Member Publications

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95 Member Publications for November 2018

Conformational sampling of CpxA: Connecting HAMP motions to the histidine kinase function.
1. PLoS One - published November 30, 2018
2. Duclert-Savatier N, Bouvier G, Nilges M, Malliavin TE
Correction to: The Retrovirus Capsid Core.
1. Subcell Biochem - published November 30, 2018
2. Zhang W, Mendonça LM, Mansky LM
The Hypervariable Loops of Free TCRs Sample Multiple Distinct Metastable Conformations in Solution.
1. Front Mol Biosci - published November 29, 2018
2. Crooks JE, Boughter CT, Scott LR, Adams EJ
ProSave: an application for restoring quantitative data to manipulated subsets of protein lists.
1. Source Code Biol Med - published November 22, 2018
2. Machlab DA, Velez G, Bassuk AG, Mahajan VB
Characterization of Lhr-Core DNA helicase and manganese- dependent DNA nuclease components of a bacterial gene cluster encoding nucleic acid repair enzymes.
1. J Biol Chem - published November 9, 2018
2. Ejaz A, Shuman S
Structural basis for the second step of group II intron splicing.
1. Nat Commun - published November 8, 2018
2. Chan RT, Peters JK, Robart AR, Wiryaman T, Rajashankar KR, Toor N
Convergence of independent DISC1 mutations on impaired neurite growth via decreased UNC5D expression.
1. Transl Psychiatry - published November 8, 2018
2. Srikanth P, Lagomarsino VN, Pearse RV 2nd, Liao M, Ghosh S, Nehme R, Seyfried N, Eggan K, Young-Pearse TL
Biochemical Studies Provide Insights into the Necessity for MultipleArabidopsis thalianaProtein-Only RNase P Isoenzymes.
1. J Mol Biol - published November 8, 2018
2. Chen TH, Sotomayor M, Gopalan V
RNA Modifications: Reversal Mechanisms and Cancer.
1. Biochemistry - published November 7, 2018
2. Thapar R, Bacolla A, Oyeniran C, Brickner JR, Chinnam NB, Mosammaparast N, Tainer JA
Predicting CD4 T-cell epitopes based on antigen cleavage, MHCII presentation, and TCR recognition.
1. PLoS One - published November 7, 2018
2. Schneidman-Duhovny D, Khuri N, Dong GQ, Winter MB, Shifrut E, Friedman N, Craik CS, Pratt KP, Paz P, Aswad F, Sali A
Germline VRC01 antibody recognition of a modified clade C HIV-1 envelope trimer and a glycosylated HIV-1 gp120 core.
1. Elife - published November 7, 2018
2. Borst AJ, Weidle CE, Gray MD, Frenz B, Snijder J, Joyce MG, Georgiev IS, Stewart-Jones GB, Kwong PD, McGuire AT, DiMaio F, Stamatatos L, Pancera M, Veesler D
Subcellular Localization and Activity of the Mitogen-activated Protein Kinase Kinase 7 (MKK7) γ Isoform are Regulated through Binding to the Phosphatase Calcineurin.
1. Mol Pharmacol - published November 7, 2018
2. Gibson ES, Woolfrey KM, Li H, Hogan PG, Nemenoff RA, Heasley LE, Dell'Acqua ML
HIV-1 Protease Uses Bi-Specific S2/S2' Subsites to Optimize Cleavage of Two Classes of Target Sites.
1. J Mol Biol - published November 7, 2018
2. Potempa M, Lee SK, Kurt Yilmaz N, Nalivaika EA, Rogers A, Spielvogel E, Carter CW Jr, Schiffer CA, Swanstrom R
Isolation and Characterization of Nanobodies against a Zinc-Transporting P-Type ATPase.
1. Antibodies (Basel) - published November 7, 2018
2. Longhin E, Grønberg C, Hu Q, Duelli AS, Andersen KR, Laursen NS, Gourdon P
The N-Terminal GTPase Domain of p190RhoGAP Proteins Is a PseudoGTPase.
1. Structure - published November 6, 2018
2. Stiegler AL, Boggon TJ
Noncanonical role for the binding protein in substrate uptake by the MetNI methionine ATP Binding Cassette (ABC) transporter.
