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147 Member Publications for February 2019

Mismatch repair deficiency in high-grade meningioma: a rare but recurrent event associated with dramatic immune activation and clinical response to PD-1 blockade.
1. JCO Precis Oncol - published February 26, 2019
2. Dunn IF, Du Z, Touat M, Sisti MB, Wen PY, Umeton R, Dubuc AM, Ducar M, Canoll PD, Severson E, Elvin JA, Ramkissoon SH, Lin JR, Cabrera L, Acevedo B, Sorger PK, Ligon KL, Santagata S, Reardon DA
A phenome-wide association study to discover pleiotropic effects of PCSK9, APOB, and LDLR.
1. NPJ Genom Med - published February 19, 2019
2. Safarova MS, Satterfield BA, Fan X, Austin EE, Ye Z, Bastarache L, Zheng N, Ritchie MD, Borthwick KM, Williams MS, Larson EB, Scrol A, Jarvik GP, Crosslin DR, Leppig K, Rasmussen-Torvik LJ, Pendergrass SA, Sturm AC, Namjou B, Shah AS, Carroll RJ, Chung WK, Wei WQ, Feng Q, Stein CM, Roden DM, Manolio TA, Schaid DJ, Denny JC, Hebbring SJ, de Andrade M, Kullo IJ
Chaperone-Mediated Autophagy Upregulation Rescues Megalin Expression and Localization in Cystinotic Proximal Tubule Cells.
1. Front Endocrinol (Lausanne) - published February 19, 2019
2. Zhang J, He J, Johnson JL, Rahman F, Gavathiotis E, Cuervo AM, Catz SD
Structural Adaptation of Darunavir Analogues against Primary Mutations in HIV-1 Protease.
1. ACS Infect Dis - published February 8, 2019
2. Lockbaum GJ, Leidner F, Rusere LN, Henes M, Kosovrasti K, Nachum GS, Nalivaika EA, Ali A, Yilmaz NK, Schiffer CA
Crystal structures of human lysosomal EPDR1 reveal homology with the superfamily of bacterial lipoprotein transporters.
1. Commun Biol - published February 8, 2019
2. Wei Y, Xiong ZJ, Li J, Zou C, Cairo CW, Klassen JS, Privé GG
Recent Advances in Half-life Extension Strategies for Therapeutic Peptides and Proteins.
1. Curr Pharm Des - published February 8, 2019
2. Tan H, Su W, Zhang W, Wang P, Sattler M, Zou P
PUMILIO hyperactivity drives premature aging of Norad-deficient mice.
1. Elife - published February 8, 2019
2. Kopp F, Elguindy MM, Yalvac ME, Zhang H, Chen B, Gillett FA, Lee S, Sivakumar S, Yu H, Xie Y, Mishra P, Sahenk Z, Mendell JT
Next Generation ERα Inhibitors for Endocrine-Resistant ER+ Breast Cancers.
1. Endocrinology - published February 8, 2019
2. Fanning SW, Greene GL
4-Cyanoindole-2'-deoxyribonucleoside as a Dual Fluorescence and Infrared Probe of DNA Structure and Dynamics.
1. Molecules - published February 8, 2019
2. Ahmed IA, Acharyya A, Eng CM, Rodgers JM, DeGrado WF, Jo H, Gai F
Mechanism of Cross-talk between H2B Ubiquitination and H3 Methylation by Dot1L.
1. Cell - published February 8, 2019
2. Worden EJ, Hoffmann NA, Hicks CW, Wolberger C
The Solution Structure of FUS Bound to RNA Reveals a Bipartite Mode of RNA Recognition with Both Sequence and Shape Specificity.
1. Mol Cell - published February 7, 2019
2. Loughlin FE, Lukavsky PJ, Kazeeva T, Reber S, Hock EM, Colombo M, Von Schroetter C, Pauli P, Cléry A, Mühlemann O, Polymenidou M, Ruepp MD, Allain FH
Mechanistic Insights into the cis- and trans-Acting DNase Activities of Cas12a.
1. Mol Cell - published February 7, 2019
2. Swarts DC, Jinek M
IPSE, a urogenital parasite-derived immunomodulatory protein, ameliorates ifosfamide-induced hemorrhagic cystitis through downregulation of pro-inflammatory pathways.
1. Sci Rep - published February 7, 2019
2. Mbanefo EC, Le L, Zee R, Banskota N, Ishida K, Pennington LF, Odegaard JI, Jardetzky TS, Alouffi A, Falcone FH, Hsieh MH
Seven-enzyme in vitro cascade to (3R)-3-hydroxybutyryl-CoA.
1. Org Biomol Chem - published February 6, 2019
2. Valencia LE, Zhang Z, Cepeda AJ, Keatinge-Clay AT
Blocking HIV-1 infection by chromosomal integrative expression of human CD4 on the surface of Lactobacillus helveticus R0052.
1. J Virol - published February 6, 2019
2. Wei W, Wiggins J, Hu D, Vrbanac V, Bowder D, Mellon M, Tager A, Sodroski J, Xiang SH
Inhibiting APOBEC3 Activity with Single-Stranded DNA Containing 2'-Deoxyzebularine Analogues.
1. Biochemistry - published February 5, 2019
2. Kvach MV, Barzak FM, Harjes S, Schares HAM, Jameson GB, Ayoub AM, Moorthy R, Aihara H, Harris RS, Filichev VV, Harki DA, Harjes E
Recent Structural Insights into Polycomb Repressive Complex 2 Regulation and Substrate Binding.
