullock C, Deem SL, Oppenheimer J, Shapiro B, Wang T, Cherry S, Coyne CB, Handley SA, Landis MJ, Fremont DH, Diamond MS
Analysis of asymmetry in lipid and content mixing assays with reconstituted proteoliposomes containing the neuronal SNAREs.
1. Sci Rep - published February 1, 2020
2. Pan YZ, Liu X, Rizo J
Publisher Correction: In vivo structure of the Legionella type II secretion system by electron cryotomography.
1. Nat Microbiol - published February 1, 2020
2. Ghosal D, Kim KW, Zheng H, Kaplan M, Truchan HK, Lopez AE, McIntire IE, Vogel JP, Cianciotto NP, Jensen GJ
Cellular mRNA export factor UAP56 recognizes nucleic acid binding site of influenza virus NP protein.
1. Biochem Biophys Res Commun - published February 1, 2020
2. Morris AK, Wang Z, Ivey AL, Xie Y, Hill PS, Schey KL, Ren Y
Calmodulin Mutations Associated with Heart Arrhythmia: A Status Report.
1. Int J Mol Sci - published February 1, 2020
2. Chazin WJ, Johnson CN
Cryo-EM Structure of the 2019-nCoV Spike in the Prefusion Conformation.
1. bioRxiv - published February 1, 2020
2. Wrapp D, Wang N, Corbett KS, Goldsmith JA, Hsieh CL, Abiona O, Graham BS, McLellan JS
Discovering the anti-cancer potential of non-oncology drugs by systematic viability profiling.
1. Nat Cancer - published February 1, 2020
2. Corsello SM, Nagari RT, Spangler RD, Rossen J, Kocak M, Bryan JG, Humeidi R, Peck D, Wu X, Tang AA, Wang VM, Bender SA, Lemire E, Narayan R, Montgomery P, Ben-David U, Garvie CW, Chen Y, Rees MG, Lyons NJ, McFarland JM, Wong BT, Wang L, Dumont N, O'Hearn PJ, Stefan E, Doench JG, Harrington CN, Greulich H, Meyerson M, Vazquez F, Subramanian A, Roth JA, Bittker JA, Boehm JS, Mader CC, Tsherniak A, Golub TR