1. Proc Natl Acad Sci U S A - published November 6, 2018
2. Nguyen PT, Lai JY, Lee AT, Kaiser JT, Rees DC
The Cellular NMD Pathway Restricts Zika Virus Infection and Is Targeted by the Viral Capsid Protein.
1. mBio - published November 6, 2018
2. Fontaine KA, Leon KE, Khalid MM, Tomar S, Jimenez-Morales D, Dunlap M, Kaye JA, Shah PS, Finkbeiner S, Krogan NJ, Ott M
A Combination of Two Human Monoclonal Antibodies Prevents Zika Virus Escape Mutations in Non-human Primates.
1. Cell Rep - published November 6, 2018
2. Keeffe JR, Van Rompay KKA, Olsen PC, Wang Q, Gazumyan A, Azzopardi SA, Schaefer-Babajew D, Lee YE, Stuart JB, Singapuri A, Watanabe J, Usachenko J, Ardeshir A, Saeed M, Agudelo M, Eisenreich T, Bournazos S, Oliveira TY, Rice CM, Coffey LL, MacDonald MR, Bjorkman PJ, Nussenzweig MC, Robbiani DF
Pan-Filovirus Serum Neutralizing Antibodies in a Subset of Congolese Ebolavirus Infection Survivors.
1. J Infect Dis - published November 5, 2018
2. Bramble MS, Hoff N, Gilchuk P, Mukadi P, Lu K, Doshi RH, Steffen I, Nicholson BP, Lipson A, Vashist N, Sinai C, Spencer D, Olinger G, Wemakoy EO, Illunga BK, Pettitt J, Logue J, Marchand J, Varughese J, Bennett RS, Jahrling P, Cavet G, Serafini T, Ollmann Saphire E, Vilain E, Muyembe-Tamfum JJ, Hensely LE, Simmons G, Crowe JE Jr, Rimoin AW
Intracellular Delivery of Human Purine Nucleoside Phosphorylase by Engineered Diphtheria Toxin Rescues Function in Target Cells.
1. Mol Pharm - published November 5, 2018
2. Park M, Xu X, Min W, Sugiman-Marangos SN, Beilhartz GL, Adams JJ, Sidhu SS, Grunebaum E, Melnyk RA
An allosteric mechanism of inactivation in the calcium-dependent chloride channel BEST1.
1. J Gen Physiol - published November 5, 2018
2. Vaisey G, Long SB
Processing of N5-substituted formamidopyrimidine DNA adducts by DNA glycosylases NEIL1 and NEIL3.
1. DNA Repair (Amst) - published November 5, 2018
2. Minko IG, Christov PP, Li L, Stone MP, McCullough AK, Lloyd RS
Structural and mechanistic basis for preferential deadenylation of U6 snRNA by Usb1.
1. Nucleic Acids Res - published November 3, 2018
2. Nomura Y, Roston D, Montemayor EJ, Cui Q, Butcher SE
Distinguishing crystallographic from biological interfaces in protein complexes: role of intermolecular contacts and energetics for classification.
1. BMC Bioinformatics - published November 3, 2018
2. Elez K, Bonvin AMJJ, Vangone A
Force-dependent allostery of the α-catenin actin-binding domain controls adherens junction dynamics and functions.
1. Nat Commun - published November 3, 2018
2. Ishiyama N, Sarpal R, Wood MN, Barrick SK, Nishikawa T, Hayashi H, Kobb AB, Flozak AS, Yemelyanov A, Fernandez-Gonzalez R, Yonemura S, Leckband DE, Gottardi CJ, Tepass U, Ikura M
Plasma redox imbalance caused by albumin oxidation promotes lung-predominant NETosis and pulmonary cancer metastasis.
1. Nat Commun - published November 3, 2018
2. Inoue M, Nakashima R, Enomoto M, Koike Y, Zhao X, Yip K, Huang SH, Waldron JN, Ikura M, Liu FF, Bratman SV
Publisher Correction: Structural insights into binding specificity, efficacy and bias of a β2AR partial agonist.