1. Biochemistry - published February 5, 2019
2. Kasinath V, Poepsel S, Nogales E
The Structure of the SPOP-Pdx1 Interface Reveals Insights into the Phosphorylation-Dependent Binding Regulation.
1. Structure - published February 5, 2019
2. Ostertag MS, Messias AC, Sattler M, Popowicz GM
Mechanism of Enhanced Immature Dengue Virus Attachment to Endosomal Membrane Induced by prM Antibody.
1. Structure - published February 5, 2019
2. Wirawan M, Fibriansah G, Marzinek JK, Lim XX, Ng TS, Sim AYL, Zhang Q, Kostyuchenko VA, Shi J, Smith SA, Verma CS, Anand G, Crowe JE Jr, Bond PJ, Lok SM
The induction of RANKL molecule clustering could stimulate early osteoblast differentiation.
1. Biochem Biophys Res Commun - published February 5, 2019
2. Sone E, Noshiro D, Ikebuchi Y, Nakagawa M, Khan M, Tamura Y, Ikeda M, Oki M, Murali R, Fujimori T, Yoda T, Honma M, Suzuki H, Ando T, Aoki K
How Structural Biologists and the Protein Data Bank Contributed to Recent FDA New Drug Approvals.
1. Structure - published February 5, 2019
2. Westbrook JD, Burley SK
Small molecule ISRIB suppresses the integrated stress response within a defined window of activation.
1. Proc Natl Acad Sci U S A - published February 5, 2019
2. Rabouw HH, Langereis MA, Anand AA, Visser LJ, de Groot RJ, Walter P, van Kuppeveld FJM
Emerging Themes in PDZ Domain Signaling: Structure, Function, and Inhibition.
1. Int Rev Cell Mol Biol - published February 5, 2019
2. Liu X, Fuentes EJ
Delayed inhibition mechanism for secondary channel factor regulation of ribosomal RNA transcription.
1. Elife - published February 5, 2019
2. Stumper SK, Ravi H, Friedman LJ, Mooney RA, Corrêa IR Jnr, Gershenson A, Landick R, Gelles J
Dengue and Zika Virus Cross-Reactive Human Monoclonal Antibodies Protect against Spondweni Virus Infection and Pathogenesis in Mice.
1. Cell Rep - published February 5, 2019
2. Salazar V, Jagger BW, Mongkolsapaya J, Burgomaster KE, Dejnirattisai W, Winkler ES, Fernandez E, Nelson CA, Fremont DH, Pierson TC, Crowe JE Jr, Screaton GR, Diamond MS
Structures in multiple conformations reveal distinct transition metal and proton pathways in an Nramp transporter.
1. Elife - published February 4, 2019
2. Bozzi AT, Zimanyi CM, Nicoludis JM, Lee BK, Zhang CH, Gaudet R
Small-molecule allosteric inhibitors of BAX.
1. Nat Chem Biol - published February 4, 2019
2. Garner TP, Amgalan D, Reyna DE, Li S, Kitsis RN, Gavathiotis E
CasX enzymes comprise a distinct family of RNA-guided genome editors.
1. Nature - published February 4, 2019
2. Liu JJ, Orlova N, Oakes BL, Ma E, Spinner HB, Baney KLM, Chuck J, Tan D, Knott GJ, Harrington LB, Al-Shayeb B, Wagner A, Brötzmann J, Staahl BT, Taylor KL, Desmarais J, Nogales E, Doudna JA
Constrained mutational sampling of amino acids in HIV-1 protease evolution.
1. Mol Biol Evol - published February 4, 2019
2. Boucher JI, Whitfield TW, Dauphin A, Nachum G, Hollins C 3rd, Zeldovich KB, Swanstrom R, Schiffer CA, Luban J, Bolon DNA
Expression and Purification of Calmodulin for NMR and Other Biophysical Applications.
1. Methods Mol Biol - published February 3, 2019
2. Grant BMM, Marshall CB, Ikura M
S100 Proteins in the Innate Immune Response to Pathogens.
1. Methods Mol Biol - published February 3, 2019
2. Kozlyuk N, Monteith AJ, Garcia V, Damo SM, Skaar EP, Chazin WJ
Peptide binding affinity redistributes preassembled repeat protein fragments.
1. Biol Chem - published February 2, 2019
2. Michel E, Plückthun A, Zerbe O
Crystal structures of HpSoj-DNA complexes and the nucleoid-adaptor complex formation in chromosome segregation.
1. Nucleic Acids Res - published February 2, 2019
2. Chu CH, Yen CY, Chen BW, Lin MG, Wang LH, Tang KZ, Hsiao CD, Sun YJ
The molecular mechanism of DHHC protein acyltransferases.
1. Biochem Soc Trans - published February 2, 2019
2. Rana MS, Lee CJ, Banerjee A
Homolog-Selective Degradation as a Strategy to Probe the Function of CDK6 in AML.
1. Cell Chem Biol - published February 2, 2019
2. Brand M, Jiang B, Bauer S, Donovan KA, Liang Y, Wang ES, Nowak RP, Yuan JC, Zhang T, Kwiatkowski N, Müller AC, Fischer ES, Gray NS, Winter GE
Automated Sequence Design of 3D Polyhedral Wireframe DNA Origami with Honeycomb Edges.
1. ACS Nano - published February 2, 2019
2. Jun H, Shepherd TR, Zhang K, Bricker WP, Li S, Chiu W, Bathe M
An Isoprene Lipid-Binding Protein Promotes Eukaryotic Coenzyme Q Biosynthesis.