1. Nat Chem Biol - published November 3, 2018
2. Masureel M, Zou Y, Picard LP, van der Westhuizen E, Mahoney JP, Rodrigues JPGLM, Mildorf TJ, Dror RO, Shaw DE, Bouvier M, Pardon E, Steyaert J, Sunahara RK, Weis WI, Zhang C, Kobilka BK
High resolution X-ray and NMR structural study of human T-cell immunoglobulin and mucin domain containing protein-3.
1. Sci Rep - published November 3, 2018
2. Gandhi AK, Kim WM, Sun ZJ, Huang YH, Bonsor DA, Sundberg EJ, Kondo Y, Wagner G, Kuchroo VK, Petsko G, Blumberg RS
Automated Text Message Reminders Improve Radiation Therapy Compliance.
1. Int J Radiat Oncol Biol Phys - published November 3, 2018
2. Tan J, Christie A, Montalvo SK, Wallace C, Yan Y, Folkerts M, Yingling A, Sher D, Choy H, Jiang S, Westover KD
Efficacy of Human Monoclonal Antibody Monotherapy Against Bundibugyo Virus Infection in Nonhuman Primates.
1. J Infect Dis - published November 2, 2018
2. Gilchuk P, Mire CE, Geisbert JB, Agans KN, Deer DJ, Cross RW, Slaughter JC, Flyak AI, Mani J, Pauly MH, Velasco J, Whaley KJ, Zeitlin L, Geisbert TW, Crowe JE Jr
Ebolavirus Chimerization for the Development of a Mouse Model for Screening of Bundibugyo-Specific Antibodies.
1. J Infect Dis - published November 2, 2018
2. Ilinykh PA, Graber J, Kuzmina NA, Huang K, Ksiazek TG, Crowe JE Jr, Bukreyev A
Who's In and Who's Out-Compositional Control of Biomolecular Condensates.
1. J Mol Biol - published November 2, 2018
2. Ditlev JA, Case LB, Rosen MK
Mechanistic insights into histone deposition and nucleosome assembly by the chromatin assembly factor-1.
1. Nucleic Acids Res - published November 2, 2018
2. Sauer PV, Gu Y, Liu WH, Mattiroli F, Panne D, Luger K, Churchill ME
CRISPro: An Automated Pipeline for Protein Conformation Stabilization by Proline.
1. J Chem Inf Model - published November 2, 2018
2. Rawi R, Shen CH, Kwong PD, Chuang GY
LCP1 preferentially binds clasped αMβ2 integrin and attenuates leukocyte adhesion under flow.
1. J Cell Sci - published November 2, 2018
2. Tseng HY, Samarelli AV, Kammerer P, Scholze S, Ziegler T, Immler R, Zent R, Sperandio M, Sanders CR, Fässler R, Böttcher RT
Two Mutations Commonly Associated with Daptomycin Resistance in Enterococcus faecium LiaST120A and LiaRW73C Appear To Function Epistatically in LiaFSR Signaling.
1. Biochemistry - published November 2, 2018
2. Davlieva M, Wu C, Zhou Y, Arias CA, Shamoo Y
Structure-based design of a quadrivalent fusion glycoprotein vaccine for human parainfluenza virus types 1-4.
1. Proc Natl Acad Sci U S A - published November 2, 2018
2. Stewart-Jones GBE, Chuang GY, Xu K, Zhou T, Acharya P, Tsybovsky Y, Ou L, Zhang B, Fernandez-Rodriguez B, Gilardi V, Silacci-Fregni C, Beltramello M, Baxa U, Druz A, Kong WP, Thomas PV, Yang Y, Foulds KE, Todd JP, Wei H, Salazar AM, Scorpio DG, Carragher B, Potter CS, Corti D, Mascola JR, Lanzavecchia A, Kwong PD
Role of humoral immunity against hepatitis B virus core antigen in the pathogenesis of acute liver failure.
1. Proc Natl Acad Sci U S A - published November 2, 2018
2. Chen Z, Diaz G, Pollicino T, Zhao H, Engle RE, Schuck P, Shen CH, Zamboni F, Long Z, Kabat J, De Battista D, Bock KW, Moore IN, Wollenberg K, Soto C, Govindarajan S, Kwong PD, Kleiner DE, Purcell RH, Farci P
Label-Free Electrophoretic Mobility Shift Assay (EMSA) for Measuring Dissociation Constants of Protein-RNA Complexes.
1. Curr Protoc Nucleic Acid Chem - published November 2, 2018
2. Seo M, Lei L, Egli M
Structural plasticity of D3-D14 ubiquitin ligase in strigolactone signalling.
1. Nature - published November 2, 2018
2. Shabek N, Ticchiarelli F, Mao H, Hinds TR, Leyser O, Zheng N
Cryo-EM structures of KdpFABC suggest a K⁺ transport mechanism via two inter-subunit half-channels.
1. Nat Commun - published November 2, 2018
2. Stock C, Hielkema L, Tascón I, Wunnicke D, Oostergetel GT, Azkargorta M, Paulino C, Hänelt I
Differential induction of interferon stimulated genes between type I and type III interferons is independent of interferon receptor abundance.
1. PLoS Pathog - published November 2, 2018
2. Pervolaraki K, Rastgou Talemi S, Albrecht D, Bormann F, Bamford C, Mendoza JL, Garcia KC, McLauchlan J, Höfer T, Stanifer ML, Boulant S
The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells.
1. Elife - published November 2, 2018
2. Fanning SW, Jeselsohn R, Dharmarajan V, Mayne CG, Karimi M, Buchwalter G, Houtman R, Toy W, Fowler CE, Han R, Lainé M, Carlson KE, Martin TA, Nowak J, Nwachukwu JC, Hosfield DJ, Chandarlapaty S, Tajkhorshid E, Nettles KW, Griffin PR, Shen Y, Katzenellenbogen JA, Brown M, Greene GL
Analysis of discrete local variability and structural covariance in macromolecular assemblies using Cryo-EM and focused classification.
1. Ultramicroscopy - published November 2, 2018
2. Zhang C, Cantara W, Jeon Y, Musier-Forsyth K, Grigorieff N, Lyumkis D
The CryoEM Method MicroED as a Powerful Tool for Small Molecule Structure Determination.
1. ACS Cent Sci - published November 2, 2018
2. Jones CG, Martynowycz MW, Hattne J, Fulton TJ, Stoltz BM, Rodriguez JA, Nelson HM, Gonen T
α_2A- and α_2C-Adrenoceptors as Potential Targets for Dopamine and Dopamine Receptor Ligands.
1. Mol Neurobiol - published November 1, 2018
2. Sánchez-Soto M, Casadó-Anguera V, Yano H, Bender BJ, Cai NS, Moreno E, Canela EI, Cortés A, Meiler J, Casadó V, Ferré S
Baicalein Targets GTPase-Mediated Autophagy to Eliminate Liver Tumor-Initiating Stem Cell-Like Cells Resistant to mTORC1 Inhibition.
1. Hepatology - published November 1, 2018
2. Wu R, Murali R, Kabe Y, French SW, Chiang YM, Liu S, Sher L, Wang CC, Louie S, Tsukamoto H
Structure of the monotopic membrane protein (S)-mandelate dehydrogenase at 2.2 Å resolution.
1. Biochimie - published November 1, 2018
2. Sukumar N, Liu S, Li W, Mathews FS, Mitra B, Kandavelu P
Rates of Bone Spicule Pigment Appearance in Patients With Retinitis Pigmentosa Sine Pigmento.
1. Am J Ophthalmol - published November 1, 2018
2. Takahashi VKL, Takiuti JT, Jauregui R, Mahajan VB, Tsang SH
Conformational plasticity of the response regulator CpxR, a key player in Gammaproteobacteria virulence and drug-resistance.
1. J Struct Biol - published November 1, 2018
2. Mechaly AE, Haouz A, Sassoon N, Buschiazzo A, Betton JM, Alzari PM
The Human Cytomegalovirus Trimer and Pentamer Promote Sequential Steps in Entry into Epithelial and Endothelial Cells at Cell Surfaces and Endosomes.