1. Mol Cell - published February 2, 2019
2. Lohman DC, Aydin D, Von Bank HC, Smith RW, Linke V, Weisenhorn E, McDevitt MT, Hutchins P, Wilkerson EM, Wancewicz B, Russell J, Stefely MS, Beebe ET, Jochem A, Coon JJ, Bingman CA, Dal Peraro M, Pagliarini DJ
Exposing the Nucleation Site in α-Helix Folding: A Joint Experimental and Simulation Study.
1. J Phys Chem B - published February 2, 2019
2. Acharyya A, Ge Y, Wu H, DeGrado WF, Voelz VA, Gai F
BCL::MolAlign: Three-Dimensional Small Molecule Alignment for Pharmacophore Mapping.
1. J Chem Inf Model - published February 2, 2019
2. Brown BP, Mendenhall J, Meiler J
pdb-tools: a swiss army knife for molecular structures.
1. F1000Res - published February 2, 2019
2. Rodrigues JPGLM, Teixeira JMC, Trellet M, Bonvin AMJJ
ELTA: Enzymatic Labeling of Terminal ADP-Ribose.
1. Mol Cell - published February 2, 2019
2. Ando Y, Elkayam E, McPherson RL, Dasovich M, Cheng SJ, Voorneveld J, Filippov DV, Ong SE, Joshua-Tor L, Leung AKL
Insights into Urease Inhibition by N-( n-Butyl) Phosphoric Triamide through an Integrated Structural and Kinetic Approach.
1. J Agric Food Chem - published February 2, 2019
2. Mazzei L, Cianci M, Contaldo U, Ciurli S
Structure-Based Design of N-(5-Phenylthiazol-2-yl)acrylamides as Novel and Potent Glutathione S-Transferase Omega 1 Inhibitors.
1. J Med Chem - published February 2, 2019
2. Dai W, Samanta S, Xue D, Petrunak EM, Stuckey JA, Han Y, Sun D, Wu Y, Neamati N
HCMV trimer- and pentamer-specific antibodies synergize for virus neutralization but do not correlate with congenital transmission.
1. Proc Natl Acad Sci U S A - published February 2, 2019
2. Vanarsdall AL, Chin AL, Liu J, Jardetzky TS, Mudd JO, Orloff SL, Streblow D, Mussi-Pinhata MM, Yamamoto AY, Duarte G, Britt WJ, Johnson DC
Structural, functional, and behavioral insights of dopamine dysfunction revealed by a deletion in SLC6A3.
1. Proc Natl Acad Sci U S A - published February 2, 2019
2. Campbell NG, Shekar A, Aguilar JI, Peng D, Navratna V, Yang D, Morley AN, Duran AM, Galli G, O'Grady B, Ramachandran R, Sutcliffe JS, Sitte HH, Erreger K, Meiler J, Stockner T, Bellan LM, Matthies HJG, Gouaux E, Mchaourab HS, Galli A
Stepwise activation mechanism of the scramblase nhTMEM16 revealed by cryo-EM.
1. Elife - published February 2, 2019
2. Kalienkova V, Clerico Mosina V, Bryner L, Oostergetel GT, Dutzler R, Paulino C
Mps1 regulates spindle morphology through MCRS1 to promote chromosome alignment.
1. Mol Biol Cell - published February 2, 2019
2. Yang H, Zhang F, Huang CJ, Liao J, Han Y, Hao P, Chu Y, Lu X, Li W, Yu H, Kang J
Cryo-EM structures and functional characterization of the murine lipid scramblase TMEM16F.
1. Elife - published February 2, 2019
2. Alvadia C, Lim NK, Clerico Mosina V, Oostergetel GT, Dutzler R, Paulino C
IPSE, a parasite-derived host immunomodulatory protein, is a potential therapeutic for hemorrhagic cystitis.
1. Am J Physiol Renal Physiol - published February 2, 2019
2. Zee RS, Mbanefo EC, Le LH, Pennington LF, Odegaard J, Jardetzky TS, Alouffi A, Akinwale J, Falcone FH, Hsieh MH
The anti-resection activity of the X protein encoded by Hepatitis Virus B.
1. Hepatology - published February 2, 2019
2. Ren L, Zeng M, Tang Z, Li M, Wang X, Xu Y, Weng Y, Wang X, Wang H, Guo L, Zuo B, Wang X, Wang S, Lou J, Tang Y, Mu D, Zheng N, Wu X, Han J, Carr AM, Jeggo P, Liu C
Assembly and cryo-EM structures of RNA-specific measles virus nucleocapsids provide mechanistic insight into paramyxoviral replication.
1. Proc Natl Acad Sci U S A - published February 2, 2019
2. Desfosses A, Milles S, Jensen MR, Guseva S, Colletier JP, Maurin D, Schoehn G, Gutsche I, Ruigrok RWH, Blackledge M
Mutations in sigma 70 transcription factor improves expression of functional eukaryotic membrane proteins in Escherichia coli.
1. Sci Rep - published February 2, 2019
2. Tomatis PE, Schütz M, Umudumov E, Plückthun A
Dimerization of a ubiquitin variant leads to high affinity interactions with a ubiquitin interacting motif.
1. Protein Sci - published February 2, 2019
2. Manczyk N, Veggiani G, Gish GD, Yates BP, Ernst A, Sidhu SS, Sicheri F
Hachimoji DNA and RNA: A genetic system with eight building blocks.
1. Science - published February 2, 2019
2. Hoshika S, Leal NA, Kim MJ, Kim MS, Karalkar NB, Kim HJ, Bates AM, Watkins NE Jr, SantaLucia HA, Meyer AJ, DasGupta S, Piccirilli JA, Ellington AD, SantaLucia J Jr, Georgiadis MM, Benner SA
A conserved genetic interaction between Spt6 and Set2 regulates H3K36 methylation.