1. J Virol - published November 1, 2018
2. Liu J, Jardetzky TS, Chin AL, Johnson DC, Vanarsdall AL
Inhibition of K-RAS4B by a Unique Mechanism of Action: Stabilizing Membrane-Dependent Occlusion of the Effector-Binding Site.
1. Cell Chem Biol - published November 1, 2018
2. Fang Z, Marshall CB, Nishikawa T, Gossert AD, Jansen JM, Jahnke W, Ikura M
Interaction between smoking and ATG16L1T300A triggers Paneth cell defects in Crohn's disease.
1. J Clin Invest - published November 1, 2018
2. Liu TC, Kern JT, VanDussen KL, Xiong S, Kaiko GE, Wilen CB, Rajala MW, Caruso R, Holtzman MJ, Gao F, McGovern DP, Nunez G, Head RD, Stappenbeck TS
A new algorithm for high-resolution reconstruction of single particles by electron microscopy.
1. J Struct Biol - published November 1, 2018
2. Sorzano COS, Vargas J, de la Rosa-Trevín JM, Jiménez A, Maluenda D, Melero R, Martínez M, Ramírez-Aportela E, Conesa P, Vilas JL, Marabini R, Carazo JM
Inhibitors of the M2 Proton Channel Engage and Disrupt Transmembrane Networks of Hydrogen-Bonded Waters.
1. J Am Chem Soc - published November 1, 2018
2. Thomaston JL, Polizzi NF, Konstantinidi A, Wang J, Kolocouris A, DeGrado WF
Celastrol-Induced Weight Loss Is Driven by Hypophagia and Independent From UCP1.
1. Diabetes - published November 1, 2018
2. Pfuhlmann K, Schriever SC, Baumann P, Kabra DG, Harrison L, Mazibuko-Mbeje SE, Contreras RE, Kyriakou E, Simonds SE, Tiganis T, Cowley MA, Woods SC, Jastroch M, Clemmensen C, De Angelis M, Schramm KW, Sattler M, Messias AC, Tschöp MH, Pfluger PT
The comings and goings of PARP-1 in response to DNA damage.
1. DNA Repair (Amst) - published November 1, 2018
2. Pascal JM
Local and Global Dynamics in Intrinsically Disordered Synuclein.
1. Angew Chem Int Ed Engl - published November 1, 2018
2. Rezaei-Ghaleh N, Parigi G, Soranno A, Holla A, Becker S, Schuler B, Luchinat C, Zweckstetter M
Therapeutically Active RIG-I Agonist Induces Immunogenic Tumor Cell Killing in Breast Cancers.
1. Cancer Res - published November 1, 2018
2. Elion DL, Jacobson ME, Hicks DJ, Rahman B, Sanchez V, Gonzales-Ericsson PI, Fedorova O, Pyle AM, Wilson JT, Cook RS
Gain-of-function screen of α-transducin identifies an essential phenylalanine residue necessary for full effector activation.
1. J Biol Chem - published November 1, 2018
2. Milano SK, Wang C, Erickson JW, Cerione RA, Ramachandran S
Publisher Correction: Mycobacterium tuberculosis carrying a rifampicin drug resistance mutation reprograms macrophage metabolism through cell wall lipid changes.
1. Nat Microbiol - published November 1, 2018
2. Howard NC, Marin ND, Ahmed M, Rosa BA, Martin J, Bambouskova M, Sergushichev A, Loginicheva E, Kurepina N, Rangel-Moreno J, Chen L, Kreiswirth BN, Klein RS, Balada-Llasat JM, Torrelles JB, Amarasinghe GK, Mitreva M, Artyomov MN, Hsu FF, Mathema B, Khader SA
Structural insights into binding specificity, efficacy and bias of a β2AR partial agonist.
1. Nat Chem Biol - published November 1, 2018
2. Masureel M, Zou Y, Picard LP, van der Westhuizen E, Mahoney JP, Rodrigues JPGLM, Mildorf TJ, Dror RO, Shaw DE, Bouvier M, Pardon E, Steyaert J, Sunahara RK, Weis WI, Zhang C, Kobilka BK
Forecasting life expectancy, years of life lost, and all-cause and cause-specific mortality for 250 causes of death: reference and alternative scenarios for 2016-40 for 195 countries and territories.
1. Lancet - published November 1, 2018
2. Foreman KJ, Marquez N, Dolgert A, Fukutaki K, Fullman N, McGaughey M, Pletcher MA, Smith AE, Tang K, Yuan CW, Brown JC, Friedman J, He J, Heuton KR, Holmberg M, Patel DJ, Reidy P, Carter A, Cercy K, Chapin A, Douwes-Schultz D, Frank T, Goettsch F, Liu PY, Nandakumar V, Reitsma MB, Reuter V, Sadat N, Sorensen RJD, Srinivasan V, Updike RL, York H, Lopez AD, Lozano R, Lim SS, Mokdad AH, Vollset SE, Murray CJL
Selective Usage of Isozymes for Stress Response.
1. ACS Chem Biol - published November 1, 2018
2. Zhang Y, Lin Z, Wang M, Lin H
A C9orf72-CARM1 axis regulates lipid metabolism under glucose starvation-induced nutrient stress.
1. Genes Dev - published November 1, 2018
2. Liu Y, Wang T, Ji YJ, Johnson K, Liu H, Johnson K, Bailey S, Suk Y, Lu YN, Liu M, Wang J
A unique supramolecular organization of photosystem I in the moss Physcomitrella patens.
1. Nat Plants - published November 1, 2018
2. Iwai M, Grob P, Iavarone AT, Nogales E, Niyogi KK
Who mentors whom?
1. Mol Biol Cell - published November 1, 2018
2. Nogales E
Structural Control of Nonnative Ligand Binding in Engineered Mutants of Phosphoenolpyruvate Carboxykinase.
1. Biochemistry - published November 1, 2018
2. Tang HYH, Shin DS, Hura GL, Yang Y, Hu X, Lightstone FC, McGee MD, Padgett HS, Yannone SM, Tainer JA
Crystal structures and kinetics of N-acetylneuraminate lyase from Fusobacterium nucleatum.
1. Acta Crystallogr F Struct Biol Commun - published November 1, 2018
2. Kumar JP, Rao H, Nayak V, Ramaswamy S
Programmed Secretion Arrest and Receptor-Triggered Toxin Export during Antibacterial Contact-Dependent Growth Inhibition.
1. Cell - published November 1, 2018
2. Ruhe ZC, Subramanian P, Song K, Nguyen JY, Stevens TA, Low DA, Jensen GJ, Hayes CS
Crystal structure of native α-L-rhamnosidase from Aspergillus terreus.
1. Acta Crystallogr D Struct Biol - published November 1, 2018
2. Pachl P, Škerlová J, Šimčíková D, Kotik M, Křenková A, Mader P, Brynda J, Kapešová J, Křen V, Otwinowski Z, Řezáčová P
Competing protein-protein interactions regulate binding of Hsp27 to its client protein tau.
1. Nat Commun - published November 1, 2018
2. Freilich R, Betegon M, Tse E, Mok SA, Julien O, Agard DA, Southworth DR, Takeuchi K, Gestwicki JE
A Cancer Cell Program Promotes T Cell Exclusion and Resistance to Checkpoint Blockade.
1. Cell - published November 1, 2018
2. Jerby-Arnon L, Shah P, Cuoco MS, Rodman C, Su MJ, Melms JC, Leeson R, Kanodia A, Mei S, Lin JR, Wang S, Rabasha B, Liu D, Zhang G, Margolais C, Ashenberg O, Ott PA, Buchbinder EI, Haq R, Hodi FS, Boland GM, Sullivan RJ, Frederick DT, Miao B, Moll T, Flaherty KT, Herlyn M, Jenkins RW, Thummalapalli R, Kowalczyk MS, Cañadas I, Schilling B, Cartwright ANR, Luoma AM, Malu S, Hwu P, Bernatchez C, Forget MA, Barbie DA, Shalek AK, Tirosh I, Sorger PK, Wucherpfennig K, Van Allen EM, Schadendorf D, Johnson BE, Rotem A, Rozenblatt-Rosen O, Garraway LA, Yoon CH, Izar B, Regev A
HIV-1 envelope glycan modifications that permit neutralization by germline-reverted VRC01-class broadly neutralizing antibodies.