1. Nucleic Acids Res - published February 2, 2019
2. Gopalakrishnan R, Marr SK, Kingston RE, Winston F
Structural and functional characterization of the membrane-permeabilizing activity of Nicotiana occidentalis defensin NoD173 and protein engineering to enhance oncolysis.
1. FASEB J - published February 2, 2019
2. Lay FT, Ryan GF, Caria S, Phan TK, Veneer PK, White JA, Kvansakul M, Hulett MD
Optimal therapeutic activity of monoclonal antibodies against chikungunya virus requires Fc-FcγR interaction on monocytes.
1. Sci Immunol - published February 2, 2019
2. Fox JM, Roy V, Gunn BM, Huang L, Edeling MA, Mack M, Fremont DH, Doranz BJ, Johnson S, Alter G, Diamond MS
Electrostatic Steering Enables Flow-Activated von Willebrand Factor to Bind Platelet Glycoprotein, Revealed by Single-Molecule Stretching and Imaging.
1. J Mol Biol - published February 2, 2019
2. Jiang Y, Fu H, Springer TA, Wong WP
Development of dual and selective degraders of cyclin-dependent kinases 4 and 6.
1. Angew Chem Int Ed Engl - published February 2, 2019
2. Jiang B, Wang ES, Donovan KA, Liang Y, Fischer ES, Zhang T, Gray NS
Structure, dynamics and roX2-lncRNA binding of tandem double-stranded RNA binding domains dsRBD1,2 of Drosophila helicase Maleless.
1. Nucleic Acids Res - published February 2, 2019
2. Ankush Jagtap PK, Müller M, Masiewicz P, von Bülow S, Hollmann NM, Chen PC, Simon B, Thomae AW, Becker PB, Hennig J
Respiratory Enterovirus (Like Parainfluenza Virus) Can Cause Chronic Lung Disease If Protection by Airway Epithelial STAT1 Is Lost.
1. J Immunol - published February 2, 2019
2. Zhang Y, Mao D, Keeler SP, Wang X, Wu K, Gerovac BJ, Shornick LL, Agapov EV, Holtzman MJ
Transcriptional gene silencing requires dedicated interaction between HP1 protein Chp2 and chromatin remodeler Mit1.
1. Genes Dev - published February 2, 2019
2. Leopold K, Stirpe A, Schalch T
Using Exploratory Trials to Identify Relevant Contexts and Mechanisms in Complex Electronic Health Interventions: Evaluating the Electronic Patient-Reported Outcome Tool.
1. JMIR Form Res - published February 2, 2019
2. Steele Gray C, Gravesande J, Hans PK, Nie JX, Sharpe S, Loganathan M, Lyons R, Cott C
Author Correction: Structural insights into the activation of metabotropic glutamate receptors.
1. Nature - published February 2, 2019
2. Koehl A, Hu H, Feng D, Sun B, Zhang Y, Robertson MJ, Chu M, Kobilka TS, Laeremans T, Steyaert J, Tarrasch J, Dutta S, Fonseca R, Weis WI, Mathiesen JM, Skiniotis G, Kobilka BK
Structure of the IFNγ receptor complex guides design of biased agonists.
1. Nature - published February 2, 2019
2. Mendoza JL, Escalante NK, Jude KM, Sotolongo Bellon J, Su L, Horton TM, Tsutsumi N, Berardinelli SJ, Haltiwanger RS, Piehler J, Engleman EG, Garcia KC
OAS-RNase L innate immune pathway mediates the cytotoxicity of a DNA-demethylating drug.
1. Proc Natl Acad Sci U S A - published February 2, 2019
2. Banerjee S, Gusho E, Gaughan C, Dong B, Gu X, Holvey-Bates E, Talukdar M, Li Y, Weiss SR, Sicheri F, Saunthararajah Y, Stark GR, Silverman RH
NMR: an essential structural tool for integrative studies of T cell development, pMHC ligand recognition and TCR mechanobiology.
1. J Biomol NMR - published February 2, 2019
2. Mallis RJ, Brazin KN, Duke-Cohan JS, Hwang W, Wang JH, Wagner G, Arthanari H, Lang MJ, Reinherz EL
The IKK-binding domain of NEMO is an irregular coiled coil with a dynamic binding interface.
1. Sci Rep - published February 2, 2019
2. Barczewski AH, Ragusa MJ, Mierke DF, Pellegrini M
Structural Determinants of Isoform Selectivity in PI3K Inhibitors.
1. Biomolecules - published February 2, 2019
2. Miller MS, Thompson PE, Gabelli SB
Improving engraftment of hepatocyte transplantation using alpha-1 antitrypsin as an immune modulator.
1. J Mol Med (Berl) - published February 2, 2019
2. Lee C, Dhawan A, Iansante V, Filippi C, Mitry R, Tang J, Walker S, Fernandez DaCosta R, Sinha S, Hughes RD, Koulmanda M, Fitzpatrick E
Electron cryo-tomography of vestibular hair-cell stereocilia.
1. J Struct Biol - published February 2, 2019
2. Metlagel Z, Krey JF, Song J, Swift MF, Tivol WJ, Dumont RA, Thai J, Chang A, Seifikar H, Volkmann N, Hanein D, Barr-Gillespie PG, Auer M
Characterization, Dynamics, and Mechanism of CXCR4 Antagonists on a Constitutively Active Mutant.