1. PLoS Pathog - published November 1, 2018
2. LaBranche CC, McGuire AT, Gray MD, Behrens S, Kwong PDK, Chen X, Zhou T, Sattentau QJ, Peacock J, Eaton A, Greene K, Gao H, Tang H, Perez LG, Chen X, Saunders KO, Kwong PD, Mascola JR, Haynes BF, Stamatatos L, Montefiori DC
Evidence that regulation of intramembrane proteolysis is mediated by substrate gating during sporulation in Bacillus subtilis.
1. PLoS Genet - published November 1, 2018
2. Ramírez-Guadiana FH, Rodrigues CDA, Marquis KA, Campo N, Barajas-Ornelas RDC, Brock K, Marks DS, Kruse AC, Rudner DZ
Histone Acetylation Inhibits RSC and Stabilizes the +1 Nucleosome.
1. Mol Cell - published November 1, 2018
2. Lorch Y, Maier-Davis B, Kornberg RD
Structural Basis for Cholesterol Transport-like Activity of the Hedgehog Receptor Patched.
1. Cell - published November 1, 2018
2. Zhang Y, Bulkley DP, Xin Y, Roberts KJ, Asarnow DE, Sharma A, Myers BR, Cho W, Cheng Y, Beachy PA
Structural basis of tubulin recruitment and assembly by microtubule polymerases with tumor overexpressed gene (TOG) domain arrays.
1. Elife - published November 1, 2018
2. Nithianantham S, Cook BD, Beans M, Guo F, Chang F, Al-Bassam J
Human adipose glycerol flux is regulated by a pH gate in AQP10.
1. Nat Commun - published November 1, 2018
2. Gotfryd K, Mósca AF, Missel JW, Truelsen SF, Wang K, Spulber M, Krabbe S, Hélix-Nielsen C, Laforenza U, Soveral G, Pedersen PA, Gourdon P
Crystallographic and kinetic analyses of human IPMK reveal disordered domains modulate ATP binding and kinase activity.
1. Sci Rep - published November 1, 2018
2. Seacrist CD, Blind RD
Class II MHC antigen processing in immune tolerance and inflammation.
1. Immunogenetics - published November 1, 2018
2. Jurewicz MM, Stern LJ
CENP-T bears the load in mitosis.
1. Nat Cell Biol - published November 1, 2018
2. Yang Y, Yu H
In Vivo Delivery of Synthetic Human DNA-Encoded Monoclonal Antibodies Protect against Ebolavirus Infection in a Mouse Model.
1. Cell Rep - published November 1, 2018
2. Patel A, Park DH, Davis CW, Smith TRF, Leung A, Tierney K, Bryan A, Davidson E, Yu X, Racine T, Reed C, Gorman ME, Wise MC, Elliott STC, Esquivel R, Yan J, Chen J, Muthumani K, Doranz BJ, Saphire EO, Crowe JE, Broderick KE, Kobinger GP, He S, Qiu X, Kobasa D, Humeau L, Sardesai NY, Ahmed R, Weiner DB
Trisomy of a Down Syndrome Critical Region Globally Amplifies Transcription via HMGN1 Overexpression.
1. Cell Rep - published November 1, 2018
2. Mowery CT, Reyes JM, Cabal-Hierro L, Higby KJ, Karlin KL, Wang JH, Kimmerling RJ, Cejas P, Lim K, Li H, Furusawa T, Long HW, Pellman D, Chapuy B, Bustin M, Manalis SR, Westbrook TF, Lin CY, Lane AA
Broadly Neutralizing Antibody Mediated Clearance of Human Hepatitis C Virus Infection.
1. Cell Host Microbe - published November 1, 2018
2. Kinchen VJ, Zahid MN, Flyak AI, Soliman MG, Learn GH, Wang S, Davidson E, Doranz BJ, Ray SC, Cox AL, Crowe JE Jr, Bjorkman PJ, Shaw GM, Bailey JR
HCV Broadly Neutralizing Antibodies Use a CDRH3 Disulfide Motif to Recognize an E2 Glycoprotein Site that Can Be Targeted for Vaccine Design.