1. Cell Chem Biol - published February 2, 2019
2. Rosenberg EM Jr, Harrison RES, Tsou LK, Drucker N, Humphries B, Rajasekaran D, Luker KE, Wu CH, Song JS, Wang CJ, Murphy JW, Cheng YC, Shia KS, Luker GD, Morikis D, Lolis EJ
FIP200 Claw Domain Binding to p62 Promotes Autophagosome Formation at Ubiquitin Condensates.
1. Mol Cell - published February 2, 2019
2. Turco E, Witt M, Abert C, Bock-Bierbaum T, Su MY, Trapannone R, Sztacho M, Danieli A, Shi X, Zaffagnini G, Gamper A, Schuschnig M, Fracchiolla D, Bernklau D, Romanov J, Hartl M, Hurley JH, Daumke O, Martens S
A reverse TCA cycle 2-oxoacid:ferredoxin oxidoreductase that makes C-C bonds from CO₂.
1. Joule - published February 2, 2019
2. Chen PY, Li B, Drennan CL, Elliott SJ
Endoplasmic Reticulum Network Formation with Xenopus Egg Extracts.
1. Cold Spring Harb Protoc - published February 1, 2019
2. Wang S, Romano FB, Rapoport TA
The Interdependent Activation of Son-of-Sevenless and Ras.
1. Cold Spring Harb Perspect Med - published February 1, 2019
2. Bandaru P, Kondo Y, Kuriyan J
Signaling through non-membrane nuclear phosphoinositide binding proteins in human health and disease.
1. J Lipid Res - published February 1, 2019
2. Bryant JM, Blind RD
The FGFR1 V561M Gatekeeper Mutation Drives AZD4547 Resistance through STAT3 Activation and EMT.
1. Mol Cancer Res - published February 1, 2019
2. Ryan MR, Sohl CD, Luo B, Anderson KS
The Bear Giant-Skipper genome suggests genetic adaptations to living inside yucca roots.
1. Mol Genet Genomics - published February 1, 2019
2. Cong Q, Li W, Borek D, Otwinowski Z, Grishin NV
Rationally derived drug combinations with the novel Mcl-1 inhibitor EU-5346 in breast cancer.
1. Breast Cancer Res Treat - published February 1, 2019
2. Vallet S, Fan F, Malvestiti S, Pecherstorfer M, Sattler M, Schneeweiss A, Schulze-Bergkamen H, Opferman JT, Cardone MH, Jäger D, Podar K
iSEE: Interface structure, evolution, and energy-based machine learning predictor of binding affinity changes upon mutations.
1. Proteins - published February 1, 2019
2. Geng C, Vangone A, Folkers GE, Xue LC, Bonvin AMJJ
How cells exploit tubulin diversity to build functional cellular microtubule mosaics.
1. Curr Opin Cell Biol - published February 1, 2019
2. Roll-Mecak A
Ribosome assembly coming into focus.
1. Nat Rev Mol Cell Biol - published February 1, 2019
2. Klinge S, Woolford JL Jr
Common binding sites for cholesterol and neurosteroids on a pentameric ligand-gated ion channel.
1. Biochim Biophys Acta Mol Cell Biol Lipids - published February 1, 2019
2. Budelier MM, Cheng WWL, Chen ZW, Bracamontes JR, Sugasawa Y, Krishnan K, Mydock-McGrane L, Covey DF, Evers AS
Amorphous Quantum Nanomaterials.
1. Adv Mater - published February 1, 2019
2. Kohle FFE, Hinckley JA, Li S, Dhawan N, Katt WP, Erstling JA, Werner-Zwanziger U, Zwanziger J, Cerione RA, Wiesner UB
Target Engagement and Binding Mode of an Antituberculosis Drug to Its Bacterial Target Deciphered in Whole Living Cells by NMR.
1. Biochemistry - published February 1, 2019
2. Bouvier G, Simenel C, Jang J, Kalia NP, Choi I, Nilges M, Pethe K, Izadi-Pruneyre N
Antibody-Mediated Protective Mechanisms Induced by a Trivalent Parainfluenza Virus-Vectored Ebolavirus Vaccine.
1. J Virol - published February 1, 2019
2. Kimble JB, Malherbe DC, Meyer M, Gunn BM, Karim MM, Ilinykh PA, Iampietro M, Mohamed KS, Negi S, Gilchuk P, Huang K, Wolf YI, Braun W, Crowe JE, Alter G, Bukreyev A
Disulfide bridge formation influences ligand recognition by the ATAD2 bromodomain.
1. Proteins - published February 1, 2019
2. Gay JC, Eckenroth BE, Evans CM, Langini C, Carlson S, Lloyd JT, Caflisch A, Glass KC
A Tandem Mass Spectrometry Sequence Database Search Method for Identification of O-Fucosylated Proteins by Mass Spectrometry.
1. J Proteome Res - published February 1, 2019
2. Swearingen KE, Eng JK, Shteynberg D, Vigdorovich V, Springer TA, Mendoza L, Sather DN, Deutsch EW, Kappe SHI, Moritz RL
Virus and host interactions critical for filoviral RNA synthesis as therapeutic targets.
1. Antiviral Res - published February 1, 2019
2. Basler CF, Krogan NJ, Leung DW, Amarasinghe GK
Design, Validation, and Application of an Enzyme-Coupled Hydrogen Sulfide Detection Assay.
1. Biochemistry - published February 1, 2019
2. Lynch MJ, Crane BR
SCAPER-associated nonsyndromic autosomal recessive retinitis pigmentosa.
1. Am J Med Genet A - published February 1, 2019
2. Jauregui R, Thomas AL, Liechty B, Velez G, Mahajan VB, Clark L, Tsang SH
Structural Evidence for Dimer-Interface-Driven Regulation of the Type II Cysteine Desulfurase, SufS.
1. Biochemistry - published February 1, 2019
2. Dunkle JA, Bruno MR, Outten FW, Frantom PA
The Ebola Viral Protein 35 N-Terminus Is a Parallel Tetramer.
1. Biochemistry - published February 1, 2019
2. Chanthamontri CK, Jordan DS, Wang W, Wu C, Lin Y, Brett TJ, Gross ML, Leung DW
Regulation of Atrial Fibrosis by the Bone.
1. Hypertension - published February 1, 2019
2. Yi Y, Du L, Qin M, Chen XQ, Sun XN, Li C, Du LJ, Liu Y, Liu Y, Sun JY, Tang Z, Xu M, Fang B, Liu X, Duan SZ
Natural helix 9 mutants of PPARγ differently affect its transcriptional activity.
1. Mol Metab - published February 1, 2019
2. Broekema MF, Massink MPG, Donato C, de Ligt J, Schaarschmidt J, Borgman A, Schooneman MG, Melchers D, Gerding MN, Houtman R, Bonvin AMJJ, Majithia AR, Monajemi H, van Haaften GW, Soeters MR, Kalkhoven E
Enabling genetic analysis of diverse bacteria with Mobile-CRISPRi.
1. Nat Microbiol - published February 1, 2019
2. Peters JM, Koo BM, Patino R, Heussler GE, Hearne CC, Qu J, Inclan YF, Hawkins JS, Lu CHS, Silvis MR, Harden MM, Osadnik H, Peters JE, Engel JN, Dutton RJ, Grossman AD, Gross CA, Rosenberg OS
RNA Polymerase Clamp Movement Aids Dissociation from DNA but Is Not Required for RNA Release at Intrinsic Terminators.
1. J Mol Biol - published February 1, 2019
2. Bellecourt MJ, Ray-Soni A, Harwig A, Mooney RA, Landick R
Rapid tilt-series acquisition for electron cryotomography.
1. J Struct Biol - published February 1, 2019
2. Chreifi G, Chen S, Metskas LA, Kaplan M, Jensen GJ
The FKBP12 subunit modifies the long-range allosterism of the ryanodine receptor.
1. J Struct Biol - published February 1, 2019
2. Steele TWE, Samsó M
Structure of the post-translational protein translocation machinery of the ER membrane.
1. Nature - published February 1, 2019
2. Wu X, Cabanos C, Rapoport TA
A Click Chemistry Approach Reveals the Chromatin-Dependent Histone H3K36 Deacylase Nature of SIRT7.
1. J Am Chem Soc - published February 1, 2019
2. Wang WW, Angulo-Ibanez M, Lyu J, Kurra Y, Tong Z, Wu B, Zhang L, Sharma V, Zhou J, Lin H, Gao YQ, Li W, Chua KF, Liu WR
Retro Styles for Vesicle Coats.
1. Biochemistry - published February 1, 2019
2. Hurley JH, Johannes L
Whole-Exome Sequencing Enables a Precision Medicine Approach for Kidney Transplant Recipients.
1. J Am Soc Nephrol - published February 1, 2019
2. Mann N, Braun DA, Amann K, Tan W, Shril S, Connaughton DM, Nakayama M, Schneider R, Kitzler TM, van der Ven AT, Chen J, Ityel H, Vivante A, Majmundar AJ, Daga A, Warejko JK, Lovric S, Ashraf S, Jobst-Schwan T, Widmeier E, Hugo H, Mane SM, Spaneas L, Somers MJG, Ferguson MA, Traum AZ, Stein DR, Baum MA, Daouk GH, Lifton RP, Manzi S, Vakili K, Kim HB, Rodig NM, Hildebrandt F
Crystal Structure of the Transcription Regulator RsrR Reveals a [2Fe-2S] Cluster Coordinated by Cys, Glu, and His Residues.
1. J Am Chem Soc - published February 1, 2019
2. Volbeda A, Martinez MTP, Crack JC, Amara P, Gigarel O, Munnoch JT, Hutchings MI, Darnault C, Le Brun NE, Fontecilla-Camps JC
Insight on mutation-induced resistance to anaplastic lymphoma kinase inhibitor ceritinib from molecular dynamics simulations.
1. Biopolymers - published February 1, 2019
2. He MY, Li WK, Meiler J, Zheng QC, Zhang HX
Human coronaviruses OC43 and HKU1 bind to 9-O-acetylated sialic acids via a conserved receptor-binding site in spike protein domain A.
1. Proc Natl Acad Sci U S A - published February 1, 2019
2. Hulswit RJG, Lang Y, Bakkers MJG, Li W, Li Z, Schouten A, Ophorst B, van Kuppeveld FJM, Boons GJ, Bosch BJ, Huizinga EG, de Groot RJ
The pseudokinase TRIB1 toggles an intramolecular switch to regulate COP1 nuclear export.
1. EMBO J - published February 1, 2019
2. Kung JE, Jura N
Simple High-Resolution NMR Spectroscopy as A Tool in Molecular Biology.
1. FEBS J - published February 1, 2019
2. Mureddu L, Vuister GW
Potent anti-influenza H7 human monoclonal antibody induces separation of hemagglutinin receptor-binding head domains.
1. PLoS Biol - published February 1, 2019
2. Turner HL, Pallesen J, Lang S, Bangaru S, Urata S, Li S, Cottrell CA, Bowman CA, Crowe JE Jr, Wilson IA, Ward AB
A Reader-Based Assay for m⁶A Writers and Erasers.