1. Cell Host Microbe - published November 1, 2018
2. Flyak AI, Ruiz S, Colbert MD, Luong T, Crowe JE Jr, Bailey JR, Bjorkman PJ
Conformational Differences Between Functional Human Immunodeficiency Virus (HIV-1) Envelope Glycoprotein Trimers and Stabilized Soluble Trimers.
1. J Virol - published November 1, 2018
2. Castillo-Menendez LR, Nguyen HT, Sodroski J
Author Correction: Germline HAVCR2 mutations altering TIM-3 characterize subcutaneous panniculitis-like T cell lymphomas with hemophagocytic lymphohistiocytic syndrome.
1. Nat Genet - published November 1, 2018
2. Gayden T, Sepulveda FE, Khuong-Quang DA, Pratt J, Valera ET, Garrigue A, Kelso S, Sicheri F, Mikael LG, Hamel N, Bajic A, Dali R, Deshmukh S, Dervovic D, Schramek D, Guerin F, Taipale M, Nikbakht H, Majewski J, Moshous D, Charlebois J, Abish S, Bole-Feysot C, Nitschke P, Bader-Meunier B, Mitchell D, Thieblemont C, Battistella M, Gravel S, Nguyen VH, Conyers R, Diana JS, McCormack C, Prince HM, Besnard M, Blanche S, Ekert PG, Fraitag S, Foulkes WD, Fischer A, Neven B, Michonneau D, de Saint Basile G, Jabado N
Structural Basis of Membrane Protein Chaperoning through the Mitochondrial Intermembrane Space.
1. Cell - published November 1, 2018
2. Weinhäupl K, Lindau C, Hessel A, Wang Y, Schütze C, Jores T, Melchionda L, Schönfisch B, Kalbacher H, Bersch B, Rapaport D, Brennich M, Lindorff-Larsen K, Wiedemann N, Schanda P
IP6 Regulation of HIV Capsid Assembly, Stability, and Uncoating.
1. Viruses - published November 1, 2018
2. Dick RA, Mallery DL, Vogt VM, James LC
Does self-organized criticality drive leading edge protrusion?
1. Biophys Rev - published November 1, 2018
2. Anderson KL, Swift MF, Hanein D, Volkmann N
Actionable Activating Oncogenic ERBB2/HER2 Transmembrane and Juxtamembrane Domain Mutations.
1. Cancer Cell - published November 1, 2018
2. Pahuja KB, Nguyen TT, Jaiswal BS, Prabhash K, Thaker TM, Senger K, Chaudhuri S, Kljavin NM, Antony A, Phalke S, Kumar P, Mravic M, Stawiski EW, Vargas D, Durinck S, Gupta R, Khanna-Gupta A, Trabucco SE, Sokol ES, Hartmaier RJ, Singh A, Chougule A, Trivedi V, Dutt A, Patil V, Joshi A, Noronha V, Ziai J, Banavali SD, Ramprasad V, DeGrado WF, Bueno R, Jura N, Seshagiri S
Protective antibodies against Eastern equine encephalitis virus bind to epitopes in domains A and B of the E2 glycoprotein.
1. Nat Microbiol - published November 1, 2018
2. Kim AS, Austin SK, Gardner CL, Zuiani A, Reed DS, Trobaugh DW, Sun C, Basore K, Williamson LE, Crowe JE Jr, Slifka MK, Fremont DH, Klimstra WB, Diamond MS
Borylated reagents for multicomponent reactions.
1. Drug Discov Today Technol - published November 1, 2018
2. Tan J, Yudin AK
High-Throughput Functional Evaluation of KCNQ1 Decrypts Variants of Unknown Significance.
1. Circ Genom Precis Med - published November 1, 2018
2. Vanoye CG, Desai RR, Fabre KL, Gallagher SL, Potet F, DeKeyser JM, Macaya D, Meiler J, Sanders CR, George AL Jr