1. Anal Chem - published February 1, 2019
2. Wiedmer L, Eberle SA, Bedi RK, Śledź P, Caflisch A
Recurrent Loss-of-Function Mutations Reveal Costs to OAS1 Antiviral Activity in Primates.
1. Cell Host Microbe - published February 1, 2019
2. Carey CM, Govande AA, Cooper JM, Hartley MK, Kranzusch PJ, Elde NC
Iterative screen optimization maximizes the efficiency of macromolecular crystallization.
1. Acta Crystallogr F Struct Biol Commun - published February 1, 2019
2. Jones HG, Wrapp D, Gilman MSA, Battles MB, Wang N, Sacerdote S, Chuang GY, Kwong PD, McLellan JS
Molecular basis for AU-rich element recognition and dimerization by the HuR C-terminal RRM.
1. Proc Natl Acad Sci U S A - published February 1, 2019
2. Ripin N, Boudet J, Duszczyk MM, Hinniger A, Faller M, Krepl M, Gadi A, Schneider RJ, Šponer J, Meisner-Kober NC, Allain FH
CD4 receptor diversity in chimpanzees protects against SIV infection.
1. Proc Natl Acad Sci U S A - published February 1, 2019
2. Bibollet-Ruche F, Russell RM, Liu W, Stewart-Jones GBE, Sherrill-Mix S, Li Y, Learn GH, Smith AG, Gondim MVP, Plenderleith LJ, Decker JM, Easlick JL, Wetzel KS, Collman RG, Ding S, Finzi A, Ayouba A, Peeters M, Leendertz FH, van Schijndel J, Goedmakers A, Ton E, Boesch C, Kuehl H, Arandjelovic M, Dieguez P, Murai M, Colin C, Koops K, Speede S, Gonder MK, Muller MN, Sanz CM, Morgan DB, Atencia R, Cox D, Piel AK, Stewart FA, Ndjango JN, Mjungu D, Lonsdorf EV, Pusey AE, Kwong PD, Sharp PM, Shaw GM, Hahn BH
Regulatory cascade involving transcriptional and N-end rule pathways in rice under submergence.
1. Proc Natl Acad Sci U S A - published February 1, 2019
2. Lin CC, Chao YT, Chen WC, Ho HY, Chou MY, Li YR, Wu YL, Yang HA, Hsieh H, Lin CS, Wu FH, Chou SJ, Jen HC, Huang YH, Irene D, Wu WJ, Wu JL, Gibbs DJ, Ho MC, Shih MC
Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS-STING signalling.
1. Nature - published February 1, 2019
2. Eaglesham JB, Pan Y, Kupper TS, Kranzusch PJ
Small Molecule SOS1 Agonists Modulate MAPK and PI3K Signaling via Independent Cellular Responses.
1. ACS Chem Biol - published February 1, 2019
2. Akan DT, Howes JE, Sai J, Arnold AL, Beesetty Y, Phan J, Olejniczak ET, Waterson AG, Fesik SW
Electron cryo-tomography provides insight into procentriole architecture and assembly mechanism.
1. Elife - published February 1, 2019
2. Li S, Fernandez JJ, Marshall WF, Agard DA
Increased drug permeability of a stiffened mycobacterial outer membrane in cells lacking MFS transporter Rv1410 and lipoprotein LprG.
1. Mol Microbiol - published February 1, 2019
2. Hohl M, Remm S, Eskandarian HA, Dal Molin M, Arnold FM, Hürlimann LM, Krügel A, Fantner GE, Sander P, Seeger MA
Fish-hunting cone snail venoms are a rich source of minimized ligands of the vertebrate insulin receptor.
1. Elife - published February 1, 2019
2. Ahorukomeye P, Disotuar MM, Gajewiak J, Karanth S, Watkins M, Robinson SD, Flórez Salcedo P, Smith NA, Smith BJ, Schlegel A, Forbes BE, Olivera B, Hung-Chieh Chou D, Safavi-Hemami H
ACBD3 Is an Essential Pan-enterovirus Host Factor That Mediates the Interaction between Viral 3A Protein and Cellular Protein PI4KB.
1. mBio - published February 1, 2019
2. Lyoo H, van der Schaar HM, Dorobantu CM, Rabouw HH, Strating JRPM, van Kuppeveld FJM
MDM2 and MDM4 are Therapeutic Vulnerabilities in Malignant Rhabdoid Tumors.
1. Cancer Res - published February 1, 2019
2. Howard TP, Arnoff TE, Song MR, Giacomelli AO, Wang X, Hong AL, Dharia NV, Wang S, Vazquez F, Pham MT, Morgan AM, Wachter F, Bird GH, Kugener G, Oberlick EM, Rees MG, Tiv HL, Hwang JH, Walsh KH, Cook A, Krill-Burger JM, Tsherniak A, Gokhale PC, Park PJ, Stegmaier K, Walensky LD, Hahn WC, Roberts CWM
Purification of Functional Human TRP Channels Recombinantly Produced in Yeast.
1. Cells - published February 1, 2019
2. Zhang L, Wang K, Klaerke DA, Calloe K, Lowrey L, Pedersen PA, Gourdon P, Gotfryd K
High frequency of shared clonotypes in human B cell receptor repertoires.
1. Nature - published February 1, 2019
2. Soto C, Bombardi RG, Branchizio A, Kose N, Matta P, Sevy AM, Sinkovits RS, Gilchuk P, Finn JA, Crowe JE Jr
Structure of an archaeal B-family DNA polymerase in complex with a chemically modified nucleotide.
1. Angew Chem Int Ed Engl - published February 1, 2019
2. Marx A, Kropp H, Diederichs K
The structure of the Ctf19c/CCAN from budding yeast.
1. Elife - published February 1, 2019
2. Hinshaw SM, Harrison SC
Yeast Two-Hybrid Analysis for Ubiquitin-Variant Inhibitors of Human Deubiquitinases.
1. J Mol Biol - published February 1, 2019
2. Pascoe N, Seetharaman A, Teyra J, Manczyk N, Satori MA, Tjandra D, Makhnevych T, Schwerdtfeger C, Brasher BB, Moffat J, Costanzo M, Boone C, Sicheri F, Sidhu S
Improvement of antibody functionality by structure-guided paratope engraftment.
1. Nat Commun - published February 1, 2019
2. Liu Q, Lai YT, Zhang P, Louder MK, Pegu A, Rawi R, Asokan M, Chen X, Shen CH, Chuang GY, Yang ES, Miao H, Wang Y, Fauci AS, Kwong PD, Mascola JR, Lusso P
Phosphoregulated FMRP phase separation models activity-dependent translation through bidirectional control of mRNA granule formation.
1. Proc Natl Acad Sci U S A - published February 1, 2019
2. Tsang B, Arsenault J, Vernon RM, Lin H, Sonenberg N, Wang LY, Bah A, Forman-Kay JD
Cryo-EM structures of the DCPIB-inhibited volume-regulated anion channel LRRC8A in lipid nanodiscs.
1. Elife - published February 1, 2019
2. Kern DM, Oh S, Hite RK, Brohawn SG
Picornavirus infection induces temporal release of multiple extracellular vesicle subsets that differ in molecular composition and infectious potential.
1. PLoS Pathog - published February 1, 2019
2. van der Grein SG, Defourny KAY, Rabouw HH, Galiveti CR, Langereis MA, Wauben MHM, Arkesteijn GJA, van Kuppeveld FJM, Nolte-'t Hoen ENM
A dynamic view of the proteomic landscape during differentiation of ReNcell VM cells, an immortalized human neural progenitor line.
1. Sci Data - published February 1, 2019
2. Song Y, Subramanian K, Berberich MJ, Rodriguez S, Latorre IJ, Luria CM, Everley R, Albers MW, Mitchison TJ, Sorger PK
Automated evaluation of consistency within the PubChem Compound database.
1. Sci Data - published February 1, 2019
2. Dashti H, Wedell JR, Westler WM, Markley JL, Eghbalnia HR
Endopeptidase Regulation as a Novel Function of the Zur-Dependent Zinc Starvation Response.
1. mBio - published February 1, 2019
2. Murphy SG, Alvarez L, Adams MC, Liu S, Chappie JS, Cava F, Dörr T
RIG-I Selectively Discriminates against 5'-Monophosphate RNA.
1. Cell Rep - published February 1, 2019
2. Ren X, Linehan MM, Iwasaki A, Pyle AM
An Acinetobacter baumannii, Zinc-Regulated Peptidase Maintains Cell Wall Integrity during Immune-Mediated Nutrient Sequestration.
1. Cell Rep - published February 1, 2019
2. Lonergan ZR, Nairn BL, Wang J, Hsu YP, Hesse LE, Beavers WN, Chazin WJ, Trinidad JC, VanNieuwenhze MS, Giedroc DP, Skaar EP
NR4A Nuclear Receptors Target Poly-ADP-Ribosylated DNA-PKcs Protein to Promote DNA Repair.
1. Cell Rep - published February 1, 2019
2. Munnur D, Somers J, Skalka G, Weston R, Jukes-Jones R, Bhogadia M, Dominguez C, Cain K, Ahel I, Malewicz M
Decoding the 5' nucleotide bias of PIWI-interacting RNAs.
1. Nat Commun - published February 1, 2019
2. Stein CB, Genzor P, Mitra S, Elchert AR, Ipsaro JJ, Benner L, Sobti S, Su Y, Hammell M, Joshua-Tor L, Haase AD
Ephrin Receptor A4 is a New Kaposi's Sarcoma-Associated Herpesvirus Virus Entry Receptor.
1. MBio - published February 1, 2019
2. Chen J, Zhang X, Schaller S, Jardetzky TS, Longnecker R
Resolving indexing ambiguities in X-ray free-electron laser diffraction patterns.
1. Acta Crystallogr D Struct Biol - published February 1, 2019
2. Uervirojnangkoorn M, Lyubimov AY, Zhou Q, Weis WI, Brunger AT
Challenge data set for macromolecular multi-microcrystallography.
1. Acta Crystallogr D Struct Biol - published February 1, 2019
2. Holton JM
Neurexins - versatile molecular platforms in the synaptic cleft.
1. Curr Opin Struct Biol - published February 1, 2019
2. Rudenko G
The Detection of Bacteria and Matrix Proteins on Clinically Benign and Pathologic Implants.
1. Plast Reconstr Surg Glob Open - published February 1, 2019
2. Walker JN, Pinkner CL, Pinkner JS, Hultgren SJ, Myckatyn TM
Teneurins and latrophilins: two giants meet at the synapse.
1. Curr Opin Struct Biol - published February 1, 2019
2. Araç D, Li J
The pre-synaptic fusion machinery.
1. Curr Opin Struct Biol - published February 1, 2019
2. Brunger AT, Choi UB, Lai Y, Leitz J, White KI, Zhou Q
Editorial overview: Synapses: bridging the gap between their structure and function.
1. Curr Opin Struct Biol - published February 1, 2019
2. Rudenko G, Takahashi H